[POCKETOME]
 

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2896 entries [expand]
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1433C_TOBAC_1_252 [text] 14-3-3-like protein C [14-3-3 family]

volume: 699. Å3; shape: 0.75; buriedness: 0.6

negative: 0.08; positive: 0.19; polar: 0.15; backbone: 0.18; hydrophobic: 0.4

PDB: 1o9c, 1o9d, 1o9e, 1o9f, 2o98, 3e6y, 3m50, 3m51

HET: cw1, ebt, fsc, yr1

1433S_HUMAN_1_233 [text] 14-3-3 protein sigma [14-3-3 family]

volume: 1458. Å3; shape: 0.41; buriedness: 0.57

negative: 0.06; positive: 0.18; polar: 0.21; backbone: 0.21; hydrophobic: 0.35

PDB: 1ywt, 1yz5, 3iqj, 3iqu, 3iqv, 3lw1, 3mhr, 3o8i, 3p1n, 3p1o, 3p1p, 3p1q, 3p1r, 3p1s, 3smk, 3sml, 3smm, 3smn, 3smo, 3sp5, 3spr, 3t0l, 3t0m, 3u9x, 3ux0, 4dat, 4dau, 4dhm, 4dhn, 4dho, 4dhp, 4dhq, 4dhr, 4dhs, 4dht, 4dhu, 4fl5, 4fr3, 4hqw, 4hru, 4iea, 4jc3, 4jdd, 4qli, 4y32, 4y3b, 4y5i, 5btv, 5hf3

HET: 0dv, 0kb, 0kc, 0kg, 0kh, 0v4, 1ct, 2ct, 49f, 60h, ace, ca, cw7, cx7, fc7, fja, fsc, fw1, m1t, pip, plp, sep, tpo, y03, y04, y06, y07, y09

1433Z_HUMAN_1_244_pep [text] 14-3-3 protein zeta/delta [14-3-3 family]

volume: 2158. Å3; shape: 0.46; buriedness: 0.52

negative: 0.06; positive: 0.2; polar: 0.18; backbone: 0.2; hydrophobic: 0.36

PDB: 1a38, 1a4o, 1ib1, 1qja, 1qjb, 2c1j, 2c1n, 2o02, 2v7d, 2wh0, 3cu8, 3nkx, 3rdh, 4bg6, 4fj3, 4hkc, 4ihl, 4n7g, 4n7y, 4n84, 4wrq, 4zdr, 5d2d, 5d3f, 5ewz, 5exa, 5j31

HET: 1f5, 2jn, 3rd, 5so, aly, far, fsc, k, mg, mk8, mkd, p6g, pe4, sep, tpo, zs8

1A02_HUMAN_25_199_pep [text] HLA class I histocompatibility antigen, A-2 alpha chain [MHC class I family]

volume: 1787. Å3; shape: 0.66; buriedness: 0.72

negative: 0.06; positive: 0.13; polar: 0.38; backbone: 0.15; hydrophobic: 0.29

Domains/regions: [R] Alpha-1, [R] Alpha-2

PDB: 1akj, 1ao7, 1b0g, 1b0r, 1bd2, 1duy, 1duz, 1eey, 1eez, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hla, 1i1f, 1i1y, 1i4f, 1i7r, 1i7t, 1i7u, 1im3, 1jf1, 1jht, 1lp9, 1oga, 1p7q, 1qew, 1qr1, 1qrn, 1qse, 1qsf, 1s8d, 1s9w, 1s9x, 1s9y, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1tvb, 1tvh, 2av1, 2av7, 2bnq, 2bnr, 2c7u, 2clr, 2f53, 2f54, 2git, 2gj6, 2gt9, 2gtw, 2gtz, 2guo, 2j8u, 2jcc, 2p5e, 2p5w, 2pye, 2uwe, 2v2w, 2v2x, 2vlj, 2vlk, 2vll, 2vlr, 2x4n, 2x4o, 2x4p, 2x4q, 2x4r, 2x4s, 2x4t, 2x4u, 2x70, 3bgm, 3bh8, 3bh9, 3bhb, 3d25, 3d39, 3d3v, 3fqn, 3fqr, 3fqt, 3fqu, 3fqw, 3fqx, 3ft2, 3ft3, 3ft4, 3giv, 3gjf, 3gsn, 3gso, 3gsq, 3gsr, 3gsu, 3gsv, 3gsw, 3gsx, 3h7b, 3h9h, 3h9s, 3hae, 3hg1, 3hla, 3hpj, 3i6g, 3i6k, 3ixa, 3kla, 3mgo, 3mgt, 3mr9, 3mrb, 3mrc, 3mrd, 3mre, 3mrf, 3mrg, 3mrh, 3mri, 3mrj, 3mrk, 3mrl, 3mrm, 3mrn, 3mro, 3mrp, 3mrq, 3mrr, 3myj, 3o3a, 3o3b, 3o3d, 3o3e, 3o4l, 3ox8, 3oxr, 3oxs, 3pwj, 3pwl, 3pwn, 3pwp, 3qdg, 3qdj, 3qdm, 3qeq, 3qfd, 3qfj, 3rew, 3to2, 3utq, 3uts, 3utt, 3v5d, 3v5h, 3v5k, 4e5x, 4eup, 4ftv, 4gkn, 4gks, 4i4w, 4jfd, 4jfe, 4jff, 4jfo, 4jfp, 4jfq, 4k7f, 4l3e, 4mnq, 4nnx, 4nny, 4no0, 4no2, 4no3, 4no5, 4qok, 4u6x, 4u6y, 4uq3, 4wj5, 4wuu, 4zez, 5c07, 5c08, 5c09, 5c0a, 5c0b, 5c0c, 5c0d, 5c0e, 5c0f, 5c0g, 5c0h, 5c0i, 5c0j, 5d2n, 5d9s, 5ddh, 5e9d, 5enw, 5eu3, 5eu4, 5eu5, 5eu6, 5euo, 5hhm, 5hhn, 5hho, 5hhp, 5hhq, 5hyj, 5iro, 5swq

HET: 3ib, cde, grn, lph, mse, na, nva, prq, prv, prw, xfw, xy1

1A12_SOLLC_11_438 [text] 1-aminocyclopropane-1-carboxylate synthase 2 [Class-I pyridoxal-phosphate-dependent aminotransferase family]

volume: 109. Å3; shape: 0.63; buriedness: 0.56

negative: 0.; positive: 0.28; polar: 0.12; backbone: 0.24; hydrophobic: 0.36

PDB: 1iax, 1iay

HET: avg

1A1C_MALDO_2_433 [text] 1-aminocyclopropane-1-carboxylate synthase [Class-I pyridoxal-phosphate-dependent aminotransferase family]

volume: 402. Å3; shape: 0.63; buriedness: 0.92

negative: 0.05; positive: 0.18; polar: 0.38; backbone: 0.17; hydrophobic: 0.22

PDB: 1b8g, 1m4n, 1m7y, 1ynu, 3piu

HET: aad, mrd, plp, plr, ppg, py4

1A1D_CYBSA_1_341 [text] 1-aminocyclopropane-1-carboxylate deaminase [ACC deaminase/D-cysteine desulfhydrase family]

volume: 240. Å3; shape: 0.86; buriedness: 0.99

negative: 0.04; positive: 0.06; polar: 0.33; backbone: 0.51; hydrophobic: 0.05

PDB: 1f2d, 1j0c, 1j0d, 1j0e

HET: 1ac, 5pa, plp

1B57_HUMAN_25_300 [text] HLA class I histocompatibility antigen, B-57 alpha chain [MHC class I family]

volume: 1240. Å3; shape: 0.52; buriedness: 0.75

negative: 0.08; positive: 0.03; polar: 0.51; backbone: 0.1; hydrophobic: 0.28

Domains/regions: [R] Alpha-1, [R] Alpha-2

PDB: 2bvo, 2bvp, 2bvq, 2hjk, 2hjl, 2rfx, 2ypk, 2ypl, 3upr, 3vh8, 3vri, 3vrj, 3wuw, 3x11, 3x12, 5b38, 5b39

HET: 1kx

3HAO_CUPMC_1_172 [text] 3-hydroxyanthranilate 3,4-dioxygenase [3-HAO family]

volume: 118. Å3; shape: 0.68; buriedness: 0.92

negative: 0.24; positive: 0.46; polar: 0.; backbone: 0.; hydrophobic: 0.3

PDB: 1yfu, 1yfw, 1yfx, 1yfy, 4hsj, 4hsl, 4hvo, 4hvq, 4hvr, 4i3p, 4l2n, 4r52, 4wzc

HET: 1cw, 1uc, 3ha, 4aa, 6pc, sal

3MG2_ECOLI_1_282 [text] DNA-3-methyladenine glycosylase 2 [Alkylbase DNA glycosidase AlkA family]

volume: 335. Å3; shape: 0.56; buriedness: 0.41

negative: 0.08; positive: 0.; polar: 0.26; backbone: 0.46; hydrophobic: 0.2

PDB: 1diz, 1mpg, 1pvs, 3cvs, 3cvt, 3cw7, 3cwa, 3cws, 3cwt, 3cwu, 3d4v, 3ogd, 3oh6, 3oh9

HET: 7hp, 8og, nri

3SA3_NAJAT_22_81_SGC [text] Cytotoxin 3 [Snake three-finger toxin family. Short- chain subfamily. Type IA cytotoxin sub-subfamily]

volume: 2641. Å3; shape: 0.65; buriedness: 0.22

negative: 0.; positive: 0.19; polar: 0.1; backbone: 0.44; hydrophobic: 0.27

PDB: 1h0j, 1xt3, 2bhi

HET: c10, ids, sds, sft, sgn

4CL2_TOBAC_1_542 [text] 4-coumarate--CoA ligase 2 [ATP-dependent AMP-binding enzyme family]

volume: 360. Å3; shape: 0.92; buriedness: 0.97

negative: 0.04; positive: 0.13; polar: 0.22; backbone: 0.39; hydrophobic: 0.22

PDB: 5bsm, 5bsr, 5bst, 5bsu, 5bsv, 5bsw

HET: 4uu, 4uv, 4uw, amp, atp, mg

4OT_BACSU_2_62 [text] 2-hydroxymuconate tautomerase [4-oxalocrotonate tautomerase family]

volume: 120. Å3; shape: 0.58; buriedness: 0.68

negative: 0.; positive: 0.18; polar: 0.12; backbone: 0.35; hydrophobic: 0.35

Domains/regions: [R] Substrate binding

PDB: 2op8, 2opa

HET: fhc

5EAS_TOBAC_3_548 [text] 5-epi-aristolochene synthase [Terpene synthase family]

volume: 374. Å3; shape: 0.69; buriedness: 0.87

negative: 0.18; positive: 0.11; polar: 0.29; backbone: 0.13; hydrophobic: 0.3

PDB: 1hx9, 1hxa, 1hxc, 1hxg, 3lz9, 3m00, 3m01, 3m02, 4di5, 4rnq, 5dhi, 5dhk, 5eas, 5eat, 5eau, 5ik0, 5ik6, 5ik9, 5ika, 5ikh

HET: 1ga, 2cf, 6bw, a4s, cre, dpo, far, fff, fhp, fjp, fpf, fpp, mg

5HT1B_HUMAN_31_390 [text] 5-hydroxytryptamine receptor 1B [G-protein coupled receptor 1 family]

volume: 376. Å3; shape: 0.55; buriedness: 0.89

negative: 0.1; positive: 0.; polar: 0.12; backbone: 0.27; hydrophobic: 0.51

Domains/regions: [R] Agonist binding

PDB: 4iaq, 4iar

HET: 2gm, erm

5HT2B_HUMAN_33_405 [text] 5-hydroxytryptamine receptor 2B [G-protein coupled receptor 1 family]

volume: 418. Å3; shape: 0.65; buriedness: 0.93

negative: 0.04; positive: 0.02; polar: 0.17; backbone: 0.28; hydrophobic: 0.49

Domains/regions: [R] Agonist binding

PDB: 4ib4, 4nc3

HET: erm

5NTC_HUMAN_1_536 [text] Cytosolic purine 5'-nucleotidase [5'(3')-deoxyribonucleotidase family]

volume: 228. Å3; shape: 0.63; buriedness: 0.7

negative: 0.05; positive: 0.04; polar: 0.1; backbone: 0.46; hydrophobic: 0.36

PDB: 2j2c, 2jc9, 2jcm, 2xcv, 2xcw, 2xcx, 2xjb, 2xjc, 2xjd, 2xje, 2xjf, 4h4b, 5cqz, 5cr7, 5k7y, 5l4z, 5l50

HET: 5wo

5NTD_HUMAN_24_549 [text] 5'-nucleotidase [5'-nucleotidase family]

volume: 401. Å3; shape: 0.65; buriedness: 0.68

negative: 0.19; positive: 0.26; polar: 0.1; backbone: 0.27; hydrophobic: 0.17

Domains/regions: [R] Substrate binding

PDB: 4h1s, 4h1y, 4h2b, 4h2f, 4h2g, 4h2i

HET: 0xe, 0yq, a12, adn, zn

6PGD_ECOLI_1_468 [text] 6-phosphogluconate dehydrogenase, decarboxylating [6-phosphogluconate dehydrogenase family]

volume: 146. Å3; shape: 0.52; buriedness: 0.93

negative: 0.08; positive: 0.39; polar: 0.24; backbone: 0.14; hydrophobic: 0.14

Domains/regions: [R] Substrate binding

PDB: 2zya, 2zyd, 2zyg, 3fwn

HET: 6pg, glo

6PGD_HUMAN_1_476 [text] 6-phosphogluconate dehydrogenase, decarboxylating [6-phosphogluconate dehydrogenase family]

volume: 821. Å3; shape: 0.41; buriedness: 0.75

negative: 0.03; positive: 0.2; polar: 0.2; backbone: 0.4; hydrophobic: 0.17

Domains/regions: [R] Substrate binding

PDB: 1pgn, 1pgo, 1pgp, 1pgq, 2jkv, 2pgd, 4gwg, 4gwk

HET: 3pg, 6pg, nap, nbp, ndp

6PGD_LACLM_1_472 [text] 6-phosphogluconate dehydrogenase, decarboxylating [6-phosphogluconate dehydrogenase family]

volume: 143. Å3; shape: 0.52; buriedness: 0.72

negative: 0.14; positive: 0.45; polar: 0.41; backbone: 0.; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 2iyo, 2iyp, 2iz0, 2iz1

HET: 5rp, 6pg, res

7OMT8_MEDSA_1_352 [text] Isoflavone-7-O-methyltransferase 8 [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 196. Å3; shape: 0.42; buriedness: 0.9

negative: 0.; positive: 0.07; polar: 0.27; backbone: 0.27; hydrophobic: 0.4

Domains/regions: [R] Substrate binding

PDB: 1fp2, 1fpx

HET: hmo

8ODP_HUMAN_42_197 [text] 7,8-dihydro-8-oxoguanine triphosphatase [Nudix hydrolase family]

volume: 383. Å3; shape: 0.83; buriedness: 0.92

negative: 0.11; positive: 0.; polar: 0.11; backbone: 0.31; hydrophobic: 0.48

Domains/regions: [D] Nudix hydrolase, [R] Substrate binding

PDB: 3q93, 3whw, 3zr0, 3zr1, 4c9w, 4c9x, 4n1t, 4n1u, 5ans, 5ant, 5anu, 5anv, 5anw, 5fsi, 5fsk, 5fsl, 5fsm, 5fsn

HET: 2gd, 2ge, 58t, 6q3, 8dg, 8og, 9cq, h6y, n91, rgj, rje, rux, rx8, uan, vgh, vhs

A1AG2_HUMAN_18_201 [text] Alpha-1-acid glycoprotein 2 [Calycin superfamily. Lipocalin family]

volume: 250. Å3; shape: 0.89; buriedness: 0.92

negative: 0.08; positive: 0.11; polar: 0.12; backbone: 0.23; hydrophobic: 0.45

PDB: 3apu, 3apv, 3apw, 3apx

HET: dp0, pg4, tp0, z80

A1HB2_LOXIN_17_302 [text] Phospholipase D LiSicTox-alphaIA1bii [Arthropod phospholipase D family. Class II subfamily]

volume: 130. Å3; shape: 0.55; buriedness: 0.87

negative: 0.31; positive: 0.22; polar: 0.28; backbone: 0.; hydrophobic: 0.19

Domains/regions: [D] GDPD

PDB: 3rlg, 4rw3, 4rw5

HET: ipd, oca

AA2AR_HUMAN_1_315 [text] Adenosine receptor A2a [G-protein coupled receptor 1 family]

volume: 734. Å3; shape: 0.82; buriedness: 0.78

negative: 0.05; positive: 0.15; polar: 0.22; backbone: 0.11; hydrophobic: 0.48

Domains/regions: [R] Agonist binding

PDB: 2ydo, 2ydv, 3eml, 3pwh, 3qak, 3rey, 3uza, 3uzc, 3vg9, 3vga, 4eiy, 4ug2, 4uhr, 5g53, 5iu4, 5iu7, 5iu8, 5iua, 5iub, 5k2a, 5k2b, 5k2c, 5k2d

HET: 6dv, 6dx, 6dy, 6dz, adn, nec, ngi, ola, olc, t4e, t4g, uka, xac, zma

AAAA_PENCH_1_357 [text] Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form [Peptidase C45 family]

volume: 107. Å3; shape: 0.77; buriedness: 0.86

negative: 0.; positive: 0.11; polar: 0.11; backbone: 0.59; hydrophobic: 0.2

PDB: 2x1c, 2x1d, 2x1e

HET: x1e

AACL1_BRADU_2_326 [text] Amino acid--[acyl-carrier-protein] ligase 1 [Class-II aminoacyl-tRNA synthetase family. Amino acid--[acyl-carrier-protein] ligase subfamily]

volume: 736. Å3; shape: 0.35; buriedness: 0.79

negative: 0.09; positive: 0.17; polar: 0.16; backbone: 0.3; hydrophobic: 0.28

PDB: 3mey, 3mf1, 3mf2, 3pzc, 4h2s, 4h2t, 4h2u, 4h2v, 4h2w, 4h2x, 4h2y

HET: 5gp, amp, atp, coa, g5a, gap, h2v, mg, pns

AADAT_HUMAN_1_425 [text] Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [Class-I pyridoxal-phosphate-dependent aminotransferase family]

volume: 862. Å3; shape: 0.39; buriedness: 0.96

negative: 0.03; positive: 0.12; polar: 0.31; backbone: 0.25; hydrophobic: 0.29

PDB: 2qlr, 2r2n, 2vgz, 2xh1, 3dc1, 3ue8, 4gdy, 4ge4, 4ge7, 4ge9, 4geb, 5efs, 5eun, 5tf5

HET: 09m, 0k5, 0ke, 0l0, 0ld, 0x1, 7ar, bf5, kyn, plp, pmp

AAK1_HUMAN_28_358 [text] AP2-associated protein kinase 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 452. Å3; shape: 0.51; buriedness: 0.8

negative: 0.09; positive: 0.05; polar: 0.1; backbone: 0.33; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 4wsq, 5l4q, 5te0

HET: ksa, lkb, xin

AAKB1_HUMAN_70_159 [text] 5'-AMP-activated protein kinase subunit beta-1 [5'-AMP-activated protein kinase beta subunit family]

volume: 1377. Å3; shape: 0.8; buriedness: 0.34

negative: 0.07; positive: 0.1; polar: 0.32; backbone: 0.31; hydrophobic: 0.21

Domains/regions: [R] Glycogen-binding domain

PDB: 1z0m, 1z0n, 4cfe, 4qfg, 4qfr, 4yef, 4zhx, 5ezv, 5kq5

HET: 32j, 4cq, 6vt, 992, c1v

AAKG1_HUMAN_182_330 [text] 5'-AMP-activated protein kinase subunit gamma-1 [5'-AMP-activated protein kinase gamma subunit family]

volume: 337. Å3; shape: 0.53; buriedness: 0.83

negative: 0.06; positive: 0.16; polar: 0.24; backbone: 0.32; hydrophobic: 0.23

Domains/regions: [D] CBS 2, [D] CBS 3, [D] CBS 4

PDB: 2uv4, 2uv5, 2uv6, 2uv7, 2v8q, 2v92, 2v9j, 2y8l, 2y8q, 2ya3, 4cfe, 4cfh, 4eag, 4eai, 4eaj, 4eak, 4eal, 4qfg, 4qfr, 4zhx, 5ezv, 5kq5

HET: amp, amz, atp, c2z

AAKG1_HUMAN_5_182 [text] 5'-AMP-activated protein kinase subunit gamma-1 [5'-AMP-activated protein kinase gamma subunit family]

volume: 359. Å3; shape: 0.4; buriedness: 0.87

negative: 0.05; positive: 0.21; polar: 0.18; backbone: 0.34; hydrophobic: 0.22

Domains/regions: [D] CBS 1, [D] CBS 2, [D] CBS 3, [D] CBS 4

PDB: 4cfe, 4eag, 4eak, 4eal, 4qfg, 4qfr, 4zhx, 5ezv, 5kq5

HET: adp, amp, atp, c2z

AAPK1_HUMAN_15_295 [text] 5'-AMP-activated protein kinase catalytic subunit alpha-1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 357. Å3; shape: 0.65; buriedness: 0.53

negative: 0.1; positive: 0.25; polar: 0.08; backbone: 0.19; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 4cfh, 4qfg, 4qfr, 4red, 5kq5

HET: 32j, 6vt

AAPK2_HUMAN_2_280_ATPsite [text] 5'-AMP-activated protein kinase catalytic subunit alpha-2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 413. Å3; shape: 0.57; buriedness: 0.87

negative: 0.09; positive: 0.04; polar: 0.08; backbone: 0.42; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 2h6d, 2yza, 3aqv, 4cfe, 4zhx, 5ezv

HET: 4o7, stu, tak

AAPK2_HUMAN_2_280_beta [text] 5'-AMP-activated protein kinase catalytic subunit alpha-2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 289. Å3; shape: 0.48; buriedness: 0.54

negative: 0.12; positive: 0.19; polar: 0.12; backbone: 0.23; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 2h6d, 2yza, 3aqv, 4cfe, 4zhx, 5ezv

HET: 992, c1v

AATC_HUMAN_7_413 [text] Aspartate aminotransferase, cytoplasmic [Class-I pyridoxal-phosphate-dependent aminotransferase family]

volume: 244. Å3; shape: 0.85; buriedness: 0.98

negative: 0.08; positive: 0.17; polar: 0.31; backbone: 0.21; hydrophobic: 0.23

PDB: 1ajr, 1ajs, 3ii0, 3wzf

HET: pla, plp, tar

AAT_ECOLI_1_396 [text] Aspartate aminotransferase [Class-I pyridoxal-phosphate-dependent aminotransferase family]

volume: 295. Å3; shape: 0.87; buriedness: 0.96

negative: 0.05; positive: 0.19; polar: 0.35; backbone: 0.21; hydrophobic: 0.19

PDB: 1aam, 1aaw, 1ahe, 1ahf, 1ahg, 1ahx, 1ahy, 1aia, 1aib, 1aic, 1amq, 1amr, 1ams, 1arg, 1arh, 1ari, 1ars, 1art, 1asa, 1asb, 1asc, 1asd, 1ase, 1asf, 1asg, 1asl, 1asm, 1asn, 1b4x, 1bqa, 1bqd, 1c9c, 1cq6, 1cq7, 1cq8, 1czc, 1cze, 1g4v, 1g4x, 1g7w, 1g7x, 1ix6, 1ix7, 1ix8, 1qir, 1qis, 1qit, 1spa, 1toe, 1tog, 1toi, 1toj, 1tok, 1x28, 1x29, 1x2a, 1yoo, 2aat, 2d5y, 2d61, 2d63, 2d64, 2d65, 2d66, 2d7y, 2d7z, 2q7w, 2qa3, 2qb2, 2qb3, 2qbt, 3aat, 3pa9, 3paa, 3qn6, 3qpg, 3uak, 3zzj, 3zzk, 4a00, 4dbc, 4f5f, 4f5g, 4f5h, 4f5i, 4f5j, 4f5k, 4f5l, 4f5m, 5eaa

HET: 0a0, 3qp, hci, iop, iva, mae, mpl, nop, npl, pdg, pgu, pj7, pla, plp, pmg, pmp, pp3, ppd, psz, py4, py5, py6

AATM_CHICK_23_423 [text] Aspartate aminotransferase, mitochondrial [Class-I pyridoxal-phosphate-dependent aminotransferase family]

volume: 242. Å3; shape: 0.97; buriedness: 0.91

negative: 0.06; positive: 0.16; polar: 0.32; backbone: 0.18; hydrophobic: 0.28

PDB: 1aka, 1akb, 1akc, 1ama, 1ivr, 1map, 1maq, 1oxo, 1oxp, 1tar, 1tas, 1tat, 7aat, 8aat, 9aat

HET: cba, ik2, ket, pgu, pla, plp, pmp, ppd, ppe

AAUA_ALCFA_57_182 [text] Aralkylamine dehydrogenase light chain [Aromatic amine dehydrogenase light chain family]

volume: 141. Å3; shape: 0.62; buriedness: 1.

negative: 0.13; positive: 0.; polar: 0.17; backbone: 0.45; hydrophobic: 0.25

Multimer with: Aralkylamine dehydrogenase heavy chain (AAUB_ALCFA) [Aromatic amine dehydrogenase heavy chain family]
Domains/regions (AAUA): [R] Substrate-binding

PDB: 2agl, 2agw, 2agx, 2agy, 2agz, 2ah0, 2ah1, 2h3x, 2h47, 2hj4, 2hjb, 2hkm, 2hkr, 2hxc, 2i0r, 2i0s, 2i0t, 2iaa, 2iup, 2iuq, 2iur, 2iuv, 2oiz, 2ojy, 2ok4, 2ok6, 2q7q

HET: abn, bez, c2b, hy1, pea, pel, phz, pnz, pzm, tsc, tsh, tsr, tss, zhh, zhz

AAUB_ALCFA_30_390 [text] Aralkylamine dehydrogenase heavy chain [Aromatic amine dehydrogenase heavy chain family]

volume: 138. Å3; shape: 0.63; buriedness: 1.

negative: 0.13; positive: 0.; polar: 0.14; backbone: 0.47; hydrophobic: 0.26

Multimer with: Aralkylamine dehydrogenase light chain (AAUA_ALCFA) [Aromatic amine dehydrogenase light chain family]
Domains/regions (AAUA): [R] Substrate-binding

PDB: 2agl, 2agw, 2agx, 2agy, 2agz, 2ah0, 2ah1, 2h3x, 2h47, 2hj4, 2hjb, 2hkm, 2hkr, 2hxc, 2i0r, 2i0s, 2i0t, 2iaa, 2iup, 2iuq, 2iur, 2iuv, 2oiz, 2ojy, 2ok4, 2ok6, 2q7q

HET: abn, bez, c2b, hy1, pea, pel, phz, pnz, pzm, tsc, tsh, tsr, tss, zhh, zhz

ABC3G_HUMAN_191_383 [text] DNA dC->dU-editing enzyme APOBEC-3G [Cytidine and deoxycytidylate deaminase family]

volume: 109. Å3; shape: 0.66; buriedness: 0.62

negative: 0.; positive: 0.55; polar: 0.14; backbone: 0.; hydrophobic: 0.31

Domains/regions: [D] CMP/dCMP-type deaminase 2, [R] Necessary for homooligomerization

PDB: 3e1u, 3iqs, 3ir2, 3v4j, 3v4k, 4rov, 4row

HET: pqr

ABCBA_HUMAN_151_738 [text] ATP-binding cassette sub-family B member 10, mitochondrial [ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily]

volume: 454. Å3; shape: 0.32; buriedness: 0.48

negative: 0.; positive: 0.27; polar: 0.38; backbone: 0.; hydrophobic: 0.35

Domains/regions: [D] ABC transmembrane type-1

PDB: 3zdq, 4ayt, 4ayw, 4ayx

HET: lmt

ABL1_HUMAN_228_509_allosteric [text] Tyrosine-protein kinase ABL1 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

volume: 438. Å3; shape: 0.63; buriedness: 0.74

negative: 0.03; positive: 0.; polar: 0.07; backbone: 0.41; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 1fpu, 1iep, 1m52, 1opj, 1opk, 1opl, 2e2b, 2f4j, 2fo0, 2g1t, 2g2f, 2g2h, 2g2i, 2gqg, 2hiw, 2hyy, 2hz0, 2hz4, 2hzi, 2hzn, 2qoh, 2v7a, 2z60, 3cs9, 3dk3, 3dk6, 3dk7, 3ik3, 3k5v, 3kf4, 3kfa, 3ms9, 3mss, 3oxz, 3oy3, 3pyy, 3qri, 3qrj, 3qrk, 3ue4, 4twp, 4wa9, 4xey, 4yc8, 4zog, 5hu9

HET: 3yy, ms7, ms9, myr, stj

ABL1_HUMAN_228_509_ATPsite [text] Tyrosine-protein kinase ABL1 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

volume: 777. Å3; shape: 0.35; buriedness: 0.88

negative: 0.05; positive: 0.05; polar: 0.06; backbone: 0.47; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 1fpu, 1iep, 1m52, 1opj, 1opk, 1opl, 2e2b, 2f4j, 2fo0, 2g1t, 2g2f, 2g2h, 2g2i, 2gqg, 2hiw, 2hyy, 2hz0, 2hz4, 2hzi, 2hzn, 2qoh, 2v7a, 2z60, 3cs9, 3dk3, 3dk6, 3dk7, 3ik3, 3k5v, 3kf4, 3kfa, 3ms9, 3mss, 3oxz, 3oy3, 3pyy, 3qri, 3qrj, 3qrk, 3ue4, 4twp, 4wa9, 4xey, 4yc8, 4zog, 5hu9

HET: 0li, 112, 1n1, 406, 4b7, 4st, 627, 66k, 7mp, 919, 9dp, adp, ags, axi, b90, b91, db8, gin, jin, kin, mg, nil, p16, p17, p3y, prc, sti, sx7, vx6, xy3

ABL1_HUMAN_61_120_SH3 [text] Tyrosine-protein kinase ABL1 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

volume: 912. Å3; shape: 0.39; buriedness: 0.39

negative: 0.12; positive: 0.; polar: 0.42; backbone: 0.13; hydrophobic: 0.33

Domains/regions: [D] SH3

PDB: 1abo, 1abq, 1bbz, 1opk, 1opl, 2abl, 2fo0, 2o88, 3eg0, 3eg1, 3eg2, 3eg3, 3egu, 4j9b, 4j9c, 4j9d, 4j9e, 4j9f, 4j9g, 4j9h, 4j9i, 4jjb, 4jjc, 4jjd

HET: ace

ABL2_HUMAN_274_551 [text] Abelson tyrosine-protein kinase 2 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

volume: 614. Å3; shape: 0.35; buriedness: 0.78

negative: 0.05; positive: 0.03; polar: 0.12; backbone: 0.49; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 2xyn, 3gvu, 3hmi, 4xli

HET: 1n1, dki, sti, vx6

ABP1_MAIZE_39_201 [text] Auxin-binding protein 1

volume: 134. Å3; shape: 0.69; buriedness: 0.98

negative: 0.09; positive: 0.14; polar: 0.18; backbone: 0.05; hydrophobic: 0.55

Domains/regions: [R] Auxin binding

PDB: 1lr5, 1lrh

HET: nla

ACACB_HUMAN_1692_2449 [text] Acetyl-CoA carboxylase 2

volume: 358. Å3; shape: 0.55; buriedness: 0.81

negative: 0.17; positive: 0.02; polar: 0.08; backbone: 0.43; hydrophobic: 0.3

Domains/regions: [D] CoA carboxyltransferase C-terminal, [D] CoA carboxyltransferase N-terminal, [R] Carboxyltransferase

PDB: 3ff6, 3tdc

HET: 0eu, rcp

ACACB_HUMAN_228_767 [text] Acetyl-CoA carboxylase 2

volume: 462. Å3; shape: 0.9; buriedness: 0.82

negative: 0.05; positive: 0.13; polar: 0.09; backbone: 0.36; hydrophobic: 0.37

Domains/regions: [D] ATP-grasp, [D] Biotin carboxylation

PDB: 2hjw, 3gid, 3glk, 3jrw, 3jrx, 4hq6, 5kkn

HET: 6u3, s1a

ACAC_YEAST_1477_2229_ACoA [text] Acetyl-CoA carboxylase

volume: 840. Å3; shape: 0.36; buriedness: 0.89

negative: 0.; positive: 0.06; polar: 0.1; backbone: 0.43; hydrophobic: 0.41

Domains/regions: [D] CoA carboxyltransferase C-terminal, [D] CoA carboxyltransferase N-terminal, [R] Acetyl-CoA binding, [R] Carboxyltransferase

PDB: 1od2, 1od4, 1uyr, 1uys, 1uyt, 1uyv, 1w2x, 3h0j, 3h0q, 3h0s, 3k8x, 3pgq, 3tv5, 3tvu, 3tvw, 3tz3, 4wyo, 4wz8, 5csk, 5csl, 5ctb, 5ctc, 5cte

HET: aco, ade, b89, coa, d1l, gy3, h1l

ACAC_YEAST_1477_2229_inhibitor [text] Acetyl-CoA carboxylase

volume: 428. Å3; shape: 0.52; buriedness: 0.85

negative: 0.08; positive: 0.1; polar: 0.13; backbone: 0.45; hydrophobic: 0.24

Domains/regions: [D] CoA carboxyltransferase C-terminal, [D] CoA carboxyltransferase N-terminal, [R] Carboxyltransferase

PDB: 1od2, 1od4, 1uyr, 1uys, 1uyt, 1uyv, 1w2x, 3h0j, 3h0q, 3h0s, 3k8x, 3pgq, 3tv5, 3tvu, 3tvw, 3tz3, 4wyo, 4wz8, 5csk, 5csl, 5ctb, 5ctc, 5cte

HET: 07h, 3w2, 3w7, 57j, 57k, 57l, b36, b37, b38, bti, rcp

ACAC_YEAST_18_567 [text] Acetyl-CoA carboxylase

volume: 366. Å3; shape: 0.84; buriedness: 0.77

negative: 0.07; positive: 0.17; polar: 0.15; backbone: 0.29; hydrophobic: 0.32

Domains/regions: [D] ATP-grasp, [D] Biotin carboxylation

PDB: 1w93, 1w96, 5csk, 5csl

HET: s1a

ACCC_ECOLI_1_449_catalytic [text] Biotin carboxylase

volume: 296. Å3; shape: 0.85; buriedness: 0.79

negative: 0.16; positive: 0.24; polar: 0.16; backbone: 0.28; hydrophobic: 0.16

Domains/regions: [D] ATP-grasp, [D] Biotin carboxylation

PDB: 1bnc, 1dv1, 1dv2, 2gps, 2gpw, 2j9g, 2v58, 2v59, 2v5a, 2vr1, 2w6m, 2w6n, 2w6o, 2w6p, 2w6q, 2w6z, 2w70, 2w71, 3g8c, 3g8d, 3jzf, 3jzi, 3rup, 3rv3, 3rv4, 4hr7

HET: adp, btn

ACCC_HAEIN_2_448 [text] Biotin carboxylase

volume: 159. Å3; shape: 0.39; buriedness: 0.79

negative: 0.15; positive: 0.28; polar: 0.27; backbone: 0.15; hydrophobic: 0.15

Domains/regions: [D] ATP-grasp, [D] Biotin carboxylation

PDB: 4mv1, 4mv3, 4mv4, 4mv6, 4mv7, 4mv8, 4mv9, 4rzq

HET: pct, ppf, y7y

ACCD_STAA8_1_285 [text] Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta [AccD/PCCB family]

volume: 361. Å3; shape: 0.68; buriedness: 0.78

negative: 0.; positive: 0.; polar: 0.12; backbone: 0.56; hydrophobic: 0.32

Multimer with: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (ACCA_STAA8) [AccA family]
Domains/regions (ACCD): [D] CoA carboxyltransferase N-terminal
Domains/regions (ACCA): [D] CoA carboxyltransferase C-terminal

PDB: 2f9i, 5kdr

HET: yt5

ACE2_HUMAN_18_615 [text] Angiotensin-converting enzyme 2 [Peptidase M2 family]

volume: 311. Å3; shape: 0.57; buriedness: 0.78

negative: 0.39; positive: 0.27; polar: 0.33; backbone: 0.; hydrophobic: 0.

PDB: 1r42, 1r4l, 2ajf, 3d0g, 3d0h, 3d0i, 3kbh, 3sci, 3scj, 3sck, 3scl

HET: xx5, zn

ACE_DROME_16_614 [text] Angiotensin-converting enzyme [Peptidase M2 family]

volume: 591. Å3; shape: 0.51; buriedness: 0.78

negative: 0.13; positive: 0.26; polar: 0.26; backbone: 0.13; hydrophobic: 0.22

PDB: 1j36, 1j37, 1j38, 2x8y, 2x8z, 2x90, 2x91, 2x92, 2x93, 2x94, 2x95, 2x96, 2x97, 2xhm, 3zqz, 4aa1, 4aa2, 4asq, 4asr, 4ca7, 4ca8, 5a2r

HET: 3ef, 3es, eal, k26, lpr, mlt, rx3, rx4, slc, x8z, x92, x93, x94, x95

ACE_HUMAN_30_649 [text] Angiotensin-converting enzyme [Peptidase M2 family]

volume: 643. Å3; shape: 0.5; buriedness: 0.77

negative: 0.09; positive: 0.27; polar: 0.32; backbone: 0.13; hydrophobic: 0.18

Domains/regions: [R] Peptidase M2 1

PDB: 2c6f, 2c6n, 2xyd, 3nxq, 4bxk, 4bzs, 4ca6, 4ufa, 4ufb, 5am8, 5am9, 5ama, 5amb, 5amc

HET: 1iu, 3ef, 3es, 9x6, k26, lpr, niy, p6g, rx4, sac

ACE_HUMAN_649_1230 [text] Angiotensin-converting enzyme [Peptidase M2 family]

volume: 901. Å3; shape: 0.38; buriedness: 0.79

negative: 0.13; positive: 0.21; polar: 0.2; backbone: 0.14; hydrophobic: 0.31

Domains/regions: [R] Peptidase M2 2

PDB: 1o86, 1o8a, 1uze, 1uzf, 2iul, 2iux, 2oc2, 2xy9, 2ydm, 3bkk, 3bkl, 3l3n, 4aph, 4apj, 4bzr, 4c2n, 4c2o, 4c2p, 4c2q, 4c2r, 4ca5

HET: 3ef, 3es, eal, k26, kaf, kaw, lpr, lsw, mco, nxa, pca, rx3, slc, x8z

ACES_DROME_39_623 [text] Acetylcholinesterase [Type-B carboxylesterase/lipase family]

volume: 211. Å3; shape: 0.82; buriedness: 0.94

negative: 0.11; positive: 0.04; polar: 0.26; backbone: 0.26; hydrophobic: 0.33

PDB: 1dx4, 1qo9, 1qon

HET: 760, i40

ACES_HUMAN_33_574 [text] Acetylcholinesterase [Type-B carboxylesterase/lipase family]

volume: 753. Å3; shape: 0.48; buriedness: 0.91

negative: 0.08; positive: 0.04; polar: 0.25; backbone: 0.36; hydrophobic: 0.28

Domains/regions: [R] Galanthamine binding

PDB: 1b41, 1f8u, 2x8b, 3lii, 4bdt, 4ey4, 4ey5, 4ey6, 4ey7, 4ey8, 4m0e, 4m0f, 4pqe, 5fpq, 5hf5, 5hf6, 5hf8, 5hf9, 5hfa, 5hq3

HET: 1yk, 1yl, dep, e20, efs, fp1, gnt, hi6, hup, huw, vx

ACES_MOUSE_32_575 [text] Acetylcholinesterase [Type-B carboxylesterase/lipase family]

volume: 896. Å3; shape: 0.43; buriedness: 0.85

negative: 0.07; positive: 0.04; polar: 0.25; backbone: 0.42; hydrophobic: 0.21

PDB: 1j06, 1j07, 1ku6, 1maa, 1mah, 1n5m, 1n5r, 1q83, 1q84, 2c0p, 2c0q, 2gyu, 2gyv, 2gyw, 2h9y, 2ha0, 2ha2, 2ha3, 2ha4, 2ha5, 2ha6, 2ha7, 2jey, 2jez, 2jf0, 2jge, 2jgf, 2jgi, 2jgj, 2jgk, 2jgl, 2jgm, 2whp, 2whq, 2whr, 2wls, 2wu3, 2wu4, 2xud, 2xuf, 2xug, 2xuh, 2xui, 2xuj, 2xuk, 2xuo, 2xup, 2xuq, 2y2u, 2y2v, 3dl4, 3dl7, 3zlt, 3zlu, 3zlv, 4a16, 4a23, 4ara, 4arb, 4b7z, 4b80, 4b81, 4b82, 4b83, 4b84, 4b85, 4bc0, 4bc1, 4btl, 5dti, 5dtj, 5ehn, 5ehq, 5ehz, 5eia, 5eie, 5eih, 5fkj, 5foq, 5fpp, 5fum, 5hcu

HET: 1ka, 4oj, 5g8, 5gz, 5nz, 5o2, a36, ach, ae3, at3, atj, b3v, b3w, b3z, bch, bua, c56, c57, chh, cht, dcu, dme, etm, g0w, gc8, gmn, h34, hbp, hi6, hlo, k27, me2, naf, ntj, nwa, obi, pe3, pg0, pg4, pge, prm, pz5, q4q, sck, scu, sof, tqv, tz2, tz4, tz5, x13, z5k, zn4

ACES_TETCF_22_559 [text] Acetylcholinesterase [Type-B carboxylesterase/lipase family]

volume: 798. Å3; shape: 0.49; buriedness: 0.82

negative: 0.06; positive: 0.04; polar: 0.23; backbone: 0.29; hydrophobic: 0.38

PDB: 1acj, 1acl, 1amn, 1ax9, 1cfj, 1dx6, 1e3q, 1e66, 1ea5, 1eve, 1fss, 1gpk, 1gpn, 1gqr, 1gqs, 1h22, 1h23, 1hbj, 1jjb, 1oce, 1odc, 1qid, 1qie, 1qif, 1qig, 1qih, 1qii, 1qij, 1qik, 1qim, 1qti, 1som, 1u65, 1ut6, 1vot, 1vxo, 1vxr, 1w4l, 1w6r, 1w75, 1w76, 1zgb, 1zgc, 2ace, 2ack, 2bag, 2c4h, 2c58, 2c5f, 2c5g, 2cek, 2ckm, 2cmf, 2dfp, 2j3d, 2j3q, 2j4f, 2v96, 2v97, 2v98, 2va9, 2vja, 2vjb, 2vjc, 2vjd, 2vq6, 2vt6, 2vt7, 2w6c, 2wfz, 2wg0, 2wg1, 2wg2, 2xi4, 3gel, 3i6m, 3i6z, 3m3d, 3zv7, 4tvk, 4w63, 4x3c, 5bwb, 5bwc, 5dlp, 5e2i, 5e4j, 5e4t, 5ehx, 5ei5

HET: 03s, 1pe, 4vv, a1e, a2e, a8b, a8n, aa7, ae4, aft, at3, bm4, ccd, chh, cp0, dme, e10, e12, e20, ebw, edr, emm, etm, f11, fbq, fp1, g3x, g6x, gb, gd8, gl8, gnt, gsg, hbp, htb, hub, hup, hux, mbt, mf2, n8t, naf, nhg, nwa, pe7, pg4, pge, saf, tfl, tha, tjh, tnh, vx

ACFR2_ARATH_1_230 [text] Probable transmembrane ascorbate ferrireductase 2

volume: 100. Å3; shape: 0.69; buriedness: 0.64

negative: 0.; positive: 0.33; polar: 0.22; backbone: 0.22; hydrophobic: 0.22

Domains/regions: [D] Cytochrome b561

PDB: 4o6y, 4o79, 4o7g

HET: asc

ACHA2_HUMAN_59_265 [text] Neuronal acetylcholine receptor subunit alpha-2 [Ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 2/CHRNA2 sub-subfamily]

volume: 127. Å3; shape: 0.52; buriedness: 0.99

negative: 0.; positive: 0.; polar: 0.36; backbone: 0.31; hydrophobic: 0.33

PDB: 5fjv

HET: epj

ACHA9_HUMAN_26_237 [text] Neuronal acetylcholine receptor subunit alpha-9 [Ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 9/CHRNA9 sub-subfamily]

volume: 504. Å3; shape: 0.73; buriedness: 0.43

negative: 0.; positive: 0.; polar: 0.3; backbone: 0.42; hydrophobic: 0.27

PDB: 4d01, 4uxu, 4uy2

HET: mlk

ACHP_LYMST_16_229 [text] Acetylcholine-binding protein

volume: 419. Å3; shape: 0.55; buriedness: 0.97

negative: 0.; positive: 0.05; polar: 0.21; backbone: 0.46; hydrophobic: 0.28

Domains/regions: [D] Ig-like

PDB: 1i9b, 1uv6, 1uw6, 1ux2, 2zju, 2zjv, 3u8j, 3u8k, 3u8l, 3u8m, 3u8n, 3wip, 3wth, 3wti, 3wtj, 3wtk, 3wtl, 3wtm, 3wtn, 3wto, 3zdg, 3zdh, 4alx, 4nzb, 4qaa, 4qab, 4qac, 4um1, 4zjt, 4zk1, 4zr6, 4zru, 5bp0

HET: 09o, 09p, 09q, 09r, 09s, 1pe, 4p6, 4p7, 4qw, ach, cce, ct4, fn1, im4, izn, kk1, kk2, kk3, mg, n1y, n2y, nct, nse, th4, ti9, xrs, xrx

ACK1_HUMAN_113_392 [text] Activated CDC42 kinase 1 [Protein kinase superfamily. Tyr protein kinase family]

volume: 624. Å3; shape: 0.58; buriedness: 0.74

negative: 0.07; positive: 0.04; polar: 0.07; backbone: 0.44; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 1u46, 1u4d, 1u54, 3eqp, 3eqr, 4ewh, 4hzr, 4hzs, 4id7

HET: 1g0, acp, dbq, mg, t74, t77, t95

ACM1_HUMAN_1_460 [text] Muscarinic acetylcholine receptor M1 [G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily]

volume: 217. Å3; shape: 0.7; buriedness: 0.99

negative: 0.07; positive: 0.; polar: 0.53; backbone: 0.13; hydrophobic: 0.27

PDB: 5cxv

HET: 0hk

ACM2_HUMAN_1_466_TM [text] Muscarinic acetylcholine receptor M2 [G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily]

volume: 220. Å3; shape: 0.77; buriedness: 0.99

negative: 0.06; positive: 0.; polar: 0.36; backbone: 0.18; hydrophobic: 0.39

Domains/regions: [R] Agonist binding

PDB: 3uon, 4mqs

HET: ixo, qnb

ACM3_HUMAN_57_580 [text] Muscarinic acetylcholine receptor M3 [G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily]

volume: 238. Å3; shape: 0.75; buriedness: 0.99

negative: 0.07; positive: 0.; polar: 0.47; backbone: 0.1; hydrophobic: 0.36

Domains/regions: [R] Agonist binding

PDB: 4daj, 4u15

HET: 0hk

ACM4_HUMAN_20_479 [text] Muscarinic acetylcholine receptor M4 [G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily]

volume: 216. Å3; shape: 0.7; buriedness: 0.99

negative: 0.; positive: 0.; polar: 0.48; backbone: 0.16; hydrophobic: 0.35

PDB: 5dsg

HET: 0hk

ACMSD_HUMAN_1_333 [text] 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [ACMSD family]

volume: 121. Å3; shape: 0.65; buriedness: 0.95

negative: 0.1; positive: 0.27; polar: 0.; backbone: 0.09; hydrophobic: 0.54

PDB: 2wm1, 4igm, 4ign, 4ih3, 4ofc

HET: 13p, pdc

ACON_BOVIN_28_780 [text] Aconitate hydratase, mitochondrial [Aconitase/IPM isomerase family]

volume: 118. Å3; shape: 0.82; buriedness: 0.96

negative: 0.06; positive: 0.28; polar: 0.29; backbone: 0.24; hydrophobic: 0.13

Domains/regions: [R] Substrate binding

PDB: 1aco, 1ami, 1amj, 1b0j, 1b0k, 1b0m, 1c96, 1c97, 1fgh, 1nis, 1nit, 5acn, 6acn, 7acn, 8acn

HET: ath, ict, mic, nic, ntc, tra

ACOX_SYNY3_1_490 [text] Apocarotenoid-15,15'-oxygenase [Carotenoid oxygenase family]

volume: 476. Å3; shape: 0.37; buriedness: 0.8

negative: 0.14; positive: 0.15; polar: 0.15; backbone: 0.07; hydrophobic: 0.49

PDB: 2biw, 2bix, 4ou8, 4ou9, 5kja, 5kjb, 5kjd, 5kk0

HET: 3on, c8e

ACP1_SPIOL_57_138 [text] Acyl carrier protein 1, chloroplastic

volume: 77. Å3; shape: 0.77; buriedness: 0.38

negative: 0.; positive: 0.; polar: 0.; backbone: 0.5; hydrophobic: 0.5

PDB: 2xz0, 2xz1

HET: pny

ACP_ECOLI_2_78 [text] Acyl carrier protein

volume: 2857. Å3; shape: 0.9; buriedness: 0.22

negative: 0.14; positive: 0.; polar: 0.12; backbone: 0.39; hydrophobic: 0.35

PDB: 1l0h, 1l0i, 1t8k, 2fac, 2fad, 2fae, 2fhs, 3ejb, 3ejd, 3eje, 3ny7, 4etw, 4ihf, 4ihg, 4ihh, 4keh

HET: 1f7, 1r3, htg, pm4, pm5, pm8, pns, pse, psr, sxm, zmk, zmo, zmp, zmq, zn

ACPS_MYCTU_1_130 [text] Holo-[acyl-carrier-protein] synthase [P-Pant transferase superfamily. AcpS family]

volume: 104. Å3; shape: 0.81; buriedness: 0.6

negative: 0.22; positive: 0.24; polar: 0.14; backbone: 0.39; hydrophobic: 0.

PDB: 3h7q, 3hqj, 3ne1, 3ne3, 4hc6

HET: bcn

ACRB_ECOLI_1_1048_ampicillin [text] Multidrug efflux pump subunit AcrB [Resistance-nodulation-cell division (RND) (TC 2.A.6) family]

volume: 2016. Å3; shape: 0.6; buriedness: 0.41

negative: 0.; positive: 0.05; polar: 0.05; backbone: 0.54; hydrophobic: 0.37

PDB: 1iwg, 1oye, 1t9t, 1t9u, 1t9w, 1t9x, 2dhh, 2dr6, 2drd, 2gif, 2hqf, 2hqg, 2i6w, 2j8s, 2rdd, 3aoa, 3aob, 3aoc, 3aod, 3d9b, 3noc, 3nog, 3w9h, 4c48, 4dx5, 4dx6, 4dx7, 4k7q, 4u8v, 4u8y, 4u95, 4u96, 4zlj, 4zll, 5en5, 5eno, 5enp, 5enq, 5enr, 5ens, 5ent

HET: aic, cpf, d12, dd9, et, lmt, nfn, zld

ACRB_ECOLI_1_1048_doxorubicin [text] Multidrug efflux pump subunit AcrB [Resistance-nodulation-cell division (RND) (TC 2.A.6) family]

volume: 1992. Å3; shape: 0.53; buriedness: 0.7

negative: 0.03; positive: 0.05; polar: 0.16; backbone: 0.38; hydrophobic: 0.38

PDB: 1iwg, 1oye, 1t9t, 1t9u, 1t9w, 1t9x, 2dhh, 2dr6, 2drd, 2gif, 2hqf, 2hqg, 2i6w, 2j8s, 2rdd, 3aoa, 3aob, 3aoc, 3aod, 3d9b, 3noc, 3nog, 3w9h, 4c48, 4dx5, 4dx6, 4dx7, 4k7q, 4u8v, 4u8y, 4u95, 4u96, 4zlj, 4zll, 5en5, 5eno, 5enp, 5enq, 5enr, 5ens, 5ent

HET: 5qe, 5qf, 5qg, cpf, dm2, ery, et, lmu, mbx, miy, nfn, p9d, rfp, rhq

ACRB_ECOLI_1_39 [text] Multidrug efflux pump subunit AcrB [Resistance-nodulation-cell division (RND) (TC 2.A.6) family]

volume: 196. Å3; shape: 0.34; buriedness: 0.37

negative: 0.; positive: 0.; polar: 0.; backbone: 0.; hydrophobic: 1.

PDB: 1iwg, 1oye, 1t9t, 1t9u, 1t9w, 1t9x, 2dhh, 2dr6, 2drd, 2gif, 2hqf, 2hqg, 2i6w, 2j8s, 2rdd, 3aoa, 3aob, 3aoc, 3aod, 3d9b, 3noc, 3nog, 3w9h, 4c48, 4dx5, 4dx6, 4dx7, 4k7q, 4u8v, 4u8y, 4u95, 4u96, 4zlj, 4zll

HET: c14, d10, d12

ACRB_ECOLI_869_1048 [text] Multidrug efflux pump subunit AcrB [Resistance-nodulation-cell division (RND) (TC 2.A.6) family]

volume: 312. Å3; shape: 0.41; buriedness: 0.36

negative: 0.; positive: 0.; polar: 0.28; backbone: 0.18; hydrophobic: 0.54

PDB: 1iwg, 1oye, 1t9t, 1t9u, 1t9w, 1t9x, 2dhh, 2dr6, 2drd, 2gif, 2hqf, 2hqg, 2i6w, 2j8s, 2rdd, 3aoa, 3aob, 3aoc, 3aod, 3d9b, 3noc, 3nog, 3w9h, 4c48, 4dx5, 4dx6, 4dx7, 4k7q, 4u8v, 4u8y, 4u95, 4u96, 4zlj, 4zll

HET: d10, d12, oct

ACS2A_HUMAN_30_577 [text] Acyl-coenzyme A synthetase ACSM2A, mitochondrial [ATP-dependent AMP-binding enzyme family]

volume: 475. Å3; shape: 0.81; buriedness: 0.9

negative: 0.07; positive: 0.06; polar: 0.26; backbone: 0.44; hydrophobic: 0.16

PDB: 2vze, 2wd9, 3b7w, 3c5e, 3day, 3eq6, 3gpc

HET: amp, apc, atp, coa, ibp, mg, unl

ACSE_MOOTH_1_262 [text] 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase [Vitamin-B12 dependent methionine synthase family]

volume: 369. Å3; shape: 0.35; buriedness: 0.71

negative: 0.2; positive: 0.07; polar: 0.25; backbone: 0.14; hydrophobic: 0.34

Domains/regions: [D] Pterin-binding, [R] Cobalamin binding

PDB: 1f6y, 2e7f, 2ogy, 4djd, 4djf

HET: c2f

ACT3_STRCO_2_261 [text] Putative ketoacyl reductase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 345. Å3; shape: 0.78; buriedness: 0.78

negative: 0.; positive: 0.; polar: 0.34; backbone: 0.27; hydrophobic: 0.4

PDB: 1w4z, 1x7g, 1x7h, 1xr3, 2rh4, 2rhc, 2rhr, 3csd, 3qrw, 3ri3, 4dbz, 4dc0, 4dc1

HET: emo, isz

ACTB_HUMAN_1_375_ATPsite [text] Actin, cytoplasmic 1 [Actin family]

volume: 364. Å3; shape: 0.42; buriedness: 0.87

negative: 0.08; positive: 0.15; polar: 0.11; backbone: 0.56; hydrophobic: 0.09

PDB: 1c0f, 1c0g, 1d4x, 1dej, 1hlu, 1nlv, 1nm1, 1nmd, 2btf, 2hf3, 2hf4, 2oan, 3a5l, 3a5m, 3a5n, 3a5o, 3chw, 3ci5, 3cip, 3eks, 3eku, 3el2, 3mmv, 3mn6, 3mn7, 3mn9, 3u4l, 3ub5, 4ci6, 4efh, 4jhd, 4m63, 4rwt, 5ce3

HET: adp, anp, atp, ca

ACTB_HUMAN_1_375_CY9 [text] Actin, cytoplasmic 1 [Actin family]

volume: 531. Å3; shape: 0.56; buriedness: 0.48

negative: 0.; positive: 0.; polar: 0.22; backbone: 0.44; hydrophobic: 0.34

PDB: 1c0f, 1c0g, 1d4x, 1dej, 1hlu, 1nlv, 1nm1, 1nmd, 2btf, 2hf3, 2hf4, 2oan, 3a5l, 3a5m, 3a5n, 3a5o, 3chw, 3ci5, 3cip, 3eks, 3eku, 3el2, 3mmv, 3mn6, 3mn7, 3mn9, 3u4l, 3ub5, 4ci6, 4efh, 4jhd, 4m63, 4rwt, 5ce3

HET: cy9

ACTN_ACTCH_127_345 [text] Actinidain [Peptidase C1 family]

volume: 309. Å3; shape: 0.65; buriedness: 0.72

negative: 0.03; positive: 0.11; polar: 0.17; backbone: 0.53; hydrophobic: 0.17

PDB: 1aec, 2act

HET: e64

ACTP2_STIHL_1_175 [text] DELTA-stichotoxin-She4b [Actinoporin family. Sea anemone subfamily]

volume: 108. Å3; shape: 0.54; buriedness: 0.88

negative: 0.; positive: 0.15; polar: 0.54; backbone: 0.31; hydrophobic: 0.

Domains/regions: [R] N-terminal region

PDB: 1gwy, 1o71, 1o72

HET: pc

ACTPC_ACTFR_1_179 [text] DELTA-actitoxin-Afr1a [Actinoporin family. Sea anemone subfamily]

volume: 1532. Å3; shape: 0.96; buriedness: 0.5

negative: 0.04; positive: 0.07; polar: 0.35; backbone: 0.37; hydrophobic: 0.17

Domains/regions: [R] Trp-rich region

PDB: 3lim, 3vwi, 3w9p, 3zwg, 3zwj, 4tsl, 4tsn, 4tso, 4tsp, 4tsq, 4tsy, 4wdc, 5bpg

HET: hxg, hxj, lda, pc

ACTS_HUMAN_3_377 [text] Actin, alpha skeletal muscle [Actin family]

volume: 3089. Å3; shape: 0.59; buriedness: 0.37

negative: 0.06; positive: 0.02; polar: 0.27; backbone: 0.45; hydrophobic: 0.2

PDB: 1atn, 1eqy, 1esv, 1h1v, 1ijj, 1j6z, 1kxp, 1lcu, 1lot, 1ma9, 1mdu, 1nwk, 1p8z, 1qz5, 1qz6, 1rdw, 1rfq, 1rgi, 1s22, 1sqk, 1t44, 1wua, 1y64, 1yxq, 2a3z, 2a40, 2a41, 2a42, 2a5x, 2asm, 2aso, 2asp, 2d1k, 2ff3, 2ff6, 2fxu, 2gwj, 2gwk, 2hmp, 2pav, 2pbd, 2q0r, 2q0u, 2q1n, 2q31, 2q36, 2q97, 2v51, 2v52, 2vcp, 2vyp, 2yje, 2yjf, 2zwh, 3buz, 3cjb, 3daw, 3ffk, 3hbt, 3m1f, 3m6g, 3mn5, 3sjh, 3tpq, 3tu5, 3u8x, 3u9d, 3u9z, 3ue5, 3w3d, 4b1u, 4b1v, 4b1w, 4b1x, 4b1y, 4b1z, 4eah, 4gy2, 4h03, 4h0t, 4h0v, 4h0x, 4h0y, 4k41, 4k42, 4k43, 4pkg, 4pkh, 4pki, 4pl8, 4z94

HET: 1pe, 1po, 211, ap8, bid, jas, kab, lo3, nwm, rga, rgc, rh9, rho, spd, spx, swi, ula

ACVR1_HUMAN_199_499 [text] Activin receptor type-1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 343. Å3; shape: 0.44; buriedness: 0.78

negative: 0.04; positive: 0.09; polar: 0.15; backbone: 0.4; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 3h9r, 3mtf, 3oom, 3q4u, 4bgg, 4c02, 4dym

HET: 507, 844, a3f, iyz, ldn, tak

ADA17_HUMAN_215_479 [text] Disintegrin and metalloproteinase domain-containing protein 17

volume: 662. Å3; shape: 0.55; buriedness: 0.75

negative: 0.07; positive: 0.11; polar: 0.07; backbone: 0.55; hydrophobic: 0.2

Domains/regions: [D] Peptidase M12B

PDB: 1bkc, 1zxc, 2a8h, 2ddf, 2fv5, 2fv9, 2i47, 2oi0, 3b92, 3cki, 3e8r, 3edz, 3ewj, 3g42, 3kmc, 3kme, 3l0t, 3l0v, 3le9, 3lea, 3lgp, 3o64

HET: 002, 283, 403, 440, 4nh, 50x, 541, 550, 615, 642, 724, 727, 786, 792, ih6, inn, kgy, z59, z93, z94

ADA33_HUMAN_204_410 [text] Disintegrin and metalloproteinase domain-containing protein 33

volume: 209. Å3; shape: 0.66; buriedness: 0.73

negative: 0.08; positive: 0.19; polar: 0.15; backbone: 0.46; hydrophobic: 0.12

Domains/regions: [D] Peptidase M12B

PDB: 1r54, 1r55

HET: 097

ADA_HUMAN_2_358 [text] Adenosine deaminase [Adenosine and AMP deaminases family]

volume: 385. Å3; shape: 0.7; buriedness: 0.9

negative: 0.2; positive: 0.1; polar: 0.05; backbone: 0.27; hydrophobic: 0.38

PDB: 1krm, 1ndv, 1ndw, 1ndy, 1ndz, 1o5r, 1qxl, 1uml, 1v79, 1v7a, 1vfl, 1w1i, 1wxy, 1wxz, 2bgn, 2e1w, 2z7g, 3iar

HET: 3d1, eh9, fr0, fr2, fr3, fr4, fr5, fr6, fr7, fr8, fr9, frc, frk, frl, prh

ADA_MOUSE_4_352 [text] Adenosine deaminase [Adenosine and AMP deaminases family]

volume: 163. Å3; shape: 0.52; buriedness: 0.97

negative: 0.26; positive: 0.14; polar: 0.01; backbone: 0.17; hydrophobic: 0.42

PDB: 1a4l, 1a4m, 1add, 1fkw, 1fkx, 1uio, 1uip, 2ada, 3km8, 3mvi, 3mvt, 3t1g

HET: 1da, 9di, dcf, hpr, prh, pur

ADAS_CAVPO_15_658 [text] Alkyldihydroxyacetonephosphate synthase, peroxisomal [FAD-binding oxidoreductase/transferase type 4 family]

volume: 1306. Å3; shape: 0.37; buriedness: 0.94

negative: 0.02; positive: 0.05; polar: 0.19; backbone: 0.48; hydrophobic: 0.25

Domains/regions: [D] FAD-binding PCMH-type, [R] Important for enzyme activity

PDB: 4bby, 4bc7, 4bc9, 4bca, 5adz, 5ae1, 5ae2, 5ae3

HET: 1do, awb, b2z, cnv, fad, fyc, kqs

ADCY2_RAT_870_1082 [text] Adenylate cyclase type 2 [Adenylyl cyclase class-4/guanylyl cyclase family]

volume: 698. Å3; shape: 0.92; buriedness: 0.37

negative: 0.1; positive: 0.16; polar: 0.19; backbone: 0.32; hydrophobic: 0.23

PDB: 1ab8, 1azs, 1cjk, 1cjt, 1cju, 1cjv, 1cs4, 1cul, 1tl7, 1u0h, 2gvd, 2gvz, 3c14, 3c15, 3c16, 3g82, 3maa

HET: 101, 103, 128, 3po, atp, dad, fok, mi3, ona, onm, tat

ADCYA_HUMAN_1_469 [text] Adenylate cyclase type 10 [Adenylyl cyclase class-4/guanylyl cyclase family]

volume: 256. Å3; shape: 0.5; buriedness: 0.8

negative: 0.07; positive: 0.07; polar: 0.25; backbone: 0.39; hydrophobic: 0.23

Domains/regions: [D] Guanylate cyclase 2

PDB: 4clf, 4clk, 4cll, 4clp, 4cls, 4clt, 4clu, 4clw, 4cly, 4clz, 4cm0, 4cm2, 4oya, 4oyb, 4oyi, 4oym, 4oyo, 4oyp, 4oyw, 4oyx, 4oyz, 4oz2, 4oz3, 4ust, 4usu, 4usv, 4usw, 5d0r, 5iv3, 5iv4

HET: 4ds

ADE_PSEAE_1_316 [text] Adenine deaminase [Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily]

volume: 77. Å3; shape: 0.87; buriedness: 1.

negative: 0.34; positive: 0.26; polar: 0.09; backbone: 0.09; hydrophobic: 0.23

PDB: 3ou8, 3pan, 3pao, 3pbm

HET: ade, es4, hpa

ADH1A_HUMAN_2_375 [text] Alcohol dehydrogenase 1A [Zinc-containing alcohol dehydrogenase family]

volume: 124. Å3; shape: 0.72; buriedness: 0.92

negative: 0.; positive: 0.09; polar: 0.09; backbone: 0.04; hydrophobic: 0.78

PDB: 1hso, 1u3t

HET: ccb, pyz

ADH1E_HORSE_2_375 [text] Alcohol dehydrogenase E chain [Zinc-containing alcohol dehydrogenase family. Class-I subfamily]

volume: 807. Å3; shape: 0.41; buriedness: 0.91

negative: 0.02; positive: 0.13; polar: 0.06; backbone: 0.44; hydrophobic: 0.35

PDB: 1a71, 1a72, 1adb, 1adc, 1adf, 1adg, 1axe, 1axg, 1bto, 1het, 1heu, 1hf3, 1hld, 1ju9, 1lde, 1ldy, 1mg0, 1mgo, 1n8k, 1n92, 1p1r, 1qlh, 1qlj, 1qv6, 1qv7, 1ye3, 2jhf, 2jhg, 2ohx, 2oxi, 3bto, 3oq6, 4dwv, 4dxh, 4nfh, 4nfs, 4ng5, 4xd2, 5adh, 5cdg, 5cds, 5cdt, 5cdu, 5kcp, 5kcz, 5kj1, 5kj6, 5kjc, 5kje, 5kjf, 6adh, 7adh, 8adh

HET: 24b, apr, brb, cnd, cxf, dfb, etf, fpi, ibo, mrd, nad, nai, naj, nmh, pad, pfb, pyz, pzo, sad, ssb, tad

ADH1G_HUMAN_2_375 [text] Alcohol dehydrogenase 1C [Zinc-containing alcohol dehydrogenase family]

volume: 139. Å3; shape: 0.43; buriedness: 0.95

negative: 0.; positive: 0.08; polar: 0.12; backbone: 0.08; hydrophobic: 0.72

PDB: 1ht0, 1u3w

HET: fxy

ADHX_HUMAN_2_374 [text] Alcohol dehydrogenase class-3 [Zinc-containing alcohol dehydrogenase family. Class-III subfamily]

volume: 340. Å3; shape: 0.65; buriedness: 0.79

negative: 0.; positive: 0.21; polar: 0.28; backbone: 0.; hydrophobic: 0.51

PDB: 1m6h, 1m6w, 1ma0, 1mc5, 1mp0, 1teh, 2fze, 2fzw, 3qj5

HET: 022, 12h, ahe, dao, zn

ADK_HUMAN_18_362 [text] Adenosine kinase [Carbohydrate kinase PfkB family]

volume: 290. Å3; shape: 0.49; buriedness: 0.96

negative: 0.08; positive: 0.; polar: 0.2; backbone: 0.41; hydrophobic: 0.31

PDB: 1bx4, 2i6a, 2i6b, 4o1l

HET: 5i5, 89i, adn, ho4

ADK_TOXGO_2_361 [text] Adenosine kinase [Carbohydrate kinase PfkB family]

volume: 199. Å3; shape: 0.51; buriedness: 0.92

negative: 0.17; positive: 0.; polar: 0.41; backbone: 0.25; hydrophobic: 0.16

PDB: 1dgm, 1lii, 1lij, 1lik, 1lio, 2a9y, 2a9z, 2aa0, 2ab8, 2abs

HET: 26a, adn, mtp, rpp

ADRB1_MELGA_31_367_TM [text] Beta-1 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily]

volume: 298. Å3; shape: 0.54; buriedness: 0.92

negative: 0.07; positive: 0.; polar: 0.37; backbone: 0.12; hydrophobic: 0.45

Domains/regions: [R] Agonist and antagonist binding

PDB: 2vt4, 2y00, 2y01, 2y02, 2y03, 2y04, 2ycw, 2ycx, 2ycy, 3zpq, 3zpr, 4ami, 4amj, 4bvn, 4gpo, 5a8e, 5f8u

HET: 3wc, 5fw, 68h, cau, cvd, g90, p32, whj, xf5, xtk, y00

ADRB2_HUMAN_26_357_cholesterol [text] Beta-2 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily]

volume: 532. Å3; shape: 0.58; buriedness: 0.54

negative: 0.; positive: 0.09; polar: 0.21; backbone: 0.; hydrophobic: 0.7

PDB: 2r4r, 2r4s, 2rh1, 3d4s, 3kj6, 3ny8, 3ny9, 3nya, 3p0g, 3pds, 3sn6, 4lde, 4ldl, 4ldo, 4qkx, 5d5a, 5d6l, 5jqh

HET: clr

ADRB2_HUMAN_26_357_Galpha [text] Beta-2 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily]

volume: 527. Å3; shape: 0.78; buriedness: 0.56

negative: 0.04; positive: 0.19; polar: 0.15; backbone: 0.45; hydrophobic: 0.17

PDB: 2r4r, 2r4s, 2rh1, 3d4s, 3kj6, 3ny8, 3ny9, 3nya, 3p0g, 3pds, 3sn6, 4lde, 4ldl, 4ldo, 4qkx, 5d5a, 5d6l, 5jqh

ADRB2_HUMAN_26_357_TM [text] Beta-2 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily]

volume: 306. Å3; shape: 0.53; buriedness: 0.94

negative: 0.07; positive: 0.04; polar: 0.38; backbone: 0.1; hydrophobic: 0.42

Domains/regions: [R] Agonist and antagonist binding

PDB: 2r4r, 2r4s, 2rh1, 3d4s, 3kj6, 3ny8, 3ny9, 3nya, 3p0g, 3pds, 3sn6, 4lde, 4ldl, 4ldo, 4qkx, 5d5a, 5d6l, 5jqh

HET: 35v, ale, cau, erc, jrz, jsz, jtz, p0g, tim, xqc

ADT1_BOVIN_2_298_cxt [text] ADP/ATP translocase 1 [Mitochondrial carrier (TC 2.A.29) family]

volume: 466. Å3; shape: 0.59; buriedness: 0.72

negative: 0.06; positive: 0.24; polar: 0.21; backbone: 0.33; hydrophobic: 0.15

PDB: 1okc, 2c3e

HET: cxt

AEQ2_AEQVI_8_196 [text] Aequorin-2 [Aequorin family]

volume: 359. Å3; shape: 0.7; buriedness: 1.

negative: 0.; positive: 0.14; polar: 0.14; backbone: 0.18; hydrophobic: 0.55

Domains/regions: [D] EF-hand 1, [D] EF-hand 2, [D] EF-hand 3, [D] EF-hand 4, [R] May interact with the chromophore

PDB: 1ej3, 1uhh, 1uhi, 1uhj, 1uhk

HET: czb, czh, czi, czn, czp

AFLC_ASPPU_1304_1660 [text] Norsolorinic acid synthase

volume: 460. Å3; shape: 0.26; buriedness: 0.9

negative: 0.; positive: 0.05; polar: 0.11; backbone: 0.43; hydrophobic: 0.4

Domains/regions: [R] Product template (PT) domain

PDB: 3hrq, 3hrr

HET: hc8, plm

AGAL_HUMAN_32_429 [text] Alpha-galactosidase A [Glycosyl hydrolase 27 family]

volume: 186. Å3; shape: 0.78; buriedness: 0.93

negative: 0.44; positive: 0.19; polar: 0.18; backbone: 0.; hydrophobic: 0.19

Domains/regions: [R] Substrate binding

PDB: 1r46, 1r47, 3gxn, 3gxp, 3gxt, 3hg2, 3hg3, 3hg4, 3hg5, 3lx9, 3lxa, 3lxb, 3lxc, 3s5y, 3s5z, 3tv8, 4nxs

HET: 2oz, 7jz, dgj, gla, glc, noj

AGI1_WHEAT_27_201 [text] Agglutinin isolectin 1

volume: 475. Å3; shape: 0.48; buriedness: 0.57

negative: 0.2; positive: 0.; polar: 0.4; backbone: 0.13; hydrophobic: 0.27

Domains/regions: [D] Chitin-binding type-1 2, [D] Chitin-binding type-1 3, [R] Substrate binding

PDB: 1wgc, 2cwg, 2uvo, 2x3t, 4aml, 7wga

HET: dbb, gyu, gyv, ndg

AGM1_CANAX_1_544 [text] Phosphoacetylglucosamine mutase [Phosphohexose mutase family]

volume: 208. Å3; shape: 0.57; buriedness: 0.81

negative: 0.11; positive: 0.18; polar: 0.3; backbone: 0.32; hydrophobic: 0.11

Domains/regions: [R] Substrate binding

PDB: 2dka, 2dkc, 2dkd

HET: 16g, ng1

AGO2_HUMAN_438_575 [text] Protein argonaute-2 [Argonaute family. Ago subfamily]

volume: 1516. Å3; shape: 0.56; buriedness: 0.66

negative: 0.; positive: 0.17; polar: 0.28; backbone: 0.46; hydrophobic: 0.08

Domains/regions: [D] Piwi, [R] Interaction with guide RNA

PDB: 3luc, 3lud, 3lug, 3luh, 3luj, 3luk, 3qx8, 3qx9, 4f3t, 4ola, 4olb, 4w5n, 4w5o, 4w5q, 4w5r, 4w5t, 4z4c, 4z4d, 4z4e, 4z4f, 4z4g, 4z4h, 4z4i, 5js1, 5js2, 5ki6

HET: 5gp, 6nw, 6oo, 6op, 6u0, amp, atp, c5p, f2t, gtg, u5p, uft

AGOG_PYRAE_1_256 [text] N-glycosylase/DNA lyase [Archaeal N-glycosylase/DNA lyase (AGOG) family]

volume: 166. Å3; shape: 0.76; buriedness: 0.94

negative: 0.17; positive: 0.13; polar: 0.09; backbone: 0.3; hydrophobic: 0.3

Domains/regions: [R] Helix-hairpin-helix

PDB: 1xqo, 1xqp

HET: 8hg

AGTR1_HUMAN_14_317 [text] Type-1 angiotensin II receptor [G-protein coupled receptor 1 family]

volume: 338. Å3; shape: 0.55; buriedness: 0.81

negative: 0.; positive: 0.08; polar: 0.31; backbone: 0.15; hydrophobic: 0.46

PDB: 4yay, 4zud

HET: olm, zd7

AHK4_ARATH_149_418 [text] Histidine kinase 4

volume: 167. Å3; shape: 0.49; buriedness: 0.99

negative: 0.07; positive: 0.; polar: 0.07; backbone: 0.34; hydrophobic: 0.53

Domains/regions: [D] CHASE

PDB: 3t4j, 3t4k, 3t4l, 3t4o, 3t4q, 3t4s, 3t4t

HET: emu, h35, wa1, wa2, zea, zip

AHLLA_BACTK_1_250 [text] N-acyl homoserine lactonase AiiA [Metallo-beta-lactamase superfamily]

volume: 333. Å3; shape: 0.53; buriedness: 0.87

negative: 0.15; positive: 0.21; polar: 0.11; backbone: 0.2; hydrophobic: 0.33

PDB: 2a7m, 2br6, 2btn, 3dha, 3dhb, 3dhc, 4j5f, 4j5h, 5eh9, 5eht

HET: 1k4, c6l, cyk, hed, hsl

AK1A1_HUMAN_1_325 [text] Alcohol dehydrogenase [NADP(+)] [Aldo/keto reductase family]

volume: 220. Å3; shape: 0.92; buriedness: 0.79

negative: 0.; positive: 0.1; polar: 0.08; backbone: 0.21; hydrophobic: 0.62

PDB: 1ae4, 1cwn, 1hqt, 2alr, 3cv7, 3fx4, 3h4g, 4gac

HET: c2u, fid, fx4

AK1BA_HUMAN_1_316 [text] Aldo-keto reductase family 1 member B10 [Aldo/keto reductase family]

volume: 395. Å3; shape: 0.76; buriedness: 0.82

negative: 0.; positive: 0.09; polar: 0.09; backbone: 0.14; hydrophobic: 0.68

PDB: 1zua, 4ga8, 4gab, 4gq0, 4gqg, 4i5x, 4icc, 4jih, 4jii, 4wev, 4xzl, 4xzm, 4xzn, 5lik, 5liu, 5liw, 5lix, 5liy

HET: 1wx, 388, 64i, dqp, epr, f49, fid, flf, mk4, qap, sbi, suz, tol, w8x, zst

AK1C1_HUMAN_1_323 [text] Aldo-keto reductase family 1 member C1 [Aldo/keto reductase family]

volume: 338. Å3; shape: 0.58; buriedness: 0.83

negative: 0.05; positive: 0.16; polar: 0.16; backbone: 0.; hydrophobic: 0.62

PDB: 1mrq, 3c3u, 3gug, 3nty, 4yvp

HET: 5p3, c2u, gbm, str

AK1C2_HUMAN_1_323 [text] Aldo-keto reductase family 1 member C2 [Aldo/keto reductase family]

volume: 277. Å3; shape: 0.51; buriedness: 0.76

negative: 0.; positive: 0.1; polar: 0.2; backbone: 0.1; hydrophobic: 0.59

PDB: 1ihi, 1j96, 1xjb, 2hdj, 2ipj, 4jq1, 4jq2, 4jq3, 4jq4, 4jqa, 4jtq, 4jtr, 4l1w, 4l1x, 4xo6, 4xo7

HET: 5sd, aox, asd, ffa, flp, ibp, id8, imn, iu5, izp, nps, str, suz, tes, zom

AK1C3_HUMAN_1_323 [text] Aldo-keto reductase family 1 member C3 [Aldo/keto reductase family]

volume: 472. Å3; shape: 0.82; buriedness: 0.87

negative: 0.; positive: 0.07; polar: 0.44; backbone: 0.; hydrophobic: 0.49

PDB: 1ry0, 1ry8, 1s1p, 1s1r, 1s2a, 1s2c, 1xf0, 1zq5, 2f38, 2fgb, 3r43, 3r58, 3r6i, 3r7m, 3r8g, 3r8h, 3r94, 3ufy, 3ug8, 3ugr, 3uwe, 4dbs, 4dbu, 4dbw, 4dz5, 4fa3, 4fal, 4fam, 4h7c, 4hmn, 4wdt, 4wdu, 4wdw, 4wdx, 4wrh, 4xvd, 4xve, 4yvv, 4yvx, 4zfc

HET: 0hv, 0sl, 0sz, 0t0, 10h, 15m, 16j, 511, asd, bt9, e04, flf, flr, gbm, gcz, gmr, id8, imn, izp, jms, nps, npx, p6g, pg2, pg4, rut, suz, vjj, wds, wdt, wdu, wdv, wdw, wdx, yy1, yy2, zom

AK1CL_MOUSE_2_323 [text] Aldo-keto reductase family 1 member C21 [Aldo/keto reductase family]

volume: 228. Å3; shape: 0.6; buriedness: 0.86

negative: 0.; positive: 0.17; polar: 0.42; backbone: 0.17; hydrophobic: 0.24

PDB: 2he5, 2he8, 2hej, 2ipf, 2ipg, 2p5n, 3cv6, 3fjn

HET: ffa, hxs

AK1D1_HUMAN_2_326 [text] 3-oxo-5-beta-steroid 4-dehydrogenase [Aldo/keto reductase family]

volume: 295. Å3; shape: 0.68; buriedness: 0.79

negative: 0.09; positive: 0.04; polar: 0.38; backbone: 0.; hydrophobic: 0.5

PDB: 3bur, 3buv, 3bv7, 3caq, 3cas, 3cav, 3cmf, 3cot, 3dop, 3g1r, 3uzw, 3uzx, 3uzy, 3uzz

HET: aom, aox, asd, bdt, ci2, fit, pdn, str, tes

AKT1_HUMAN_1_137 [text] RAC-alpha serine/threonine-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily]

volume: 554. Å3; shape: 0.74; buriedness: 0.83

negative: 0.; positive: 0.11; polar: 0.25; backbone: 0.31; hydrophobic: 0.33

Domains/regions: [D] PH

PDB: 1h10, 1unp, 1unq, 1unr, 2uvm, 2uzr, 2uzs, 3o96, 4ejn, 5kcv

HET: 0r4, 6s1, iqo

AKT1_HUMAN_137_445 [text] RAC-alpha serine/threonine-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily]

volume: 671. Å3; shape: 0.72; buriedness: 0.6

negative: 0.09; positive: 0.03; polar: 0.14; backbone: 0.44; hydrophobic: 0.3

Domains/regions: [D] AGC-kinase C-terminal, [D] Protein kinase, [R] Inhibitor binding

PDB: 3cqu, 3cqw, 3mv5, 3mvh, 3o96, 3ocb, 3ow4, 3qkk, 3qkl, 3qkm, 4ejn, 4ekk, 4ekl, 4gv1, 5kcv

HET: 0rf, 0xz, anp, cqu, cqw, mn, sm9, smh, smr, smy, wfe, xfe, xm1

AKT2_HUMAN_145_478 [text] RAC-beta serine/threonine-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily]

volume: 380. Å3; shape: 0.71; buriedness: 0.89

negative: 0.11; positive: 0.03; polar: 0.14; backbone: 0.4; hydrophobic: 0.32

Domains/regions: [D] Protein kinase, [R] Inhibitor binding

PDB: 1gzk, 1gzn, 1gzo, 1mrv, 1mry, 1o6k, 1o6l, 2jdo, 2jdr, 2uw9, 2x39, 2xh5, 3d0e, 3e87, 3e88, 3e8d

HET: anp, g93, g95, g96, g98, gvp, i5s, l20, mn, x37, x39

AL1A1_HUMAN_3_501 [text] Retinal dehydrogenase 1 [Aldehyde dehydrogenase family]

volume: 363. Å3; shape: 0.75; buriedness: 0.83

negative: 0.; positive: 0.; polar: 0.19; backbone: 0.27; hydrophobic: 0.54

PDB: 1bxs, 4wb9, 4wj9, 4wp7, 4wpn, 4x4l, 5abm, 5ac0, 5ac1, 5ac2

HET: 3sr, 3st, 3xg, k9p

AL1L1_HUMAN_1_307 [text] Cytosolic 10-formyltetrahydrofolate dehydrogenase

volume: 110. Å3; shape: 0.66; buriedness: 0.96

negative: 0.06; positive: 0.; polar: 0.; backbone: 0.55; hydrophobic: 0.39

Domains/regions: [R] GART, [R] Substrate binding

PDB: 1s3i, 2bw0, 2cfi

HET: zzz

AL3A1_HUMAN_2_453 [text] Aldehyde dehydrogenase, dimeric NADP-preferring [Aldehyde dehydrogenase family]

volume: 266. Å3; shape: 0.49; buriedness: 0.96

negative: 0.04; positive: 0.06; polar: 0.39; backbone: 0.13; hydrophobic: 0.38

PDB: 3sza, 3szb, 4h80, 4l1o, 4l2o

HET: 04t, 1dd, 1vl, i1e

AL7A1_HUMAN_27_537 [text] Alpha-aminoadipic semialdehyde dehydrogenase [Aldehyde dehydrogenase family]

volume: 185. Å3; shape: 0.85; buriedness: 0.92

negative: 0.07; positive: 0.; polar: 0.19; backbone: 0.25; hydrophobic: 0.5

PDB: 2j6l, 4x0t, 4x0u, 4zuk, 4zul, 4zvw, 4zvx, 4zvy

HET: 3w9, un1

ALBU_BOVIN_25_607 [text] Serum albumin [ALB/AFP/VDB family]

volume: 411. Å3; shape: 0.36; buriedness: 0.96

negative: 0.04; positive: 0.18; polar: 0.2; backbone: 0.15; hydrophobic: 0.43

Domains/regions: [D] Albumin 1, [D] Albumin 2, [D] Albumin 3

PDB: 3v03, 4f5s, 4jk4, 4luf, 4luh, 4or0

HET: 2q5, diu, nps

ALBU_HORSE_25_607 [text] Serum albumin [ALB/AFP/VDB family]

volume: 413. Å3; shape: 0.58; buriedness: 0.83

negative: 0.05; positive: 0.1; polar: 0.1; backbone: 0.34; hydrophobic: 0.42

Domains/regions: [D] Albumin 2, [D] Albumin 3

PDB: 3v08, 4f5t, 4f5u, 4j2v, 4ot2, 4zbq, 4zbr, 5dby, 5dqf, 5hoz, 5id9, 5iih, 5iiu, 5iix, 5ij5, 5ije

HET: 6a4, cze, mli, nps

ALBU_HUMAN_25_609_diazepamSite [text] Serum albumin [ALB/AFP/VDB family]

volume: 652. Å3; shape: 0.79; buriedness: 0.95

negative: 0.02; positive: 0.11; polar: 0.12; backbone: 0.26; hydrophobic: 0.48

Domains/regions: [D] Albumin 2, [D] Albumin 3

PDB: 1ao6, 1bj5, 1bke, 1bm0, 1e78, 1e7a, 1e7b, 1e7c, 1e7e, 1e7f, 1e7g, 1e7h, 1e7i, 1gni, 1gnj, 1h9z, 1ha2, 1hk1, 1hk2, 1hk3, 1hk4, 1hk5, 1n5u, 1o9x, 1tf0, 1uor, 2bx8, 2bxa, 2bxb, 2bxc, 2bxd, 2bxe, 2bxf, 2bxg, 2bxh, 2bxi, 2bxk, 2bxl, 2bxm, 2bxn, 2bxo, 2bxp, 2bxq, 2i2z, 2i30, 2vdb, 2vue, 2vuf, 2xsi, 2xvq, 2xvu, 2xvv, 2xvw, 2xw0, 2xw1, 2ydf, 3a73, 3b9l, 3b9m, 3cx9, 3jqz, 3jry, 3lu6, 3lu7, 3lu8, 3sqj, 3tdl, 3uiv, 4bke, 4e99, 4emx, 4g03, 4g04, 4hgk, 4hgm, 4iw1, 4iw2, 4k2c, 4k71, 4l8u, 4l9k, 4l9q, 4la0, 4lb2, 4lb9, 4n0f, 4s1y, 4z69, 5id7, 5ifo, 5ijf

HET: 1fl, 6a4, 9dn, 9ds, 9nf, 9nv, acd, c1f, dao, dka, dzp, f15, hlt, ibp, io3, ios, myr, ola, p8s, pfl, plm, ste, t44

ALBU_HUMAN_25_609_halothaneSite [text] Serum albumin [ALB/AFP/VDB family]

volume: 1237. Å3; shape: 0.76; buriedness: 0.84

negative: 0.03; positive: 0.14; polar: 0.08; backbone: 0.39; hydrophobic: 0.35

Domains/regions: [D] Albumin 2, [D] Albumin 3

PDB: 1ao6, 1bj5, 1bke, 1bm0, 1e78, 1e7a, 1e7b, 1e7c, 1e7e, 1e7f, 1e7g, 1e7h, 1e7i, 1gni, 1gnj, 1h9z, 1ha2, 1hk1, 1hk2, 1hk3, 1hk4, 1hk5, 1n5u, 1o9x, 1tf0, 1uor, 2bx8, 2bxa, 2bxb, 2bxc, 2bxd, 2bxe, 2bxf, 2bxg, 2bxh, 2bxi, 2bxk, 2bxl, 2bxm, 2bxn, 2bxo, 2bxp, 2bxq, 2i2z, 2i30, 2vdb, 2vue, 2vuf, 2xsi, 2xvq, 2xvu, 2xvv, 2xvw, 2xw0, 2xw1, 2ydf, 3a73, 3b9l, 3b9m, 3cx9, 3jqz, 3jry, 3lu6, 3lu7, 3lu8, 3sqj, 3tdl, 3uiv, 4bke, 4e99, 4emx, 4g03, 4g04, 4hgk, 4hgm, 4iw1, 4iw2, 4k2c, 4k71, 4l8u, 4l9k, 4l9q, 4la0, 4lb2, 4lb9, 4n0f, 4s1y, 4z69, 5id7, 5ifo, 5ijf

HET: 11d, 1fl, 6a4, 9nf, acd, dao, dif, dka, hlt, ibp, idb, imn, imx, ipx, myr, ola, p8s, plm, rwf, ste, swf

ALBU_HUMAN_25_609_naproxenSite [text] Serum albumin [ALB/AFP/VDB family]

volume: 916. Å3; shape: 0.67; buriedness: 0.88

negative: 0.02; positive: 0.18; polar: 0.1; backbone: 0.38; hydrophobic: 0.32

Domains/regions: [D] Albumin 1, [D] Albumin 2

PDB: 1ao6, 1bj5, 1bke, 1bm0, 1e78, 1e7a, 1e7b, 1e7c, 1e7e, 1e7f, 1e7g, 1e7h, 1e7i, 1gni, 1gnj, 1h9z, 1ha2, 1hk1, 1hk2, 1hk3, 1hk4, 1hk5, 1n5u, 1o9x, 1tf0, 1uor, 2bx8, 2bxa, 2bxb, 2bxc, 2bxd, 2bxe, 2bxf, 2bxg, 2bxh, 2bxi, 2bxk, 2bxl, 2bxm, 2bxn, 2bxo, 2bxp, 2bxq, 2i2z, 2i30, 2vdb, 2vue, 2vuf, 2xsi, 2xvq, 2xvu, 2xvv, 2xvw, 2xw0, 2xw1, 2ydf, 3a73, 3b9l, 3b9m, 3cx9, 3jqz, 3jry, 3lu6, 3lu7, 3lu8, 3sqj, 3tdl, 3uiv, 4bke, 4e99, 4emx, 4g03, 4g04, 4hgk, 4hgm, 4iw1, 4iw2, 4k2c, 4k71, 4l8u, 4l9k, 4l9q, 4la0, 4lb2, 4lb9, 4n0f, 4s1y, 4z69, 5id7, 5ifo, 5ijf

HET: 198, 9az, 9dn, 9ne, 9nr, 9tp, acd, azq, azz, b3i, bla, dao, dif, dka, dm5, ehf, f15, fe, fua, hem, imn, io3, iqx, myr, nps, ola, pj2, plm, sal, ste

ALBU_HUMAN_25_609_warfarinSite [text] Serum albumin [ALB/AFP/VDB family]

volume: 1062. Å3; shape: 0.54; buriedness: 0.87

negative: 0.04; positive: 0.17; polar: 0.12; backbone: 0.26; hydrophobic: 0.4

Domains/regions: [D] Albumin 1, [D] Albumin 2, [D] Albumin 3

PDB: 1ao6, 1bj5, 1bke, 1bm0, 1e78, 1e7a, 1e7b, 1e7c, 1e7e, 1e7f, 1e7g, 1e7h, 1e7i, 1gni, 1gnj, 1h9z, 1ha2, 1hk1, 1hk2, 1hk3, 1hk4, 1hk5, 1n5u, 1o9x, 1tf0, 1uor, 2bx8, 2bxa, 2bxb, 2bxc, 2bxd, 2bxe, 2bxf, 2bxg, 2bxh, 2bxi, 2bxk, 2bxl, 2bxm, 2bxn, 2bxo, 2bxp, 2bxq, 2i2z, 2i30, 2vdb, 2vue, 2vuf, 2xsi, 2xvq, 2xvu, 2xvv, 2xvw, 2xw0, 2xw1, 2ydf, 3a73, 3b9l, 3b9m, 3cx9, 3jqz, 3jry, 3lu6, 3lu7, 3lu8, 3sqj, 3tdl, 3uiv, 4bke, 4e99, 4emx, 4g03, 4g04, 4hgk, 4hgm, 4iw1, 4iw2, 4k2c, 4k71, 4l8u, 4l9k, 4l9q, 4la0, 4lb2, 4lb9, 4n0f, 4s1y, 4z69, 5id7, 5ifo, 5ijf

HET: 11d, 1fl, 308, 6a4, 9dn, 9ne, 9nf, 9nr, acd, azq, azz, b3i, c1f, dao, dif, diu, dka, fru, fud, glc, glo, hlt, ibp, idb, imn, imx, io3, ios, ipx, lpx, myr, ola, opb, p1z, p8s, pge, plm, rwf, sal, ste, swf, t44

ALBU_RABIT_25_608 [text] Serum albumin [ALB/AFP/VDB family]

volume: 162. Å3; shape: 0.48; buriedness: 0.96

negative: 0.; positive: 0.18; polar: 0.27; backbone: 0.15; hydrophobic: 0.39

Domains/regions: [D] Albumin 3

PDB: 3v09, 4f5v, 4po0

HET: nps, pge

ALD2_MOUSE_2_316 [text] Aldose reductase-related protein 2 [Aldo/keto reductase family]

volume: 231. Å3; shape: 0.49; buriedness: 0.87

negative: 0.; positive: 0.11; polar: 0.21; backbone: 0.05; hydrophobic: 0.63

PDB: 1c9w, 1frb

HET: zst

ALDA_ECOLI_1_479 [text] Lactaldehyde dehydrogenase [Aldehyde dehydrogenase family]

volume: 255. Å3; shape: 0.45; buriedness: 0.6

negative: 0.15; positive: 0.; polar: 0.15; backbone: 0.12; hydrophobic: 0.58

PDB: 2hg2, 2ilu, 2imp, 2opx

HET: dxc

ALDEC_SYNE7_10_230 [text] Aldehyde decarbonylase [Aldehyde decarbonylase family]

volume: 258. Å3; shape: 0.6; buriedness: 0.99

negative: 0.16; positive: 0.; polar: 0.2; backbone: 0.15; hydrophobic: 0.5

PDB: 4quw, 4rc5, 4rc6, 4rc7, 4rc8

HET: pl3, ste

ALDH2_HUMAN_19_517 [text] Aldehyde dehydrogenase, mitochondrial [Aldehyde dehydrogenase family]

volume: 1020. Å3; shape: 0.32; buriedness: 0.87

negative: 0.07; positive: 0.03; polar: 0.09; backbone: 0.34; hydrophobic: 0.47

PDB: 1a4z, 1ag8, 1cw3, 1nzw, 1nzx, 1nzz, 1o00, 1o01, 1o02, 1o04, 1o05, 2onn, 2ono, 2onp, 2vle, 3inj, 3inl, 3n80, 3n81, 3n82, 3n83, 3sz9, 4fqf, 4fr8, 4kwf, 4kwg

HET: 2ak, 3ak, adp, bxb, dzn, i3e, mg, mn, nad, nai, sm, tng

ALDOA_HUMAN_2_364 [text] Fructose-bisphosphate aldolase A [Class I fructose-bisphosphate aldolase family]

volume: 1027. Å3; shape: 0.86; buriedness: 0.86

negative: 0.12; positive: 0.25; polar: 0.14; backbone: 0.35; hydrophobic: 0.13

PDB: 1ado, 1ald, 1ewd, 1ewe, 1ex5, 1j4e, 1zah, 1zai, 1zaj, 1zal, 2ald, 2ot0, 2ot1, 2qut, 2quu, 2quv, 3b8d, 3bv4, 3dfn, 3dfo, 3dfp, 3dfq, 3dfs, 3dft, 3lge, 3tu9, 4ald, 6ald

HET: 13p, 2fp, 5mm, m2p, n3p

ALDOB_HUMAN_2_364 [text] Fructose-bisphosphate aldolase B [Class I fructose-bisphosphate aldolase family]

volume: 264. Å3; shape: 0.65; buriedness: 0.78

negative: 0.09; positive: 0.28; polar: 0.07; backbone: 0.48; hydrophobic: 0.07

PDB: 1fdj, 1xdl, 1xdm

HET: 13p, 2fp, g3p

ALDR_HUMAN_1_316 [text] Aldose reductase [Aldo/keto reductase family]

volume: 399. Å3; shape: 0.74; buriedness: 0.88

negative: 0.; positive: 0.06; polar: 0.17; backbone: 0.17; hydrophobic: 0.59

PDB: 1abn, 1ads, 1az1, 1az2, 1ef3, 1el3, 1iei, 1mar, 1pwl, 1pwm, 1t40, 1t41, 1us0, 1x96, 1x97, 1x98, 1xgd, 1z3n, 1z89, 1z8a, 2acq, 2acr, 2acs, 2acu, 2agt, 2dux, 2duz, 2dv0, 2f2k, 2fz8, 2fz9, 2fzb, 2fzd, 2hv5, 2hvn, 2hvo, 2i16, 2i17, 2ikg, 2ikh, 2iki, 2ikj, 2ine, 2inz, 2ipw, 2iq0, 2iqd, 2is7, 2isf, 2j8t, 2nvc, 2nvd, 2pd5, 2pd9, 2pdb, 2pdc, 2pdf, 2pdg, 2pdh, 2pdi, 2pdj, 2pdk, 2pdl, 2pdm, 2pdn, 2pdp, 2pdq, 2pdu, 2pdw, 2pdx, 2pdy, 2pev, 2pf8, 2pfh, 2pzn, 2qxw, 2r24, 3bcj, 3dn5, 3g5e, 3ghr, 3ghs, 3ght, 3ghu, 3lbo, 3ld5, 3len, 3lep, 3lqg, 3lql, 3lz3, 3lz5, 3m0i, 3m4h, 3m64, 3mb9, 3mc5, 3onb, 3onc, 3p2v, 3q65, 3q67, 3rx2, 3rx3, 3rx4, 3s3g, 3t42, 3u2c, 3v35, 3v36, 4gca, 4igs, 4jir, 4lau, 4laz, 4lb3, 4lb4, 4lbr, 4lbs, 4nkc, 4pr4, 4prr, 4prt, 4puu, 4puw, 4q7b, 4qbx, 4qr6, 4qx4, 4qxi, 4rpq, 4xzh, 4xzi, 4ys1, 4yu1, 5ha7

HET: 1ww, 1wx, 2cl, 2hz, 2w8, 2w9, 2wb, 2wq, 2wr, 2x9, 2yz, 30l, 37v, 388, 393, 3e2, 3na, 3t4, 3uh, 47d, 48i, 4g7, 4o8, 4o9, 53n, 62p, 64i, alr, bfi, br, bto, doy, epr, f49, fid, i84, i98, id5, ita, itb, ldt, lit, lpa, m15, nti, ohp, pac, q74, sbi, sfi, slo, suz, tgg, tlt, tol, w8x, wy1, zes, zst

ALDR_PIG_2_316 [text] Aldose reductase [Aldo/keto reductase family]

volume: 355. Å3; shape: 0.67; buriedness: 0.83

negative: 0.; positive: 0.08; polar: 0.15; backbone: 0.; hydrophobic: 0.77

PDB: 1ah0, 1ah3, 1ah4, 1dla, 1eko

HET: i84, sbi, tol

ALF1_THETK_1_263 [text] Fructose-bisphosphate aldolase class 1 [DeoC/FbaB aldolase family]

volume: 190. Å3; shape: 0.68; buriedness: 0.92

negative: 0.06; positive: 0.35; polar: 0.1; backbone: 0.37; hydrophobic: 0.12

Domains/regions: [R] Substrate binding

PDB: 1ojx, 1ok4, 1ok6, 1w8s, 2yce

HET: 13p, fbp, m2p

ALF_ECOLI_2_359 [text] Fructose-bisphosphate aldolase class 2 [Class II fructose-bisphosphate aldolase family]

volume: 102. Å3; shape: 0.54; buriedness: 0.96

negative: 0.16; positive: 0.12; polar: 0.21; backbone: 0.51; hydrophobic: 0.

Domains/regions: [R] Dihydroxyacetone phosphate binding

PDB: 1b57, 1dos, 1gyn, 1zen

HET: pgh

ALF_ENCCU_1_338 [text] Fructose-bisphosphate aldolase [Class I fructose-bisphosphate aldolase family]

volume: 191. Å3; shape: 0.56; buriedness: 0.91

negative: 0.1; positive: 0.2; polar: 0.15; backbone: 0.41; hydrophobic: 0.15

PDB: 3mbd, 3mbf, 3qrh

HET: 2fp, g3h

ALF_HELPY_1_307 [text] Fructose-bisphosphate aldolase [Class II fructose-bisphosphate aldolase family]

volume: 230. Å3; shape: 0.6; buriedness: 0.84

negative: 0.09; positive: 0.22; polar: 0.26; backbone: 0.43; hydrophobic: 0.

Domains/regions: [R] Dihydroxyacetone phosphate binding

PDB: 3c4u, 3c52, 3c56, 3n9r, 3n9s

HET: pgh, ph4, td3, td4

ALF_MYCTU_1_344 [text] Fructose-bisphosphate aldolase [Class II fructose-bisphosphate aldolase family]

volume: 246. Å3; shape: 0.55; buriedness: 0.85

negative: 0.1; positive: 0.18; polar: 0.3; backbone: 0.43; hydrophobic: 0.

Domains/regions: [R] Dihydroxyacetone phosphate binding

PDB: 3ekl, 3ekz, 3elf, 4a21, 4a22, 4def, 4del, 4lv4

HET: 13p, 2fp, g3p, pgh, so4, td4

ALF_PLAF7_1_369 [text] Fructose-bisphosphate aldolase [Class I fructose-bisphosphate aldolase family]

volume: 652. Å3; shape: 0.83; buriedness: 0.7

negative: 0.17; positive: 0.27; polar: 0.14; backbone: 0.33; hydrophobic: 0.1

PDB: 1a5c, 2eph, 2pc4, 4tr9

HET: 38d

ALF_THECA_1_305 [text] Fructose-bisphosphate aldolase [Class II fructose-bisphosphate aldolase family]

volume: 120. Å3; shape: 0.52; buriedness: 0.96

negative: 0.13; positive: 0.14; polar: 0.25; backbone: 0.48; hydrophobic: 0.

Domains/regions: [R] Dihydroxyacetone phosphate binding

PDB: 1rv8, 1rvg, 2fjk

HET: 13p, co

ALKB5_HUMAN_68_293 [text] RNA demethylase ALKBH5 [AlkB family]

volume: 138. Å3; shape: 0.45; buriedness: 0.58

negative: 0.; positive: 0.16; polar: 0.15; backbone: 0.29; hydrophobic: 0.4

PDB: 4nj4, 4nrm, 4nro, 4nrp, 4nrq, 4o61, 4o7x, 4oct

HET: un9

ALKB_ECOLI_10_215 [text] Alpha-ketoglutarate-dependent dioxygenase AlkB [AlkB family]

volume: 355. Å3; shape: 0.66; buriedness: 0.97

negative: 0.06; positive: 0.24; polar: 0.3; backbone: 0.; hydrophobic: 0.4

Domains/regions: [D] Fe2OG dioxygenase, [R] Alpha-ketoglutarate binding, [R] Substrate binding

PDB: 2fd8, 2fdf, 2fdg, 2fdh, 2fdi, 2fdj, 2fdk, 3bi3, 3bie, 3bkz, 3i2o, 3i3m, 3i3q, 3i49, 3khb, 3khc, 3o1m, 3o1o, 3o1p, 3o1r, 3o1s, 3o1t, 3o1u, 3o1v, 3t3y, 3t4h, 3t4v, 4jht, 4nid, 4nig, 4nih, 4nii, 4rfr, 4zhn

HET: 8xq, md3, md5, md6, mdv, rhn

ALK_HUMAN_1090_1410 [text] ALK tyrosine kinase receptor [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 630. Å3; shape: 0.5; buriedness: 0.77

negative: 0.07; positive: 0.03; polar: 0.; backbone: 0.51; hydrophobic: 0.38

Domains/regions: [D] Protein kinase, [R] Inhibitor binding

PDB: 2xb7, 2xba, 2xp2, 2yfx, 2yhv, 2yjr, 2yjs, 3aox, 3l9p, 3lcs, 3lct, 4anl, 4anq, 4ans, 4ccb, 4ccu, 4cd0, 4cli, 4clj, 4cmo, 4cmt, 4cmu, 4cnh, 4ctb, 4ctc, 4dce, 4fnw, 4fnx, 4fny, 4fnz, 4fob, 4foc, 4fod, 4joa, 4mkc, 4tt7, 4z55, 5a9u, 5aa8, 5aa9, 5aaa, 5aab, 5aac, 5fto, 5ftq, 5imx, 5iug, 5iuh, 5iui, 5j7h, 5kz0

HET: 0jf, 0us, 0uu, 0uv, 34y, 3dk, 3u9, 45q, 4lo, 4mk, 53p, 571, 5p8, 6gy, 6yl, 729, adp, awf, awj, cz4, emh, gui, gwh, i3k, iv7, j99, kvc, nzf, ofg, qb4, stu, u4w, vgh, ymx, ypw

ALL2_AEDAE_19_321_lipid [text] 37 kDa salivary gland allergen Aed a 2

volume: 311. Å3; shape: 0.44; buriedness: 0.92

negative: 0.; positive: 0.11; polar: 0.26; backbone: 0.26; hydrophobic: 0.37

PDB: 3dxl, 3dy9, 3dye, 3dzt

HET: eah

ALL2_AEDAE_19_321_norepinephrine [text] 37 kDa salivary gland allergen Aed a 2

volume: 111. Å3; shape: 0.63; buriedness: 0.99

negative: 0.2; positive: 0.1; polar: 0.2; backbone: 0.2; hydrophobic: 0.3

PDB: 3dxl, 3dy9, 3dye, 3dzt

HET: lnr

ALLC_ECOLI_1_411 [text] Allantoate amidohydrolase [Peptidase M20 family]

volume: 102. Å3; shape: 0.69; buriedness: 0.36

negative: 0.; positive: 1.; polar: 0.; backbone: 0.; hydrophobic: 0.

PDB: 1z2l, 2imo, 4pxd

HET: 1al

ALLN1_ALLSA_39_471 [text] Alliin lyase 1 [Alliinase family]

volume: 200. Å3; shape: 0.77; buriedness: 0.96

negative: 0.05; positive: 0.16; polar: 0.46; backbone: 0.22; hydrophobic: 0.11

PDB: 1lk9, 2hor, 2hox

HET: dha, p1t, plp

ALR1_ECOLI_2_359 [text] Alanine racemase, biosynthetic [Alanine racemase family]

volume: 203. Å3; shape: 0.98; buriedness: 0.94

negative: 0.; positive: 0.2; polar: 0.24; backbone: 0.26; hydrophobic: 0.29

PDB: 2rjg, 2rjh, 3b8t, 3b8u, 3b8v, 3b8w, 4wr3, 4xbj

HET: dcs, in5, plp

ALR_GEOSE_1_388 [text] Alanine racemase [Alanine racemase family]

volume: 228. Å3; shape: 0.96; buriedness: 0.96

negative: 0.; positive: 0.17; polar: 0.29; backbone: 0.29; hydrophobic: 0.25

PDB: 1bd0, 1epv, 1ftx, 1l6f, 1l6g, 1niu, 1sft, 1xqk, 1xql, 2sfp, 3uw6, 4ils

HET: 4ax, dcs, epc, in5, pdd, plp, pmh, pmp, pp3

ALSE_ECOLI_1_231 [text] D-allulose-6-phosphate 3-epimerase [Ribulose-phosphate 3-epimerase family]

volume: 163. Å3; shape: 0.47; buriedness: 0.98

negative: 0.1; positive: 0.1; polar: 0.14; backbone: 0.45; hydrophobic: 0.22

Domains/regions: [R] Substrate binding

PDB: 3ct7, 3ctl

HET: s6p

ALTA1_ALTAL_27_157 [text] Major allergen Alt a 1 [ALTA1 family]

volume: 82. Å3; shape: 0.9; buriedness: 0.67

negative: 0.; positive: 0.; polar: 0.67; backbone: 0.33; hydrophobic: 0.

Domains/regions: [D] AltA1

PDB: 3v0r, 4aud

HET: 0fu

ALYS_STRPN_224_318 [text] Autolysin [N-acetylmuramoyl-L-alanine amidase 2 family]

volume: 287. Å3; shape: 0.63; buriedness: 0.67

negative: 0.13; positive: 0.; polar: 0.; backbone: 0.44; hydrophobic: 0.43

PDB: 1gvm, 1h8g, 1hcx, 2bml, 4iwt, 4x36

HET: cht, ddq, xed

AMDA_BORBO_1_240 [text] Arylmalonate decarboxylase

volume: 95. Å3; shape: 0.6; buriedness: 0.96

negative: 0.; positive: 0.; polar: 0.22; backbone: 0.59; hydrophobic: 0.19

PDB: 2vlb, 3dg9, 3dtv, 3eis, 3ip8, 3ixl, 3ixm

HET: b85, pac

AMD_RAT_44_355 [text] Peptidyl-glycine alpha-amidating monooxygenase

volume: 1161. Å3; shape: 0.51; buriedness: 0.66

negative: 0.06; positive: 0.18; polar: 0.12; backbone: 0.36; hydrophobic: 0.28

Domains/regions: [R] Peptidylglycine alpha-hydroxylating monooxygenase

PDB: 1opm, 1phm, 1sdw, 1yi9, 1yip, 1yjk, 1yjl, 3mib, 3mic, 3mid, 3mie, 3mif, 3mig, 3mih, 3mlj, 3mlk, 3mll, 3phm, 4e4z

HET: iyg, iyt

AMD_RAT_498_820 [text] Peptidyl-glycine alpha-amidating monooxygenase

volume: 125. Å3; shape: 0.49; buriedness: 0.65

negative: 0.; positive: 0.5; polar: 0.17; backbone: 0.; hydrophobic: 0.33

Domains/regions: [R] Peptidyl-alpha-hydroxyglycine alpha- amidating lyase

PDB: 3fvz, 3fw0

HET: hh3

AMNB_COMTE_1_312 [text] 2-aminophenol 1,6-dioxygenase subunit beta [LigB/MhpB extradiol dioxygenase family]

volume: 100. Å3; shape: 0.78; buriedness: 0.94

negative: 0.09; positive: 0.37; polar: 0.18; backbone: 0.05; hydrophobic: 0.31

PDB: 3vsg, 3vsh, 3vsi, 3vsj

HET: 2xp, 4nc

AMN_ECOLI_1_484 [text] AMP nucleosidase [AMP nucleosidase family]

volume: 211. Å3; shape: 0.8; buriedness: 0.94

negative: 0.14; positive: 0.12; polar: 0.14; backbone: 0.35; hydrophobic: 0.25

PDB: 1t8r, 1t8s, 1t8w, 1t8y, 2guw

HET: fmp

AMP1_PLAFQ_195_1084 [text] M1 family aminopeptidase [Peptidase M1 family]

volume: 367. Å3; shape: 0.54; buriedness: 0.87

negative: 0.24; positive: 0.15; polar: 0.15; backbone: 0.25; hydrophobic: 0.2

Domains/regions: [R] Substrate binding

PDB: 3ebg, 3ebh, 3ebi, 3q43, 3q44, 3t8v, 4j3b, 4k5l, 4k5m, 4k5n, 4k5o, 4k5p, 4r5t, 4r5v, 4r5x, 4x2u, 4zqt, 4zw3, 4zw5, 4zw6, 4zw7, 4zw8, 4zx3, 4zx4, 4zx5, 4zx6

HET: 19n, 1os, 1ot, 1ou, 1ov, 4qp, 4s9, 4sa, 4sy, 4sz, 4t2, 4tk, 4tl, 4tm, 4u6, bes, bey, btj, d50, d66, mg, r5t, r5v, r5x, tod

AMPA_HELPY_1_496 [text] Cytosol aminopeptidase [Peptidase M17 family]

volume: 212. Å3; shape: 0.52; buriedness: 0.73

negative: 0.25; positive: 0.18; polar: 0.; backbone: 0.38; hydrophobic: 0.19

PDB: 4zi6, 4zla

HET: bes

AMPA_PSEPU_1_497 [text] Cytosol aminopeptidase [Peptidase M17 family]

volume: 210. Å3; shape: 0.53; buriedness: 0.74

negative: 0.2; positive: 0.14; polar: 0.03; backbone: 0.31; hydrophobic: 0.32

PDB: 3h8e, 3h8f, 3h8g

HET: bes

AMPC_CITFR_21_381 [text] Beta-lactamase [Class-C beta-lactamase family]

volume: 247. Å3; shape: 0.64; buriedness: 0.7

negative: 0.; positive: 0.07; polar: 0.43; backbone: 0.44; hydrophobic: 0.06

Domains/regions: [R] Substrate binding

PDB: 1fr1, 1fr6, 1rgy, 1zc2

HET: azr, ptx

AMPC_ECOLI_20_377 [text] Beta-lactamase [Class-C beta-lactamase family]

volume: 464. Å3; shape: 0.68; buriedness: 0.72

negative: 0.; positive: 0.05; polar: 0.39; backbone: 0.35; hydrophobic: 0.2

Domains/regions: [R] Substrate binding

PDB: 1c3b, 1fcm, 1fcn, 1fco, 1fsw, 1fsy, 1ga9, 1i5q, 1iel, 1iem, 1kds, 1kdw, 1ke0, 1ke3, 1ke4, 1kvl, 1kvm, 1l0d, 1l0e, 1l0f, 1l0g, 1l2s, 1ll5, 1ll9, 1llb, 1mxo, 1my8, 1o07, 1pi4, 1pi5, 1xgi, 1xgj, 2bls, 2ffy, 2hdq, 2hdr, 2hds, 2hdu, 2i72, 2p9v, 2pu2, 2pu4, 2r9w, 2r9x, 2rcx, 2zj9, 3bls, 3bm6, 3fkv, 3fkw, 3gqz, 3gr2, 3grj, 3gsg, 3gtc, 3gv9, 3gvb, 3iwi, 3iwo, 3iwq, 3ixb, 3ixd, 3ixg, 3ixh, 3o86, 3o87, 3o88, 4e3i, 4e3j, 4e3k, 4e3l, 4e3m, 4e3n, 4e3o, 4jxg, 4jxs, 4jxv, 4jxw, 4ken, 4kg2, 4kg5, 4kg6, 4kz3, 4kz4, 4kz5, 4kz6, 4kz7, 4kz8, 4kz9, 4kza, 4kzb, 4lv0, 4lv1, 4lv2, 4lv3, 4okp, 4old, 4olg

HET: 105, 18u, 1mu, 1mw, 1s6, 1s7, 1u1, 1u3, 1u5, 1u6, 23c, 2tv, 2uz, 3gv, 4a1, 4a3, 4cb, 4mb, apb, axl, bdb, bzb, c21, c9p, caz, cb4, ceo, cls, ctb, cvb, cxu, dk2, etp, f12, g14, gf1, gf4, gf7, gtc, gv9, htc, im2, lor, mox, mxg, npb, nst, nz2, nz9, ox6, ox7, pcn, pcz, po4, sm2, sm3, sm4, stc, suc, thn, va1, wh6, zb6

AMPC_ENTCL_21_381 [text] Beta-lactamase [Class-C beta-lactamase family]

volume: 333. Å3; shape: 0.72; buriedness: 0.68

negative: 0.; positive: 0.06; polar: 0.4; backbone: 0.43; hydrophobic: 0.11

Domains/regions: [R] Substrate binding

PDB: 1bls, 1ga0, 1gce, 1onh, 1q2q, 1rgz, 1s6r, 1xx2, 1y54, 2q9m, 2q9n, 3s4x, 4xux, 5hai

HET: 4d6, dvr, fdt, iap, ipp, lk5, lk7, ptx, wy2, wy4

AMPC_PSEAE_28_392 [text] Beta-lactamase [Class-C beta-lactamase family]

volume: 269. Å3; shape: 0.47; buriedness: 0.8

negative: 0.; positive: 0.1; polar: 0.49; backbone: 0.34; hydrophobic: 0.06

Domains/regions: [R] Substrate binding

PDB: 2wzx, 2wzz, 3s1y, 3s22, 4gzb, 4hef, 4nk3, 4ooy, 4wyy, 4wz4, 4x68

HET: 3s2, 3vt, 3vu, mk7, nxl, op0, s1y, zx0, zx1

AMPD_CITFR_1_187 [text] 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD [N-acetylmuramoyl-L-alanine amidase 2 family]

volume: 305. Å3; shape: 0.51; buriedness: 0.69

negative: 0.06; positive: 0.32; polar: 0.06; backbone: 0.37; hydrophobic: 0.18

PDB: 2y28, 2y2b, 2y2c, 2y2d, 2y2e

HET: mhi

AMPE_HUMAN_76_957 [text] Glutamyl aminopeptidase [Peptidase M1 family]

volume: 256. Å3; shape: 0.76; buriedness: 0.89

negative: 0.26; positive: 0.22; polar: 0.19; backbone: 0.19; hydrophobic: 0.13

Domains/regions: [R] Substrate binding

PDB: 4kx7, 4kx8, 4kx9, 4kxa, 4kxb, 4kxc, 4kxd

HET: bes, ca, l2o

AMPL_BOVIN_33_518 [text] Cytosol aminopeptidase [Peptidase M17 family]

volume: 520. Å3; shape: 0.66; buriedness: 0.72

negative: 0.21; positive: 0.19; polar: 0.; backbone: 0.41; hydrophobic: 0.19

PDB: 1bll, 1bpm, 1bpn, 1lam, 1lan, 1lap, 1lcp, 2ewb, 2j9a

HET: ahy, l2o, mle, plu, zed

AMPN_ECOLI_3_870 [text] Aminopeptidase N [Peptidase M1 family]

volume: 1050. Å3; shape: 0.77; buriedness: 0.88

negative: 0.18; positive: 0.21; polar: 0.2; backbone: 0.31; hydrophobic: 0.1

Domains/regions: [R] Substrate binding

PDB: 2dq6, 2dqm, 2hpo, 2hpt, 2zxg, 3b2p, 3b2x, 3b34, 3b37, 3b3b, 3ked, 3puu, 3qjx, 4q4e, 4q4i, 4xmt, 4xmu, 4xmv, 4xmw, 4xmx, 4xmz, 4xn1, 4xn2, 4xn4, 4xn5, 4xn7, 4xn8, 4xn9, 4xna, 4xnb, 4xnd, 4xo3, 4xo4, 4xo5

HET: 3fb, b3k, bal, bb2, bes, dab, dpp, ht7, l2o, mla, mli, na, s23

AMPN_HUMAN_65_967 [text] Aminopeptidase N [Peptidase M1 family]

volume: 688. Å3; shape: 0.7; buriedness: 0.81

negative: 0.13; positive: 0.24; polar: 0.25; backbone: 0.19; hydrophobic: 0.19

Domains/regions: [R] Interaction with HCoV-229E, [R] Metalloprotease, [R] Substrate binding

PDB: 4fyq, 4fyr, 4fys, 4fyt

HET: bes, l2o

AMPN_PIG_63_963 [text] Aminopeptidase N [Peptidase M1 family]

volume: 1199. Å3; shape: 0.53; buriedness: 0.71

negative: 0.13; positive: 0.04; polar: 0.33; backbone: 0.3; hydrophobic: 0.2

Domains/regions: [R] Metalloprotease, [R] Substrate binding

PDB: 4f5c, 4fke, 4fkh, 4fkk, 4hom, 4naq, 4nz8, 4ou3

HET: bes

AMPX_VIBPR_107_400 [text] Bacterial leucyl aminopeptidase [Peptidase M28 family. M28E subfamily]

volume: 229. Å3; shape: 0.66; buriedness: 0.91

negative: 0.24; positive: 0.13; polar: 0.12; backbone: 0.12; hydrophobic: 0.4

PDB: 1amp, 1cp6, 1ft7, 1igb, 1lok, 1rtq, 1txr, 1xry, 2anp, 2dea, 2iq6, 2nyq, 2prq, 3b35, 3b3c, 3b3s, 3b3t, 3b3v, 3b3w, 3b7i, 3fh4, 3vh9

HET: bes, bub, hqy, ipo, k, na, plu

AMY1_HORVU_25_431 [text] Alpha-amylase type A isozyme [Glycosyl hydrolase 13 family]

volume: 557. Å3; shape: 0.64; buriedness: 0.49

negative: 0.11; positive: 0.11; polar: 0.14; backbone: 0.46; hydrophobic: 0.18

Domains/regions: [R] Substrate binding

PDB: 1ht6, 1p6w, 1rp8, 1rp9, 1rpk, 2qps, 2qpu, 3bsg, 3bsh

HET: bgc, daf, glc, gtm, qps, qpu, sgc

AMY2_HORVU_25_427 [text] Alpha-amylase type B isozyme [Glycosyl hydrolase 13 family]

volume: 193. Å3; shape: 0.65; buriedness: 0.48

negative: 0.13; positive: 0.; polar: 0.17; backbone: 0.17; hydrophobic: 0.52

Domains/regions: [R] Substrate binding

PDB: 1amy, 1ava, 1bg9

HET: af1

AMYB_HORVU_2_504 [text] Beta-amylase [Glycosyl hydrolase 14 family]

volume: 191. Å3; shape: 0.66; buriedness: 0.79

negative: 0.26; positive: 0.23; polar: 0.; backbone: 0.17; hydrophobic: 0.34

Domains/regions: [R] Substrate binding

PDB: 1b1y, 2xff, 2xfr, 2xfy, 2xg9, 2xgb, 2xgi

HET: ebg, ebq, epg, glc, noj

AMYG_ASPNG_25_495 [text] Glucoamylase [Glycosyl hydrolase 15 family]

volume: 418. Å3; shape: 0.42; buriedness: 0.68

negative: 0.2; positive: 0.1; polar: 0.1; backbone: 0.25; hydrophobic: 0.34

PDB: 1agm, 1dog, 1gah, 1gai, 1glm, 3eqa, 3gly

HET: acr, gac, noj

AMYP_HUMAN_16_511 [text] Pancreatic alpha-amylase [Glycosyl hydrolase 13 family]

volume: 810. Å3; shape: 0.71; buriedness: 0.7

negative: 0.16; positive: 0.24; polar: 0.16; backbone: 0.21; hydrophobic: 0.23

PDB: 1b2y, 1bsi, 1cpu, 1hny, 1kb3, 1kbb, 1kbk, 1kgu, 1kgw, 1kgx, 1u2y, 1u30, 1u33, 1xcw, 1xcx, 1xd0, 1xd1, 1xgz, 1xh0, 1xh1, 1xh2, 2cpu, 2qmk, 2qv4, 3bai, 3baj, 3bak, 3baw, 3bax, 3bay, 3cpu, 3ij7, 3ij8, 3ij9, 3old, 3ole, 3olg, 3oli, 4gqq, 4gqr, 4w93, 4x9y, 5e0f, 5emy, 5td4

HET: 3l9, 3sa, 5j7, 5qp, 6sa, aao, aci, agl, are, b0d, b9d, bgc, cey, g6d, glc, gox, hmc, hsd, iab, lag, lm2, myc, na, qv4

AMYP_PIG_16_511 [text] Pancreatic alpha-amylase [Glycosyl hydrolase 13 family]

volume: 1682. Å3; shape: 0.68; buriedness: 0.58

negative: 0.18; positive: 0.25; polar: 0.13; backbone: 0.15; hydrophobic: 0.28

PDB: 1bvn, 1dhk, 1hx0, 1jfh, 1kxq, 1kxt, 1kxv, 1ose, 1pif, 1pig, 1ppi, 1ua3, 1vah, 1wo2, 3l2l, 3l2m, 4x0n

HET: ac1, agl, bgc, daf, glc, hmc, ma1, ma2, ma3, mlr, npo

AMY_PSEHA_25_475 [text] Alpha-amylase [Glycosyl hydrolase 13 family]

volume: 761. Å3; shape: 0.58; buriedness: 0.63

negative: 0.16; positive: 0.2; polar: 0.13; backbone: 0.19; hydrophobic: 0.32

Domains/regions: [R] Substrate binding

PDB: 1aqh, 1aqm, 1b0i, 1g94, 1g9h, 1jd7, 1jd9, 1kxh, 1l0p

HET: acr, daf, glc

AMYS_NEIPO_12_636 [text] Amylosucrase [Glycosyl hydrolase 13 family]

volume: 743. Å3; shape: 0.38; buriedness: 0.95

negative: 0.22; positive: 0.23; polar: 0.11; backbone: 0.24; hydrophobic: 0.19

PDB: 1g5a, 1jg9, 1jgi, 1mvy, 1mw0, 1mw1, 1mw2, 1mw3, 1s46, 1zs2, 3ueq, 4flo, 4flq, 4flr, 4fls

HET: glc, otu, suc

ANDR_HUMAN_666_919_allosteric [text] Androgen receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 382. Å3; shape: 0.59; buriedness: 0.82

negative: 0.16; positive: 0.06; polar: 0.16; backbone: 0.36; hydrophobic: 0.25

Domains/regions: [R] Interaction with KAT7, [R] Interaction with LPXN, [R] Ligand-binding

PDB: 1e3g, 1gs4, 1i37, 1i38, 1t5z, 1t63, 1t65, 1t73, 1t74, 1t76, 1t79, 1t7f, 1t7m, 1t7r, 1t7t, 1xj7, 1xnn, 1xow, 1xq3, 1z95, 2am9, 2ama, 2amb, 2ao6, 2ax6, 2ax7, 2ax8, 2ax9, 2axa, 2hvc, 2ihq, 2nw4, 2oz7, 2pio, 2pip, 2piq, 2pir, 2pit, 2piu, 2piv, 2piw, 2pix, 2pkl, 2pnu, 2q7i, 2q7j, 2q7k, 2q7l, 2qpy, 2yhd, 2ylo, 2ylp, 2ylq, 2z4j, 3b5r, 3b65, 3b66, 3b67, 3b68, 3g0w, 3l3x, 3l3z, 3rlj, 3rll, 3v49, 3v4a, 3zqt, 4hlw, 4k7a, 4oea, 4oed, 4oey, 4oez, 4ofr, 4ofu, 4ogh, 4oh5, 4oha, 4oil, 4oiu, 4oj9, 4ojb, 4ok1, 4okb, 4okt, 4okw, 4okx, 4olm, 4ql8, 5cj6

HET: 056, 17w, 2mi, 30z, 4hy, flf, ico, t3, ylo, ylq

ANDR_HUMAN_666_919_ligBind [text] Androgen receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 336. Å3; shape: 0.68; buriedness: 1.

negative: 0.; positive: 0.04; polar: 0.11; backbone: 0.26; hydrophobic: 0.59

Domains/regions: [R] Interaction with LPXN, [R] Ligand-binding

PDB: 1e3g, 1gs4, 1i37, 1i38, 1t5z, 1t63, 1t65, 1t73, 1t74, 1t76, 1t79, 1t7f, 1t7m, 1t7r, 1t7t, 1xj7, 1xnn, 1xow, 1xq3, 1z95, 2am9, 2ama, 2amb, 2ao6, 2ax6, 2ax7, 2ax8, 2ax9, 2axa, 2hvc, 2ihq, 2nw4, 2oz7, 2pio, 2pip, 2piq, 2pir, 2pit, 2piu, 2piv, 2piw, 2pix, 2pkl, 2pnu, 2q7i, 2q7j, 2q7k, 2q7l, 2qpy, 2yhd, 2ylo, 2ylp, 2ylq, 2z4j, 3b5r, 3b65, 3b66, 3b67, 3b68, 3g0w, 3l3x, 3l3z, 3rlj, 3rll, 3v49, 3v4a, 3zqt, 4hlw, 4k7a, 4oea, 4oed, 4oey, 4oez, 4ofr, 4ofu, 4ogh, 4oh5, 4oha, 4oil, 4oiu, 4oj9, 4ojb, 4ok1, 4okb, 4okt, 4okw, 4okx, 4olm, 4ql8, 5cj6

HET: 17h, 198, 3b6, 51y, 8nh, b5r, b66, b67, b68, bhm, ca4, dht, enm, fhm, hft, hyq, jad, lg7, lgb, lgd, pk0, pk1, r18, rlj, rll, tes, zk5

ANKX_LEGPH_1_484 [text] Phosphocholine transferase AnkX

volume: 321. Å3; shape: 0.61; buriedness: 0.84

negative: 0.22; positive: 0.19; polar: 0.15; backbone: 0.27; hydrophobic: 0.17

Domains/regions: [D] Fido

PDB: 4bep, 4ber, 4bes, 4bet

HET: c5p, cdc, pc

ANM3_HUMAN_209_531 [text] Protein arginine N-methyltransferase 3 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family]

volume: 237. Å3; shape: 0.38; buriedness: 0.67

negative: 0.13; positive: 0.19; polar: 0.07; backbone: 0.26; hydrophobic: 0.35

Domains/regions: [D] SAM-dependent MTase PRMT-type

PDB: 1f3l, 2fyt, 3smq, 4hsg, 4qqn, 4ryl

HET: 3bq, 3zg, ktd, tdu

ANM5_HUMAN_2_637 [text] Protein arginine N-methyltransferase 5 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family]

volume: 516. Å3; shape: 0.72; buriedness: 0.88

negative: 0.08; positive: 0.04; polar: 0.24; backbone: 0.32; hydrophobic: 0.32

Domains/regions: [D] SAM-dependent MTase PRMT-type, [R] Beta barrel, [R] S-adenosyl-L-methionine binding

PDB: 4gqb, 4x60, 4x61, 4x63, 5c9z, 5emj, 5emk, 5eml, 5emm, 5fa5

HET: 3xv, 4z2, 5qh, 5qj, 5qk, 5ql, ace

ANM6_HUMAN_5_375 [text] Protein arginine N-methyltransferase 6 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family. PRMT6 subfamily]

volume: 322. Å3; shape: 0.5; buriedness: 0.66

negative: 0.; positive: 0.; polar: 0.11; backbone: 0.55; hydrophobic: 0.34

Domains/regions: [D] SAM-dependent MTase PRMT-type

PDB: 4hc4, 4qpp, 4qqk, 4y2h, 4y30, 5e8r, 5egs, 5hzm

HET: 36s, 5nr

ANXA5_HUMAN_2_320 [text] Annexin A5 [Annexin family]

volume: 384. Å3; shape: 0.59; buriedness: 0.63

negative: 0.07; positive: 0.21; polar: 0.07; backbone: 0.25; hydrophobic: 0.39

PDB: 1a8a, 1a8b, 1anw, 1anx, 1avh, 1avr, 1bc0, 1bc3, 1bcw, 1bcy, 1bcz, 1g5n, 1hak, 1hvd, 1hve, 1hvf, 1hvg, 1n41, 1n42, 1n44, 1sav, 2h0m, 2ie6, 2ie7, 2ran, 2xo2, 2xo3

HET: k21

AOC1_HUMAN_21_751 [text] Amiloride-sensitive amine oxidase [copper-containing] [Copper/topaquinone oxidase family]

volume: 335. Å3; shape: 0.89; buriedness: 0.89

negative: 0.12; positive: 0.; polar: 0.42; backbone: 0.23; hydrophobic: 0.23

Domains/regions: [R] Substrate binding

PDB: 3hi7, 3hig, 3hii, 3k5t, 3mph

HET: brn, pnt

AOC2_ARATH_73_253 [text] Allene oxide cyclase 2, chloroplastic [Allene oxide cyclase family]

volume: 325. Å3; shape: 0.44; buriedness: 0.8

negative: 0.06; positive: 0.; polar: 0.32; backbone: 0.06; hydrophobic: 0.56

PDB: 1z8k, 2brj, 2dio, 2gin, 2q4i, 4cq6, 4cq7

HET: eod, mrd, t25, whw

AOC3_HUMAN_30_763 [text] Membrane primary amine oxidase [Copper/topaquinone oxidase family]

volume: 324. Å3; shape: 0.56; buriedness: 0.8

negative: 0.07; positive: 0.; polar: 0.37; backbone: 0.21; hydrophobic: 0.36

Domains/regions: [R] Substrate binding

PDB: 1pu4, 1us1, 2c10, 2c11, 2y73, 2y74, 4btw, 4btx, 4bty

HET: jw7, jwf, wf8

AOCX_BOVIN_17_762 [text] Primary amine oxidase, liver isozyme [Copper/topaquinone oxidase family]

volume: 115. Å3; shape: 0.64; buriedness: 0.97

negative: 0.11; positive: 0.11; polar: 0.29; backbone: 0.31; hydrophobic: 0.17

Domains/regions: [R] Substrate binding

PDB: 1tu5, 2pnc

HET: clu

AOFA_HUMAN_5_526 [text] Amine oxidase [flavin-containing] A [Flavin monoamine oxidase family]

volume: 862. Å3; shape: 0.28; buriedness: 0.98

negative: 0.03; positive: 0.05; polar: 0.12; backbone: 0.52; hydrophobic: 0.27

PDB: 2bxr, 2bxs, 2z5x, 2z5y

HET: fad, hrm, mlg

AOFB_HUMAN_1_520 [text] Amine oxidase [flavin-containing] B [Flavin monoamine oxidase family]

volume: 1023. Å3; shape: 0.25; buriedness: 0.99

negative: 0.02; positive: 0.04; polar: 0.13; backbone: 0.5; hydrophobic: 0.32

PDB: 1gos, 1oj9, 1oja, 1ojc, 1s2q, 1s2y, 1s3b, 1s3e, 2bk3, 2bk4, 2bk5, 2byb, 2c64, 2c65, 2c66, 2c67, 2c70, 2c72, 2c73, 2c75, 2c76, 2v5z, 2v60, 2v61, 2vrl, 2vrm, 2vz2, 2xcg, 2xfn, 2xfo, 2xfp, 2xfq, 2xfu, 3po7, 3zyx, 4a79, 4a7a, 4crt

HET: 1pb, 3pl, 4cr, ass, c17, c18, dpk, fa8, fad, foh, isn, laz, ma0, mbn, mbt, mfg, nyp, p1b, pnz, pyj, ras, rgz, rhp, rm1, rm2, rma, rsa, sag, xcg, zon

AOTC_BACTN_2_317 [text] N-acetylornithine carbamoyltransferase [ATCase/OTCase family]

volume: 153. Å3; shape: 0.57; buriedness: 0.95

negative: 0.12; positive: 0.35; polar: 0.; backbone: 0.09; hydrophobic: 0.45

Domains/regions: [R] N-acetylornithine binding

PDB: 1js1, 2fg6, 2fg7, 2g7m

HET: an0, sn0

AOTC_XANCP_2_339 [text] N-acetylornithine carbamoyltransferase [ATCase/OTCase family]

volume: 242. Å3; shape: 0.62; buriedness: 0.86

negative: 0.05; positive: 0.27; polar: 0.19; backbone: 0.26; hydrophobic: 0.24

Domains/regions: [R] Carbamoyl phosphate binding, [R] N-acetylornithine binding

PDB: 3kzc, 3kzk, 3kzm, 3kzn, 3kzo, 3l02, 3l04, 3l05, 3l06, 3m4j, 3m4n, 3m5c, 3m5d

HET: an0, aor, cp, oln, pa9, sn0

AOXA_HUMAN_1_1338 [text] Aldehyde oxidase [Xanthine dehydrogenase family]

volume: 241. Å3; shape: 0.7; buriedness: 0.97

negative: 0.03; positive: 0.04; polar: 0.13; backbone: 0.62; hydrophobic: 0.17

PDB: 4uhw, 4uhx, 5epg

HET: mte

AOX_TRYBB_1_329 [text] Alternative oxidase, mitochondrial [Alternative oxidase family]

volume: 256. Å3; shape: 0.53; buriedness: 0.91

negative: 0.1; positive: 0.13; polar: 0.12; backbone: 0.31; hydrophobic: 0.34

PDB: 3vv9, 3vva, 3w54

HET: chw, rnb

APEH_AERPE_2_582 [text] Acylamino-acid-releasing enzyme [Peptidase S9C family]

volume: 245. Å3; shape: 0.64; buriedness: 0.83

negative: 0.; positive: 0.1; polar: 0.17; backbone: 0.32; hydrophobic: 0.4

PDB: 1ve6, 1ve7, 2hu5, 2hu7, 2hu8, 2qr5, 2qzp, 3o4g, 3o4h, 3o4i, 3o4j, 4re5, 4re6

HET: 4np, ace, be2, y3a

APHA_ECOLI_26_237 [text] Class B acid phosphatase [Class B bacterial acid phosphatase family]

volume: 294. Å3; shape: 0.51; buriedness: 0.81

negative: 0.21; positive: 0.04; polar: 0.21; backbone: 0.32; hydrophobic: 0.21

Domains/regions: [R] Substrate binding

PDB: 1n8n, 1n9k, 1rmq, 1rmt, 1rmy, 1z5g, 1z5u, 2b82, 2b8j, 2g1a, 2heg, 2hf7, 3cz4

HET: 5hg, adn, al, au, cmp, dcz, os, spm

APHA_MYCRA_1_341 [text] Acetylpolyamine aminohydrolase [Histone deacetylase family]

volume: 268. Å3; shape: 0.48; buriedness: 0.89

negative: 0.18; positive: 0.16; polar: 0.22; backbone: 0.18; hydrophobic: 0.27

Domains/regions: [R] Substrate binding

PDB: 3q9b, 3q9c, 3q9e, 3q9f, 4zum, 4zun, 4zuo, 4zup, 4zuq, 4zur

HET: 5xa, 6xa, 7xa, b3n, fks, q9c, sp5, ss9, xs6

APOA_HUMAN_4123_4201 [text] Apolipoprotein(a) [Peptidase S1 family. Plasminogen subfamily]

volume: 236. Å3; shape: 0.51; buriedness: 0.64

negative: 0.23; positive: 0.24; polar: 0.; backbone: 0.2; hydrophobic: 0.33

Domains/regions: [D] Kringle 37

PDB: 1kiv, 3kiv, 4bv5, 4bv7, 4bvc, 4bvd, 4kiv

HET: 5c3, aca, bu6, bv5, bv7

APOD_HUMAN_23_189 [text] Apolipoprotein D [Calycin superfamily. Lipocalin family]

volume: 206. Å3; shape: 0.51; buriedness: 0.77

negative: 0.; positive: 0.; polar: 0.5; backbone: 0.; hydrophobic: 0.5

PDB: 2hzq, 2hzr

HET: str

APOM_HUMAN_21_188 [text] Apolipoprotein M [Calycin superfamily. Lipocalin family. Highly divergent]

volume: 293. Å3; shape: 0.38; buriedness: 0.93

negative: 0.06; positive: 0.19; polar: 0.12; backbone: 0.03; hydrophobic: 0.59

PDB: 2wew, 2wex, 2yg2

HET: gym, myr, s1p

APT_HUMAN_1_180 [text] Adenine phosphoribosyltransferase [Purine/pyrimidine phosphoribosyltransferase family]

volume: 279. Å3; shape: 0.88; buriedness: 0.8

negative: 0.11; positive: 0.06; polar: 0.11; backbone: 0.49; hydrophobic: 0.23

PDB: 1ore, 1zn7, 1zn8, 1zn9, 4x44, 4x45

HET: ade, amp, hsx, mg, prp

APX1_PEA_2_250_ascorbate [text] L-ascorbate peroxidase, cytosolic [Peroxidase family. Ascorbate peroxidase subfamily]

volume: 134. Å3; shape: 0.63; buriedness: 0.68

negative: 0.; positive: 0.19; polar: 0.; backbone: 0.46; hydrophobic: 0.35

PDB: 1apx, 1oaf, 1oag, 1v0h, 2ghh, 2ghk, 2vcf, 2xi6, 2xif, 2xih, 2xj6, 2y6a, 2y6b

HET: asc, isz

APX1_PEA_2_250_SHA [text] L-ascorbate peroxidase, cytosolic [Peroxidase family. Ascorbate peroxidase subfamily]

volume: 120. Å3; shape: 0.72; buriedness: 0.76

negative: 0.; positive: 0.24; polar: 0.13; backbone: 0.51; hydrophobic: 0.13

PDB: 1apx, 1oaf, 1oag, 1v0h, 2ghh, 2ghk, 2vcf, 2xi6, 2xif, 2xih, 2xj6, 2y6a, 2y6b

HET: isz, sha

ARAA_ECOLI_1_500 [text] L-arabinose isomerase [Arabinose isomerase family]

volume: 95. Å3; shape: 0.66; buriedness: 0.93

negative: 0.21; positive: 0.39; polar: 0.18; backbone: 0.; hydrophobic: 0.22

PDB: 2ajt, 2hxg, 4f2d

HET: rb0

ARAA_GEOKA_1_496 [text] L-arabinose isomerase [Arabinose isomerase family]

volume: 93. Å3; shape: 0.7; buriedness: 1.

negative: 0.17; positive: 0.25; polar: 0.23; backbone: 0.; hydrophobic: 0.35

PDB: 4r1o, 4r1p, 4r1q

HET: sst

ARC3_CBDP_41_251 [text] Mono-ADP-ribosyltransferase C3

volume: 431. Å3; shape: 0.45; buriedness: 0.81

negative: 0.18; positive: 0.19; polar: 0.14; backbone: 0.45; hydrophobic: 0.05

PDB: 1g24, 1gze, 1gzf, 1uzi, 2a78, 2a9k, 2bov, 2c89, 2c8a, 2c8b, 2c8c, 2c8d, 2c8e, 2c8f, 2c8g, 2c8h

HET: adp, nad, nca, nir

ARD1_YEAST_1_238 [text] N-terminal acetyltransferase A complex catalytic subunit ARD1 [Acetyltransferase family. ARD1 subfamily]

volume: 606. Å3; shape: 0.77; buriedness: 0.29

negative: 0.15; positive: 0.2; polar: 0.2; backbone: 0.45; hydrophobic: 0.

Domains/regions: [D] N-acetyltransferase

PDB: 4hnw, 4hnx, 4hny, 4xnh, 4xpd

HET: g4p, i6p, ihp

ARF1_HUMAN_12_181 [text] ADP-ribosylation factor 1 [Small GTPase superfamily. Arf family]

volume: 198. Å3; shape: 0.67; buriedness: 0.75

negative: 0.; positive: 0.; polar: 0.13; backbone: 0.23; hydrophobic: 0.64

PDB: 1hur, 1j2j, 1o3y, 1r8q, 1r8s, 1re0, 1rrf, 1rrg, 1s9d, 2j59, 3o47, 4c0a

HET: afb

ARF6_HUMAN_9_175 [text] ADP-ribosylation factor 6 [Small GTPase superfamily. Arf family]

volume: 333. Å3; shape: 0.46; buriedness: 0.8

negative: 0.08; positive: 0.08; polar: 0.22; backbone: 0.52; hydrophobic: 0.11

PDB: 1e0s, 2a5d, 2a5f, 2a5g, 2j5x, 2w83, 3lvq, 3lvr, 3n5c, 3pcr, 3vhx, 4kax

HET: gdp, gsp, gtp

ARG56_YEAST_58_356 [text] Protein ARG5,6, mitochondrial

volume: 123. Å3; shape: 0.62; buriedness: 0.93

negative: 0.; positive: 0.09; polar: 0.14; backbone: 0.58; hydrophobic: 0.18

PDB: 3zzf, 3zzg, 3zzh, 4ab7

HET: nlg

ARGB_ECOLI_1_258 [text] Acetylglutamate kinase [Acetylglutamate kinase family]

volume: 484. Å3; shape: 0.44; buriedness: 0.82

negative: 0.04; positive: 0.1; polar: 0.14; backbone: 0.53; hydrophobic: 0.19

Domains/regions: [R] Substrate binding

PDB: 1gs5, 1gsj, 1oh9, 1oha, 1ohb, 2wxb, 2x2w

HET: adp, alf, anp, dtu, mg, nlg, x2w

ARGD_SALTY_1_405 [text] Acetylornithine/succinyldiaminopimelate aminotransferase [Class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily]

volume: 226. Å3; shape: 0.95; buriedness: 0.84

negative: 0.17; positive: 0.05; polar: 0.24; backbone: 0.41; hydrophobic: 0.12

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 2pb0, 2pb2, 4jev, 4jew, 4jex, 4jey, 4jez, 4jf0, 4jf1

HET: p00, plp, pxg

ARGD_THET8_1_395 [text] Acetylornithine/acetyl-lysine aminotransferase [Class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily]

volume: 281. Å3; shape: 0.75; buriedness: 0.94

negative: 0.14; positive: 0.09; polar: 0.28; backbone: 0.39; hydrophobic: 0.09

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 1vef, 1wkg, 1wkh

HET: plp, poi, ppe

ARGI1_HUMAN_1_322 [text] Arginase-1 [Arginase family]

volume: 226. Å3; shape: 0.53; buriedness: 0.89

negative: 0.46; positive: 0.2; polar: 0.2; backbone: 0.13; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 1wva, 1wvb, 2aeb, 2pha, 2pho, 2pll, 2zav, 3dj8, 3e6k, 3e6v, 3f80, 3gmz, 3gn0, 3kv2, 3lp4, 3lp7, 3mfv, 3mfw, 3mjl, 3sjt, 3skk, 3tf3, 3th7, 3the, 3thh, 3thj, 4fci, 4fck, 4gsm, 4gsv, 4gsz, 4gwc, 4gwd, 4hww, 4hxq, 4ie1

HET: 1ec, 2ai, 4u7, 5ab, 6hn, abh, b3u, bcn, dmo, exy, gpa, har, nnh, orn, s2c, x7a, x8a, z70, zn

ARGI1_RAT_4_321 [text] Arginase-1 [Arginase family]

volume: 148. Å3; shape: 0.5; buriedness: 0.89

negative: 0.51; positive: 0.13; polar: 0.21; backbone: 0.14; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 1d3v, 1hq5, 1hqf, 1hqg, 1hqh, 1hqx, 1p8m, 1p8n, 1p8o, 1p8p, 1p8q, 1p8r, 1p8s, 1r1o, 1rla, 1t4p, 1t4r, 1t4s, 1t4t, 1t5f, 1t5g, 1ta1, 1tbh, 1tbj, 1tbl, 1zpe, 1zpg, 2rla, 3e8q, 3e8z, 3e9b, 3rla, 4rla, 5rla

HET: 2bh, abh, ahi, dhh, dir, har, nnh, orn, s2c, sdc

ARGR_MYCTU_92_170 [text] Arginine repressor [ArgR family]

volume: 131. Å3; shape: 0.54; buriedness: 0.96

negative: 0.19; positive: 0.04; polar: 0.16; backbone: 0.52; hydrophobic: 0.08

PDB: 2zfz, 3bue, 3cag, 3ere, 3fhz, 3laj, 3lap

HET: ggb

ARIS_ASPTE_10_320 [text] Aristolochene synthase [Terpene synthase family]

volume: 261. Å3; shape: 0.83; buriedness: 0.95

negative: 0.12; positive: 0.06; polar: 0.27; backbone: 0.16; hydrophobic: 0.4

Domains/regions: [R] Substrate-binding

PDB: 2e4o, 2oa6, 3bnx, 3bny, 3cke, 4kux, 4kvd, 4kvi, 4kvw, 4kvy, 4kwd, 5imi, 5imn, 5imp, 5in8, 5ivg

HET: 1ss, 1sv, fdf, fpf, fpp, fps, jf1, jf2, jf4

ARLY2_ANAPL_4_468 [text] Argininosuccinate lyase [Lyase 1 family. Argininosuccinate lyase subfamily]

volume: 275. Å3; shape: 0.42; buriedness: 0.79

negative: 0.02; positive: 0.22; polar: 0.45; backbone: 0.22; hydrophobic: 0.08

Domains/regions: [R] Substrate binding

PDB: 1auw, 1dcn, 1hy1, 1k7w, 1tju, 1tjv, 1tjw

HET: as1

ARNA_ECOLI_1_306 [text] Bifunctional polymyxin resistance protein ArnA

volume: 337. Å3; shape: 0.54; buriedness: 0.9

negative: 0.; positive: 0.27; polar: 0.13; backbone: 0.24; hydrophobic: 0.35

Domains/regions: [R] Formyltransferase ArnAFT

PDB: 1yrw, 1z7e, 2bln, 4wkg, 5j63

HET: g3n, u5p

ARNB_SALTY_1_385 [text] UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase [DegT/DnrJ/EryC1 family. ArnB subfamily]

volume: 412. Å3; shape: 0.48; buriedness: 0.9

negative: 0.04; positive: 0.16; polar: 0.21; backbone: 0.26; hydrophobic: 0.33

PDB: 1mdo, 1mdx, 1mdz, 4oca

HET: 2qr, dcs, plp, pmp

ARNT_HUMAN_354_467 [text] Aryl hydrocarbon receptor nuclear translocator

volume: 589. Å3; shape: 0.82; buriedness: 0.25

negative: 0.; positive: 0.23; polar: 0.18; backbone: 0.; hydrophobic: 0.59

Domains/regions: [D] PAC, [D] PAS 2

PDB: 2b02, 3f1n, 3f1o, 3f1p, 3h7w, 3h82, 4eq1, 4ghi, 4gs9, 4h6j, 4lpz, 4pky, 4xt2, 4zp4, 4zph, 4zqd, 5sy5, 5t0t, 5tbm

HET: pe5

ARO1_EMENI_1_393 [text] Pentafunctional AROM polypeptide

volume: 154. Å3; shape: 0.8; buriedness: 0.91

negative: 0.16; positive: 0.55; polar: 0.12; backbone: 0.08; hydrophobic: 0.08

Domains/regions: [R] 3-dehydroquinate synthase, [R] Substrate binding 2

PDB: 1dqs, 1nr5, 1nrx, 1nua, 1nva, 1nvb, 1nvd, 1nve, 1nvf, 1sg6

HET: crb

AROA_AGRSC_3_453 [text] 3-phosphoshikimate 1-carboxyvinyltransferase [EPSP synthase family]

volume: 260. Å3; shape: 0.73; buriedness: 0.97

negative: 0.09; positive: 0.37; polar: 0.22; backbone: 0.26; hydrophobic: 0.06

Domains/regions: [R] Phosphoenolpyruvate, [R] Shikimate-3-phosphate binding

PDB: 2gg4, 2gg6, 2gga, 2ggd, 2pqb, 2pqc, 2pqd

HET: gg9, gpj, rc1, s3p

AROA_COXBU_1_438 [text] 3-phosphoshikimate 1-carboxyvinyltransferase [EPSP synthase family]

volume: 109. Å3; shape: 0.56; buriedness: 0.97

negative: 0.15; positive: 0.4; polar: 0.16; backbone: 0.28; hydrophobic: 0.

Domains/regions: [R] Phosphoenolpyruvate, [R] Shikimate-3-phosphate binding

PDB: 3roi, 3slh, 3tr1, 4egr, 4gfp, 4znd

HET: gpj, pep

AROA_ECOLI_3_240 [text] 3-phosphoshikimate 1-carboxyvinyltransferase [EPSP synthase family]

volume: 249. Å3; shape: 0.78; buriedness: 0.98

negative: 0.09; positive: 0.37; polar: 0.36; backbone: 0.17; hydrophobic: 0.01

Domains/regions: [R] Phosphoenolpyruvate, [R] Shikimate-3-phosphate binding

PDB: 1eps, 1g6s, 1g6t, 1mi4, 1q36, 1x8r, 1x8t, 2aa9, 2aay, 2pq9, 2qfq, 2qfs, 2qft, 2qfu, 3fjx, 3fjz, 3fk0, 3fk1

HET: gg9, gpf, gpj, rc1, s3p, sc1, skm, skp

AROA_MYCTU_1_447 [text] 3-phosphoshikimate 1-carboxyvinyltransferase [EPSP synthase family]

volume: 229. Å3; shape: 0.81; buriedness: 0.98

negative: 0.09; positive: 0.46; polar: 0.29; backbone: 0.12; hydrophobic: 0.04

Domains/regions: [R] Phosphoenolpyruvate binding, [R] Shikimate-3-phosphate binding

PDB: 2bjb, 2o0b, 2o0d, 2o0e, 2o0x, 2o0z, 2o15

HET: eps, pep, s3p, skp

AROA_STRPN_1_427 [text] 3-phosphoshikimate 1-carboxyvinyltransferase [EPSP synthase family]

volume: 266. Å3; shape: 0.71; buriedness: 0.98

negative: 0.07; positive: 0.34; polar: 0.25; backbone: 0.31; hydrophobic: 0.04

Domains/regions: [R] Phosphoenolpyruvate binding, [R] Shikimate-3-phosphate binding

PDB: 1rf4, 1rf5, 1rf6, 4n3p

HET: gpj, s3p, spq

AROA_VIBCH_13_243 [text] 3-phosphoshikimate 1-carboxyvinyltransferase [EPSP synthase family]

volume: 134. Å3; shape: 0.81; buriedness: 0.94

negative: 0.; positive: 0.24; polar: 0.57; backbone: 0.19; hydrophobic: 0.

Domains/regions: [R] Shikimate-3-phosphate binding

PDB: 3nvs, 3ti2

HET: s3p, skm

AROB_STAAR_1_354 [text] 3-dehydroquinate synthase [Dehydroquinate synthase family]

volume: 159. Å3; shape: 0.78; buriedness: 0.93

negative: 0.15; positive: 0.56; polar: 0.15; backbone: 0.07; hydrophobic: 0.07

PDB: 1xag, 1xah, 1xai, 1xaj, 1xal

HET: crb

AROD_PEPD6_1_255 [text] 3-dehydroquinate dehydratase [Type-I 3-dehydroquinase family]

volume: 121. Å3; shape: 0.77; buriedness: 0.91

negative: 0.11; positive: 0.43; polar: 0.15; backbone: 0.05; hydrophobic: 0.27

Domains/regions: [R] 3-dehydroquinate binding

PDB: 3js3, 4h3d

HET: dhs, shl

AROD_SALTI_1_252 [text] 3-dehydroquinate dehydratase [Type-I 3-dehydroquinase family]

volume: 141. Å3; shape: 0.78; buriedness: 0.98

negative: 0.09; positive: 0.41; polar: 0.18; backbone: 0.1; hydrophobic: 0.22

Domains/regions: [R] 3-dehydroquinate binding

PDB: 1gqn, 1l9w, 1qfe, 4clm, 4cnn, 4cno, 4cnp, 4uio

HET: 9c4, 9py, dhs, vau, wpl

AROD_SALTY_1_252 [text] 3-dehydroquinate dehydratase [Type-I 3-dehydroquinase family]

volume: 135. Å3; shape: 0.7; buriedness: 0.98

negative: 0.08; positive: 0.39; polar: 0.19; backbone: 0.06; hydrophobic: 0.28

Domains/regions: [R] 3-dehydroquinate binding

PDB: 3l2i, 3lb0, 3m7w, 3nnt, 3o1n, 3oex, 3s42, 4gfs, 4guf, 4gug, 4guh, 4gui, 4guj, 4iuo

HET: 3ds, dqa, mla, ni, qic, skm

AROD_STAAR_1_238 [text] 3-dehydroquinate dehydratase [Type-I 3-dehydroquinase family]

volume: 98. Å3; shape: 0.67; buriedness: 0.98

negative: 0.1; positive: 0.49; polar: 0.26; backbone: 0.; hydrophobic: 0.15

Domains/regions: [R] 3-dehydroquinate binding

PDB: 1sfj, 1sfl

HET: dhk

AROE_AQUAE_1_269 [text] Shikimate dehydrogenase (NADP(+)) [Shikimate dehydrogenase family]

volume: 97. Å3; shape: 0.72; buriedness: 0.87

negative: 0.11; positive: 0.11; polar: 0.66; backbone: 0.; hydrophobic: 0.11

Domains/regions: [R] Shikimate binding

PDB: 2hk7, 2hk8, 2hk9

HET: skm

AROE_CORGL_1_283 [text] Quinate/shikimate dehydrogenase (NAD(+)) [Shikimate dehydrogenase family]

volume: 109. Å3; shape: 0.71; buriedness: 0.8

negative: 0.12; positive: 0.06; polar: 0.71; backbone: 0.; hydrophobic: 0.12

Domains/regions: [R] Quinate/shikimate binding

PDB: 2nlo, 3jyo, 3jyp, 3jyq

HET: qic, skm

AROE_HELPY_1_263 [text] Shikimate dehydrogenase (NADP(+)) [Shikimate dehydrogenase family]

volume: 112. Å3; shape: 0.75; buriedness: 0.89

negative: 0.1; positive: 0.11; polar: 0.63; backbone: 0.1; hydrophobic: 0.06

Domains/regions: [R] Shikimate binding

PDB: 3phg, 3phh, 3phi, 3phj, 4foo, 4fos, 4fpx, 4fq8, 4fr5, 4fsh

HET: dhk, skm

AROE_LISMO_1_291 [text] Shikimate dehydrogenase (NADP(+)) [Shikimate dehydrogenase family]

volume: 106. Å3; shape: 0.73; buriedness: 0.85

negative: 0.; positive: 0.07; polar: 0.8; backbone: 0.; hydrophobic: 0.13

Domains/regions: [R] Shikimate binding

PDB: 3tnl, 3toz

HET: skm

AROE_STAEQ_1_269 [text] Shikimate dehydrogenase (NADP(+)) [Shikimate dehydrogenase family]

volume: 92. Å3; shape: 0.72; buriedness: 0.84

negative: 0.11; positive: 0.11; polar: 0.67; backbone: 0.; hydrophobic: 0.11

Domains/regions: [R] Shikimate binding

PDB: 3don, 3doo

HET: skm

AROE_THET8_1_263 [text] Shikimate dehydrogenase (NADP(+)) [Shikimate dehydrogenase family]

volume: 103. Å3; shape: 0.73; buriedness: 0.88

negative: 0.1; positive: 0.09; polar: 0.61; backbone: 0.09; hydrophobic: 0.11

Domains/regions: [R] Shikimate binding

PDB: 1wxd, 2cy0, 2d5c, 2ev9

HET: skm

AROE_VIBCH_1_278 [text] Shikimate dehydrogenase (NADP(+)) [Shikimate dehydrogenase family]

volume: 107. Å3; shape: 0.74; buriedness: 0.83

negative: 0.11; positive: 0.12; polar: 0.66; backbone: 0.; hydrophobic: 0.11

Domains/regions: [R] Shikimate binding

PDB: 3o8q, 3pgj, 3sef

HET: skm

AROF_THEMA_67_338 [text] Phospho-2-dehydro-3-deoxyheptonate aldolase [Class-I DAHP synthase family]

volume: 94. Å3; shape: 0.65; buriedness: 0.94

negative: 0.11; positive: 0.44; polar: 0.11; backbone: 0.22; hydrophobic: 0.11

PDB: 1rzm, 1vr6, 3pg8, 3pg9

HET: pep

AROG_ECOLI_1_350 [text] Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive [Class-I DAHP synthase family]

volume: 201. Å3; shape: 0.53; buriedness: 0.94

negative: 0.17; positive: 0.39; polar: 0.1; backbone: 0.24; hydrophobic: 0.1

PDB: 1gg1, 1kfl, 1n8f, 1qr7, 5cks

HET: 52l, pep, pga

AROG_MYCTU_1_462 [text] Phospho-2-dehydro-3-deoxyheptonate aldolase AroG [Class-II DAHP synthase family]

volume: 205. Å3; shape: 0.55; buriedness: 0.93

negative: 0.24; positive: 0.51; polar: 0.; backbone: 0.16; hydrophobic: 0.08

Domains/regions: [R] Substrate binding

PDB: 2b7o, 2w19, 2w1a, 2ypo, 2ypp, 2ypq, 3kgf, 3nud, 3nue, 3nv8, 3pfp, 3rzi, 5ckv, 5ckx, 5e2l, 5e40, 5e4n, 5e5g, 5e7z, 5ex4

HET: 035, 036, pep

AROG_YEAST_1_370 [text] Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited [Class-I DAHP synthase family]

volume: 92. Å3; shape: 0.62; buriedness: 0.96

negative: 0.; positive: 0.51; polar: 0.13; backbone: 0.25; hydrophobic: 0.11

PDB: 1hfb, 1oab, 1of6, 1of8, 1ofa, 1ofb, 1ofo, 1ofp, 1ofq, 1ofr, 1og0

HET: pep, pga

AROH_BACSU_1_127 [text] Chorismate mutase AroH

volume: 153. Å3; shape: 0.89; buriedness: 0.91

negative: 0.07; positive: 0.16; polar: 0.13; backbone: 0.36; hydrophobic: 0.28

Domains/regions: [D] Chorismate mutase aroH-type, [R] Substrate binding

PDB: 1com, 1dbf, 1fnj, 1fnk, 2chs, 2cht, 3zo8, 3zop, 3zp4, 3zp7

HET: isj, pre, tsa

AROK_HELPY_1_162 [text] Shikimate kinase [Shikimate kinase family]

volume: 402. Å3; shape: 0.76; buriedness: 0.89

negative: 0.09; positive: 0.23; polar: 0.06; backbone: 0.24; hydrophobic: 0.38

PDB: 1zuh, 1zui, 3hr7, 3mrs, 3muf, 3n2e

HET: osa, s3p, skm

AROK_MYCTU_1_176 [text] Shikimate kinase [Shikimate kinase family]

volume: 523. Å3; shape: 0.32; buriedness: 0.76

negative: 0.04; positive: 0.18; polar: 0.08; backbone: 0.5; hydrophobic: 0.2

PDB: 1l4u, 1l4y, 1u8a, 1we2, 1zyu, 2dfn, 2dft, 2g1j, 2g1k, 2iyq, 2iyr, 2iys, 2iyt, 2iyu, 2iyv, 2iyw, 2iyx, 2iyy, 2iyz, 3baf, 4bqs

HET: acp, adp, anp, atp, dhk, k2q, mg, s3p, skm

AROQ_HELPY_1_167 [text] 3-dehydroquinate dehydratase [Type-II 3-dehydroquinase family]

volume: 210. Å3; shape: 0.61; buriedness: 0.99

negative: 0.05; positive: 0.21; polar: 0.15; backbone: 0.33; hydrophobic: 0.26

Domains/regions: [R] Substrate binding

PDB: 1j2y, 2c4v, 2c4w, 2c57, 2wks, 2xb9, 2xd9, 2xda, 4b6r, 4b6s

HET: 2hn, 9zt, cb6, dqa, fa1, gaj, jps, xd9, xnw

AROQ_MYCTU_1_147 [text] 3-dehydroquinate dehydratase [Type-II 3-dehydroquinase family]

volume: 256. Å3; shape: 0.63; buriedness: 0.91

negative: 0.; positive: 0.22; polar: 0.22; backbone: 0.4; hydrophobic: 0.16

Domains/regions: [R] Substrate binding

PDB: 1h05, 1h0r, 1h0s, 2dhq, 2xb8, 2y71, 2y76, 2y77, 3n59, 3n76, 3n7a, 3n86, 3n87, 3n8k, 3n8n, 4b6o, 4b6p, 4b6q, 4civ, 4ciw, 4cix, 4ciy, 4ckw, 4ckx, 4cky, 4ckz, 4cl0, 4ki7, 4kij, 4kiu, 4kiw, 4v0s

HET: 1r2, 2hn, 3dq, 3ds, 48p, 9py, bz5, ca2, cb6, cb7, cb8, d1x, fa1, fa6, kij, kiu, kiw, n87, n88, nd3, ndy, rjp, w4n, xh2, xnw

AROQ_STRCO_2_157 [text] 3-dehydroquinate dehydratase [Type-II 3-dehydroquinase family]

volume: 182. Å3; shape: 0.56; buriedness: 0.97

negative: 0.05; positive: 0.23; polar: 0.15; backbone: 0.39; hydrophobic: 0.17

Domains/regions: [R] Substrate binding

PDB: 1d0i, 1gtz, 1gu0, 1gu1, 1v1j, 2bt4, 2cjf

HET: ca2, dhk, fa1, fa3, rp4

ARSA_HUMAN_19_507 [text] Arylsulfatase A [Sulfatase family]

volume: 103. Å3; shape: 0.55; buriedness: 0.8

negative: 0.24; positive: 0.48; polar: 0.1; backbone: 0.08; hydrophobic: 0.09

PDB: 1auk, 1e1z, 1e2s, 1e33, 1e3c, 1n2k, 1n2l

HET: csn

ARSC_STAAU_1_131 [text] Protein ArsC [Low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family]

volume: 94. Å3; shape: 0.82; buriedness: 0.78

negative: 0.; positive: 0.; polar: 0.08; backbone: 0.42; hydrophobic: 0.5

PDB: 1jf8, 1jfv, 1ljl, 1lju, 1lk0, 1rxe, 1rxi, 2cd7, 2fxi

HET: mnb

ARS_PSEAE_1_536 [text] Arylsulfatase [Sulfatase family]

volume: 153. Å3; shape: 0.7; buriedness: 0.89

negative: 0.1; positive: 0.32; polar: 0.11; backbone: 0.18; hydrophobic: 0.29

PDB: 1hdh, 4cxk, 4cxs, 4cxu, 4cyr, 4cys, 5aj9

HET: 62y, sv7

ASIC1_CHICK_19_463 [text] Acid-sensing ion channel 1 [Amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily]

volume: 524. Å3; shape: 0.57; buriedness: 0.38

negative: 0.43; positive: 0.06; polar: 0.; backbone: 0.41; hydrophobic: 0.09

PDB: 2qts, 3ij4, 3s3w, 3s3x, 4fz0, 4fz1, 4ntw, 4ntx, 4nty, 4nyk

HET: amr

ASM3A_MOUSE_22_445 [text] Acid sphingomyelinase-like phosphodiesterase 3a [Acid sphingomyelinase family]

volume: 269. Å3; shape: 0.57; buriedness: 0.67

negative: 0.1; positive: 0.49; polar: 0.32; backbone: 0.1; hydrophobic: 0.

PDB: 5fc1, 5fc5, 5fc6, 5fc7, 5fca, 5fcb

HET: amp, ap2, pc, zn

ASM3B_MOUSE_18_435 [text] Acid sphingomyelinase-like phosphodiesterase 3b [Acid sphingomyelinase family]

volume: 115. Å3; shape: 0.55; buriedness: 0.9

negative: 0.08; positive: 0.42; polar: 0.17; backbone: 0.17; hydrophobic: 0.17

PDB: 5kar, 5kas

HET: pc, zn

ASM_HUMAN_46_629 [text] Sphingomyelin phosphodiesterase [Acid sphingomyelinase family]

volume: 102. Å3; shape: 0.56; buriedness: 0.63

negative: 0.17; positive: 0.56; polar: 0.11; backbone: 0.17; hydrophobic: 0.

PDB: 5i81, 5i85, 5jg8

HET: pc

ASM_MOUSE_164_614 [text] Sphingomyelin phosphodiesterase [Acid sphingomyelinase family]

volume: 238. Å3; shape: 0.39; buriedness: 0.68

negative: 0.13; positive: 0.45; polar: 0.07; backbone: 0.26; hydrophobic: 0.09

PDB: 5fi9, 5fib, 5fic, 5hqn

HET: nt8

ASM_MOUSE_83_164 [text] Sphingomyelin phosphodiesterase [Acid sphingomyelinase family]

volume: 612. Å3; shape: 0.43; buriedness: 0.36

negative: 0.; positive: 0.; polar: 0.; backbone: 0.41; hydrophobic: 0.59

Domains/regions: [D] Saposin B-type

PDB: 5fi9, 5fib, 5fic

HET: 6e0

ASMT_HUMAN_1_345 [text] Acetylserotonin O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family]

volume: 144. Å3; shape: 0.59; buriedness: 0.94

negative: 0.08; positive: 0.17; polar: 0.46; backbone: 0.; hydrophobic: 0.29

PDB: 4a6d, 4a6e

HET: ase

ASQJ_EMENI_109_416 [text] Iron/alpha-ketoglutarate-dependent dioxygenase asqJ [PhyH family]

volume: 198. Å3; shape: 0.57; buriedness: 0.87

negative: 0.08; positive: 0.08; polar: 0.16; backbone: 0.16; hydrophobic: 0.51

PDB: 5dap, 5daq, 5dav, 5daw, 5dax

HET: 58d, 58j, 58k, 58l

ASST_ECOL6_28_598 [text] Arylsulfate sulfotransferase AssT [Aryl sulfotransferase family]

volume: 142. Å3; shape: 0.61; buriedness: 0.82

negative: 0.; positive: 0.22; polar: 0.43; backbone: 0.15; hydrophobic: 0.2

PDB: 3elq, 3ets, 3ett, 4p04, 4p05, 4p06, 4p07

HET: 4mu, 4ns, mux, npo

ASSY_THET8_1_400 [text] Argininosuccinate synthase [Argininosuccinate synthase family. Type 1 subfamily]

volume: 1100. Å3; shape: 0.22; buriedness: 0.84

negative: 0.1; positive: 0.08; polar: 0.25; backbone: 0.48; hydrophobic: 0.1

PDB: 1j1z, 1j20, 1j21, 1kh1, 1kh2, 1kh3, 1kor

HET: amp, anp, as1, atp, cir

ASTB_ECOLI_1_447 [text] N-succinylarginine dihydrolase [Succinylarginine dihydrolase family]

volume: 202. Å3; shape: 0.38; buriedness: 1.

negative: 0.05; positive: 0.22; polar: 0.23; backbone: 0.32; hydrophobic: 0.18

Domains/regions: [R] Substrate binding

PDB: 1ynf, 1ynh, 1yni

HET: sug, suo

AT1A1_RAT_28_1023 [text] Sodium/potassium-transporting ATPase subunit alpha-1 [Cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily]

volume: 367. Å3; shape: 0.36; buriedness: 0.87

negative: 0.12; positive: 0.04; polar: 0.11; backbone: 0.34; hydrophobic: 0.39

PDB: 3b8e, 3kdp, 3wgu, 3wgv, 4hyt, 4res

HET: buf, obn

AT1B1_PIG_8_73 [text] Sodium/potassium-transporting ATPase subunit beta-1 [X(+)/potassium ATPases subunit beta family]

volume: 454. Å3; shape: 0.42; buriedness: 0.61

negative: 0.; positive: 0.11; polar: 0.; backbone: 0.41; hydrophobic: 0.48

Multimer with: Sodium/potassium-transporting ATPase subunit alpha-1 (AT1A1_RAT) [Cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily]

PDB: 3b8e, 3kdp, 3wgu, 3wgv, 4hyt, 4res

HET: ce1

AT2A1_BOVIN_1_993 [text] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [Cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily]

volume: 1507. Å3; shape: 0.46; buriedness: 0.83

negative: 0.03; positive: 0.; polar: 0.12; backbone: 0.36; hydrophobic: 0.5

PDB: 1iwo, 1su4, 1t5s, 1t5t, 1vfp, 1wpg, 1xp5, 2agv, 2by4, 2c88, 2c8k, 2c8l, 2c9m, 2dqs, 2ear, 2eat, 2eau, 2o9j, 2oa0, 2yfy, 2zbd, 2zbf, 2zbg, 3ar2, 3ar3, 3ar4, 3ar5, 3ar6, 3ar7, 3ar8, 3ar9, 3b9b, 3b9r, 3ba6, 3fgo, 3fpb, 3fps, 3j7t, 3n5k, 3n8g, 3nal, 3nam, 3nan, 3tlm, 3w5a, 3w5b, 3w5c, 3w5d, 4bew, 4h1w, 4j2t, 4kyt, 4nab, 4uu0, 4uu1, 4xou, 4ycl, 4ycm, 4ycn, 5a3q, 5a3r, 5a3s

HET: 1ht, 7bl, 7bs, 9tn, ad4, bhq, cza, dbk, hz1, mg, mn, otk, pcw, pty, tg1

ATAD2_HUMAN_980_1108 [text] ATPase family AAA domain-containing protein 2 [AAA ATPase family]

volume: 536. Å3; shape: 0.64; buriedness: 0.65

negative: 0.13; positive: 0.; polar: 0.24; backbone: 0.21; hydrophobic: 0.41

Domains/regions: [D] Bromo

PDB: 3dai, 4qsp, 4qsq, 4qsr, 4qss, 4qst, 4qsu, 4qsv, 4qsw, 4qsx, 4qut, 4quu, 4tt2, 4tt4, 4tt6, 4tte, 4tu4, 4tu6, 4tyl, 4tz2, 4tz8, 5a5n, 5a5o, 5a5p, 5a5q, 5a5r, 5a81, 5a82, 5a83, 5epb, 5lj0

HET: 12q, 36z, 37n, 38s, 38t, 39o, 39r, 39u, 5qw, 6xc, 6xx, 78j, 8ws, aly, j5i, jtf, mb3, np8, tdr, thm, yd3, yej

ATDA_VIBCH_1_173_allosteric [text] Spermidine N(1)-acetyltransferase [Acetyltransferase family]

volume: 208. Å3; shape: 0.36; buriedness: 0.56

negative: 0.29; positive: 0.; polar: 0.21; backbone: 0.39; hydrophobic: 0.11

Domains/regions: [D] N-acetyltransferase

PDB: 4jjx, 4jly, 4mhd, 4mi4, 4mj8, 4ncz, 4r57, 4r87, 4ygo, 5cnp

HET: ca, spd, spm

ATDA_VIBCH_1_173_catalytic [text] Spermidine N(1)-acetyltransferase [Acetyltransferase family]

volume: 650. Å3; shape: 0.48; buriedness: 0.67

negative: 0.; positive: 0.08; polar: 0.16; backbone: 0.65; hydrophobic: 0.11

Domains/regions: [D] N-acetyltransferase, [R] Substrate binding

PDB: 4jjx, 4jly, 4mhd, 4mi4, 4mj8, 4ncz, 4r57, 4r87, 4ygo, 5cnp

HET: aco, coa

ATGT_PYRHO_1_582 [text] tRNA-guanine(15) transglycosylase [Archaeosine tRNA-ribosyltransferase family]

volume: 182. Å3; shape: 0.61; buriedness: 0.95

negative: 0.22; positive: 0.; polar: 0.27; backbone: 0.24; hydrophobic: 0.27

PDB: 1iq8, 1it7, 1it8, 1j2b

HET: gun, pq0

ATOB_ECOLI_1_393 [text] Acetyl-CoA acetyltransferase [Thiolase family]

volume: 576. Å3; shape: 0.48; buriedness: 0.68

negative: 0.; positive: 0.15; polar: 0.03; backbone: 0.26; hydrophobic: 0.56

PDB: 4wys, 5f0v, 5f38

HET: 5ug, coz

ATOX1_HUMAN_1_68 [text] Copper transport protein ATOX1 [ATX1 family]

volume: 369. Å3; shape: 0.45; buriedness: 0.38

negative: 0.; positive: 0.17; polar: 0.12; backbone: 0.34; hydrophobic: 0.37

Domains/regions: [D] HMA

PDB: 1fe0, 1fe4, 1fee, 3cjk, 3iwl, 3iwx, 4qot, 4ydx, 4yea, 5t7l

HET: cd, cpt, cu, tce

ATPA_SPIOL_1_507 [text] ATP synthase subunit alpha, chloroplastic [ATPase alpha/beta chains family]

volume: 265. Å3; shape: 0.71; buriedness: 0.62

negative: 0.18; positive: 0.18; polar: 0.; backbone: 0.18; hydrophobic: 0.45

PDB: 1fx0, 1kmh

HET: ttx

ATS1_HUMAN_254_548 [text] A disintegrin and metalloproteinase with thrombospondin motifs 1

volume: 436. Å3; shape: 0.58; buriedness: 0.75

negative: 0.08; positive: 0.15; polar: 0.08; backbone: 0.48; hydrophobic: 0.21

Domains/regions: [D] Peptidase M12B

PDB: 2jih, 2v4b, 3q2g, 3q2h

HET: 097, qgf, qhf

ATS4_HUMAN_213_440 [text] A disintegrin and metalloproteinase with thrombospondin motifs 4

volume: 408. Å3; shape: 0.3; buriedness: 0.82

negative: 0.01; positive: 0.14; polar: 0.12; backbone: 0.5; hydrophobic: 0.23

Domains/regions: [D] Peptidase M12B

PDB: 2rjp, 3b2z, 4wk7, 4wke, 4wki

HET: 3pq, 3pu, 3pw, 886

ATS5_HUMAN_262_480 [text] A disintegrin and metalloproteinase with thrombospondin motifs 5

volume: 390. Å3; shape: 0.8; buriedness: 0.77

negative: 0.1; positive: 0.15; polar: 0.05; backbone: 0.47; hydrophobic: 0.23

Domains/regions: [D] Peptidase M12B

PDB: 2rjq, 3b8z, 3hy7, 3hy9, 3hyg, 3ljt

HET: 097, 098, 099, 294, bat, la3

ATSK_PSEPU_1_301 [text] Alpha-ketoglutarate-dependent sulfate ester dioxygenase [TfdA dioxygenase family]

volume: 140. Å3; shape: 0.6; buriedness: 0.69

negative: 0.12; positive: 0.12; polar: 0.; backbone: 0.38; hydrophobic: 0.38

PDB: 1oih, 1oii, 1oij, 1oik, 1vz4, 1vz5

HET: c26

AUD_PHACH_1_900 [text] Aldos-2-ulose dehydratase

volume: 90. Å3; shape: 0.74; buriedness: 0.88

negative: 0.12; positive: 0.35; polar: 0.; backbone: 0.12; hydrophobic: 0.42

Domains/regions: [R] Isomerase domain

PDB: 4a7k, 4a7y, 4a7z

HET: ay9, nhf

AUKBA_XENLA_78_360 [text] Aurora kinase B-A [Protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily]

volume: 601. Å3; shape: 0.4; buriedness: 0.73

negative: 0.09; positive: 0.04; polar: 0.04; backbone: 0.39; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 2bfx, 2bfy, 2vgo, 2vgp, 2vrx, 3ztx, 4b8l, 4b8m, 4c2v, 4c2w, 5eyk, 5k3y

HET: 447, 5u5, 6q4, a0p, ad5, ad6, anp, h1n, vx6, yja, ztx

AURKA_HUMAN_122_398 [text] Aurora kinase A [Protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily]

volume: 816. Å3; shape: 0.42; buriedness: 0.81

negative: 0.04; positive: 0.07; polar: 0.09; backbone: 0.45; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 1mq4, 1muo, 1ol5, 1ol6, 1ol7, 2bmc, 2c6d, 2c6e, 2dwb, 2j4z, 2j50, 2np8, 2w1c, 2w1d, 2w1e, 2w1f, 2w1g, 2wqe, 2wtv, 2wtw, 2x6d, 2x6e, 2x81, 2xne, 2xng, 2xru, 3coh, 3d14, 3d15, 3d2i, 3d2k, 3daj, 3dj5, 3dj6, 3dj7, 3e5a, 3efw, 3fdn, 3h0y, 3h0z, 3h10, 3ha6, 3k5u, 3lau, 3m11, 3myg, 3nrm, 3o50, 3o51, 3p9j, 3qbn, 3r21, 3r22, 3unz, 3uo4, 3uo5, 3uo6, 3uod, 3uoh, 3uoj, 3uok, 3uol, 3up2, 3up7, 3vap, 3w10, 3w16, 3w18, 3w2c, 4b0g, 4bn1, 4byi, 4byj, 4c3p, 4c3r, 4ceg, 4dea, 4deb, 4ded, 4dee, 4dhf, 4j8m, 4j8n, 4jai, 4jaj, 4jbo, 4jbp, 4jbq, 4o0s, 4o0u, 4o0w, 4prj, 4utd, 4uyn, 4uzd, 4uzh, 4zs0, 4ztq, 4ztr, 4zts, 5aad, 5aae, 5aaf, 5aag, 5dn3, 5dnr, 5dos, 5dpv, 5dr2, 5dr6, 5dr9, 5drd, 5dt0, 5dt3, 5dt4, 5ew9, 5g1x, 5l8j, 5l8k, 5l8l, 5lxm

HET: 0bx, 0by, 0bz, 0c0, 0c3, 0c4, 0c5, 0c6, 0c7, 0c8, 0c9, 0fy, 0k6, 2jz, 2vu, 400, 48b, 4qv, 4rj, 4rk, 4rm, 5gx, 5vc, 626, 627, 6f2, 7hd, 83h, 97b, a0h, ak1, ak2, ak3, ak4, ak5, ak6, ak7, ak8, aki, ash, cc3, cj5, d36, d37, e9z, eml, fh3, fh5, fxg, hpm, jve, l0c, l0e, l0f, l0g, lje, ljf, mg, mmh, mpy, n13, n15, nhi, nhj, nhu, nl4, nrm, ofi, p9j, pfq, qmn, ro9, ske, vek, wph, x6d, xu2, y3m, ym4, zzl

AURKB_HUMAN_54_344 [text] Aurora kinase B [Protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily]

volume: 332. Å3; shape: 0.45; buriedness: 0.77

negative: 0.; positive: 0.06; polar: 0.06; backbone: 0.44; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 4af3

HET: vx6

AVID_CHICK_25_150 [text] Avidin [Avidin/streptavidin family]

volume: 504. Å3; shape: 0.41; buriedness: 0.88

negative: 0.03; positive: 0.04; polar: 0.42; backbone: 0.17; hydrophobic: 0.34

Domains/regions: [D] Avidin-like

PDB: 1avd, 1ave, 1ij8, 1ldo, 1ldq, 1lel, 1nqn, 1rav, 1vyo, 2a5b, 2a5c, 2a8g, 2avi, 2c4i, 2cam, 3fdc, 3vgw, 3vhh, 3vhi, 3vhm, 4i60, 4jhq, 4u46, 5chk, 5iru, 5irw

HET: 55r, 8da, 8hg, b1r, b6f, b9p, bh7, bni, btf, btn, d9p, fe, gng, npk, nvz, shm, snr, vhh, vhi

AVR2A_HUMAN_190_488 [text] Activin receptor type-2A [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 339. Å3; shape: 0.47; buriedness: 0.9

negative: 0.09; positive: 0.11; polar: 0.11; backbone: 0.39; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 3q4t, 3soc, 4asx

HET: 6oj, gvd, tak

AVR2B_HUMAN_188_487_ATPsite [text] Activin receptor type-2B [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 75. Å3; shape: 0.83; buriedness: 0.9

negative: 0.; positive: 0.; polar: 0.11; backbone: 0.33; hydrophobic: 0.56

Domains/regions: [D] Protein kinase

PDB: 2qlu

HET: ade

AVR4_CHICK_25_149 [text] Avidin-related protein 4/5 [Avidin/streptavidin family]

volume: 235. Å3; shape: 0.46; buriedness: 0.84

negative: 0.04; positive: 0.03; polar: 0.42; backbone: 0.14; hydrophobic: 0.37

Domains/regions: [D] Avidin-like

PDB: 1y52, 1y53, 1y55, 2fhl, 2fhn, 2of8, 2of9, 2ofa, 2ofb, 4bcs

HET: bni, btn

AZOR1_PSEAE_1_212 [text] FMN-dependent NADH-azoreductase 1 [Azoreductase type 1 family]

volume: 318. Å3; shape: 0.57; buriedness: 0.7

negative: 0.06; positive: 0.; polar: 0.25; backbone: 0.22; hydrophobic: 0.46

PDB: 2v9c, 3keg, 3lt5, 3r6w, 4n65, 4n9q

HET: aqn, blq, mre, nfz, uq1

AZOR1_PSEPK_1_203_catalytic [text] FMN-dependent NADH-azoreductase 1 [Azoreductase type 1 family]

volume: 706. Å3; shape: 0.73; buriedness: 0.8

negative: 0.; positive: 0.03; polar: 0.24; backbone: 0.4; hydrophobic: 0.33

PDB: 4c0w, 4c0x, 4c14

HET: 12p, aqn, fd5, fmn

AZOR_ECOLI_2_201_dicoumarol [text] FMN-dependent NADH-azoreductase [Azoreductase type 1 family]

volume: 205. Å3; shape: 0.53; buriedness: 0.69

negative: 0.; positive: 0.; polar: 0.42; backbone: 0.17; hydrophobic: 0.42

PDB: 1tik, 1v4b, 2d5i, 2z98, 2z9b, 2z9c, 2z9d

HET: dtc

AZUR_PSEAE_21_148 [text] Azurin

volume: 210. Å3; shape: 0.31; buriedness: 0.53

negative: 0.01; positive: 0.15; polar: 0.; backbone: 0.44; hydrophobic: 0.39

Domains/regions: [D] Plastocyanin-like

PDB: 1ag0, 1azn, 1azr, 1azu, 1bex, 1cc3, 1e5y, 1e5z, 1e65, 1e67, 1etj, 1ezl, 1gr7, 1i53, 1ils, 1ilu, 1jvl, 1jvo, 1jze, 1jzf, 1jzg, 1jzh, 1jzi, 1jzj, 1nzr, 1r1c, 1vlx, 1xb3, 1xb6, 1xb8, 2azu, 2fnw, 2ft6, 2ft7, 2ft8, 2fta, 2ghz, 2gi0, 2hx7, 2hx8, 2hx9, 2hxa, 2i7o, 2i7s, 2idf, 2iwe, 2oj1, 2tsa, 2tsb, 2xv0, 2xv2, 2xv3, 3azu, 3fpy, 3fq1, 3fq2, 3fqy, 3fs9, 3fsa, 3fsv, 3fsw, 3fsz, 3ft0, 3ibo, 3in0, 3in2, 3jt2, 3jtb, 3n2j, 3np3, 3np4, 3oqr, 3u25, 3uge, 4azu, 4bww, 4hhg, 4hhw, 4hip, 4hz1, 4jkn, 4k9j, 4ko5, 4ko6, 4ko7, 4ko9, 4kob, 4koc, 4mfh, 4qkt, 4qlw, 4wkx, 5azu, 5i26, 5i28

HET: 2ih, cu, cu1

B2CL1_HUMAN_1_207 [text] Bcl-2-like protein 1 [Bcl-2 family]

volume: 2233. Å3; shape: 0.48; buriedness: 0.52

negative: 0.08; positive: 0.07; polar: 0.1; backbone: 0.46; hydrophobic: 0.28

PDB: 1af3, 1maz, 1pq0, 1pq1, 1r2d, 1r2e, 1r2g, 1r2h, 1r2i, 2b48, 2bzw, 2p1l, 2yj1, 2yq6, 2yq7, 2yxj, 3cva, 3fdl, 3fdm, 3ihc, 3ihd, 3ihe, 3ihf, 3iig, 3iih, 3ilb, 3ilc, 3inq, 3io8, 3pl7, 3qkd, 3r85, 3sp7, 3spf, 3wiz, 3zk6, 3zln, 3zlo, 3zlr, 4a1u, 4a1w, 4bpk, 4c52, 4c5d, 4cin, 4ehr, 4hnj, 4ppi, 4qnq, 4qve, 4qvf, 4qvx, 4tuh, 4yj4, 4yk9, 4z9v, 5c3g, 5fmj, 5fmk

HET: 03b, 0q5, 1xj, 38h, 3cq, 3fb, ace, ahp, b3a, b3d, b3e, b3l, b3q, b3y, b50, bil, h0y, h1i, hi0, hr7, ht7, lc6, mk8, n3c, nh2, nle, sep, x0b, x0d, x0j, x0r, x8u, xcp, xpc

B4GT1_HUMAN_125_398 [text] Beta-1,4-galactosyltransferase 1 [Glycosyltransferase 7 family]

volume: 1548. Å3; shape: 0.31; buriedness: 0.78

negative: 0.17; positive: 0.19; polar: 0.08; backbone: 0.27; hydrophobic: 0.28

Domains/regions: [R] N-acetyl-D-glucosamine binding, [R] UDP-alpha-D-galactose binding

PDB: 1nf5, 1nhe, 1nkh, 1nqi, 1nwg, 1o23, 1oqm, 2ae7, 2aec, 2aes, 2agd, 2ah9, 2fy7, 2fya, 2fyb, 3ee5, 4ee3, 4ee4, 4ee5, 4eea, 4eeg, 4eem, 4eeo, 4l41

HET: bgn, cto, pg4, ud2, udh, udp, upg

BACB_BACSU_1_235 [text] H2HPP isomerase

volume: 119. Å3; shape: 0.56; buriedness: 1.

negative: 0.; positive: 0.31; polar: 0.26; backbone: 0.; hydrophobic: 0.43

Domains/regions: [R] Cupin 2

PDB: 3h7j, 3h7y, 3h9a

HET: ppy

BACD_BACSU_1_469 [text] Alanine--anticapsin ligase

volume: 241. Å3; shape: 0.56; buriedness: 0.95

negative: 0.17; positive: 0.1; polar: 0.11; backbone: 0.31; hydrophobic: 0.31

Domains/regions: [D] ATP-grasp, [R] Substrate binding

PDB: 3vmm, 3wnz, 3wo0, 3wo1

HET: adp

BACE1_HUMAN_49_451 [text] Beta-secretase 1 [Peptidase A1 family]

volume: 527. Å3; shape: 0.54; buriedness: 0.81

negative: 0.09; positive: 0.03; polar: 0.19; backbone: 0.38; hydrophobic: 0.31

Domains/regions: [D] Peptidase A1

PDB: 1fkn, 1m4h, 1sgz, 1tqf, 1w50, 1w51, 1xn2, 1xn3, 1xs7, 1ym2, 1ym4, 2b8l, 2b8v, 2f3e, 2f3f, 2fdp, 2g94, 2hiz, 2hm1, 2iqg, 2irz, 2is0, 2ntr, 2oah, 2of0, 2ohk, 2ohl, 2ohm, 2ohn, 2ohp, 2ohq, 2ohr, 2ohs, 2oht, 2ohu, 2p4j, 2p83, 2p8h, 2ph6, 2ph8, 2q11, 2q15, 2qk5, 2qmd, 2qmf, 2qmg, 2qp8, 2qu2, 2qu3, 2qzk, 2qzl, 2va5, 2va6, 2va7, 2vie, 2vij, 2viy, 2viz, 2vj6, 2vj7, 2vj9, 2vkm, 2vnm, 2vnn, 2wez, 2wf0, 2wf1, 2wf2, 2wf3, 2wf4, 2wjo, 2xfi, 2xfj, 2xfk, 2zdz, 2ze1, 2zhr, 2zhs, 2zht, 2zhu, 2zhv, 2zjh, 2zji, 2zjj, 2zjk, 2zjl, 2zjm, 2zjn, 3bra, 3buf, 3bug, 3buh, 3cib, 3cic, 3cid, 3ckp, 3ckr, 3dm6, 3duy, 3dv1, 3dv5, 3exo, 3fkt, 3h0b, 3hvg, 3hw1, 3i25, 3igb, 3in3, 3in4, 3ind, 3ine, 3inf, 3inh, 3ivh, 3ivi, 3ixj, 3ixk, 3k5c, 3k5d, 3k5f, 3k5g, 3kmx, 3kmy, 3kn0, 3kyr, 3l38, 3l3a, 3l58, 3l59, 3l5b, 3l5c, 3l5d, 3l5e, 3l5f, 3lhg, 3lnk, 3lpi, 3lpj, 3lpk, 3msj, 3msk, 3msl, 3n4l, 3nsh, 3ohf, 3ohh, 3ooz, 3pi5, 3qbh, 3qi1, 3r1g, 3r2f, 3rsv, 3rsx, 3rth, 3rtm, 3rtn, 3ru1, 3rvi, 3s2o, 3s7l, 3s7m, 3skf, 3skg, 3tpj, 3tpl, 3tpp, 3tpr, 3u6a, 3udh, 3udj, 3udk, 3udm, 3udn, 3udp, 3udq, 3udr, 3udy, 3ufl, 3uqp, 3uqr, 3uqu, 3uqw, 3uqx, 3veu, 3vf3, 3vg1, 3vv6, 3vv7, 3vv8, 3wb4, 3wb5, 3zmg, 3zov, 4acu, 4acx, 4azy, 4b00, 4b05, 4b0q, 4b1c, 4b1d, 4b1e, 4b70, 4b72, 4b77, 4b78, 4bek, 4bfd, 4d83, 4d85, 4d88, 4d89, 4d8c, 4dh6, 4di2, 4dju, 4djv, 4djw, 4djx, 4djy, 4dpf, 4dpi, 4dus, 4dv9, 4dvf, 4ewo, 4exg, 4fco, 4fgx, 4fm7, 4fm8, 4fri, 4frj, 4frk, 4frs, 4fs4, 4fse, 4fsl, 4gid, 4gmi, 4h1e, 4h3f, 4h3g, 4h3i, 4h3j, 4ha5, 4hzt, 4i0d, 4i0e, 4i0f, 4i0g, 4i0h, 4i0i, 4i0j, 4i0z, 4i10, 4i11, 4i12, 4i1c, 4ivs, 4ivt, 4j0p, 4j0t, 4j0v, 4j0y, 4j0z, 4j17, 4j1c, 4j1e, 4j1f, 4j1h, 4j1i, 4j1k, 4joo, 4jp9, 4jpc, 4jpe, 4k8s, 4k9h, 4ke0, 4ke1, 4l7g, 4l7h, 4l7j, 4lc7, 4lxa, 4lxk, 4lxm, 4n00, 4pzw, 4pzx, 4r5n, 4r8y, 4r91, 4r92, 4r93, 4r95, 4rcd, 4rce, 4rcf, 4rrn, 4rro, 4rrs, 4trw, 4try, 4trz, 4wtu, 4wy1, 4wy6, 4x2l, 4x7i, 4xkx, 4xxs, 4ybi, 4zpe, 4zpf, 4zpg, 4zsm, 4zsp, 4zsq, 4zsr, 5clm, 5dqc, 5enk, 5enm, 5ezx, 5ezz, 5f00, 5f01, 5hd0, 5hdu, 5hdv, 5hdx, 5hdz, 5he4, 5he5, 5he7, 5htz, 5hu0, 5hu1, 5i3v, 5i3w, 5i3x, 5i3y, 5ie1, 5kqf, 5kr8, 5tol

HET: 09b, 09d, 09e, 09g, 0b1, 0gs, 0km, 0kp, 0kr, 0up, 0uq, 0va, 0vb, 0za, 10j, 10o, 10q, 10v, 10w, 18p, 1b7, 1b8, 1bb, 1be, 1bf, 1bs, 1h5, 1h8, 1hm, 1ho, 1hq, 1li, 1m5, 1m6, 1w1, 1w2, 2ex, 2fb, 32d, 35a, 3ko, 3kt, 3ku, 3kw, 3ll, 3ln, 3lo, 3p5, 3rs, 3ut, 3uw, 3ux, 3ys, 411, 43k, 462, 472, 4qf, 508, 54m, 569, 591, 5qu, 5qv, 5t5, 5t6, 5t7, 5t8, 60s, 60t, 60u, 60v, 60w, 60x, 60y, 625, 66f, 66h, 66j, 68m

BACE2_HUMAN_76_460 [text] Beta-secretase 2 [Peptidase A1 family]

volume: 592. Å3; shape: 0.72; buriedness: 0.78

negative: 0.08; positive: 0.03; polar: 0.27; backbone: 0.42; hydrophobic: 0.2

Domains/regions: [D] Peptidase A1

PDB: 2ewy, 3zkg, 3zki, 3zkm, 3zkn, 3zkq, 3zks, 3zkx, 3zl7, 3zlq, 4bel, 4bfb

HET: 6t9, b3p, dbo, wzv

BACR1_HALMA_1_250 [text] Bacteriorhodopsin-I [Archaeal/bacterial/fungal opsin family]

volume: 123. Å3; shape: 0.35; buriedness: 0.59

negative: 0.; positive: 0.09; polar: 0.36; backbone: 0.27; hydrophobic: 0.27

PDB: 4jr8, 4l35, 4pxk

HET: lfa

BACR2_HALS2_6_259 [text] Archaerhodopsin-2 [Archaeal/bacterial/fungal opsin family]

volume: 252. Å3; shape: 0.42; buriedness: 1.

negative: 0.05; positive: 0.05; polar: 0.27; backbone: 0.3; hydrophobic: 0.32

PDB: 1vgo, 2ei4, 2z55, 3wqj

HET: ret

BACR_HALSA_84_176 [text] Bacteriorhodopsin [Archaeal/bacterial/fungal opsin family]

volume: 269. Å3; shape: 0.43; buriedness: 1.

negative: 0.05; positive: 0.05; polar: 0.27; backbone: 0.27; hydrophobic: 0.37

PDB: 1ap9, 1at9, 1bm1, 1brd, 1brr, 1brx, 1c3w, 1c8r, 1c8s, 1cwq, 1dze, 1e0p, 1f4z, 1f50, 1fbb, 1fbk, 1iw6, 1iw9, 1ixf, 1jv6, 1jv7, 1kg8, 1kg9, 1kgb, 1kme, 1m0k, 1m0l, 1m0m, 1mgy, 1o0a, 1p8h, 1p8i, 1p8u, 1pxr, 1pxs, 1py6, 1q5i, 1q5j, 1qhj, 1qko, 1qkp, 1qm8, 1s51, 1s52, 1s53, 1s54, 1s8j, 1s8l, 1tn0, 1tn5, 1ucq, 1vjm, 1x0i, 1x0k, 1x0s, 1xji, 2at9, 2brd, 2i1x, 2i20, 2i21, 2ntu, 2ntw, 2wjk, 2wjl, 2zfe, 2zzl, 3coc, 3cod, 3han, 3hao, 3hap, 3haq, 3har, 3has, 3mbv, 3ns0, 3nsb, 3t45, 3utv, 3utw, 3utx, 3uty, 3vhz, 3vi0, 4fpd, 4hwl, 4hyx, 4md1, 4md2, 4ov0, 4x31, 4x32, 4xxj, 4y9h, 5a44, 5a45, 5b34, 5b35, 5br2, 5br5, 5j7a

HET: ret

BACS2_NATPH_1_236 [text] Sensory rhodopsin-2 [Archaeal/bacterial/fungal opsin family]

volume: 248. Å3; shape: 0.41; buriedness: 1.

negative: 0.05; positive: 0.05; polar: 0.17; backbone: 0.32; hydrophobic: 0.41

PDB: 1gu8, 1gue, 1h2s, 1h68, 1jgj, 2f93, 2f95, 3qap, 3qdc, 4gyc

HET: ret

BAG1_HUMAN_220_334 [text] BAG family molecular chaperone regulator 1

volume: 234. Å3; shape: 0.49; buriedness: 0.4

negative: 0.21; positive: 0.47; polar: 0.; backbone: 0.19; hydrophobic: 0.13

Domains/regions: [R] Interaction with PPP1R15A

PDB: 1hx1, 3fzf, 3fzh, 3fzk, 3fzl, 3fzm, 3ldq, 3m3z, 5aqf, 5aqg, 5aqh, 5aqi, 5aqj, 5aqk, 5aql, 5aqm, 5aqn, 5aqo, 5aqp, 5aqq, 5aqr, 5aqs, 5aqt, 5aqu, 5aqv

HET: gdp

BAG6_HUMAN_1056_1113 [text] Large proline-rich protein BAG6

volume: 490. Å3; shape: 0.26; buriedness: 0.27

negative: 0.; positive: 0.4; polar: 0.; backbone: 0.2; hydrophobic: 0.4

PDB: 4wwr, 4x86

HET: cps

BAK1_ARATH_253_588_ATPsite [text] BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 379. Å3; shape: 0.37; buriedness: 0.53

negative: 0.05; positive: 0.08; polar: 0.15; backbone: 0.26; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 3tl8, 3uim, 3ulz

HET: anp

BAPA_SPHXN_30_402 [text] Beta-peptidyl aminopeptidase BapA [Peptidase S58 family]

volume: 255. Å3; shape: 0.7; buriedness: 0.78

negative: 0.07; positive: 0.; polar: 0.17; backbone: 0.44; hydrophobic: 0.31

PDB: 3n2w, 3n33, 3n5i, 3ndv, 3nfb

HET: aes, aic, oae

BAS_RHEPA_1_384 [text] Polyketide synthase BAS [Chalcone/stilbene synthases family]

volume: 185. Å3; shape: 0.88; buriedness: 0.96

negative: 0.; positive: 0.; polar: 0.05; backbone: 0.33; hydrophobic: 0.62

PDB: 3a5q, 3a5r, 3a5s

HET: hc4

BAUA_PSEAE_1_448 [text] Beta-alanine--pyruvate aminotransferase [Class-III pyridoxal-phosphate-dependent aminotransferase family]

volume: 227. Å3; shape: 0.79; buriedness: 0.97

negative: 0.09; positive: 0.09; polar: 0.29; backbone: 0.38; hydrophobic: 0.15

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 4b98, 4b9b, 4bq0

HET: plp, pxg

BAZ2B_HUMAN_2054_2167 [text] Bromodomain adjacent to zinc finger domain protein 2B [WAL family]

volume: 449. Å3; shape: 0.96; buriedness: 0.62

negative: 0.; positive: 0.; polar: 0.17; backbone: 0.25; hydrophobic: 0.59

Domains/regions: [D] Bromo

PDB: 3g0l, 3q2f, 4cup, 4cuq, 4cur, 4cus, 4cut, 4cuu, 4ir3, 4ir4, 4ir5, 4ir6, 4nr9, 4nra, 4nrb, 4nrc, 4qc1, 4qc3, 4rvr, 4xua, 4xub, 5cq3, 5cq4, 5cq5, 5cq6, 5cq7, 5cq8, 5cqa, 5cu8, 5cua, 5cub, 5cuc, 5cud, 5cue, 5cug, 5dyu, 5dyx, 5e73, 5e74, 5e9i, 5e9k, 5e9l, 5e9m, 5e9y, 5l8t, 5l8u, 5l96, 5l97, 5l98, 5l99

HET: 1fk, 2lw, 2lx, 2ly, 3wq, 43c, 43d, 53b, 53c, 53g, 54t, 54u, 54v, 54w, 54y, 5k3, 5kh, 5kx, 6ai, 6rr, 6rs, 6rw, 6ry, 6rz, 6s0, ac6, ade, aly, bae, es1, es4, f60, ir4, ir5, ir6, la7, mz0, oam, pge, tyl, tyz, uo1, y6m, zyb

BCAT1_HUMAN_9_386 [text] Branched-chain-amino-acid aminotransferase, cytosolic [Class-IV pyridoxal-phosphate-dependent aminotransferase family]

volume: 229. Å3; shape: 0.55; buriedness: 0.96

negative: 0.; positive: 0.11; polar: 0.31; backbone: 0.25; hydrophobic: 0.33

PDB: 2abj, 2cog, 2coi, 2coj

HET: 4mv, cbc, gbn

BCAT2_HUMAN_28_392 [text] Branched-chain-amino-acid aminotransferase, mitochondrial [Class-IV pyridoxal-phosphate-dependent aminotransferase family]

volume: 925. Å3; shape: 0.32; buriedness: 0.94

negative: 0.02; positive: 0.12; polar: 0.22; backbone: 0.38; hydrophobic: 0.26

PDB: 1ekf, 1ekp, 1ekv, 1kt8, 1kta, 2a1h, 2hdk, 2hg8, 2hgw, 2hgx, 2hhf, 5bwr, 5bwt, 5bwu, 5bwv, 5bww, 5bwx, 5cr5, 5hne, 5i5s, 5i5t, 5i5u, 5i5v, 5i5w, 5i5x, 5i5y, 5i60

HET: 4vr, 4vs, 4vt, 4w4, 4w6, 67w, 67x, 67y, 68a, 68b, 68c, 68d, 775, el1, el2, gbn, ilp, mle, nvu, plp, pmp, trs

BCKD_RAT_31_412 [text] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [PDK/BCKDK protein kinase family]

volume: 165. Å3; shape: 0.63; buriedness: 1.

negative: 0.; positive: 0.23; polar: 0.08; backbone: 0.24; hydrophobic: 0.45

Domains/regions: [D] Histidine kinase

PDB: 1gjv, 1gkx, 1gkz, 3tz0, 3tz2, 3tz4, 3tz5, 3vad, 4dzy, 4e00, 4e01, 4e02, 4h7q, 4h81, 4h85

HET: 03h, 0f1, clt, hri, wj1, wj2

BCL2_HUMAN_2_207 [text] Apoptosis regulator Bcl-2 [Bcl-2 family]

volume: 1664. Å3; shape: 0.42; buriedness: 0.58

negative: 0.12; positive: 0.05; polar: 0.1; backbone: 0.39; hydrophobic: 0.34

PDB: 2w3l, 2xa0, 4aq3, 4ieh, 4lvt, 4lxd, 4man, 5agw, 5agx, 5jsn

HET: 1e9, 1xj, 1xv, 1y1, 398, ace, aje, dro, mh8, xcp

BCL6_HUMAN_3_129 [text] B-cell lymphoma 6 protein

volume: 591. Å3; shape: 0.69; buriedness: 0.55

negative: 0.; positive: 0.18; polar: 0.18; backbone: 0.54; hydrophobic: 0.09

Domains/regions: [D] BTB

PDB: 1r28, 1r29, 1r2b, 3bim, 3e4u, 3lbz, 4cp3

HET: rbt, z89

BEV1A_BETPN_2_160 [text] Major pollen allergen Bet v 1-A [BetVI family]

volume: 409. Å3; shape: 0.54; buriedness: 0.91

negative: 0.11; positive: 0.06; polar: 0.29; backbone: 0.22; hydrophobic: 0.32

PDB: 1bv1, 1fsk, 1llt, 1qmr, 4a80, 4a81, 4a83, 4a84, 4a85, 4a86, 4a87, 4a88, 4a8g, 4b9r, 4bk6, 4bk7, 4bkc, 4bkd, 4btz, 4mns, 4qip, 4z3l

HET: 2an, 2ax, dmx, dxc, h35, na, nar, sds

BEV1J_BETPN_2_160 [text] Major pollen allergen Bet v 1-J [BetVI family]

volume: 218. Å3; shape: 0.7; buriedness: 0.89

negative: 0.03; positive: 0.07; polar: 0.28; backbone: 0.31; hydrophobic: 0.31

PDB: 4a8u, 4a8v

HET: 2an, mrd

BFAT_VARPD_2_434 [text] Beta-phenylalanine transaminase [Class-III pyridoxal-phosphate-dependent aminotransferase family]

volume: 193. Å3; shape: 0.74; buriedness: 0.96

negative: 0.11; positive: 0.08; polar: 0.27; backbone: 0.43; hydrophobic: 0.11

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 4ao9, 4aoa

HET: ik2, plp

BGAL_HUMAN_22_677 [text] Beta-galactosidase [Glycosyl hydrolase 35 family]

volume: 216. Å3; shape: 0.64; buriedness: 0.81

negative: 0.22; positive: 0.; polar: 0.42; backbone: 0.15; hydrophobic: 0.22

PDB: 3thc, 3thd, 3wez, 3wf0, 3wf1, 3wf2, 3wf3, 3wf4

HET: 6dj, 6gj, dgj, n8v, ndj

BGAL_SULSO_1_489 [text] Beta-galactosidase [Glycosyl hydrolase 1 family]

volume: 154. Å3; shape: 0.96; buriedness: 0.92

negative: 0.25; positive: 0.08; polar: 0.25; backbone: 0.; hydrophobic: 0.41

PDB: 1gow, 1uwi, 1uwq, 1uwr, 1uws, 1uwt, 1uwu, 2ceq, 2cer, 4eam, 4ean, 5ixe

HET: g2f, gaf, gim, gox, gtl, pgi

BGAT_HUMAN_63_353 [text] Histo-blood group ABO system transferase [Glycosyltransferase 6 family]

volume: 831. Å3; shape: 0.44; buriedness: 0.65

negative: 0.19; positive: 0.11; polar: 0.12; backbone: 0.28; hydrophobic: 0.3

Domains/regions: [R] UDP-N-acetyl-galactosamine binding

PDB: 1lz0, 1lz7, 1lzi, 1lzj, 1r7t, 1r7u, 1r7v, 1r7x, 1r7y, 1r80, 1r81, 1r82, 1wsz, 1wt0, 1wt1, 1wt2, 1wt3, 1xz6, 1zhj, 1zi1, 1zi3, 1zi4, 1zi5, 1ziz, 1zj0, 1zj1, 1zj2, 1zj3, 1zjo, 1zjp, 2a8u, 2a8w, 2i7b, 2o1f, 2o1g, 2o1h, 2pgv, 2pgy, 2rit, 2rix, 2riy, 2riz, 2rj0, 2rj1, 2rj4, 2rj5, 2rj6, 2rj7, 2rj8, 2rj9, 2y7a, 3i0c, 3i0d, 3i0e, 3i0f, 3i0g, 3i0h, 3i0i, 3i0j, 3i0k, 3i0l, 3ioh, 3ioi, 3ioj, 3sx3, 3sx5, 3sx7, 3sx8, 3sxa, 3sxb, 3sxc, 3sxd, 3sxe, 3sxg, 3u0x, 3u0y, 3v0l, 3v0m, 3v0n, 3v0o, 3v0p, 3v0q, 3zgf, 3zgg, 4c2s, 4fqw, 4fra, 4frb, 4frd, 4fre, 4frh, 4frl, 4frm, 4fro, 4frp, 4frq, 4gbp, 4kc1, 4kc2, 4kc4, 4kxo, 4y62, 4y63, 4y64, 5bxc, 5c1g, 5c1h, 5c1l, 5c36, 5c38, 5c3a, 5c3b, 5c3d, 5c47, 5c48, 5c49, 5c4b, 5c4c, 5c4d, 5c4e, 5c4f, 5c8r, 5cmf, 5cmg, 5cmh, 5cmi, 5cmj, 5cql, 5cqm, 5cqn, 5cqo, 5cqp

HET: 1gw, 2gw, 48c, 48e, 48o, 4gw, 4ya, 5gw, ad7, bhe, bhg, da8, dr2, dr3, dr4, dr5, ful, gdu, gti, iug, lat, nlc, ud2, udp, urm, ws1, ws2, ws3

BGL07_ORYSJ_25_504 [text] Beta-glucosidase 7 [Glycosyl hydrolase 1 family]

volume: 390. Å3; shape: 0.36; buriedness: 0.84

negative: 0.18; positive: 0.07; polar: 0.46; backbone: 0.; hydrophobic: 0.29

Domains/regions: [R] Substrate binding

PDB: 2rgl, 2rgm, 3aht, 3ahv, 3f4v, 3f5j, 3f5k, 3f5l, 3scn, 3sco, 3scp, 3scq, 3scr, 3scs, 3sct, 3scu, 3scv, 3scw, 4qlj, 4qlk, 4qll

HET: ce5, ctt, g2f, glf, lb2

BGL12_ORYSJ_24_510 [text] Beta-glucosidase 12 [Glycosyl hydrolase 1 family]

volume: 200. Å3; shape: 0.58; buriedness: 0.95

negative: 0.22; positive: 0.07; polar: 0.29; backbone: 0.; hydrophobic: 0.41

Domains/regions: [R] Substrate binding

PDB: 3ptk, 3ptm, 3ptq

HET: g2f, nfg

BGL1A_PHACH_1_462 [text] Beta-glucosidase 1A [Glycosyl hydrolase 1 family]

volume: 100. Å3; shape: 0.85; buriedness: 0.93

negative: 0.26; positive: 0.09; polar: 0.35; backbone: 0.; hydrophobic: 0.3

Domains/regions: [R] Substrate binding

PDB: 2e3z, 2e40

HET: lgc

BGL1_ASPAC_20_860 [text] Beta-glucosidase 1 [Glycosyl hydrolase 3 family]

volume: 211. Å3; shape: 0.51; buriedness: 0.82

negative: 0.23; positive: 0.34; polar: 0.15; backbone: 0.; hydrophobic: 0.28

PDB: 4iib, 4iic, 4iid, 4iie, 4iif, 4iig, 4iih

HET: cgb, cts, ifm, mrd, noj, tcb

BGLA_PAEPO_2_448 [text] Beta-glucosidase A [Glycosyl hydrolase 1 family]

volume: 105. Å3; shape: 0.74; buriedness: 0.94

negative: 0.25; positive: 0.08; polar: 0.25; backbone: 0.; hydrophobic: 0.42

PDB: 1bga, 1bgg, 1e4i, 1tr1, 1uyq

HET: g2f, gco

BGLA_THEMA_1_446 [text] Beta-glucosidase A [Glycosyl hydrolase 1 family]

volume: 192. Å3; shape: 0.83; buriedness: 0.92

negative: 0.23; positive: 0.08; polar: 0.3; backbone: 0.; hydrophobic: 0.39

PDB: 1od0, 1oif, 1oim, 1oin, 1uz1, 1w3j, 2cbu, 2cbv, 2ces, 2cet, 2j75, 2j77, 2j78, 2j79, 2j7b, 2j7c, 2j7d, 2j7e, 2j7f, 2j7g, 2j7h, 2jal, 2vrj, 2wbg, 2wc3, 2wc4

HET: am3, amf, azf, cgb, cts, g2f, gi1, gi2, gi3, gi4, gim, gox, gtl, ide, ifl, ifm, lgs, ncw, noj, noy, ntz, oxz, pgi, yll

BGLR_ECOLI_1_603 [text] Beta-glucuronidase [Glycosyl hydrolase 2 family]

volume: 401. Å3; shape: 0.69; buriedness: 0.73

negative: 0.21; positive: 0.08; polar: 0.11; backbone: 0.22; hydrophobic: 0.38

PDB: 3k46, 3k4a, 3k4d, 3lpf, 3lpg, 4jhz, 5czk

HET: 1kv, 57z, z77, z78

BHMT1_HUMAN_1_406 [text] Betaine--homocysteine S-methyltransferase 1

volume: 184. Å3; shape: 0.4; buriedness: 0.82

negative: 0.07; positive: 0.; polar: 0.13; backbone: 0.27; hydrophobic: 0.52

Domains/regions: [D] Hcy-binding

PDB: 1lt7, 1lt8, 1umy, 4m3p

HET: cbh, hcs

BIOA_ECOLI_1_429 [text] Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily]

volume: 305. Å3; shape: 0.51; buriedness: 0.93

negative: 0.09; positive: 0.06; polar: 0.17; backbone: 0.4; hydrophobic: 0.28

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 1dty, 1mgv, 1mly, 1mlz, 1qj3, 1qj5, 1s06, 1s07, 1s08, 1s09, 1s0a

HET: acz, kap, plp, tza

BIOA_MYCTU_2_437 [text] Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily]

volume: 569. Å3; shape: 0.9; buriedness: 0.93

negative: 0.04; positive: 0.04; polar: 0.19; backbone: 0.47; hydrophobic: 0.27

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 3bv0, 3lv2, 3tft, 3tfu, 4cxq, 4cxr, 4mqp, 4mqq, 4mqr, 4w1v, 4w1w, 4w1x, 4wya, 4wyc, 4wyd, 4wye, 4wyf, 4wyg, 4xew, 4xjl, 4xjm, 4xjo, 4xjp

HET: 2b1, 2b6, 2b9, 2bg, 3g8, 3g9, 3gs, 3vq, 3vr, 3vs, 3vw, 3vx, 3w1, 40n, 41e, 41f, 41n, 41o, kap, pl8, plp, sfg

BIOD1_ECOLI_2_225 [text] ATP-dependent dethiobiotin synthetase BioD 1 [Dethiobiotin synthetase family]

volume: 524. Å3; shape: 0.37; buriedness: 0.86

negative: 0.06; positive: 0.05; polar: 0.19; backbone: 0.53; hydrophobic: 0.17

PDB: 1a82, 1bs1, 1byi, 1dad, 1dae, 1daf, 1dag, 1dah, 1dai, 1dak, 1dam, 1dbs, 1dts

HET: acp, adp, atp, ca, daa, dnn, dpu, dsd, dtb, ikt, mg, mn

BIODA_ARATH_23_833 [text] Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial

volume: 172. Å3; shape: 0.41; buriedness: 0.88

negative: 0.; positive: 0.; polar: 0.26; backbone: 0.53; hydrophobic: 0.21

Domains/regions: [R] Dethiobiotin synthetase

PDB: 4a0f, 4a0g, 4a0h, 4a0r

HET: dtb, kap

BIOD_HELPY_1_218 [text] ATP-dependent dethiobiotin synthetase BioD [Dethiobiotin synthetase family]

volume: 154. Å3; shape: 0.39; buriedness: 0.88

negative: 0.; positive: 0.; polar: 0.2; backbone: 0.55; hydrophobic: 0.25

PDB: 2qmo, 3mle, 3qxc, 3qxh, 3qxj, 3qxs, 3qxx, 3qy0

HET: 8ac

BIOD_MYCTU_1_226 [text] ATP-dependent dethiobiotin synthetase BioD [Dethiobiotin synthetase family]

volume: 208. Å3; shape: 0.48; buriedness: 0.91

negative: 0.03; positive: 0.09; polar: 0.14; backbone: 0.51; hydrophobic: 0.23

Domains/regions: [R] Substrate binding

PDB: 3fgn, 3fmf, 3fmi, 3fpa, 4wop

HET: dsd, dtb, kap

BIOF_ECOLI_1_384 [text] 8-amino-7-oxononanoate synthase [Class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily]

volume: 278. Å3; shape: 0.6; buriedness: 0.94

negative: 0.09; positive: 0.17; polar: 0.34; backbone: 0.3; hydrophobic: 0.09

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 1bs0, 1dj9, 1dje, 2g6w

HET: kam, llf, mg, plp

BIOI_BACSU_2_395 [text] Biotin biosynthesis cytochrome P450 [Cytochrome P450 family]

volume: 498. Å3; shape: 0.4; buriedness: 0.85

negative: 0.; positive: 0.06; polar: 0.24; backbone: 0.34; hydrophobic: 0.36

Multimer with: Acyl carrier protein (ACP_ECOLI)
Domains/regions (BIOI): [R] Heme binding, [R] Substrate binding

PDB: 3ejb, 3ejd, 3eje

HET: zmo, zmp, zmq

BIOK_BACSU_1_448 [text] L-Lysine--8-amino-7-oxononanoate transaminase [Class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily]

volume: 139. Å3; shape: 0.55; buriedness: 0.92

negative: 0.; positive: 0.17; polar: 0.09; backbone: 0.28; hydrophobic: 0.47

PDB: 3dod, 3drd, 3du4

HET: kap

BIRC2_HUMAN_257_357 [text] Baculoviral IAP repeat-containing protein 2 [IAP family]

volume: 1086. Å3; shape: 0.51; buriedness: 0.52

negative: 0.22; positive: 0.11; polar: 0.; backbone: 0.38; hydrophobic: 0.28

PDB: 3d9t, 3d9u, 3mup, 3oz1, 3t6p, 3uw4, 4eb9, 4hy4, 4hy5, 4kmn, 4lge, 4lgu, 4mti, 4mu7

HET: 0o6, 1aq, 1bg, 1y0, 1yh, 2dx, 2dy, 436, bmb, smk

BIRC7_HUMAN_62_175 [text] Baculoviral IAP repeat-containing protein 7 [IAP family]

volume: 395. Å3; shape: 0.56; buriedness: 0.6

negative: 0.17; positive: 0.17; polar: 0.09; backbone: 0.4; hydrophobic: 0.17

PDB: 1oxn, 1oxq, 1oy7, 1tw6, 2i3h, 2i3i, 3f7g, 3f7h, 3f7i, 3gt9, 3gta, 3uw5

HET: 0dq, 419, 516, 618, 851, chg, g13, maa

BLA1_KLEPN_19_286_maltoside [text] Beta-lactamase SHV-1 [Class-A beta-lactamase family]

volume: 773. Å3; shape: 0.72; buriedness: 0.69

negative: 0.02; positive: 0.03; polar: 0.21; backbone: 0.27; hydrophobic: 0.47

Domains/regions: [R] Substrate binding

PDB: 1n9b, 1ong, 1q2p, 1rcj, 1shv, 1tdg, 1tdl, 1vm1, 2a3u, 2a49, 2g2u, 2g2w, 2h0t, 2h0y, 2h10, 2h5s, 2zd8, 3c4o, 3c4p, 3d4f, 3mke, 3mkf, 3mxr, 3mxs, 3n4i, 3oph, 3opl, 3opp, 3opr, 3v50, 3v5m, 4fcf, 4fd8, 4fh2, 4fh4, 4gd6, 4gd8, 4gdb, 4jpm, 4mbf, 4mbh, 4mbk, 4r3b, 4zam, 5ee8

HET: ma4

BLA1_KLEPN_19_286_tazobactam2 [text] Beta-lactamase SHV-1 [Class-A beta-lactamase family]

volume: 649. Å3; shape: 0.64; buriedness: 0.65

negative: 0.1; positive: 0.13; polar: 0.3; backbone: 0.33; hydrophobic: 0.14

Domains/regions: [R] Substrate binding

PDB: 1n9b, 1ong, 1q2p, 1rcj, 1shv, 1tdg, 1tdl, 1vm1, 2a3u, 2a49, 2g2u, 2g2w, 2h0t, 2h0y, 2h10, 2h5s, 2zd8, 3c4o, 3c4p, 3d4f, 3mke, 3mkf, 3mxr, 3mxs, 3n4i, 3oph, 3opl, 3opp, 3opr, 3v50, 3v5m, 4fcf, 4fd8, 4fh2, 4fh4, 4gd6, 4gd8, 4gdb, 4jpm, 4mbf, 4mbh, 4mbk, 4r3b, 4zam, 5ee8

HET: 0rj, 0rn, 17k, 17o, 1og, 2aw, 3ge, akr, cb4, cz7, cz8, cz9, esa, ln1, mer, mxf, nxl, sa2, tau, tbe, tbi, tem, tsl, wy2, wy4, zxm

BLA1_KLEPN_19_286_tazobactam [text] Beta-lactamase SHV-1 [Class-A beta-lactamase family]

volume: 383. Å3; shape: 0.6; buriedness: 0.27

negative: 0.27; positive: 0.; polar: 0.26; backbone: 0.38; hydrophobic: 0.1

PDB: 1n9b, 1ong, 1q2p, 1rcj, 1shv, 1tdg, 1tdl, 1vm1, 2a3u, 2a49, 2g2u, 2g2w, 2h0t, 2h0y, 2h10, 2h5s, 2zd8, 3c4o, 3c4p, 3d4f, 3mke, 3mkf, 3mxr, 3mxs, 3n4i, 3oph, 3opl, 3opp, 3opr, 3v50, 3v5m, 4fcf, 4fd8, 4fh2, 4fh4, 4gd6, 4gd8, 4gdb, 4jpm, 4mbf, 4mbh, 4mbk, 4r3b, 4zam, 5ee8

HET: taz

BLA1_STEMA_22_290 [text] Metallo-beta-lactamase L1 type 3 [Metallo-beta-lactamase superfamily. Class-B beta-lactamase family]

volume: 289. Å3; shape: 0.67; buriedness: 0.71

negative: 0.07; positive: 0.44; polar: 0.16; backbone: 0.; hydrophobic: 0.33

PDB: 1sml, 2aio, 2fm6, 2fu6, 2fu7, 2fu8, 2fu9, 2gfj, 2gfk, 2h6a, 2hb9, 2qdt, 2qin, 2qjs, 5evb, 5evd, 5evk

HET: 3c7, 3r9, i38, l13, mco, mp2, mx1, vc2, vi, vii

BLA2_BACCE_32_257 [text] Metallo-beta-lactamase type 2 [Metallo-beta-lactamase superfamily. Class-B beta-lactamase family]

volume: 195. Å3; shape: 0.58; buriedness: 0.74

negative: 0.11; positive: 0.47; polar: 0.07; backbone: 0.23; hydrophobic: 0.12

PDB: 1bc2, 1bmc, 1bvt, 1dxk, 1mqo, 2bc2, 2bfk, 2bfl, 2bfz, 2bg2, 2bg6, 2bg7, 2bg8, 2bga, 2nxa, 2nyp, 2nze, 2nzf, 2uyx, 3bc2, 3fcz, 3i0v, 3i11, 3i13, 3i14, 3i15, 3knr, 3kns, 4c09, 4c1c, 4c1h, 4nq4, 4nq5, 4nq6, 4nq7, 4tyt, 5fqa, 5fqb

HET: 3c7, 3r9, mco, ok3, s3c, vc2, x8z

BLAB_AERHY_28_254 [text] Metallo-beta-lactamase type 2 [Metallo-beta-lactamase superfamily. Class-B beta-lactamase family]

volume: 234. Å3; shape: 0.85; buriedness: 0.8

negative: 0.09; positive: 0.3; polar: 0.22; backbone: 0.05; hydrophobic: 0.35

PDB: 1x8g, 1x8h, 1x8i, 2gkl, 2qds, 3f9o, 3fai, 3iof, 3iog, 3sw3, 3t9m

HET: bmh, ifs, mco, pd2, sdf

BLAB_BACFG_18_249 [text] Metallo-beta-lactamase type 2 [Metallo-beta-lactamase superfamily. Class-B beta-lactamase family]

volume: 319. Å3; shape: 0.58; buriedness: 0.75

negative: 0.1; positive: 0.34; polar: 0.13; backbone: 0.22; hydrophobic: 0.21

PDB: 1a7t, 1a8t, 1hlk, 1kr3, 1znb, 2bmi, 2znb, 3znb, 4znb

HET: 061, 113

BLAB_SERMA_18_245 [text] Metallo-beta-lactamase type 2 [Metallo-beta-lactamase superfamily. Class-B beta-lactamase family]

volume: 360. Å3; shape: 0.56; buriedness: 0.84

negative: 0.07; positive: 0.37; polar: 0.1; backbone: 0.18; hydrophobic: 0.29

PDB: 1dd6, 1ddk, 1jje, 1jjt, 1vgn, 1wuo, 1wup, 2doo, 3wxc, 4c1f, 4c1g, 4f6h, 4f6z, 4uam, 5ev6, 5ev8, 5ewa

HET: 3r9, 9bz, bds, bys, c4h, c93, mci, mco, ops, x8z

BLAC_BACLI_42_306 [text] Beta-lactamase [Class-A beta-lactamase family]

volume: 472. Å3; shape: 0.64; buriedness: 0.72

negative: 0.02; positive: 0.13; polar: 0.36; backbone: 0.36; hydrophobic: 0.13

Domains/regions: [R] Substrate binding

PDB: 1i2s, 1i2w, 1mbl, 1w7f, 2blm, 2wk0, 2x71, 2y91, 3b3x, 3ly3, 3ly4, 3m2j, 3m2k, 3sh7, 3sh8, 3sh9, 3soi, 4a5r, 4blm, 4m3k, 4n1h, 4n92, 4n9k, 4n9l

HET: 98j, a33, bb0, biy, ced, cfx, dwz, f5m, ict, l4c, na, pcz, pnm, tbe

BLAC_MYCTU_42_307 [text] Beta-lactamase [Class-A beta-lactamase family]

volume: 477. Å3; shape: 0.78; buriedness: 0.66

negative: 0.04; positive: 0.13; polar: 0.31; backbone: 0.42; hydrophobic: 0.1

Domains/regions: [R] Substrate binding

PDB: 2gdn, 3cg5, 3dwz, 3iqa, 3m6b, 3m6h, 3n6i, 3n7w, 3n8l, 3n8r, 3n8s, 3nbl, 3nc8, 3nck, 3nde, 3ndg, 3ny4, 3vff, 3vfh, 3zhh, 4df6, 4ebl, 4ebn, 4ebp, 4jlf, 4q8i, 4qb8, 4qhc, 4x6t

HET: 1rg, 1te, 2rg, 33v, 3y6, 7ep, 9ep, aix, axl, cb9, cd6, cd8, dh4, drw, dwz, dxf, iss, nff, nxl, pcz, sfr, smx, teb, xd1, xd2

BLAC_STAAU_23_244 [text] Beta-lactamase [Class-A beta-lactamase family]

volume: 258. Å3; shape: 0.8; buriedness: 0.76

negative: 0.; positive: 0.06; polar: 0.38; backbone: 0.39; hydrophobic: 0.17

Domains/regions: [R] Substrate binding

PDB: 1alq, 1blc, 1blh, 1blp, 1dja, 1djb, 1djc, 1ghi, 1ghm, 1ghp, 1kge, 1kgf, 1kgg, 1ome, 1pio, 3blm

HET: ced, cem, fos, pnm, tem

BLAN1_KLEPN_32_270 [text] Metallo-beta-lactamase type 2 [Metallo-beta-lactamase superfamily. Class-B beta-lactamase family]

volume: 310. Å3; shape: 0.62; buriedness: 0.72

negative: 0.07; positive: 0.31; polar: 0.15; backbone: 0.26; hydrophobic: 0.2

PDB: 3pg4, 3q6x, 3rkj, 3rkk, 3s0z, 3sbl, 3sfp, 3spu, 3srx, 3zr9, 4exs, 4exy, 4ey2, 4eyb, 4eyf, 4eyl, 4gyq, 4gyu, 4h0d, 4hky, 4hl1, 4hl2, 4ram, 4raw, 4rbs, 4rl0, 4rl2, 4rm5, 4tyf, 4tz9, 4tzb, 4tze, 4tzf, 4u4l, 5a5z

HET: 0rm, 0rv, 0wo, 3c7, 3s0, 3s3, fpm, pnk, pnm, sfr, wjz, x8z, zz7

BLAN_ENTCL_28_292 [text] Imipenem-hydrolyzing beta-lactamase [Class-A beta-lactamase family]

volume: 153. Å3; shape: 0.68; buriedness: 0.79

negative: 0.08; positive: 0.12; polar: 0.5; backbone: 0.25; hydrophobic: 0.04

Domains/regions: [R] Substrate binding

PDB: 1bue, 1bul

HET: ap3

BLAR_STAAU_332_584 [text] Regulatory protein BlaR1 [Peptidase M56 family]

volume: 413. Å3; shape: 0.74; buriedness: 0.71

negative: 0.04; positive: 0.09; polar: 0.28; backbone: 0.42; hydrophobic: 0.17

Domains/regions: [R] Penicillin-binding

PDB: 1xa1, 1xa7, 1xkz, 3q7v, 3q7z, 3q81, 3q82, 3uy6

HET: bou, caz, im2, mer

BLAT_ECOLX_23_286 [text] Beta-lactamase TEM [Class-A beta-lactamase family]

volume: 358. Å3; shape: 0.77; buriedness: 0.73

negative: 0.; positive: 0.; polar: 0.07; backbone: 0.5; hydrophobic: 0.42

PDB: 1axb, 1bt5, 1btl, 1ck3, 1erm, 1ero, 1erq, 1esu, 1fqg, 1htz, 1jtd, 1jtg, 1jvj, 1jwp, 1jwv, 1jwz, 1lhy, 1li0, 1li9, 1m40, 1nxy, 1ny0, 1nym, 1nyy, 1pzo, 1pzp, 1s0w, 1tem, 1xpb, 1xxm, 1yt4, 1zg4, 1zg6, 2b5r, 2v1z, 2v20, 3c7u, 3c7v, 3cmz, 3dtm, 3gmw, 3jyi, 3p98, 3toi, 4gku, 4ibr, 4ibx, 4id4, 4mez, 4op5, 4op8, 4opq, 4opr, 4opy, 4opz, 4oq0, 4oqg, 4oqh, 4oqi, 4qy5, 4qy6, 4r4r, 4r4s, 4rva, 4rx2, 4rx3, 4zj1, 4zj2, 4zj3, 5aq8, 5aq9, 5aqb

HET: cbt, fta

BLC97_ECOLX_30_291 [text] Beta-lactamase CTX-M-97 [Class-A beta-lactamase family]

volume: 279. Å3; shape: 0.6; buriedness: 0.76

negative: 0.05; positive: 0.08; polar: 0.35; backbone: 0.45; hydrophobic: 0.07

Domains/regions: [R] Substrate binding

PDB: 2wyx, 2xqz, 2xr0, 2zq7, 2zq8, 2zq9, 2zqa, 2zqc, 2zqd, 4bd0, 4bd1, 4c3q, 5a90, 5a91, 5a92, 5a93, 5g18, 5ksc

HET: azr, bzb, caz, ceo, pcz

BLKPC_KLEPN_28_291 [text] Carbapenem-hydrolyzing beta-lactamase KPC [Class-A beta-lactamase family]

volume: 421. Å3; shape: 0.6; buriedness: 0.79

negative: 0.05; positive: 0.1; polar: 0.38; backbone: 0.33; hydrophobic: 0.14

Domains/regions: [R] Substrate binding

PDB: 2ov5, 3c5a, 3dw0, 3e2k, 3e2l, 3rxw, 3rxx, 4zbe, 5eec

HET: bcn, npb, nxl, sr3, zxm

BLO10_PSEAI_20_266 [text] Beta-lactamase OXA-10 [Class-D beta-lactamase family]

volume: 421. Å3; shape: 0.93; buriedness: 0.73

negative: 0.; positive: 0.08; polar: 0.16; backbone: 0.45; hydrophobic: 0.32

Domains/regions: [R] Substrate binding

PDB: 1e3u, 1e4d, 1ewz, 1fof, 1h5x, 1h8y, 1h8z, 1k4e, 1k4f, 1k54, 1k55, 1k56, 1k57, 1k6r, 1k6s, 2hp5, 2hp6, 2hp9, 2hpb, 2rl3, 2wgi, 2wgv, 2wgw, 2wkh, 2wki, 2x01, 2x02, 3lce, 3qnb, 3qnc, 4s2o, 4wz5, 4yin, 5fq9

HET: 3vu, au, auc, c6s, ca, hoq, iap, im2, lce, mer, mx1, nxl, pnm, zz7

BLO1_ECOLX_26_276 [text] Beta-lactamase OXA-1 [Class-D beta-lactamase family]

volume: 346. Å3; shape: 0.79; buriedness: 0.69

negative: 0.06; positive: 0.; polar: 0.24; backbone: 0.4; hydrophobic: 0.3

PDB: 1m6k, 3isg, 4mll

HET: 1s6, drw

BLS_STRCL_1_513 [text] Carboxyethyl-arginine beta-lactam-synthase [Asparagine synthetase family]

volume: 530. Å3; shape: 0.46; buriedness: 0.83

negative: 0.14; positive: 0.07; polar: 0.14; backbone: 0.43; hydrophobic: 0.22

PDB: 1jgt, 1m1z, 1mb9, 1mbz, 1mc1

HET: amp, apc, atp, cma, iot, pcx

BLT1_ECOLX_30_291 [text] Beta-lactamase Toho-1 [Class-A beta-lactamase family]

volume: 259. Å3; shape: 0.55; buriedness: 0.81

negative: 0.05; positive: 0.11; polar: 0.38; backbone: 0.41; hydrophobic: 0.05

Domains/regions: [R] Substrate binding

PDB: 1bza, 1iyo, 1iyp, 1iyq, 1iys, 1we4, 4x69

HET: cef, cep, op0, pnm

BLVRB_HUMAN_1_206 [text] Flavin reductase (NADPH)

volume: 233. Å3; shape: 0.59; buriedness: 0.67

negative: 0.; positive: 0.08; polar: 0.08; backbone: 0.46; hydrophobic: 0.38

PDB: 1hdo, 1he2, 1he3, 1he4, 1he5

HET: bla, fmn, lum, mbv

BMP2K_HUMAN_40_344 [text] BMP-2-inducible protein kinase [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 341. Å3; shape: 0.54; buriedness: 0.89

negative: 0.07; positive: 0.; polar: 0.17; backbone: 0.4; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4w9w, 4w9x, 5i3o, 5i3r, 5ikw

HET: 3jw, 6bu, idk, idv, ydj

BMPR2_HUMAN_189_518 [text] Bone morphogenetic protein receptor type-2 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 244. Å3; shape: 0.54; buriedness: 0.91

negative: 0.05; positive: 0.05; polar: 0.18; backbone: 0.46; hydrophobic: 0.26

Domains/regions: [D] Protein kinase

PDB: 3g2f

HET: adp

BMR1B_HUMAN_167_502 [text] Bone morphogenetic protein receptor type-1B [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 290. Å3; shape: 0.38; buriedness: 0.75

negative: 0.11; positive: 0.; polar: 0.16; backbone: 0.42; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 3mdy

HET: ldn

BMRR_BACSU_1_120 [text] Multidrug-efflux transporter 1 regulator

volume: 244. Å3; shape: 0.97; buriedness: 0.41

negative: 0.; positive: 0.; polar: 0.85; backbone: 0.15; hydrophobic: 0.

Domains/regions: [D] HTH merR-type

PDB: 1exi, 1exj, 1r8e, 3d6y, 3d6z, 3d70, 3d71, 3iao, 3q1m, 3q2y, 3q3d, 3q5p, 3q5r, 3q5s

HET: 118, p4p, sb

BMRR_BACSU_120_278 [text] Multidrug-efflux transporter 1 regulator

volume: 427. Å3; shape: 0.67; buriedness: 0.75

negative: 0.06; positive: 0.; polar: 0.42; backbone: 0.2; hydrophobic: 0.32

PDB: 1bow, 1exi, 1exj, 1r8e, 2bow, 3d6y, 3d6z, 3d70, 3d71, 3iao, 3q1m, 3q2y, 3q3d, 3q5p, 3q5r, 3q5s

HET: 118, ach, ber, et, kan, m4a, p4p, puy, rhq, sb, tac

BMX_HUMAN_404_675 [text] Cytoplasmic tyrosine-protein kinase BMX [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

volume: 344. Å3; shape: 0.35; buriedness: 0.69

negative: 0.; positive: 0.05; polar: 0.15; backbone: 0.38; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 3sxr, 3sxs

HET: 1n1, pp2

BODG_HUMAN_1_387 [text] Gamma-butyrobetaine dioxygenase [Gamma-BBH/TMLD family]

volume: 187. Å3; shape: 0.73; buriedness: 0.97

negative: 0.08; positive: 0.; polar: 0.49; backbone: 0.16; hydrophobic: 0.27

PDB: 3ms5, 3n6w, 3o2g, 4bg1, 4bgk, 4bgm, 4bhf, 4bhg, 4bhi, 4c5w, 4c8r, 4cwd

HET: 449, 6yt, c2t, dlt, ivl, mzt, nm2, nm3, oga, ree, rtk, ruj

BPHA1_RHOJR_1_460 [text] Biphenyl 2,3-dioxygenase subunit alpha [Bacterial ring-hydroxylating dioxygenase alpha subunit family]

volume: 110. Å3; shape: 0.57; buriedness: 1.

negative: 0.; positive: 0.22; polar: 0.07; backbone: 0.21; hydrophobic: 0.5

Domains/regions: [R] Substrate binding

PDB: 1uli, 1ulj

HET: bnl

BPHA_BURXL_1_459 [text] Biphenyl dioxygenase subunit alpha [Bacterial ring-hydroxylating dioxygenase alpha subunit family]

volume: 148. Å3; shape: 0.64; buriedness: 0.96

negative: 0.; positive: 0.19; polar: 0.09; backbone: 0.27; hydrophobic: 0.45

PDB: 2xsh, 2yfi, 2yfj, 2yfl, 5aeu

HET: 1it, dc4, dc5

BPHA_COMTE_1_457 [text] Biphenyl dioxygenase subunit alpha [Bacterial ring-hydroxylating dioxygenase alpha subunit family]

volume: 105. Å3; shape: 0.53; buriedness: 0.97

negative: 0.; positive: 0.24; polar: 0.12; backbone: 0.35; hydrophobic: 0.29

PDB: 3gzx, 3gzy

HET: bnl

BPHB_COMTE_1_281 [text] Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 115. Å3; shape: 0.55; buriedness: 0.85

negative: 0.; positive: 0.; polar: 0.49; backbone: 0.26; hydrophobic: 0.25

PDB: 2y93, 2y99, 3zv3, 3zv4, 3zv5, 3zv6

HET: 4hb, bpy

BPHC_BURXL_2_298 [text] Biphenyl-2,3-diol 1,2-dioxygenase [Extradiol ring-cleavage dioxygenase family]

volume: 138. Å3; shape: 0.61; buriedness: 0.91

negative: 0.13; positive: 0.35; polar: 0.16; backbone: 0.05; hydrophobic: 0.31

PDB: 1han, 1kmy, 1knd, 1knf, 1lgt, 1lkd

HET: bp3, bp6, bpy, caq, mbd

BPHC_PSES1_2_293 [text] Biphenyl-2,3-diol 1,2-dioxygenase [Extradiol ring-cleavage dioxygenase family]

volume: 129. Å3; shape: 0.59; buriedness: 0.92

negative: 0.13; positive: 0.37; polar: 0.23; backbone: 0.; hydrophobic: 0.26

PDB: 1dhy, 1eil, 1eiq, 1eir, 1kw3, 1kw6, 1kw8, 1kw9, 1kwb, 1kwc

HET: bpy

BPHD_BURXL_2_286 [text] 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase [AB hydrolase superfamily. BphD family]

volume: 270. Å3; shape: 0.34; buriedness: 0.96

negative: 0.; positive: 0.06; polar: 0.1; backbone: 0.33; hydrophobic: 0.51

Domains/regions: [R] Substrate binding

PDB: 2og1, 2pu5, 2pu7, 2puh, 2puj, 2rht, 2rhw, 2ri6, 3v1k, 3v1l, 3v1m, 3v1n

HET: bez, c0e, c1e, hpk, hpz, mla, mli

BPHL_HUMAN_38_291 [text] Valacyclovir hydrolase [AB hydrolase superfamily. Lipase family]

volume: 119. Å3; shape: 0.5; buriedness: 0.92

negative: 0.05; positive: 0.05; polar: 0.13; backbone: 0.37; hydrophobic: 0.4

Domains/regions: [D] AB hydrolase-1

PDB: 2ocg, 2oci, 2ock, 2ocl

HET: tyc

BPHY_DEIRA_1_322 [text] Bacteriophytochrome

volume: 490. Å3; shape: 0.86; buriedness: 0.95

negative: 0.02; positive: 0.15; polar: 0.27; backbone: 0.21; hydrophobic: 0.35

Domains/regions: [D] GAF, [D] PAS, [R] Chromophore binding domain

PDB: 1ztu, 2o9b, 2o9c, 3s7n, 3s7o, 3s7p, 3s7q, 4cqh, 4ijg, 4o01, 4o8g, 4q0h, 4q0i, 4q0j, 4y3i, 4y5f, 4z1w, 4zrr, 5ajg, 5c5k, 5k5b, 5l8m, 5lbr

HET: bla, lbv, lbw

BPPS_SALOF_50_598 [text] (+)-bornyl diphosphate synthase, chloroplastic [Terpene synthase family]

volume: 203. Å3; shape: 0.57; buriedness: 0.96

negative: 0.2; positive: 0.15; polar: 0.14; backbone: 0.17; hydrophobic: 0.35

PDB: 1n1b, 1n1z, 1n20, 1n21, 1n22, 1n23, 1n24

HET: 2bn, 3ag, 7a8, bp2, btb, mg

BRAF_HUMAN_438_724 [text] Serine/threonine-protein kinase B-raf [Protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily]

volume: 892. Å3; shape: 0.46; buriedness: 0.88

negative: 0.05; positive: 0.06; polar: 0.03; backbone: 0.44; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 1uwh, 1uwj, 2fb8, 3c4c, 3d4q, 3idp, 3ii5, 3og7, 3ppk, 3prf, 3pri, 3psb, 3q4c, 3q96, 3skc, 3tv4, 3tv6, 4cqe, 4dbn, 4e26, 4ehe, 4ehg, 4fc0, 4fk3, 4g9c, 4g9r, 4h58, 4jvg, 4ksp, 4ksq, 4mne, 4mnf, 4pp7, 4r5y, 4rzv, 4rzw, 4wo5, 4xv1, 4xv2, 4xv3, 4xv9, 4yht, 5c9c, 5csw, 5csx, 5ct7, 5fd2, 5hi2, 5hid, 5hie, 5ita, 5jrq, 5jsm, 5jt2

HET: 032, 0ja, 0nf, 0t2, 0wp, 10z, 1oo, 1su, 1sw, 215, 29l, 2vx, 324, 325, 3k3, 4ef, 4z5, 54j, 55j, 5xj, 6dc, 6n9, 6nb, 6nc, 734, 831, 904, b0r, b1e, b96, bax, br2, cqe, fni, fp3, fp4, glc, l1e, p02, p06, ri8, ri9, rsw, sm5, sm6, tv4

BRD1_HUMAN_555_688 [text] Bromodomain-containing protein 1

volume: 230. Å3; shape: 0.51; buriedness: 0.74

negative: 0.06; positive: 0.; polar: 0.27; backbone: 0.19; hydrophobic: 0.47

Domains/regions: [D] Bromo

PDB: 3rcw, 5ame, 5amf, 5fg6

HET: 5xe, mb3, pw3, twl

BRD1_HUMAN_924_1049 [text] Bromodomain-containing protein 1

volume: 105. Å3; shape: 0.58; buriedness: 0.91

negative: 0.08; positive: 0.; polar: 0.58; backbone: 0.25; hydrophobic: 0.08

Domains/regions: [D] PWWP

PDB: 3lyi, 4z02

HET: 4k8, ocs

BRD2_HUMAN_343_458 [text] Bromodomain-containing protein 2

volume: 511. Å3; shape: 0.59; buriedness: 0.62

negative: 0.04; positive: 0.07; polar: 0.15; backbone: 0.08; hydrophobic: 0.66

Domains/regions: [D] Bromo 2

PDB: 2dvv, 2e3k, 3oni, 4j1p, 4mr5, 4mr6, 4qeu, 4qev, 4qew, 4uyg, 5bt5, 5dfb, 5dfc, 5dfd, 5dw1, 5ek9, 5hfq, 5ibn, 5ig6

HET: 1k0, 2lo, 31o, 31p, 59e, 5gd, 5p4, 6b3, 73b, aly, eam, jq1

BRD2_HUMAN_69_198 [text] Bromodomain-containing protein 2

volume: 644. Å3; shape: 0.42; buriedness: 0.73

negative: 0.05; positive: 0.; polar: 0.23; backbone: 0.2; hydrophobic: 0.52

Domains/regions: [D] Bromo 1

PDB: 1x0j, 2dvq, 2dvr, 2dvs, 2ydw, 2yek, 3aqa, 4a9e, 4a9f, 4a9h, 4a9i, 4a9j, 4a9m, 4a9n, 4a9o, 4akn, 4alg, 4alh, 4uyf, 4uyh, 5hel, 5hem, 5hen

HET: 1gh, 3pf, 73b, 9s3, a9n, a9o, a9p, aly, byh, dtt, eam, mb3, p9i, p9m, s5b, tvp, tyl, wsh

BRD3_HUMAN_22_147 [text] Bromodomain-containing protein 3

volume: 288. Å3; shape: 0.97; buriedness: 0.65

negative: 0.04; positive: 0.; polar: 0.12; backbone: 0.15; hydrophobic: 0.69

Domains/regions: [D] Bromo 1

PDB: 2nxb, 3s91

HET: jq1

BRD3_HUMAN_305_416 [text] Bromodomain-containing protein 3

volume: 420. Å3; shape: 0.77; buriedness: 0.68

negative: 0.07; positive: 0.09; polar: 0.09; backbone: 0.09; hydrophobic: 0.66

Domains/regions: [D] Bromo 2

PDB: 2oo1, 3s92, 5a7c, 5hfr, 5hjc

HET: 5d4, aly, jq1

BRD4_HUMAN_340_460 [text] Bromodomain-containing protein 4

volume: 919. Å3; shape: 0.78; buriedness: 0.58

negative: 0.07; positive: 0.07; polar: 0.13; backbone: 0.14; hydrophobic: 0.6

Domains/regions: [D] Bromo 2

PDB: 2dww, 2ouo, 2yem, 3jvl, 3jvm, 4kv4, 4z93, 5jwm

HET: 4ld, 6on, aly, wsh

BRD4_HUMAN_42_168 [text] Bromodomain-containing protein 4

volume: 697. Å3; shape: 0.84; buriedness: 0.65

negative: 0.06; positive: 0.; polar: 0.24; backbone: 0.16; hydrophobic: 0.54

Domains/regions: [D] Bromo 1

PDB: 2oss, 2yel, 3jvj, 3jvk, 3muk, 3mul, 3mxf, 3p5o, 3svf, 3svg, 3u5j, 3u5k, 3u5l, 3uvw, 3uvx, 3uvy, 3uw9, 3zyu, 4a9l, 4bw1, 4bw2, 4bw3, 4bw4, 4c66, 4c67, 4cfk, 4cfl, 4cl9, 4clb, 4don, 4e96, 4f3i, 4gpj, 4hbv, 4hbw, 4hbx, 4hby, 4hxk, 4hxl, 4hxm, 4hxn, 4hxo, 4hxp, 4hxr, 4hxs, 4ioo, 4ioq, 4ior, 4j0r, 4j0s, 4j3i, 4kv1, 4lr6, 4lrg, 4lyi, 4lys, 4lyw, 4lzr, 4lzs, 4men, 4meo, 4mep, 4meq, 4mr3, 4mr4, 4nqm, 4nr8, 4nuc, 4nud, 4nue, 4o70, 4o71, 4o72, 4o74, 4o75, 4o76, 4o77, 4o78, 4o7a, 4o7b, 4o7c, 4o7e, 4o7f, 4ogi, 4ogj, 4pce, 4pci, 4ps5, 4qb3, 4qr3, 4qr4, 4qr5, 4qzs, 4uix, 4uiy, 4uiz, 4uyd, 4whw, 4wiv, 4x2i, 4xy9, 4xya, 4yh3, 4yh4, 4z1q, 4z1s, 4zc9, 4zw1, 5a5s, 5a85, 5acy, 5ad2, 5ad3, 5bt4, 5cfw, 5coi, 5cp5, 5cpe, 5cqt, 5crm, 5crz, 5cs8, 5ctl, 5cy9, 5d0c, 5d24, 5d25, 5d26, 5d3h, 5d3j, 5d3l, 5d3n, 5d3p, 5d3r, 5d3s, 5d3t, 5dlx, 5dlz, 5dw2, 5dx4, 5e0r, 5egu, 5ei4, 5eis, 5fbx, 5hls, 5hm0, 5i80, 5i88, 5igk, 5khm, 5ku3, 5lj1, 5lj2, 5luu

HET: 08j, 08k, 0ns, 0q1, 0s6, 1a3, 1a8, 1a9, 1gh, 1xb, 21q, 24y, 2ll, 2r4, 2re, 2rf, 2rj, 2rk, 2rn, 2rq, 2sj, 3ot, 3p2, 3x0, 435, 4v1, 53w, 558, 55k, 56m, 56y, 579, 57c, 57e, 57f, 57g, 5d1, 5d2, 5gd, 5j5, 5nq, 5nv, 5v2, 5w4, 62g, 69g, 6xh, 6xw, 78j, 83t, 8dq, 9b6, 9bm, 9s3, bnm, ca, e0a, e0b, e0c, eb0, eb2, eb3, eb7, eb8, eb9, etu, l26, l28, l33, l40, n1d, np8, nud, nue, pge, s5b, sav, tvu, uth, xnh, y80, y81

BRD9_HUMAN_133_241 [text] Bromodomain-containing protein 9

volume: 784. Å3; shape: 0.61; buriedness: 0.66

negative: 0.; positive: 0.03; polar: 0.2; backbone: 0.43; hydrophobic: 0.34

Domains/regions: [D] Bromo

PDB: 3hme, 4nqn, 4uit, 4uiu, 4uiv, 4uiw, 4xy8, 4yy4, 4yy6, 4yyd, 4yyg, 4yyh, 4yyi, 4yyj, 4yyk, 4z6h, 4z6i, 5e9v, 5eu1, 5f1h, 5f1l, 5f25, 5f2p, 5i40, 5i7x, 5i7y, 5igm, 5ign, 5ji8

HET: 43u, 4l2, 4l3, 5l0, 5sw, 5tu, 5ty, 5u2, 5u6, 67b, 67n, 69g, 6b2, 6kt, aly, bmf, btk, h1b, kcr, n1d, tvu, xzb, y1z

BRDT_HUMAN_19_137 [text] Bromodomain testis-specific protein

volume: 363. Å3; shape: 0.88; buriedness: 0.63

negative: 0.09; positive: 0.; polar: 0.12; backbone: 0.33; hydrophobic: 0.47

Domains/regions: [D] Bromo 1

PDB: 2rfj, 4flp, 4kcx

HET: 1qk, jq1

BRI1_ARATH_26_786 [text] Protein BRASSINOSTEROID INSENSITIVE 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 327. Å3; shape: 0.39; buriedness: 0.8

negative: 0.; positive: 0.11; polar: 0.55; backbone: 0.1; hydrophobic: 0.24

PDB: 3rgx, 3rgz, 3riz, 3rj0, 4lsa, 4lsx

HET: bld

BRI1_ARATH_864_1168 [text] Protein BRASSINOSTEROID INSENSITIVE 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 266. Å3; shape: 0.52; buriedness: 0.83

negative: 0.1; positive: 0.03; polar: 0.2; backbone: 0.35; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 4oh4, 4q5j, 5lpb, 5lpv, 5lpw, 5lpy, 5lpz

HET: adp, anp, atp, mn

BRPF1_HUMAN_1076_1205 [text] Peregrin

volume: 1387. Å3; shape: 0.4; buriedness: 0.45

negative: 0.05; positive: 0.05; polar: 0.18; backbone: 0.38; hydrophobic: 0.34

Domains/regions: [D] PWWP

PDB: 2x35, 2x4w, 2x4x, 2x4y, 3l42, 3mo8, 5c6s

HET: 4k8, m3l

BRPF1_HUMAN_625_740 [text] Peregrin

volume: 619. Å3; shape: 0.6; buriedness: 0.68

negative: 0.13; positive: 0.; polar: 0.2; backbone: 0.21; hydrophobic: 0.47

Domains/regions: [D] Bromo, [R] Required for RUNX1 and RUNX2 transcriptional activation

PDB: 4lc2, 4qyd, 4qyl, 4uye, 5c7n, 5c85, 5c87, 5c89, 5d7x, 5dy7, 5dya, 5dyc, 5e3d, 5e3g, 5em3, 5epr, 5eps, 5eq1, 5etb, 5etd, 5ev9, 5eva, 5ewc, 5ewd, 5ewh, 5ewv, 5eww, 5ffv, 5ffw, 5ffy, 5fg4, 5fg5, 5g4r, 5g4s

HET: 4yo, 4ys, 4yt, 5gt, 5gu, 5gv, 5jl, 5jq, 5q0, 5qx, 5qy, 5rn, 5ro, 5s9, 5sb, 5sg, 5sh, 5sj, 5sk, 5sn, 5xd, 5xe, 5xf, 8vi, 9f9, aly, bea, bmf, lf1, xz8

BSD_ASPTE_1_130 [text] Blasticidin-S deaminase [Cytidine and deoxycytidylate deaminase family]

volume: 296. Å3; shape: 0.37; buriedness: 0.72

negative: 0.17; positive: 0.05; polar: 0.19; backbone: 0.35; hydrophobic: 0.24

Domains/regions: [D] CMP/dCMP-type deaminase

PDB: 1wn5, 1wn6, 2z3g, 2z3h, 2z3i, 2z3j

HET: blo, bls, bst

BST1_HUMAN_33_297 [text] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 [ADP-ribosyl cyclase family]

volume: 430. Å3; shape: 0.64; buriedness: 0.81

negative: 0.24; positive: 0.08; polar: 0.13; backbone: 0.16; hydrophobic: 0.39

PDB: 1isf, 1isg, 1ish, 1isi, 1isj, 1ism

HET: ags, enp, enq, nca, nmn

BSUHB_ARCFU_1_252 [text] Fructose-1,6-bisphosphatase/inositol-1-monophosphatase [Inositol monophosphatase family]

volume: 197. Å3; shape: 0.73; buriedness: 0.76

negative: 0.16; positive: 0.14; polar: 0.15; backbone: 0.45; hydrophobic: 0.1

Domains/regions: [R] Substrate binding

PDB: 1lbv, 1lbw, 1lbx, 1lby, 1lbz

HET: f6p, fbp, ipd

BSUHB_METJA_1_252 [text] Fructose-1,6-bisphosphatase/inositol-1-monophosphatase [Inositol monophosphatase family]

volume: 145. Å3; shape: 0.66; buriedness: 0.79

negative: 0.24; positive: 0.17; polar: 0.08; backbone: 0.43; hydrophobic: 0.08

Domains/regions: [R] Substrate binding

PDB: 1dk4, 1g0h, 1g0i

HET: ipd

BT3A1_HUMAN_29_143 [text] Butyrophilin subfamily 3 member A1 [Immunoglobulin superfamily. BTN/MOG family]

volume: 184. Å3; shape: 0.66; buriedness: 0.68

negative: 0.07; positive: 0.12; polar: 0.38; backbone: 0.33; hydrophobic: 0.1

Domains/regions: [D] Ig-like V-type 1

PDB: 4f80, 4f9l, 4jkw, 4k55

HET: h6p, ipe

BT3A1_HUMAN_326_513 [text] Butyrophilin subfamily 3 member A1 [Immunoglobulin superfamily. BTN/MOG family]

volume: 160. Å3; shape: 0.51; buriedness: 0.62

negative: 0.14; positive: 0.41; polar: 0.; backbone: 0.18; hydrophobic: 0.27

Domains/regions: [D] B30.2/SPRY

PDB: 4n7i, 4n7u, 4v1p

HET: 2ja

BTK_HUMAN_2_170 [text] Tyrosine-protein kinase BTK [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

volume: 435. Å3; shape: 0.67; buriedness: 0.59

negative: 0.; positive: 0.29; polar: 0.31; backbone: 0.36; hydrophobic: 0.04

Domains/regions: [D] PH, [R] Inositol-(1,3,4,5)-tetrakisphosphate 1- binding

PDB: 1b55, 1btk, 1bwn, 2z0p, 4y93, 4y94

HET: 4ip, 4pt, ihp

BTK_HUMAN_387_659 [text] Tyrosine-protein kinase BTK [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

volume: 734. Å3; shape: 0.52; buriedness: 0.74

negative: 0.04; positive: 0.04; polar: 0.18; backbone: 0.46; hydrophobic: 0.28

Domains/regions: [D] Protein kinase, [R] Inhibitor-binding

PDB: 1k2p, 3gen, 3k54, 3ocs, 3oct, 3p08, 3pix, 3piy, 3piz, 3pj1, 3pj2, 3pj3, 4nwm, 4ot5, 4ot6, 4otf, 4otq, 4otr, 4rfy, 4rfz, 4rg0, 4rx5, 4xi2, 4y93, 4y95, 4yhf, 4z3v, 4zly, 4zlz, 5bpy, 5bq0, 5fbn, 5fbo, 5jrs, 5kup

HET: 027, 03c, 04k, 04l, 1n1, 2p5, 2v1, 2v2, 2v3, 2vl, 3ou, 3ov, 3p0, 3yo, 481, 4c9, 4l6, 4ru, 4rv, 4uq, 4us, 585, 5wf, 5wh, 6mv, 6xl, 746, b43, ca, lhl

BTRN_BACCI_2_250 [text] S-adenosyl-L-methionine-dependent 2-deoxy-scyllo-inosamine dehydrogenase [Radical SAM superfamily]

volume: 235. Å3; shape: 0.5; buriedness: 0.9

negative: 0.08; positive: 0.19; polar: 0.15; backbone: 0.5; hydrophobic: 0.08

PDB: 4m7s, 4m7t

HET: sam

BTUB_ECOLI_21_614 [text] Vitamin B12 transporter BtuB [TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily]

volume: 126. Å3; shape: 0.84; buriedness: 0.86

negative: 0.12; positive: 0.11; polar: 0.23; backbone: 0.43; hydrophobic: 0.11

PDB: 1nqe, 1nqf, 1nqg, 1nqh, 1ujw, 2gsk, 2guf, 2ysu, 3m8b, 3m8d, 3rgm, 3rgn

HET: mtn

BUD32_YEAST_1_261 [text] EKC/KEOPS complex subunit BUD32 [Protein kinase superfamily. BUD32 family]

volume: 263. Å3; shape: 0.58; buriedness: 0.81

negative: 0.08; positive: 0.06; polar: 0.08; backbone: 0.25; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 4ww5, 4ww7, 4ww9, 4wwa

HET: adp, amp, anp, mg

BXA1_CLOBO_2_425 [text] Botulinum neurotoxin type A [Peptidase M27 family]

volume: 895. Å3; shape: 0.94; buriedness: 0.7

negative: 0.2; positive: 0.16; polar: 0.11; backbone: 0.34; hydrophobic: 0.19

PDB: 1xtf, 1xtg, 2ilp, 2ima, 2imb, 2imc, 2ise, 2isg, 2ish, 2nyy, 2w2d, 3bok, 3bon, 3boo, 3bta, 3bwi, 3c88, 3c89, 3c8a, 3c8b, 3dda, 3ddb, 3ds9, 3dse, 3k3q, 3nf3, 3qix, 3qiy, 3qiz, 3qj0, 3qw5, 3qw6, 3qw7, 3qw8, 3v0a, 3zur, 3zus, 4ej5, 4el4, 4elc, 4hev, 4ks6, 4ktx, 4kuf, 4zjx

HET: 01w, ace, ahl, aib, axm, cso, dab, dar, dpn, dpp, gb4, gb5, lmr, mpt, na, nh2, qi1, qi2, qi3

BXA2_CLOBO_2_424 [text] Botulinum neurotoxin type A [Peptidase M27 family]

volume: 126. Å3; shape: 0.54; buriedness: 0.65

negative: 0.33; positive: 0.21; polar: 0.; backbone: 0.21; hydrophobic: 0.25

PDB: 1e1h, 2g7k, 2g7n, 2g7p, 2g7q

HET: ahl

BXB_CLOBO_2_438 [text] Botulinum neurotoxin type B [Peptidase M27 family]

volume: 254. Å3; shape: 0.4; buriedness: 0.87

negative: 0.11; positive: 0.05; polar: 0.27; backbone: 0.5; hydrophobic: 0.07

PDB: 1epw, 1f31, 1f82, 1g9a, 1g9b, 1g9c, 1g9d, 1i1e, 1s0b, 1s0c, 1s0d, 1s0e, 1s0f, 1s0g, 2etf, 2np0, 2xhl, 3zuq

HET: bab, ca, zn

BXB_CLOBO_438_856 [text] Botulinum neurotoxin type B [Peptidase M27 family]

volume: 259. Å3; shape: 0.49; buriedness: 0.91

negative: 0.24; positive: 0.14; polar: 0.14; backbone: 0.16; hydrophobic: 0.31

PDB: 1epw, 1f31, 1g9a, 1g9b, 1g9c, 1g9d, 1i1e, 1s0b, 1s0c, 1s0d, 1s0e, 1s0f, 1s0g, 2np0, 2xhl, 3zuq

HET: bab

BXB_CLOBO_856_1291 [text] Botulinum neurotoxin type B [Peptidase M27 family]

volume: 440. Å3; shape: 0.55; buriedness: 0.52

negative: 0.15; positive: 0.14; polar: 0.15; backbone: 0.42; hydrophobic: 0.15

PDB: 1epw, 1f31, 1g9a, 1g9b, 1g9c, 1g9d, 1i1e, 1s0b, 1s0c, 1s0d, 1s0e, 1s0f, 1s0g, 1z0h, 2nm1, 2np0, 4kbb

HET: agc, dm2, gla, sia

BZNB_PSEFL_1_563 [text] Benzaldehyde lyase [TPP enzyme family]

volume: 392. Å3; shape: 0.73; buriedness: 0.96

negative: 0.05; positive: 0.; polar: 0.26; backbone: 0.54; hydrophobic: 0.15

PDB: 2ag0, 2ag1, 2uz1, 3d7k, 3iae, 3iaf, 4qpz, 4qq8

HET: d7k, tpp

C1581_STRCO_1_407 [text] Biflaviolin synthase CYP158A1 [Cytochrome P450 family]

volume: 140. Å3; shape: 0.83; buriedness: 0.58

negative: 0.; positive: 0.58; polar: 0.19; backbone: 0.23; hydrophobic: 0.

PDB: 2dkk, 2nz5, 2nza

HET: 226

C1582_STRCO_1_404 [text] Biflaviolin synthase CYP158A2 [Cytochrome P450 family]

volume: 199. Å3; shape: 0.6; buriedness: 0.81

negative: 0.; positive: 0.22; polar: 0.; backbone: 0.22; hydrophobic: 0.56

PDB: 1s1f, 1se6, 1t93, 2d09, 2d0e, 3tzo, 5de9

HET: flv, mla, nq, pim

C167_SORCE_1_419 [text] Cytochrome P450 167A1 [Cytochrome P450 family]

volume: 355. Å3; shape: 0.78; buriedness: 0.89

negative: 0.; positive: 0.; polar: 0.11; backbone: 0.39; hydrophobic: 0.5

PDB: 1pkf, 1q5d, 1q5e

HET: epb, epd

C1S_HUMAN_423_688 [text] Complement C1s subcomponent [Peptidase S1 family]

volume: 130. Å3; shape: 0.59; buriedness: 0.57

negative: 0.1; positive: 0.1; polar: 0.31; backbone: 0.38; hydrophobic: 0.1

Domains/regions: [D] Peptidase S1

PDB: 1elv, 4j1y

HET: nes

C1TC_HUMAN_1_305 [text] C-1-tetrahydrofolate synthase, cytoplasmic

volume: 416. Å3; shape: 0.44; buriedness: 0.61

negative: 0.09; positive: 0.05; polar: 0.16; backbone: 0.37; hydrophobic: 0.33

Domains/regions: [R] Methylenetetrahydrofolate dehydrogenase and cyclohydrolase, [R] Substrate binding

PDB: 1a4i, 1dia, 1dib, 1dig

HET: l24, l34, l37

C209B_MOUSE_183_324 [text] CD209 antigen-like protein B

volume: 405. Å3; shape: 0.38; buriedness: 0.47

negative: 0.25; positive: 0.08; polar: 0.34; backbone: 0.16; hydrophobic: 0.17

Domains/regions: [D] C-type lectin

PDB: 3zhg, 4c9f, 4caj

HET: gq2, gq4

C43BP_HUMAN_346_624 [text] Collagen type IV alpha-3-binding protein

volume: 514. Å3; shape: 0.53; buriedness: 0.97

negative: 0.1; positive: 0.14; polar: 0.27; backbone: 0.03; hydrophobic: 0.46

Domains/regions: [D] START

PDB: 2e3m, 2e3n, 2e3o, 2e3p, 2e3q, 2e3r, 2e3s, 2z9y, 2z9z, 3h3q, 3h3r, 3h3s, 3h3t

HET: 14h, 16c, 16h, 18c, 6cm, ddr, h13, h15

C562_ECOLX_23_128_phen [text] Soluble cytochrome b562 [Cytochrome b562 family]

volume: 431. Å3; shape: 0.79; buriedness: 0.51

negative: 0.09; positive: 0.09; polar: 0.; backbone: 0.57; hydrophobic: 0.25

PDB: 1lm3, 1m6t, 256b, 2bc5, 2qla, 3c62, 3c63, 3de8, 3de9, 3foo, 3fop, 3l1m, 3nmi, 3nmj, 3nmk, 5awi

HET: cu, ni, pxx, zn

C562_ECOLX_23_128_quin [text] Soluble cytochrome b562 [Cytochrome b562 family]

volume: 141. Å3; shape: 0.73; buriedness: 0.48

negative: 0.13; positive: 0.14; polar: 0.; backbone: 0.44; hydrophobic: 0.28

PDB: 1lm3, 1m6t, 256b, 2bc5, 2qla, 3c62, 3c63, 3de8, 3de9, 3foo, 3fop, 3l1m, 3nmi, 3nmj, 3nmk, 5awi

HET: hqi, ni, zn

C5C4_AMYOR_1_406_catalytic [text] Cytochrome P450 165C4 [Cytochrome P450 family]

volume: 166. Å3; shape: 0.55; buriedness: 0.66

negative: 0.; positive: 0.; polar: 0.5; backbone: 0.25; hydrophobic: 0.25

PDB: 1ued

HET: pg4

C74A2_PARAR_1_473 [text] Allene oxide synthase [Cytochrome P450 family]

volume: 221. Å3; shape: 0.51; buriedness: 0.77

negative: 0.; positive: 0.11; polar: 0.11; backbone: 0.29; hydrophobic: 0.5

Domains/regions: [R] Substrate binding

PDB: 3dam, 3dan, 3dbm

HET: ho2

CACP_HUMAN_30_625 [text] Carnitine O-acetyltransferase [Carnitine/choline acetyltransferase family]

volume: 102. Å3; shape: 0.66; buriedness: 0.84

negative: 0.12; positive: 0.12; polar: 0.56; backbone: 0.; hydrophobic: 0.19

PDB: 1nm8, 1s5o

HET: 152

CACP_MOUSE_30_625 [text] Carnitine O-acetyltransferase [Carnitine/choline acetyltransferase family]

volume: 168. Å3; shape: 0.64; buriedness: 0.86

negative: 0.06; positive: 0.08; polar: 0.54; backbone: 0.; hydrophobic: 0.32

PDB: 1ndb, 1ndf, 1ndi, 1t7n, 1t7o, 1t7q, 2h3p, 2h3u, 2h3w

HET: 152, hc5

CADH1_HUMAN_155_255_pep [text] Cadherin-1

volume: 541. Å3; shape: 0.7; buriedness: 0.75

negative: 0.; positive: 0.; polar: 0.21; backbone: 0.44; hydrophobic: 0.36

Domains/regions: [D] Cadherin 1

PDB: 1o6s, 2o72, 2omt, 2omu, 2omv, 2omx, 2omy, 2omz, 3ff7, 3ff8, 4zt1, 4zte

HET: 4rl

CAH12_HUMAN_29_291 [text] Carbonic anhydrase 12 [Alpha-carbonic anhydrase family]

volume: 307. Å3; shape: 0.66; buriedness: 0.81

negative: 0.; positive: 0.22; polar: 0.34; backbone: 0.19; hydrophobic: 0.25

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 1jcz, 1jd0, 4ht2, 4kp5, 4kp8, 4q0l, 4qj0, 4qjo, 4qjw, 4ww8

HET: azm, e1f, e1g, v14, v1f, v50, vd9, wwo, wwx

CAH13_HUMAN_1_262 [text] Carbonic anhydrase 13 [Alpha-carbonic anhydrase family]

volume: 347. Å3; shape: 0.77; buriedness: 0.78

negative: 0.; positive: 0.23; polar: 0.23; backbone: 0.12; hydrophobic: 0.43

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 3czv, 3d0n, 3da2, 4hu1, 4knm, 4knn, 4qiz, 4qjp, 4qjx, 4qsj, 5e2n

HET: 4md, azm, e1e, e1f, eww, v13, v14, v1f, wwo, wwx

CAH14_HUMAN_16_291 [text] Carbonic anhydrase 14 [Alpha-carbonic anhydrase family]

volume: 218. Å3; shape: 0.4; buriedness: 0.74

negative: 0.; positive: 0.23; polar: 0.27; backbone: 0.19; hydrophobic: 0.31

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 4lu3, 5cjf

HET: 520, azm

CAH14_MOUSE_18_278 [text] Carbonic anhydrase 14 [Alpha-carbonic anhydrase family]

volume: 135. Å3; shape: 0.5; buriedness: 0.8

negative: 0.; positive: 0.25; polar: 0.3; backbone: 0.2; hydrophobic: 0.25

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 1rj5, 1rj6

HET: azm

CAH1_HUMAN_2_261 [text] Carbonic anhydrase 1 [Alpha-carbonic anhydrase family]

volume: 316. Å3; shape: 0.56; buriedness: 0.81

negative: 0.; positive: 0.29; polar: 0.12; backbone: 0.18; hydrophobic: 0.41

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 1azm, 1bzm, 1crm, 1czm, 1hcb, 1hug, 1huh, 1j9w, 1jv0, 2cab, 2foy, 2fw4, 2it4, 2nmx, 2nn1, 2nn7, 3lxe, 3w6h, 3w6i, 4wr7, 4wup, 4wuq, 5e2m

HET: 3tv, 3uf, 3ug, aas, au, auc, azm, b30, flb, m25, m28, m29, mzm, ppf, tor, v14, zn

CAH2_HUMAN_2_260 [text] Carbonic anhydrase 2 [Alpha-carbonic anhydrase family]

volume: 625. Å3; shape: 0.61; buriedness: 0.69

negative: 0.05; positive: 0.14; polar: 0.18; backbone: 0.22; hydrophobic: 0.42

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 12ca, 1a42, 1am6, 1avn, 1bcd, 1bic, 1bn1, 1bn3, 1bn4, 1bnm, 1bnn, 1bnq, 1bnt, 1bnu, 1bnv, 1bnw, 1bv3, 1ca2, 1ca3, 1cah, 1cai, 1caj, 1cak, 1cal, 1cam, 1can, 1cao, 1cay, 1caz, 1ccs, 1cct, 1ccu, 1cil, 1cim, 1cin, 1cnb, 1cnc, 1cng, 1cnh, 1cni, 1cnj, 1cnk, 1cnw, 1cnx, 1cny, 1cra, 1cva, 1cvb, 1cvc, 1cvd, 1cve, 1cvf, 1cvh, 1dca, 1dcb, 1eou, 1f2w, 1fql, 1fqm, 1fqn, 1fqr, 1fr4, 1fr7, 1fsn, 1fsq, 1fsr, 1g0e, 1g0f, 1g1d, 1g3z, 1g45, 1g46, 1g48, 1g4j, 1g4o, 1g52, 1g53, 1g54, 1g6v, 1h4n, 1h9n, 1h9q, 1hca, 1hea, 1heb, 1hec, 1hed, 1hva, 1i8z, 1i90, 1i91, 1i9l, 1i9m, 1i9n, 1i9o, 1i9p, 1i9q, 1if4, 1if5, 1if6, 1if7, 1if8, 1if9, 1kwq, 1kwr, 1lg5, 1lg6, 1lgd, 1lug, 1lzv, 1moo, 1mua, 1okl, 1okm, 1okn, 1oq5, 1ray, 1raz, 1rza, 1rzb, 1rzc, 1rzd, 1rze, 1t9n, 1tb0, 1tbt, 1te3, 1teq, 1teu, 1tg3, 1tg9, 1th9, 1thk, 1ttm, 1uga, 1ugb, 1ugc, 1ugd, 1uge, 1ugf, 1ugg, 1xeg, 1xev, 1xpz, 1xq0, 1yda, 1ydb, 1ydc, 1ydd, 1yo0, 1yo1, 1yo2, 1z9y, 1ze8, 1zfk, 1zfq, 1zge, 1zgf, 1zh9, 1zsa, 1zsb, 1zsc, 2abe, 2aw1, 2ax2, 2ca2, 2cba, 2cbb, 2cbc, 2cbd, 2cbe, 2eu2, 2eu3, 2ez7, 2f14, 2fmg, 2fmz, 2fnk, 2fnm, 2fnn, 2foq, 2fos, 2fou, 2fov, 2gd8, 2geh, 2h15, 2h4n, 2hd6, 2hkk, 2hl4, 2hnc, 2hoc, 2ili, 2nng, 2nno, 2nns, 2nnv, 2nwo, 2nwp, 2nwy, 2nwz, 2nxr, 2nxs, 2nxt, 2o4z, 2osf, 2osm, 2pou, 2pov, 2pow, 2q1b, 2q1q, 2q38, 2qo8, 2qoa, 2qp6, 2vva, 2vvb, 2wd2, 2wd3, 2weg, 2weh, 2wej, 2weo, 2x7s, 2x7t, 2x7u, 3b4f, 3bet, 3bl0, 3bl1, 3c7p, 3ca2, 3caj, 3cyu, 3d8w, 3d92, 3d93, 3d9z, 3daz, 3dbu, 3dc3, 3dc9, 3dcc, 3dcs, 3dcw, 3dd0, 3dd8, 3dv7, 3dvb, 3dvc, 3dvd, 3efi, 3eft, 3f4x, 3f8e, 3ffp, 3gz0, 3hfp, 3hkn, 3hkq, 3hkt, 3hku, 3hlj, 3hs4, 3ibi, 3ibl, 3ibn, 3ibu, 3ieo, 3igp, 3k2f, 3k34, 3k7k, 3kig, 3kkx, 3kne, 3koi, 3kok, 3kon, 3ks3, 3kwa, 3l14, 3m04, 3m14, 3m1j, 3m1k, 3m1q, 3m1w, 3m2n, 3m2x, 3m2y, 3m2z, 3m3x, 3m40, 3m5e, 3m5s, 3m5t, 3m67, 3m96, 3m98, 3mhc, 3mhi, 3mhl, 3mhm, 3mho, 3ml2, 3mmf, 3mna, 3mnh, 3mni, 3mnj, 3mnk, 3mnu, 3mwo, 3myq, 3mzc, 3n0n, 3n2p, 3n3j, 3n4b, 3nb5, 3ni5, 3nj9, 3oik, 3oil, 3oim, 3oku, 3okv, 3oy0, 3oyq, 3oys, 3p3h, 3p3j, 3p44, 3p4v, 3p55, 3p58, 3p5a, 3p5l, 3pjj, 3po6, 3pyk, 3qyk, 3r16, 3r17, 3rg3, 3rg4, 3rge, 3rj7, 3rld, 3ryj, 3ryv, 3ryx, 3ryy, 3ryz, 3rz0, 3rz1, 3rz5, 3rz7, 3rz8, 3s71, 3s72, 3s73, 3s74, 3s75, 3s76, 3s77, 3s78, 3s8x, 3s9t, 3sap, 3sax, 3sbh, 3sbi, 3t5u, 3t5z, 3t82, 3t83, 3t84, 3t85, 3tmj, 3tvn, 3tvo, 3u3a, 3u45, 3u47, 3u7c, 3v2j, 3v2m, 3v3f, 3v3g, 3v3h, 3v3i, 3v3j, 3v5g, 3v7x, 3vbd, 3zp9, 4bcw, 4bf1, 4bf6, 4ca2, 4cac, 4cq0, 4dz7, 4dz9, 4e3d, 4e3f, 4e3g, 4e3h, 4e49, 4e4a, 4e5q, 4fik, 4fl7, 4fpt, 4frc, 4fu5, 4fvn, 4fvo, 4g0c, 4gl1, 4hba, 4hew, 4hey, 4hez, 4hf3, 4ht0, 4idr, 4ilx, 4ito, 4itp, 4iwz, 4js6, 4jsa, 4jss, 4jsw, 4jsz, 4k0s, 4k0t, 4k0z, 4k13, 4k1q, 4kap, 4kni, 4knj, 4kuv, 4kuw, 4kuy, 4kv0, 4l5u, 4l5v, 4l5w, 4lhi, 4lp6, 4m2r, 4m2u, 4m2v, 4m2w, 4mdg, 4mdl, 4mdm, 4mlt, 4mlx, 4mo8, 4mty, 4n0x, 4n16, 4pq7, 4pxx, 4pyx, 4pyy, 4pzh, 4q06, 4q07, 4q08, 4q09, 4q49, 4q6d, 4q6e, 4q78, 4q7p, 4q7s, 4q7v, 4q7w, 4q81, 4q83, 4q87, 4q8x, 4q8y, 4q8z, 4q90, 4q99, 4q9y, 4qef, 4qiy, 4qjm, 4qk1, 4qk2, 4qk3, 4qsa, 4qsb, 4qsi, 4qtl, 4qy3, 4r59, 4r5a, 4r5b, 4rfc, 4rfd, 4rh2, 4riu, 4riv, 4rn4, 4rux, 4ruy, 4ruz, 4wl4, 4ww6, 4xe1, 4y0j, 4ygj, 4ygk, 4ygl, 4ygn, 4yvy, 4ywp, 4yx4, 4yxi, 4yxo, 4yxu, 4yyt, 4z0q, 4z1e, 4z1j, 4z1k, 4z1n, 4zao, 4zwi, 4zwx, 4zwy, 4zwz, 4zx0, 4zx1, 5a6h, 5amd, 5amg, 5aml, 5bnl, 5bru, 5brv, 5brw, 5byi, 5c8i, 5ca2, 5cac, 5cjl, 5clu, 5dog, 5doh, 5drs, 5dsi, 5dsj, 5dsk, 5dsl, 5dsm, 5dsn, 5dso, 5dsp, 5dsq, 5dsr, 5e28, 5e2k, 5e2r, 5e2s, 5eh5, 5eh7, 5eh8, 5ehe, 5ehv, 5ehw, 5eij, 5ekh, 5ekj, 5ekm, 5eoi, 5fdc, 5fdi, 5flo, 5flp, 5flq, 5flr, 5fls, 5flt, 5fng, 5fnh, 5fni, 5fnj, 5fnk, 5fnl, 5fnm, 5g01, 5g03, 5g0b, 5g0c, 5j8z, 5jq0, 5jqt, 5lmd, 6ca2, 7ca2, 8ca2, 9ca2

HET: 1ez, 2c7, 2sd, 3bs, 3cc, 3j3, 3o1, 3qr, 45i, 4kb, 4kd, 4tr, 4tz, 520, 5dt, 5du, 5ef, 5l3, 62i, 6ke, al1, al2, al6, al8, ayx, bex, bl1, bzu, ctf, d02, d7a, daw, df5, dwh, e02, e27, e2i, e36, e38, e49, e50, eg1, eg3, ewz, fc4, ffb, id4, ie2, inl, inq, ioc, ioe, iof, j71, j74, j75, jdr, js7, mb2, mb4, mb6, mb7, mg5, ms4, ms5, nr2, p9b, po1, pof, r21, ryz, rz1, rz7, sbb, sbr, sg5, su0, vz4, vz5, wza, wzb, wzc, zn

CAH4_HUMAN_19_284 [text] Carbonic anhydrase 4 [Alpha-carbonic anhydrase family]

volume: 283. Å3; shape: 0.74; buriedness: 0.81

negative: 0.; positive: 0.27; polar: 0.34; backbone: 0.13; hydrophobic: 0.26

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 1znc, 3f7b, 3f7u, 3fw3

HET: ag4, ag5, ets

CAH4_MOUSE_22_279 [text] Carbonic anhydrase 4 [Alpha-carbonic anhydrase family]

volume: 254. Å3; shape: 0.61; buriedness: 0.71

negative: 0.; positive: 0.24; polar: 0.32; backbone: 0.16; hydrophobic: 0.28

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 2znc, 3znc

HET: bz1

CAH5A_MOUSE_52_299 [text] Carbonic anhydrase 5A, mitochondrial [Alpha-carbonic anhydrase family]

volume: 118. Å3; shape: 0.49; buriedness: 0.86

negative: 0.; positive: 0.26; polar: 0.35; backbone: 0.22; hydrophobic: 0.17

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 1dmx, 1dmy, 1keq, 1urt

HET: azm

CAH7_HUMAN_2_263 [text] Carbonic anhydrase 7 [Alpha-carbonic anhydrase family]

volume: 153. Å3; shape: 0.48; buriedness: 0.81

negative: 0.; positive: 0.22; polar: 0.22; backbone: 0.26; hydrophobic: 0.3

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Substrate binding

PDB: 3mdz, 3ml5

HET: azm, ezl

CAH9_HUMAN_136_392 [text] Carbonic anhydrase 9 [Alpha-carbonic anhydrase family]

volume: 208. Å3; shape: 0.38; buriedness: 0.69

negative: 0.; positive: 0.24; polar: 0.24; backbone: 0.16; hydrophobic: 0.37

Domains/regions: [D] Alpha-carbonic anhydrase, [R] Catalytic, [R] Substrate binding

PDB: 3iai, 5dvx, 5fl4, 5fl5, 5fl6

HET: 82e, 9fk, azm, y0r

CAIT_ECOLI_1_504 [text] L-carnitine/gamma-butyrobetaine antiporter [BCCT transporter (TC 2.A.15) family. CaiT subfamily]

volume: 103. Å3; shape: 0.64; buriedness: 0.84

negative: 0.; positive: 0.; polar: 0.24; backbone: 0.; hydrophobic: 0.76

PDB: 2wsx, 3hfx

HET: 152, nm2

CALRL_HUMAN_23_133_3N7 [text] Calcitonin gene-related peptide type 1 receptor [G-protein coupled receptor 2 family]

volume: 237. Å3; shape: 0.45; buriedness: 0.63

negative: 0.06; positive: 0.04; polar: 0.22; backbone: 0.45; hydrophobic: 0.22

PDB: 3aqf, 3n7p, 3n7r, 3n7s

HET: 3n7

CALRL_HUMAN_23_133_ECD [text] Calcitonin gene-related peptide type 1 receptor [G-protein coupled receptor 2 family]

volume: 728. Å3; shape: 0.64; buriedness: 0.45

negative: 0.06; positive: 0.11; polar: 0.16; backbone: 0.33; hydrophobic: 0.34

PDB: 3aqf, 3n7p, 3n7r, 3n7s

HET: 3n6, n7r

CAMK_RHOSO_1_257 [text] 6-oxocamphor hydrolase [Enoyl-CoA hydratase/isomerase family]

volume: 99. Å3; shape: 0.87; buriedness: 0.96

negative: 0.28; positive: 0.31; polar: 0.; backbone: 0.; hydrophobic: 0.41

PDB: 1o8u, 1szo

HET: cax

CAN1_RAT_24_356 [text] Calpain-1 catalytic subunit [Peptidase C2 family]

volume: 594. Å3; shape: 0.5; buriedness: 0.57

negative: 0.02; positive: 0.05; polar: 0.15; backbone: 0.53; hydrophobic: 0.24

Domains/regions: [D] Calpain catalytic

PDB: 1kxr, 1qxp, 1tl9, 1tlo, 2g8e, 2g8j, 2nqg, 2nqi, 2r9c, 2r9f

HET: 0m6, ace, ar7, d7g, e64, grd, k2z, nqg, nqi

CAPP_ECOLI_1_883 [text] Phosphoenolpyruvate carboxylase [PEPCase type 1 family]

volume: 116. Å3; shape: 0.78; buriedness: 0.98

negative: 0.14; positive: 0.31; polar: 0.; backbone: 0.38; hydrophobic: 0.17

PDB: 1fiy, 1jqn, 1qb4

HET: dco

CAPSD_HBVD1_1_149 [text] Capsid protein [Orthohepadnavirus core antigen family]

volume: 289. Å3; shape: 0.8; buriedness: 0.65

negative: 0.; positive: 0.; polar: 0.32; backbone: 0.18; hydrophobic: 0.5

PDB: 3kxs, 3v6z, 4bmg, 5e0i, 5gmz

HET: 5j6, 6xu

CAR4_ARATH_1_176 [text] Protein C2-DOMAIN ABA-RELATED 4 [Plant CAR protein family]

volume: 112. Å3; shape: 0.51; buriedness: 0.71

negative: 0.12; positive: 0.19; polar: 0.12; backbone: 0.46; hydrophobic: 0.12

Domains/regions: [D] C2

PDB: 4v29, 5a4x, 5a50, 5a51

HET: pc, zn

CARA_PECCC_1_503 [text] Carbapenam-3-carboxylate synthase

volume: 292. Å3; shape: 0.6; buriedness: 0.95

negative: 0.09; positive: 0.05; polar: 0.13; backbone: 0.59; hydrophobic: 0.14

Domains/regions: [D] Asparagine synthetase

PDB: 1q15, 1q19

HET: apc

CARB_PECCC_1_250 [text] Carboxymethylproline synthase [Enoyl-CoA hydratase/isomerase family]

volume: 98. Å3; shape: 0.76; buriedness: 0.93

negative: 0.07; positive: 0.; polar: 0.14; backbone: 0.48; hydrophobic: 0.31

PDB: 2a7k, 2a81

HET: bcn

CARC_PECCC_1_273 [text] (5R)-carbapenem-3-carboxylate synthase [TfdA dioxygenase family]

volume: 95. Å3; shape: 0.89; buriedness: 0.9

negative: 0.1; positive: 0.2; polar: 0.18; backbone: 0.31; hydrophobic: 0.22

PDB: 1nx4, 1nx8, 4oj8

HET: 2tq, n7p

CARM1_HUMAN_135_481 [text] Histone-arginine methyltransferase CARM1 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family]

volume: 1360. Å3; shape: 0.67; buriedness: 0.93

negative: 0.1; positive: 0.08; polar: 0.2; backbone: 0.4; hydrophobic: 0.23

Domains/regions: [D] SAM-dependent MTase PRMT-type

PDB: 2v74, 2v7e, 2y1w, 2y1x, 3b3f, 3b3g, 3b3j, 4ikp, 5dwq, 5dx0, 5dx1, 5dx8, 5dxa, 5dxj, 5k8v

HET: 4ik, 6re, 845, 849, ace, dxe, nmm, sah, sfg

CARP_CRYPA_90_419 [text] Endothiapepsin [Peptidase A1 family]

volume: 977. Å3; shape: 0.59; buriedness: 0.75

negative: 0.17; positive: 0.; polar: 0.17; backbone: 0.3; hydrophobic: 0.36

Domains/regions: [D] Peptidase A1

PDB: 1e5o, 1e80, 1e81, 1e82, 1eed, 1ent, 1epl, 1epm, 1epn, 1epo, 1epp, 1epq, 1epr, 1er8, 1gkt, 1gvt, 1gvu, 1gvv, 1gvw, 1gvx, 1od1, 1oew, 1oex, 2er0, 2er6, 2er7, 2er9, 2jji, 2jjj, 2v00, 2vs2, 3er3, 3er5, 3lzy, 3pb5, 3pbd, 3pbz, 3pcw, 3pcz, 3pgi, 3pi0, 3pld, 3pll, 3pm4, 3pmu, 3pmy, 3prs, 3psy, 3pww, 3q6y, 3t6i, 3t7p, 3t7q, 3t7x, 3uri, 3urj, 3url, 3wz6, 3wz7, 3wz8, 4ape, 4er1, 4er2, 4er4, 4kup, 4l6b, 4lap, 4lbt, 4lhh, 4lp9, 4y35, 4y36, 4y37, 4y38, 4y39, 4y3a, 4y3d, 4y3e, 4y3f, 4y3g, 4y3h, 4y3j, 4y3l, 4y3m, 4y3n, 4y3p, 4y3q, 4y3r, 4y3s, 4y3t, 4y3w, 4y3x, 4y3y, 4y3z, 4y41, 4y43, 4y44, 4y45, 4y47, 4y48, 4y4a, 4y4b, 4y4c, 4y4d, 4y4e, 4y4g, 4y4j, 4y4t, 4y4u, 4y4w, 4y4x, 4y4z, 4y50, 4y51, 4y53, 4y54, 4y56, 4y57, 4y58, 4y5a, 4y5b, 4y5c, 4y5e, 4y5g, 4y5k, 4y5l, 4y5m, 4y5n, 4y5p, 4yck, 4yct, 4ycy, 4yd3, 4yd4, 4yd5, 4yd6, 4yd7, 4ze6, 4zea, 5dpz, 5dq1, 5dq2, 5dq4, 5dq5, 5dr0, 5dr1, 5dr3, 5dr4, 5dr7, 5dr8, 5er1, 5er2, 5hct, 5oyq, 5oyr, 5oys, 5oyt, 5oyu, 5oyv, 5oyw, 5oyx, 5oyy, 5oyz, 5oz0, 5oz1, 5oz2, 5oz3, 5oz4, 5oz5, 5oz6, 5oz7, 5oz8, 5oz9, 5oza, 5ozb, 5ozc, 5ozd, 5oze, 5ozf, 5ozg, 5ozh, 5ozi, 5ozj, 5ozk, 5ozl, 5ozm, 5ozn, 5ozo, 5ozp, 5ozq, 5ozr, 5ozs, 5ozt, 5ozu, 5ozv, 5ozw, 5ozx, 5ozy, 5ozz, 5p00, 5p01, 5p02, 5p03, 5p04, 5p05, 5p06, 5p07, 5p08, 5p09, 5p0a, 5p0b, 5p0c, 5p0d, 5p0e, 5p0f, 5p0g, 5p0h, 5p0i, 5p0j, 5p0k, 5p0l, 5p0m, 5p0n, 5p0o, 5p0p, 5p0q, 5p0r, 5p0s, 5p0t, 5p0u, 5p0v, 5p0w, 5p0x, 5p0y, 5p0z, 5p10, 5p11, 5p12, 5p13, 5p14, 5p15, 5p16, 5p17, 5p18, 5p19, 5p1a, 5p1b, 5p1c, 5p1d, 5p1e, 5p1f, 5p1g, 5p1h, 5p1i, 5p1j, 5p1k, 5p1l, 5p1m, 5p1n, 5p1o, 5p1p, 5p1q, 5p1r, 5p1s, 5p1t, 5p1u, 5p1v, 5p1w, 5p1x, 5p1y, 5p1z, 5p20, 5p22, 5p23, 5p24, 5p25, 5p26, 5p27, 5p28, 5p29, 5p2a, 5p2b, 5p2c, 5p2d, 5p2e, 5p2f, 5p2g, 5p2h, 5p2i, 5p2j, 5p2k, 5p2l, 5p2m, 5p2n, 5p2o, 5p2q, 5p2r, 5p2s, 5p2t, 5p2u, 5p2v, 5p2w, 5p2x, 5p2y, 5p2z, 5p30, 5p31, 5p32, 5p33, 5p34, 5p35, 5p36, 5p37, 5p38, 5p39, 5p3a, 5p3b, 5p3c, 5p3d, 5p3e, 5p3f, 5p3g, 5p3h, 5p3i, 5p3j, 5p3k, 5p3l, 5p3m, 5p3n, 5p3o, 5p3p, 5p3q, 5p3r, 5p3s, 5p3t, 5p3u, 5p3v, 5p3w, 5p3x, 5p3y, 5p3z, 5p40, 5p41, 5p42, 5p43, 5p44, 5p45, 5p46, 5p47, 5p48, 5p49, 5p4a, 5p4b, 5p4c, 5p4d, 5p4e, 5p4f, 5p4g, 5p4h, 5p4i, 5p4j, 5p4k, 5p4l, 5p4m, 5p4n, 5p4o, 5p4p, 5p4q, 5p4r, 5p4s, 5p4t, 5p4u, 5p4v, 5p4w, 5p4x, 5p4y, 5p4z, 5p50, 5p51, 5p52, 5p53, 5p54, 5p55, 5p56, 5p57, 5p58, 5p59, 5p5a, 5p5b, 5p5c, 5p5d, 5p5e, 5p5f, 5p5g, 5p5h, 5p5i, 5p5j, 5p5k, 5p5l, 5p5m, 5p5n, 5p5o, 5p5p, 5p5q, 5p5r, 5p5s, 5p5t, 5p5u, 5p5v, 5p5w, 5p5x, 5p5y, 5p5z, 5p60, 5p61, 5p62, 5p63, 5p64, 5p65, 5p66, 5p67, 5p68, 5p69, 5p6a, 5p6b, 5p6c, 5p6d, 5p6e, 5p6f, 5p6g, 5p6h, 5p6i, 5p6j, 5p6k, 5p6l, 5p6m, 5p6n, 5p6o, 5p6p, 5p6q, 5p6r, 5p6s, 5p6t, 5p6u, 5p6v, 5p6w, 5p6x, 5p6y, 5p6z, 5p70, 5p71, 5p72, 5p73, 5p74, 5p75, 5p76, 5p77, 5p78, 5p79, 5p7a, 5p7b, 5p7c, 5p7d, 5p7e, 5p7f, 5p7g, 5p7h, 5p7i, 5p7j, 5p7k, 5p7l, 5p7m, 5p7n, 5p7o, 5p7p, 5p7q, 5p7r, 5p7s, 5p7t, 5p7u, 5p7v, 5p7w, 5p7x, 5p7y, 5p7z, 5p80, 5p81, 5p82, 5p83, 5p84, 5p85, 5p86, 5p87, 5p88, 5p89, 5p8a, 5p8b, 5p8c, 5p8d, 5p8e, 5p8f, 5p8g, 5p8h, 5p8i, 5p8j, 5p8k, 5p8l, 5p8m, 5p8n, 5p8o, 5p8p, 5p8q, 5p8r, 5p8s, 5p8t, 5p8u, 5p8v

HET: 1pe, 1tz, 1vs, 1vt, 41l, 45l, 45m, 45n, 45o, 45v, 45y, 463, 46h, 46j, 46l, 46o, 46p, 46q, 46r, 46s, 46t, 46v, 46w, 46x, 46y, 479, 47a, 47b, 47g, 47h, 47k, 47l, 47m, 47p, 47q, 47s, 47t, 47u, 47v, 47y, 483, 487, 489, 4ao, 4aq, 4av, 5g1, 5gc, 5gj, 5gl, 5gq, 5hj, 5hl, 5ho, 5hq, 5hs, 61p, 78b, 7sp, cff, f02, f06, f41, f5n, f63, f7l, f90, f91, fbf, ggb, imi, ixv, ixy, ixz, lnr, nc8, nc9, pg4, pge, rb4, rb9, s47, v15, z82

CAS1_STRC2_1_324 [text] Clavaminate synthase 1 [Clavaminate synthase family]

volume: 157. Å3; shape: 0.64; buriedness: 0.93

negative: 0.24; positive: 0.16; polar: 0.16; backbone: 0.24; hydrophobic: 0.21

PDB: 1drt, 1dry, 1ds0, 1ds1, 1gvg

HET: aag, pcv, pcx

CASP1_HUMAN_121_404 [text] Caspase-1 [Peptidase C14A family]

volume: 548. Å3; shape: 0.6; buriedness: 0.28

negative: 0.; positive: 0.22; polar: 0.11; backbone: 0.55; hydrophobic: 0.11

PDB: 1bmq, 1ibc, 1ice, 1rwk, 1rwm, 1rwn, 1rwo, 1rwp, 1rwv, 1rww, 1rwx, 1sc1, 1sc3, 1sc4, 2fqq, 2h48, 2h4w, 2h4y, 2h51, 2h54, 2hbq, 2hbr, 2hby, 2hbz, 3d6f, 3d6h, 3d6m, 3e4c, 3ns7

HET: 158, 3ns, 4qb, 5ph, ace, asa, bth, cf0, hqc, mli, mno, oqb, phq, q2y, ybh

CASP6_HUMAN_18_293 [text] Caspase-6 [Peptidase C14A family]

volume: 332. Å3; shape: 0.5; buriedness: 0.52

negative: 0.; positive: 0.25; polar: 0.; backbone: 0.26; hydrophobic: 0.49

PDB: 2wdp, 3k7e, 3nkf, 3nr2, 3od5, 3p45, 3p4u, 3qnw, 3s70, 3s8e, 3v6l, 3v6m, 4ejf, 4fxo, 4hva, 4iyr, 4n5d, 4n6g, 4n7j, 4n7m, 4nbk, 4nbl, 4nbn

HET: 4hv

CASP7_HUMAN_52_303_allosteric [text] Caspase-7 [Peptidase C14A family]

volume: 513. Å3; shape: 0.65; buriedness: 0.48

negative: 0.; positive: 0.07; polar: 0.15; backbone: 0.3; hydrophobic: 0.48

PDB: 1f1j, 1gqf, 1i4o, 1i51, 1k86, 1k88, 1kmc, 1shj, 1shl, 2ql5, 2ql7, 2ql9, 2qlb, 2qlf, 2qlj, 3edr, 3h1p, 3ibc, 3ibf, 3r5k, 4fdl, 4hq0, 4hqr, 4jb8, 4jj8, 4jr1, 4jr2, 4lsz, 4zvo, 4zvp, 4zvq, 4zvr, 4zvs, 4zvt, 4zvu, 5ic6

HET: fxn, nxn

CASP7_HUMAN_52_303_catalytic [text] Caspase-7 [Peptidase C14A family]

volume: 659. Å3; shape: 0.52; buriedness: 0.54

negative: 0.; positive: 0.07; polar: 0.22; backbone: 0.43; hydrophobic: 0.27

PDB: 1f1j, 1gqf, 1i4o, 1i51, 1k86, 1k88, 1kmc, 1shj, 1shl, 2ql5, 2ql7, 2ql9, 2qlb, 2qlf, 2qlj, 3edr, 3h1p, 3ibc, 3ibf, 3r5k, 4fdl, 4hq0, 4hqr, 4jb8, 4jj8, 4jr1, 4jr2, 4lsz, 4zvo, 4zvp, 4zvq, 4zvr, 4zvs, 4zvt, 4zvu, 5ic6

HET: 0qe, 1mh, 1u8, ace, akz, asa, asj, b3l, hlx, mke

CASP8_HUMAN_219_478 [text] Caspase-8 [Peptidase C14A family]

volume: 768. Å3; shape: 0.49; buriedness: 0.42

negative: 0.; positive: 0.27; polar: 0.17; backbone: 0.47; hydrophobic: 0.09

PDB: 1f9e, 1i4e, 1qdu, 1qtn, 2c2z, 2fun, 2y1l, 3h11, 3kjn, 3kjq, 4jj7, 4prz, 4ps1

HET: 0qe, 1mh, 1u8, ace, asa, asj, b3l, b93, b94, bal, hlx, hyp, mx5, phq

CASR_HUMAN_2_541_ECD [text] Extracellular calcium-sensing receptor [G-protein coupled receptor 3 family]

volume: 135. Å3; shape: 0.55; buriedness: 0.89

negative: 0.06; positive: 0.05; polar: 0.26; backbone: 0.47; hydrophobic: 0.16

PDB: 5fbh, 5fbk, 5k5s, 5k5t

HET: tcr

CAT3_ECOLX_1_213 [text] Chloramphenicol acetyltransferase 3 [Chloramphenicol acetyltransferase family]

volume: 398. Å3; shape: 0.68; buriedness: 0.87

negative: 0.; positive: 0.06; polar: 0.37; backbone: 0.16; hydrophobic: 0.41

PDB: 1cia, 1cla, 1qca, 2cla, 3cla, 4cla

HET: clm, fua

CAT4_PSEAE_1_212 [text] Chloramphenicol acetyltransferase [Transferase hexapeptide repeat family]

volume: 191. Å3; shape: 0.67; buriedness: 0.88

negative: 0.; positive: 0.08; polar: 0.25; backbone: 0.38; hydrophobic: 0.29

PDB: 1xat, 2xat

HET: clm

CATA_RHOOP_2_270 [text] Catechol 1,2-dioxygenase [Intradiol ring-cleavage dioxygenase family]

volume: 107. Å3; shape: 0.86; buriedness: 1.

negative: 0.; positive: 0.26; polar: 0.25; backbone: 0.09; hydrophobic: 0.41

PDB: 3hgi, 3hhx, 3hhy, 3hj8, 3hjq, 3hjs, 3hkp, 3i4v, 3i4y, 3i51

HET: 35c, 3ce, 45c, 4cl, bez, caq, dhb, mbd, mct, pyg

CATB_BOVIN_126_334 [text] Cathepsin B [Peptidase C1 family]

volume: 462. Å3; shape: 0.39; buriedness: 0.79

negative: 0.04; positive: 0.13; polar: 0.04; backbone: 0.48; hydrophobic: 0.3

PDB: 1ito, 1qdq, 1sp4, 2dc6, 2dc7, 2dc8, 2dc9, 2dca, 2dcb, 2dcc, 2dcd

HET: 042, 074, 59a, 73v, 74m, 75v, 76v, 77b, 78a, e6c, ep2

CATB_HUMAN_127_335 [text] Cathepsin B [Peptidase C1 family]

volume: 623. Å3; shape: 0.4; buriedness: 0.66

negative: 0.05; positive: 0.1; polar: 0.08; backbone: 0.49; hydrophobic: 0.27

PDB: 1csb, 1gmy, 1huc, 1pbh, 2ipp, 2pbh, 3ai8, 3cbj, 3cbk, 3k9m, 3pbh

HET: aem, apd, dfa, ep0, hnq, pys

CATC_HUMAN_25_463 [text] Dipeptidyl peptidase 1 [Peptidase C1 family]

volume: 294. Å3; shape: 0.68; buriedness: 0.6

negative: 0.09; positive: 0.; polar: 0.17; backbone: 0.58; hydrophobic: 0.16

PDB: 1k3b, 2djf, 2djg, 3pdf, 4cdc, 4cdd, 4cde, 4cdf, 4oel, 4oem

HET: 1zb, 6ao, gdi, lxv, u6b, w2c

CATD_HUMAN_63_411 [text] Cathepsin D [Peptidase A1 family]

volume: 628. Å3; shape: 0.58; buriedness: 0.8

negative: 0.11; positive: 0.; polar: 0.25; backbone: 0.31; hydrophobic: 0.33

Domains/regions: [D] Peptidase A1

PDB: 1lya, 1lyb, 1lyw, 4obz, 4oc6, 4od9

HET: 2rz, 2s1, 2s4, iva, sta

CAT_ECOLX_1_219 [text] Chloramphenicol acetyltransferase [Chloramphenicol acetyltransferase family]

volume: 341. Å3; shape: 0.62; buriedness: 0.88

negative: 0.; positive: 0.07; polar: 0.26; backbone: 0.1; hydrophobic: 0.57

PDB: 1noc, 1pd5, 1q23, 3u9b, 3u9f

HET: clm, fua

CATG_HUMAN_21_248 [text] Cathepsin G [Peptidase S1 family]

volume: 491. Å3; shape: 0.73; buriedness: 0.65

negative: 0.06; positive: 0.11; polar: 0.14; backbone: 0.56; hydrophobic: 0.13

Domains/regions: [D] Peptidase S1

PDB: 1au8, 1cgh, 1kyn, 1t32

HET: 0h8, 1zg, ktp, ohh

CATK_HUMAN_114_329 [text] Cathepsin K [Peptidase C1 family]

volume: 760. Å3; shape: 0.49; buriedness: 0.67

negative: 0.03; positive: 0.03; polar: 0.1; backbone: 0.56; hydrophobic: 0.27

PDB: 1atk, 1au0, 1au2, 1au3, 1au4, 1ayu, 1ayv, 1ayw, 1bgo, 1by8, 1mem, 1nl6, 1nlj, 1q6k, 1snk, 1tu6, 1u9v, 1u9w, 1u9x, 1vsn, 1yk7, 1yk8, 1yt7, 2ato, 2aux, 2auz, 2bdl, 2f7d, 2ftd, 2r6n, 3c9e, 3h7d, 3kw9, 3kwb, 3kwz, 3kx1, 3o0u, 3o1g, 3ovz, 4dmx, 4dmy, 4n79, 4n8w, 4x6h, 4x6i, 4x6j, 4yv8, 4yva, 5j94, 5ja7, 5jh3, 7pck

HET: 0d6, 0lb, 0lc, 2ca, 3fc, 3xt, 3y1, 3y2, 4pr, 750, ag2, cke, ct1, ct2, e64, fsp, i10, ihe, ihi, ihj, ili, in3, in6, ina, inp, kwz, kx1, mye, myq, nbl, nft, noq, o47, o75, o96, org, orh, pcm, pos, rgl, sdk, t2m, tco, tfa, ure

CATL1_HUMAN_114_333 [text] Cathepsin L1 [Peptidase C1 family]

volume: 2460. Å3; shape: 0.52; buriedness: 0.63

negative: 0.07; positive: 0.03; polar: 0.11; backbone: 0.51; hydrophobic: 0.28

PDB: 1cjl, 1cs8, 1icf, 1mhw, 2nqd, 2vhs, 2xu1, 2xu3, 2xu4, 2xu5, 2yj2, 2yj8, 2yj9, 2yjb, 2yjc, 3bc3, 3h89, 3h8b, 3h8c, 3hha, 3hwn, 3iv2, 3k24, 3kse, 3of8, 3of9, 4axl, 4axm, 5f02, 5i4h

HET: 424, 5t9, bd3, bp4, btb, dar, djt, i0x, i0y, now, nsx, nsy, nsz, opt, pea, pg4, pge, v65, xu3, xu5, yj2, yj8, yj9, zn

CATS_HUMAN_114_331 [text] Cathepsin S [Peptidase C1 family]

volume: 1259. Å3; shape: 0.53; buriedness: 0.39

negative: 0.; positive: 0.08; polar: 0.08; backbone: 0.55; hydrophobic: 0.29

PDB: 1glo, 1ms6, 1npz, 1nqc, 2c0y, 2f1g, 2fq9, 2fra, 2frq, 2ft2, 2fud, 2fye, 2g6d, 2g7y, 2h7j, 2hh5, 2hhn, 2hxz, 2op3, 2r9m, 2r9n, 2r9o, 3iej, 3kwn, 3mpe, 3mpf, 3n3g, 3n4c, 3ovx, 4p6e, 4p6g

HET: 23z, 2fc, 2fz, 599, 935, bcq, bln, c1p, c28, c4p, c71, crj, crl, crv, ef3, gnf, gnq, h7j, mo9, mqq, n2a, n2d, o64, p15, peu, tf5, y11, y14, y15, zn

CATS_MOUSE_116_340 [text] Cathepsin S [Peptidase C1 family]

volume: 379. Å3; shape: 0.6; buriedness: 0.67

negative: 0.; positive: 0.1; polar: 0.16; backbone: 0.53; hydrophobic: 0.21

PDB: 4bpv, 4bqv, 4bs5, 4bs6, 4bsq, 4mzo, 4mzs

HET: 2ev, 2ew, 8pw, jg7, mg2, ofh, qqv

CBBY_RHOSH_1_230 [text] Protein CbbY [HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family]

volume: 170. Å3; shape: 0.54; buriedness: 0.96

negative: 0.11; positive: 0.22; polar: 0.27; backbone: 0.36; hydrophobic: 0.04

PDB: 4uar, 4uas, 4uat, 4uau

HET: xbp

CBG_HUMAN_33_405 [text] Corticosteroid-binding globulin [Serpin family]

volume: 243. Å3; shape: 0.53; buriedness: 0.81

negative: 0.; positive: 0.19; polar: 0.3; backbone: 0.17; hydrophobic: 0.34

PDB: 2vdx, 2vdy, 4bb2, 4c41, 4c49

HET: hcy, str

CBH_CLOPE_1_329 [text] Choloylglycine hydrolase [Peptidase C59 family]

volume: 264. Å3; shape: 0.5; buriedness: 0.86

negative: 0.; positive: 0.07; polar: 0.06; backbone: 0.28; hydrophobic: 0.59

PDB: 2bjf, 2bjg, 2rf8, 2rg2, 2rlc

HET: chd, dxc

CBP2_WHEAT_3_441 [text] Serine carboxypeptidase 2 [Peptidase S10 family]

volume: 145. Å3; shape: 0.59; buriedness: 0.83

negative: 0.22; positive: 0.06; polar: 0.32; backbone: 0.32; hydrophobic: 0.08

Domains/regions: [R] Substrate binding

PDB: 1bcr, 1bcs, 1whs, 1wht, 3sc2

HET: bzs

CBPA1_BOVIN_111_418 [text] Carboxypeptidase A1 [Peptidase M14 family]

volume: 537. Å3; shape: 0.6; buriedness: 0.9

negative: 0.1; positive: 0.26; polar: 0.26; backbone: 0.15; hydrophobic: 0.23

Domains/regions: [R] Substrate binding

PDB: 1arl, 1arm, 1bav, 1cbx, 1cps, 1cpx, 1ee3, 1ell, 1elm, 1f57, 1hdq, 1hdu, 1hee, 1iy7, 1m4l, 1pyt, 1yme, 1zlh, 2abz, 2ctb, 2ctc, 2rfh, 3cpa, 3fvl, 3fx6, 3hlp, 3huv, 3i1u, 3kgq, 4cpa, 5cpa, 6cpa, 7cpa, 8cpa

HET: 23n, agf, bhk, bip, bpx, btw, bzs, cpm, cu, cxa, dcy, fvf, hfa, inf, ing, lhy, mrd, zaf, zn

CBPA1_HUMAN_111_419 [text] Carboxypeptidase A1 [Peptidase M14 family]

volume: 346. Å3; shape: 0.58; buriedness: 0.79

negative: 0.11; positive: 0.27; polar: 0.31; backbone: 0.11; hydrophobic: 0.2

Domains/regions: [R] Substrate binding

PDB: 2v77, 3fju, 4uee, 4uef, 4uez, 4uf4

HET: la9, lff, o2v, pay, tje

CBPB1_PIG_192_416 [text] Carboxypeptidase B [Peptidase M14 family]

volume: 528. Å3; shape: 0.63; buriedness: 0.79

negative: 0.14; positive: 0.23; polar: 0.3; backbone: 0.18; hydrophobic: 0.16

Domains/regions: [R] Substrate binding

PDB: 1nsa, 1z5r, 1zg7, 1zg8, 1zg9, 2jew, 2piy, 2piz, 2pj0, 2pj1, 2pj2, 2pj3, 2pj4, 2pj5, 2pj6, 2pj7, 2pj8, 2pj9, 2pja, 2pjb, 2pjc, 3glj, 3wab, 3wc5, 3wc6, 3wc7, 4uia, 4uib, 4z65, 5lrg, 5lrj, 5lrk, 5lyd, 5lyf, 5lyi, 5lyl

HET: 059, 0x9, 11b, 17a, 235, 281, 33z, 343, 414, 528, 578, 606, 720, 73n, 73o, 73p, 7b0, 7b6, 864, 86a, 922, 983, ben, ddk, ddw, dly, ef1, fh9, gwx, iil, l06, l98, maa, p20, t4f, t5f, zn

CBPB2_HUMAN_115_423 [text] Carboxypeptidase B2 [Peptidase M14 family]

volume: 218. Å3; shape: 0.47; buriedness: 0.96

negative: 0.2; positive: 0.27; polar: 0.24; backbone: 0.19; hydrophobic: 0.1

Domains/regions: [R] Substrate binding

PDB: 3d66, 3d67, 3d68, 3lms, 4p10, 5hvf, 5hvg, 5hvh

HET: 2b8, gem

CBPD_LOPSP_1_380 [text] Carboxypeptidase D [Peptidase M14 family]

volume: 151. Å3; shape: 0.57; buriedness: 0.97

negative: 0.18; positive: 0.24; polar: 0.24; backbone: 0.24; hydrophobic: 0.12

Domains/regions: [R] Carboxypeptidase 2

PDB: 1h8l, 1qmu

HET: gem

CBP_HUMAN_1080_1197 [text] CREB-binding protein

volume: 525. Å3; shape: 0.74; buriedness: 0.69

negative: 0.; positive: 0.06; polar: 0.22; backbone: 0.17; hydrophobic: 0.55

Domains/regions: [D] Bromo, [R] Interaction with ASF1A, [R] Interaction with histone

PDB: 3dwy, 3p1c, 3p1d, 3p1e, 3p1f, 3svh, 4a9k, 4n3w, 4n4f, 4nr4, 4nr5, 4nr6, 4nr7, 4nyv, 4nyw, 4nyx, 4ouf, 4tqn, 4ts8, 4whu, 4yk0, 5cgp, 5dbm, 5eic, 5eng, 5ep7, 5i83, 5i86, 5i89, 5i8b, 5i8g, 5j0d, 5ktu, 5ktw, 5ktx, 5tb6

HET: 15e, 2lk, 2ll, 2ln, 2lo, 2o3, 2o4, 3ot, 3pf, 53w, 58n, 5j5, 5qn, 5qr, 68y, 69a, 69b, 69e, 69f, 6f9, 6xb, 6xg, 6xh, 77x, 98, aly, k, krg, mb3, na, tyl, ul4, xz8

CBP_HUMAN_1197_1314 [text] CREB-binding protein

volume: 211. Å3; shape: 0.73; buriedness: 0.62

negative: 0.; positive: 0.; polar: 0.44; backbone: 0.33; hydrophobic: 0.22

Domains/regions: [D] Bromo, [R] Interaction with ASF1A

PDB: 4n3w, 4n4f, 5i8b, 5i8g

HET: b3p

CBPT_THEVU_99_423 [text] Carboxypeptidase T [Peptidase M14 family]

volume: 250. Å3; shape: 0.54; buriedness: 0.93

negative: 0.17; positive: 0.24; polar: 0.26; backbone: 0.18; hydrophobic: 0.14

PDB: 1obr, 3prt, 3qnv, 3v38, 3v7z, 4djl, 4duk, 4f8z, 4gm5, 4iav, 4ihm, 4ik2

HET: 0x9, bl2, bzs, cxa, gem

CBR1_HUMAN_2_277 [text] Carbonyl reductase [NADPH] 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 539. Å3; shape: 0.73; buriedness: 0.75

negative: 0.; positive: 0.09; polar: 0.15; backbone: 0.39; hydrophobic: 0.37

Domains/regions: [R] Glutathione binding

PDB: 1wma, 2pfg, 3bhi, 3bhj, 3bhm, 4z3d

HET: ab3, ahe, ddd, gsh, pe5

CBX7_HUMAN_6_65 [text] Chromobox protein homolog 7

volume: 2013. Å3; shape: 0.79; buriedness: 0.47

negative: 0.07; positive: 0.1; polar: 0.09; backbone: 0.4; hydrophobic: 0.34

Domains/regions: [D] Chromo

PDB: 4mn3, 4x3k, 4x3s, 4x3t, 4x3u, 5ejw, 5epj

HET: 45e, 5r0, 5r5, ace, ely, fe, m3l, nh2, svr, zn

CCL5_HUMAN_25_91 [text] C-C motif chemokine 5 [Intercrine beta (chemokine CC) family]

volume: 318. Å3; shape: 0.84; buriedness: 0.32

negative: 0.; positive: 0.12; polar: 0.37; backbone: 0.5; hydrophobic: 0.

PDB: 1b3a, 1eqt, 1u4l, 1u4m, 1u4p, 1u4r, 2vxw, 5cmd, 5coy, 5dnf

HET: h1s, h3s, swe

CCPA_BACME_53_332 [text] Catabolite control protein A

volume: 402. Å3; shape: 0.9; buriedness: 0.5

negative: 0.; positive: 0.29; polar: 0.; backbone: 0.11; hydrophobic: 0.6

PDB: 1rzr, 1sxg, 1sxh, 1sxi, 1zvv, 2hsg, 2jcg, 2nzu, 2nzv, 2oen

HET: 171, sep

CCPR_YEAST_69_361 [text] Cytochrome c peroxidase, mitochondrial [Peroxidase family. Cytochrome c peroxidase subfamily]

volume: 181. Å3; shape: 0.75; buriedness: 0.92

negative: 0.07; positive: 0.06; polar: 0.07; backbone: 0.6; hydrophobic: 0.2

PDB: 1a2f, 1a2g, 1aa4, 1ac4, 1ac8, 1aeb, 1aed, 1aee, 1aef, 1aeg, 1aeh, 1aej, 1aek, 1aem, 1aen, 1aeo, 1aeq, 1aes, 1aet, 1aeu, 1aev, 1bej, 1bek, 1bem, 1bep, 1beq, 1bes, 1bj9, 1bva, 1cca, 1ccb, 1ccc, 1cce, 1ccg, 1cci, 1ccj, 1cck, 1ccl, 1ccp, 1cmp, 1cmq, 1cmt, 1cmu, 1cpd, 1cpe, 1cpf, 1cpg, 1cyf, 1dcc, 1dj1, 1dj5, 1ds4, 1dse, 1dsg, 1dso, 1dsp, 1ebe, 1jci, 1jdr, 1kok, 1krj, 1kxm, 1kxn, 1mk8, 1mkq, 1mkr, 1ml2, 1ryc, 1s6v, 1s73, 1sbm, 1sdq, 1sog, 1stq, 1u74, 1u75, 1z53, 1zby, 1zbz, 2anz, 2aqd, 2as1, 2as2, 2as3, 2as4, 2as6, 2b0z, 2b10, 2b11, 2b12, 2bcn, 2ccp, 2cep, 2cyp, 2eun, 2euo, 2eup, 2euq, 2eur, 2eus, 2eut, 2euu, 2ia8, 2icv, 2pcb, 2pcc, 2rbt, 2rbu, 2rbv, 2rbw, 2rbx, 2rby, 2rbz, 2rc0, 2rc1, 2rc2, 2v23, 2v2e, 2x07, 2x08, 2xil, 2xj5, 2xj8, 2y5a, 2ycg, 3ccp, 3ccx, 3e2n, 3e2o, 3exb, 3m23, 3m25, 3m26, 3m27, 3m28, 3m29, 3m2a, 3m2b, 3m2c, 3m2d, 3m2e, 3m2f, 3m2g, 3m2h, 3m2i, 3r98, 3r99, 4a6z, 4a71, 4a78, 4a7m, 4ccp, 4ccx, 4cvi, 4cvj, 4jb4, 4jm5, 4jm6, 4jm8, 4jm9, 4jma, 4jmb, 4jms, 4jmt, 4jmv, 4jmw, 4jmz, 4jn0, 4jpl, 4jpt, 4jpu, 4jqj, 4jqk, 4jqm, 4jqn, 4nfg, 4nva, 4nvb, 4nvc, 4nvd, 4nve, 4nvf, 4nvg, 4nvh, 4nvi, 4nvj, 4nvk, 4nvl, 4nvm, 4nvn, 4nvo, 4oq7, 4p4q, 4xv4, 4xv5, 4xv6, 4xv7, 4xv8, 4xva, 5ccp, 5cib, 5cic, 5cid, 5cie, 5cif, 5cig, 5cih, 5d6m, 5ejt, 5ejx, 6ccp, 7ccp

HET: 1lm, 1ln, 1lq, 1lw, 1lx, 1ly, 1lz, 1m2, 1mj, 1mz, 24t, 25t, 2ap, 2ez, 2mz, 2n9, 2nb, 2nw, 2nx, 2ny, 2nz, 2o0, 2o1, 3ap, 3mt, 4ap, 51r, 556, amt, anl, dmi, dti, exb, idm, k, mpi, nh2, nvi, q24, tmt, tmz

CCR5_HUMAN_1_352 [text] C-C chemokine receptor type 5 [G-protein coupled receptor 1 family]

volume: 400. Å3; shape: 0.57; buriedness: 0.82

negative: 0.06; positive: 0.; polar: 0.38; backbone: 0.09; hydrophobic: 0.47

PDB: 4mbs

HET: mrv

CD1A_HUMAN_18_295 [text] T-cell surface glycoprotein CD1a

volume: 837. Å3; shape: 0.4; buriedness: 0.91

negative: 0.03; positive: 0.08; polar: 0.11; backbone: 0.28; hydrophobic: 0.51

Domains/regions: [D] Ig-like, [R] Glycolipid binding

PDB: 1onq, 1xz0, 4x6c, 4x6d, 4x6e, 4x6f, 5j1a

HET: 3xu, 42h, 6f8, jh0, ola, pam, slf

CD1B_HUMAN_18_300 [text] T-cell surface glycoprotein CD1b

volume: 1732. Å3; shape: 0.81; buriedness: 0.86

negative: 0.02; positive: 0.03; polar: 0.11; backbone: 0.33; hydrophobic: 0.51

Domains/regions: [D] Ig-like

PDB: 1gzp, 1gzq, 1uqs, 2h26, 3t8x, 5l2j, 5l2k

HET: 6pl, 6ul, 70e, d12, gm2, gmm, pii, t8x, twt, uli

CD1D_HUMAN_20_296 [text] Antigen-presenting glycoprotein CD1d

volume: 1218. Å3; shape: 0.9; buriedness: 0.86

negative: 0.05; positive: 0.05; polar: 0.12; backbone: 0.14; hydrophobic: 0.64

Domains/regions: [D] Ig-like, [R] Glycolipid binding

PDB: 1zt4, 2po6, 3huj, 3sdx, 3tzv, 3u0p, 3vwj, 3vwk, 4en3, 4lhu, 4wo4, 4ww2, 4wwk

HET: 4gh, agh, d12, db3, gcy, hex, jls, lsc, und

CD38_HUMAN_44_300 [text] ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [ADP-ribosyl cyclase family]

volume: 711. Å3; shape: 0.8; buriedness: 0.78

negative: 0.11; positive: 0.08; polar: 0.22; backbone: 0.32; hydrophobic: 0.27

PDB: 1yh3, 1zvm, 2ef1, 2hct, 2i65, 2i66, 2i67, 2o3q, 2o3r, 2o3s, 2o3t, 2o3u, 2pgj, 2pgl, 3dzf, 3dzg, 3dzh, 3dzi, 3dzj, 3dzk, 3f6y, 3i9m, 3i9n, 3ofs, 3raj, 3rok, 3rom, 3rop, 3roq, 3u4h, 3u4i, 4cmh, 4f45, 4f46, 4ogw, 4tmf, 4xjs, 4xjt, 5f1k, 5f1o, 5f21

HET: 27c, 41z, 46z, 48z, 50a, 733, apr, avu, avw, c8r, ca, cgr, cvr, cxr, dn4, dvn, g1r, g2r, gtp, hsx, js2, n, n1c, na7, nad, nca, ngd, nmn, rf5, rgt

CD44_MOUSE_21_171 [text] CD44 antigen

volume: 374. Å3; shape: 0.54; buriedness: 0.67

negative: 0.07; positive: 0.21; polar: 0.14; backbone: 0.51; hydrophobic: 0.07

Domains/regions: [D] Link

PDB: 2jcp, 2jcq, 2jcr, 4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, 4np3, 5bzc, 5bze, 5bzf, 5bzg, 5bzh, 5bzi, 5bzj, 5bzk, 5bzl, 5bzm, 5bzn, 5bzo, 5bzp, 5bzq, 5bzr, 5bzs, 5bzt

HET: 24w, 2c9, 2ck, 2l1, 2l2, 4wn, 4wo, 4wp, 4wt, 4wu, 4x1, 4x3, 4x6, 4x8, 4xc, 4xd, 4xg, 4xj, 4xk, 4xl, 4xm, 68n, 6bt, bdp, nag

CDC20_HUMAN_162_495 [text] Cell division cycle protein 20 homolog [WD repeat CDC20/Fizzy family]

volume: 219. Å3; shape: 0.88; buriedness: 0.74

negative: 0.; positive: 0.; polar: 0.15; backbone: 0.15; hydrophobic: 0.7

PDB: 4gga, 4ggc, 4ggd, 4n14

HET: mrd, wr7

CDC2H_PLAFK_1_288 [text] Cell division control protein 2 homolog [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 334. Å3; shape: 0.61; buriedness: 0.86

negative: 0.09; positive: 0.13; polar: 0.03; backbone: 0.41; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 1ob3, 1v0b, 1v0o, 1v0p

HET: inr, pvb

CDC42_HUMAN_1_184 [text] Cell division control protein 42 homolog [Small GTPase superfamily. Rho family. CDC42 subfamily]

volume: 318. Å3; shape: 0.46; buriedness: 0.83

negative: 0.05; positive: 0.05; polar: 0.14; backbone: 0.54; hydrophobic: 0.22

PDB: 1a4r, 1am4, 1an0, 1doa, 1grn, 1gzs, 1ki1, 1kz7, 1kzg, 1nf3, 2dfk, 2ngr, 2odb, 2qrz, 2wm9, 2wmn, 2wmo, 3eg5, 3gcg, 3qbv, 3vhl, 4did, 4itr, 4js0, 4yc7, 5c2j, 5cjp, 5fi1

HET: al, gcp, gdp, gnh, gnp, gtp, mg

CDC4_YEAST_266_744 [text] Cell division control protein 4

volume: 210. Å3; shape: 0.76; buriedness: 0.82

negative: 0.; positive: 0.28; polar: 0.15; backbone: 0.48; hydrophobic: 0.1

PDB: 1nex, 3mks, 3v7d

HET: c1c

CDC7_HUMAN_36_574 [text] Cell division cycle 7-related protein kinase [Protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily]

volume: 217. Å3; shape: 0.56; buriedness: 0.88

negative: 0.06; positive: 0.12; polar: 0.18; backbone: 0.23; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 4f99, 4f9a, 4f9b, 4f9c

HET: 0sx, 0sy, adp

CDD_ECOLI_1_294 [text] Cytidine deaminase [Cytidine and deoxycytidylate deaminase family]

volume: 152. Å3; shape: 0.67; buriedness: 0.81

negative: 0.15; positive: 0.07; polar: 0.22; backbone: 0.37; hydrophobic: 0.19

Domains/regions: [D] CMP/dCMP-type deaminase 1, [R] Substrate binding

PDB: 1af2, 1aln, 1ctt, 1ctu

HET: ctd, dhz, zeb

CDD_MOUSE_1_146 [text] Cytidine deaminase [Cytidine and deoxycytidylate deaminase family]

volume: 155. Å3; shape: 0.65; buriedness: 1.

negative: 0.11; positive: 0.; polar: 0.17; backbone: 0.39; hydrophobic: 0.32

Domains/regions: [D] CMP/dCMP-type deaminase, [R] Substrate binding

PDB: 1zab, 2fr5, 2fr6

HET: ctn, tyu, urd, uri

CDGT2_BACCI_28_713 [text] Cyclomaltodextrin glucanotransferase [Glycosyl hydrolase 13 family]

volume: 472. Å3; shape: 0.58; buriedness: 0.53

negative: 0.; positive: 0.; polar: 0.43; backbone: 0.42; hydrophobic: 0.15

Domains/regions: [D] CBM20, [R] B, [R] E

PDB: 1cdg, 1cgv, 1cgw, 1cgx, 1cgy, 1cxe, 1cxf, 1cxh, 1cxi, 1cxk, 1cxl, 1d3c, 1dtu, 1eo5, 1eo7, 1kck, 1kcl, 1ot1, 1ot2, 1pez, 1pj9, 1tcm, 2cxg, 2dij

HET: acx, agc, bgc, g4d, glc, mal

CDGT_BACS0_28_713 [text] Cyclomaltodextrin glucanotransferase [Glycosyl hydrolase 13 family]

volume: 659. Å3; shape: 0.66; buriedness: 0.75

negative: 0.25; positive: 0.24; polar: 0.13; backbone: 0.14; hydrophobic: 0.24

Domains/regions: [R] A1, [R] A2, [R] B, [R] Substrate binding

PDB: 1d7f, 1ded, 1i75, 1pam, 1ukq, 1uks, 1ukt, 1v3j, 1v3k, 1v3l, 1v3m

HET: aci, bgc, g6d, gal, glc, gld, noj, qps

CDK12_HUMAN_714_1051 [text] Cyclin-dependent kinase 12 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 605. Å3; shape: 0.71; buriedness: 0.87

negative: 0.12; positive: 0.03; polar: 0.13; backbone: 0.46; hydrophobic: 0.27

Domains/regions: [D] Protein kinase

PDB: 4cxa, 4nst, 4un0, 5acb

HET: 5i1, adp, al, anp, mg

CDK13_HUMAN_692_1029 [text] Cyclin-dependent kinase 13 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 235. Å3; shape: 0.53; buriedness: 0.89

negative: 0.13; positive: 0.13; polar: 0.13; backbone: 0.29; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 5efq

HET: adp

CDK16_HUMAN_162_479 [text] Cyclin-dependent kinase 16 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 549. Å3; shape: 0.49; buriedness: 0.9

negative: 0.08; positive: 0.06; polar: 0.08; backbone: 0.39; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 3mtl, 5g6v

HET: 919, fef

CDK1_HUMAN_1_297 [text] Cyclin-dependent kinase 1 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 257. Å3; shape: 0.62; buriedness: 0.9

negative: 0.11; positive: 0.07; polar: 0.07; backbone: 0.35; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 4y72, 4yc3, 5hq0

HET: lz9

CDK2_HUMAN_1_298 [text] Cyclin-dependent kinase 2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 511. Å3; shape: 0.71; buriedness: 0.84

negative: 0.08; positive: 0.07; polar: 0.06; backbone: 0.42; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 1aq1, 1b38, 1b39, 1buh, 1ckp, 1di8, 1dm2, 1e1v, 1e1x, 1e9h, 1f5q, 1fin, 1fq1, 1fvt, 1fvv, 1g5s, 1gih, 1gii, 1gij, 1gy3, 1gz8, 1h00, 1h01, 1h07, 1h08, 1h0v, 1h0w, 1h1p, 1h1q, 1h1r, 1h1s, 1h24, 1h25, 1h26, 1h27, 1h28, 1hck, 1hcl, 1jst, 1jsu, 1jsv, 1jvp, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1ogu, 1oi9, 1oiq, 1oir, 1oit, 1oiu, 1oiy, 1okv, 1okw, 1ol1, 1ol2, 1p2a, 1p5e, 1pf8, 1pkd, 1pw2, 1pxi, 1pxj, 1pxk, 1pxl, 1pxm, 1pxn, 1pxo, 1pxp, 1pye, 1qmz, 1r78, 1urc, 1urw, 1v1k, 1vyw, 1vyz, 1w0x, 1w8c, 1w98, 1wcc, 1y8y, 1y91, 1ykr, 2a0c, 2a4l, 2b52, 2b53, 2b54, 2b55, 2bhe, 2bhh, 2bkz, 2bpm, 2btr, 2bts, 2c4g, 2c5n, 2c5o, 2c5v, 2c5x, 2c5y, 2c68, 2c69, 2c6i, 2c6k, 2c6l, 2c6m, 2c6o, 2c6t, 2cch, 2cci, 2cjm, 2clx, 2ds1, 2duv, 2exm, 2fvd, 2g9x, 2i40, 2iw6, 2iw8, 2iw9, 2j9m, 2jgz, 2r3f, 2r3g, 2r3h, 2r3i, 2r3j, 2r3k, 2r3l, 2r3m, 2r3n, 2r3o, 2r3p, 2r3q, 2r3r, 2r64, 2uue, 2uzb, 2uzd, 2uze, 2uzl, 2uzn, 2uzo, 2v0d, 2v22, 2vta, 2vth, 2vti, 2vtj, 2vtl, 2vtm, 2vtn, 2vto, 2vtp, 2vtq, 2vtr, 2vts, 2vtt, 2vu3, 2vv9, 2w05, 2w06, 2w17, 2w1h, 2wev, 2wfy, 2whb, 2wih, 2wip, 2wma, 2wmb, 2wpa, 2wxv, 2x1n, 2xmy, 2xnb, 3bht, 3bhu, 3bhv, 3ddp, 3ddq, 3dog, 3eid, 3ej1, 3eoc, 3ezr, 3ezv, 3f5x, 3fz1, 3ig7, 3igg, 3le6, 3lfn, 3lfq, 3lfs, 3my5, 3ns9, 3pj8, 3pxf, 3pxq, 3pxr, 3pxy, 3pxz, 3py0, 3py1, 3qhr, 3qhw, 3ql8, 3qqf, 3qqg, 3qqh, 3qqj, 3qqk, 3qql, 3qrt, 3qru, 3qtq, 3qtr, 3qts, 3qtu, 3qtw, 3qtx, 3qtz, 3qu0, 3qwj, 3qwk, 3qx2, 3qx4, 3qxo, 3qxp, 3qzf, 3qzg, 3qzh, 3qzi, 3r1q, 3r1s, 3r1y, 3r28, 3r6x, 3r71, 3r73, 3r7e, 3r7i, 3r7u, 3r7v, 3r7y, 3r83, 3r8l, 3r8m, 3r8p, 3r8u, 3r8v, 3r8z, 3r9d, 3r9h, 3r9n, 3r9o, 3rah, 3rai, 3rak, 3ral, 3rjc, 3rk5, 3rk7, 3rk9, 3rkb, 3rm6, 3rm7, 3rmf, 3rni, 3roy, 3rpo, 3rpr, 3rpv, 3rpy, 3rzb, 3s00, 3s0o, 3s1h, 3s2p, 3sqq, 3sw4, 3sw7, 3ti1, 3tiy, 3tiz, 3tnw, 3uli, 3unj, 3unk, 3wbl, 4acm, 4bck, 4bcm, 4bcn, 4bco, 4bcp, 4bcq, 4bgh, 4bzd, 4cfm, 4cfn, 4cfu, 4cfv, 4cfw, 4cfx, 4d1x, 4d1z, 4ek3, 4ek4, 4ek5, 4ek6, 4ek8, 4eoi, 4eoj, 4eok, 4eol, 4eom, 4eon, 4eoo, 4eop, 4eoq, 4eor, 4eos, 4erw, 4ez3, 4ez7, 4fkg, 4fki, 4fkj, 4fkl, 4fko, 4fkp, 4fkq, 4fkr, 4fks, 4fkt, 4fku, 4fkv, 4fkw, 4fx3, 4gcj, 4i3z, 4ii5, 4kd1, 4lyn, 4nj3, 4rj3, 5a14, 5and, 5ane, 5ang, 5ani, 5anj, 5ank, 5ano, 5cyi, 5d1j, 5fp5, 5fp6, 5iev, 5iex, 5iey, 5if1, 5k4j, 5l2w

HET: 04z, 107, 11k, 18z, 19k, 1cd, 1n3, 1yg, 20z, 22z, 24z, 26z, 2pu, 2wc, 371, 3fp, 3sc, 404, 45k, 46k, 48k, 55s, 56z, 5sc, 61k, 628, 62k, 6af, 740, 75x, 889, 99z, a27, blz, c94, cdk, ck9, ct9, d05, d23, d31, d42, d6i, dt1, dt2, dt4, ezr, fmd, frt, frv, g6t, hdt, hdy, i17, i19, i1p, im9, lia, ls2, ls3, ls4, mtz, n41, n76, nnn, ns9, nu5, p48, pm1, qq2, r0n, ryu, scx, scz, sq9, st8, t2a, tjf, wxv, x14

CDK5_HUMAN_1_292 [text] Cyclin-dependent-like kinase 5 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 262. Å3; shape: 0.63; buriedness: 0.89

negative: 0.09; positive: 0.09; polar: 0.03; backbone: 0.39; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 1h4l, 1ung, 1unh, 1unl, 3o0g, 4au8

HET: 3o0, alh, ixm, rrc, z3r

CDK6_HUMAN_1_312 [text] Cyclin-dependent kinase 6 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 548. Å3; shape: 0.61; buriedness: 0.73

negative: 0.08; positive: 0.07; polar: 0.09; backbone: 0.43; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 1bi7, 1bi8, 1blx, 1g3n, 1jow, 1xo2, 2euf, 2f2c, 3nup, 3nux, 4aua, 4ez5, 4tth, 5l2i, 5l2s, 5l2t

HET: 0rs, 24v, 3nu, 3nv, 4au, 6zv, 6zz, ap9, fse, lqq

CDK7_HUMAN_1_346_ATPsite [text] Cyclin-dependent kinase 7 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 302. Å3; shape: 0.61; buriedness: 0.84

negative: 0.; positive: 0.05; polar: 0.16; backbone: 0.47; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 1ua2

HET: atp

CDK8_HUMAN_1_363 [text] Cyclin-dependent kinase 8 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 641. Å3; shape: 0.52; buriedness: 0.88

negative: 0.09; positive: 0.12; polar: 0.05; backbone: 0.36; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 3rgf, 4crl, 4f6s, 4f6u, 4f6w, 4f70, 4f7j, 4f7l, 4f7n, 4f7s, 4g6l, 5bnj, 5cei, 5fgk, 5hbe, 5hbh, 5hbj, 5hnb, 5hvy, 5i5z

HET: 0so, 0sq, 0sr, 0ss, 0st, 0su, 0sv, 0sw, 4tv, 50r, 5xg, 5y6, 5y7, 5y8, 62m, 66x, 68u, bax, c1i

CDK9_HUMAN_1_331 [text] Cyclin-dependent kinase 9 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 399. Å3; shape: 0.88; buriedness: 0.84

negative: 0.13; positive: 0.04; polar: 0.07; backbone: 0.3; hydrophobic: 0.47

Domains/regions: [D] Protein kinase, [R] T-loop

PDB: 3blh, 3blq, 3blr, 3lq5, 3mi9, 3mia, 3my1, 3tn8, 3tnh, 3tni, 4bcf, 4bcg, 4bch, 4bci, 4bcj, 4ec9, 4imy, 4ogr, 4or5

HET: adn, amp, anp, atp, cpb, f18, mg, rfz, slq, t3c, t3e, t6q, t7z, t9n, yt3

CDKL1_HUMAN_1_304 [text] Cyclin-dependent kinase-like 1 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 347. Å3; shape: 0.59; buriedness: 0.82

negative: 0.06; positive: 0.09; polar: 0.13; backbone: 0.39; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 4agu

HET: d15

CDKL2_HUMAN_1_308 [text] Cyclin-dependent kinase-like 2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 391. Å3; shape: 0.44; buriedness: 0.81

negative: 0.12; positive: 0.; polar: 0.1; backbone: 0.37; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 4aaa, 4bbm

HET: dki, tc0

CDKL3_HUMAN_1_324 [text] Cyclin-dependent kinase-like 3 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 245. Å3; shape: 0.83; buriedness: 0.95

negative: 0.15; positive: 0.05; polar: 0.1; backbone: 0.35; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 3zdu

HET: 38r

CDKL5_HUMAN_1_303 [text] Cyclin-dependent kinase-like 5 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 234. Å3; shape: 0.84; buriedness: 0.95

negative: 0.07; positive: 0.; polar: 0.14; backbone: 0.43; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4bgq

HET: 38r

CDLS_BACLD_1_249 [text] Cyclo(L-leucyl-L-leucyl) synthase [CDPS family]

volume: 148. Å3; shape: 0.47; buriedness: 0.94

negative: 0.11; positive: 0.11; polar: 0.31; backbone: 0.31; hydrophobic: 0.14

Domains/regions: [R] Substrate binding

PDB: 3oqh, 3oqi, 3oqj, 3s7t

HET: 3cx

CDPK2_PLAFK_25_334 [text] Calcium-dependent protein kinase 2 [Protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily]

volume: 274. Å3; shape: 0.93; buriedness: 0.79

negative: 0.07; positive: 0.07; polar: 0.; backbone: 0.5; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4mvf

HET: stu

CDPK4_PLAF7_9_528 [text] Calcium-dependent protein kinase 4 [Protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily]

volume: 183. Å3; shape: 0.59; buriedness: 0.91

negative: 0.04; positive: 0.08; polar: 0.17; backbone: 0.46; hydrophobic: 0.25

Domains/regions: [D] Protein kinase

PDB: 4qox, 4rgj

HET: dxr

CEAS_STRCL_1_573 [text] N(2)-(2-carboxyethyl)arginine synthase [TPP enzyme family]

volume: 490. Å3; shape: 0.76; buriedness: 0.97

negative: 0.07; positive: 0.09; polar: 0.21; backbone: 0.45; hydrophobic: 0.18

Domains/regions: [R] Substrate binding, [R] Thiamine pyrophosphate binding

PDB: 1upa, 1upb, 1upc, 2iht, 2ihu, 2ihv

HET: gva, tar, tp8, tp9, tpp

CECR1_HUMAN_28_511 [text] Adenosine deaminase CECR1 [Adenosine and AMP deaminases family. ADGF subfamily]

volume: 174. Å3; shape: 0.54; buriedness: 0.98

negative: 0.32; positive: 0.32; polar: 0.; backbone: 0.07; hydrophobic: 0.29

Domains/regions: [R] Substrate binding

PDB: 3lgd, 3lgg

HET: cfe

CEFE_STRC2_1_311 [text] Deacetoxycephalosporin C synthase [Iron/ascorbate-dependent oxidoreductase family]

volume: 466. Å3; shape: 0.6; buriedness: 0.89

negative: 0.06; positive: 0.29; polar: 0.09; backbone: 0.16; hydrophobic: 0.41

Domains/regions: [D] Fe2OG dioxygenase

PDB: 1dcs, 1e5h, 1e5i, 1hjf, 1hjg, 1rxf, 1rxg, 1unb, 1uo9, 1uob, 1uof, 1uog, 1w28, 1w2a, 1w2n, 1w2o, 2jb8

HET: hkv, p1c, pn1, pnn

CELA1_PIG_27_266 [text] Chymotrypsin-like elastase family member 1 [Peptidase S1 family. Elastase subfamily]

volume: 1254. Å3; shape: 0.75; buriedness: 0.71

negative: 0.; positive: 0.08; polar: 0.2; backbone: 0.46; hydrophobic: 0.26

Domains/regions: [D] Peptidase S1

PDB: 1b0e, 1bma, 1btu, 1c1m, 1e34, 1e35, 1e36, 1e37, 1e38, 1eai, 1eas, 1eat, 1eau, 1ela, 1elb, 1elc, 1eld, 1ele, 1elf, 1elg, 1esa, 1esb, 1est, 1fle, 1fzz, 1gvk, 1gwa, 1h9l, 1hax, 1hay, 1haz, 1hb0, 1hv7, 1inc, 1jim, 1l0z, 1l1g, 1lka, 1lkb, 1lvy, 1mcv, 1mmj, 1nes, 1okx, 1qgf, 1qix, 1qnj, 1qr3, 1uo6, 1uvo, 1uvp, 2a7c, 2a7j, 2bb4, 2bd2, 2bd3, 2bd4, 2bd5, 2bd7, 2bd8, 2bd9, 2bda, 2bdb, 2bdc, 2blo, 2blq, 2cv3, 2d26, 2de8, 2de9, 2est, 2fo9, 2foa, 2fob, 2foc, 2fod, 2foe, 2fof, 2fog, 2foh, 2g4t, 2g4u, 2h1u, 2iot, 2oqu, 2v0b, 2v35, 3e3t, 3est, 3hgn, 3hgp, 3mnb, 3mnc, 3mns, 3mnx, 3mo3, 3mo6, 3mo9, 3moc, 3mty, 3mu0, 3mu1, 3mu4, 3mu5, 3mu8, 3odd, 3odf, 3uou, 4est, 4gvu, 4ym9, 5avd, 5est, 6est, 7est, 8est, 9est

HET: 0qh, 0qn, 0z0, 0z1, 0z3, 0z4, 1bo, 2bl, 2z5, 4e4, 616, 681, ace, alq, baa, baf, bbl, bdk, cir, cnt, dbu, fpa, fr1, frw, gis, glj, ibr, icl, icu, il0, j54, pea, sei, so4, suj, tfi, tfk, tpx, tpy, tsu, tyj, vai

CEL_BOVIN_19_550 [text] Bile salt-activated lipase [Type-B carboxylesterase/lipase family]

volume: 349. Å3; shape: 0.47; buriedness: 0.73

negative: 0.; positive: 0.04; polar: 0.14; backbone: 0.46; hydrophobic: 0.37

PDB: 1akn, 1aql, 2bce

HET: tch

CETP_HUMAN_18_493 [text] Cholesteryl ester transfer protein [BPI/LBP/Plunc superfamily. BPI/LBP family]

volume: 1427. Å3; shape: 0.77; buriedness: 0.93

negative: 0.; positive: 0.05; polar: 0.13; backbone: 0.17; hydrophobic: 0.66

PDB: 2obd, 4ews, 4f2a

HET: 0rp, 0sf, 2ob, pcw, pge

CFAB_HUMAN_471_764 [text] Complement factor B [Peptidase S1 family]

volume: 158. Å3; shape: 0.57; buriedness: 0.77

negative: 0.03; positive: 0.11; polar: 0.15; backbone: 0.7; hydrophobic: 0.

Domains/regions: [D] Peptidase S1

PDB: 1dle, 1rrk, 1rs0, 1rtk, 2ok5, 3hrz, 3hs0

HET: dfp, gbs

CFAD_HUMAN_25_253 [text] Complement factor D [Peptidase S1 family]

volume: 363. Å3; shape: 0.69; buriedness: 0.82

negative: 0.; positive: 0.11; polar: 0.1; backbone: 0.59; hydrophobic: 0.19

Domains/regions: [D] Peptidase S1

PDB: 1bio, 1dfp, 1dic, 1dst, 1dsu, 1fdp, 1hfd, 2xw9, 2xwa, 4cbn, 4cbo, 4d9q, 4d9r, 5fbe, 5fbi, 5fck, 5tca, 5tcc

HET: 5w5, 5wc, 5wd, dfp, dic, j55, j56, o, soa

CFI1_MEDSA_1_222 [text] Chalcone--flavonone isomerase 1 [Chalcone isomerase family]

volume: 226. Å3; shape: 0.53; buriedness: 0.93

negative: 0.; positive: 0.15; polar: 0.27; backbone: 0.2; hydrophobic: 0.39

PDB: 1eyp, 1eyq, 1fm7, 1fm8, 1jep, 1jx0, 1jx1

HET: ddc, dfl, dfv, nar

CGGR_BACSU_86_340 [text] Central glycolytic genes regulator [SorC transcriptional regulatory family]

volume: 154. Å3; shape: 0.56; buriedness: 0.94

negative: 0.11; positive: 0.18; polar: 0.12; backbone: 0.53; hydrophobic: 0.05

Domains/regions: [R] Effector binding

PDB: 2okg, 3bxe, 3bxf, 3bxg, 3bxh

HET: 13p, bg6, f6p, fbp, g3h

CH3L1_BOVIN_22_383 [text] Chitinase-3-like protein 1 [Glycosyl hydrolase 18 family]

volume: 1801. Å3; shape: 0.84; buriedness: 0.64

negative: 0.06; positive: 0.17; polar: 0.16; backbone: 0.23; hydrophobic: 0.37

Domains/regions: [R] Chitooligosaccharide binding

PDB: 1ljy, 1owq, 1sr0, 1syt, 1tfv, 1xhg, 1xrv, 1zb5, 1zbc, 1zbk, 1zbv, 1zbw, 1zl1, 1zu8, 2aos, 2b31, 2dpe, 2dsu, 2dsv, 2dsw, 2dsz, 2dt0, 2dt1, 2dt2, 2dt3, 2esc, 2fdm, 2g41, 2g8z, 2o92, 2o9o, 2olh, 2pi6, 2qf8, 4mav, 4ml4, 4mpk, 4mtv, 4nsb, 4q7n, 4s06, 4s19

HET: 2zo, ain, cbi, nag, ndg, pye, rib

CHIA1_ASPFM_28_337 [text] Endochitinase A1 [Glycosyl hydrolase 18 family. Chitinase class III subfamily]

volume: 258. Å3; shape: 0.76; buriedness: 0.79

negative: 0.21; positive: 0.; polar: 0.41; backbone: 0.09; hydrophobic: 0.29

Domains/regions: [R] Inhibitor binding

PDB: 2xtk, 2xuc, 2xvn, 2xvp, 4tx6

HET: 38b, azm, kls, xrg

CHIA_HUMAN_20_404 [text] Acidic mammalian chitinase [Glycosyl hydrolase 18 family. Chitinase class II subfamily]

volume: 408. Å3; shape: 0.74; buriedness: 0.77

negative: 0.24; positive: 0.; polar: 0.23; backbone: 0.06; hydrophobic: 0.46

Domains/regions: [R] Chitooligosaccharide binding

PDB: 2ybt, 2ybu, 3fxy, 3fy1, 3rm4, 3rm8, 3rm9, 3rme

HET: 3rm, 613, ami, cx9, dw0, na1, naa, rm8, rme

CHIA_SERMA_19_563 [text] Chitinase A [Glycosyl hydrolase 18 family. Chitinase class II subfamily]

volume: 439. Å3; shape: 0.63; buriedness: 0.83

negative: 0.23; positive: 0.09; polar: 0.21; backbone: 0.1; hydrophobic: 0.37

Domains/regions: [R] Catalytic

PDB: 1ctn, 1edq, 1ehn, 1eib, 1ffq, 1ffr, 1k9t, 1nh6, 1rd6, 1x6l, 1x6n, 2wk2, 2wly, 2wlz, 2wm0

HET: ami, ao3, dio, naa, ngt, sn5

CHIB1_ASPFM_39_433 [text] Endochitinase B1 [Glycosyl hydrolase 18 family. Chitinase class V subfamily]

volume: 780. Å3; shape: 0.85; buriedness: 0.71

negative: 0.2; positive: 0.06; polar: 0.25; backbone: 0.11; hydrophobic: 0.38

Domains/regions: [R] Inhibitor binding

PDB: 1w9p, 1w9u, 1w9v, 1wno, 2a3a, 2a3b, 2a3c, 2a3e, 2iuz, 3ch9, 3chc, 3chd, 3che, 3chf

HET: 0ar, ace, ami, cff, d1h, dal, dpr, ias, mea, naa, pnx, tep, un1, vr0, wrg, xrg, zrg

CHIB_SERMA_1_499 [text] Chitinase B [Glycosyl hydrolase 18 family. Chitinase class II subfamily]

volume: 1183. Å3; shape: 0.62; buriedness: 0.74

negative: 0.22; positive: 0.09; polar: 0.15; backbone: 0.12; hydrophobic: 0.43

PDB: 1e15, 1e6n, 1e6p, 1e6r, 1e6z, 1goi, 1gpf, 1h0g, 1h0i, 1o6i, 1ogb, 1ogg, 1ur8, 1ur9, 1w1p, 1w1t, 1w1v, 1w1y, 3wd0, 3wd1, 3wd2, 3wd3, 3wd4, 4z2g, 4z2h, 4z2i, 4z2j, 4z2k, 4z2l

HET: 0ar, 0hz, a1l, alj, ami, chq, dal, dpr, gdl, gio, ias, m6a, m6b, m6e, m6f, m6g, m6v, mea, naa, nag, ngo, phj, qub, st7, typ, un1, un2, vr0

CHIT1_HUMAN_20_389 [text] Chitotriosidase-1 [Glycosyl hydrolase 18 family. Chitinase class II subfamily]

volume: 900. Å3; shape: 0.83; buriedness: 0.77

negative: 0.18; positive: 0.05; polar: 0.27; backbone: 0.13; hydrophobic: 0.37

Domains/regions: [R] Chitooligosaccharide binding

PDB: 1guv, 1hki, 1hkj, 1hkk, 1hkm, 1lg1, 1lg2, 1lq0, 1waw, 1wb0, 4wjx, 4wk9, 4wka, 4wkf, 4wkh, 5hbf

HET: 0ar, ali, ami, cbs, dal, dpr, ias, mea, na1, naa, un1, vr0

CHIT_YEAST_22_315 [text] Endochitinase [Glycosyl hydrolase 18 family. Chitinase class V subfamily]

volume: 238. Å3; shape: 0.41; buriedness: 0.76

negative: 0.14; positive: 0.; polar: 0.29; backbone: 0.19; hydrophobic: 0.38

Domains/regions: [R] Catalytic

PDB: 2uy2, 2uy3, 2uy4, 2uy5, 4txe

HET: 38f, azm, h33, h35

CHK1_HUMAN_1_283_allosteric [text] Serine/threonine-protein kinase Chk1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily]

volume: 602. Å3; shape: 0.51; buriedness: 0.62

negative: 0.2; positive: 0.; polar: 0.05; backbone: 0.45; hydrophobic: 0.3

Domains/regions: [D] Protein kinase, [R] Interaction with CLSPN

PDB: 1ia8, 1nvq, 1nvr, 1nvs, 1zlt, 1zys, 2ayp, 2br1, 2brb, 2brg, 2brh, 2brm, 2brn, 2bro, 2c3j, 2c3k, 2c3l, 2cgu, 2cgv, 2cgw, 2cgx, 2e9n, 2e9o, 2e9p, 2e9u, 2e9v, 2gdo, 2ghg, 2hog, 2hxl, 2hxq, 2hy0, 2qhm, 2qhn, 2r0u, 2wmq, 2wmr, 2wms, 2wmt, 2wmu, 2wmv, 2wmw, 2wmx, 2x8d, 2x8e, 2x8i, 2xey, 2xez, 2xf0, 2ydi, 2ydj, 2ydk, 2yer, 2yex, 2ym3, 2ym4, 2ym5, 2ym6, 2ym7, 2ym8, 2ywp, 3f9n, 3jvr, 3jvs, 3nlb, 3ot3, 3ot8, 3pa3, 3pa4, 3pa5, 3tkh, 3tki, 3u9n, 4fsm, 4fsn, 4fsq, 4fsr, 4fst, 4fsu, 4fsw, 4fsy, 4fsz, 4ft0, 4ft3, 4ft5, 4ft7, 4ft9, 4fta, 4ftc, 4fti, 4ftj, 4ftk, 4ftl, 4ftm, 4ftn, 4fto, 4ftq, 4ftr, 4ftt, 4ftu, 4gh2, 4hyh, 4hyi, 4jik, 4qye, 4qyf, 4qyg, 4qyh, 4rvk, 4rvl, 4rvm, 5dls, 5f4n

HET: 38m, agx, agy

CHK1_HUMAN_1_283_ATPsite [text] Serine/threonine-protein kinase Chk1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily]

volume: 559. Å3; shape: 0.57; buriedness: 0.79

negative: 0.14; positive: 0.05; polar: 0.09; backbone: 0.41; hydrophobic: 0.32

Domains/regions: [D] Protein kinase, [R] Interaction with CLSPN

PDB: 1ia8, 1nvq, 1nvr, 1nvs, 1zlt, 1zys, 2ayp, 2br1, 2brb, 2brg, 2brh, 2brm, 2brn, 2bro, 2c3j, 2c3k, 2c3l, 2cgu, 2cgv, 2cgw, 2cgx, 2e9n, 2e9o, 2e9p, 2e9u, 2e9v, 2gdo, 2ghg, 2hog, 2hxl, 2hxq, 2hy0, 2qhm, 2qhn, 2r0u, 2wmq, 2wmr, 2wms, 2wmt, 2wmu, 2wmv, 2wmw, 2wmx, 2x8d, 2x8e, 2x8i, 2xey, 2xez, 2xf0, 2ydi, 2ydj, 2ydk, 2yer, 2yex, 2ym3, 2ym4, 2ym5, 2ym6, 2ym7, 2ym8, 2ywp, 3f9n, 3jvr, 3jvs, 3nlb, 3ot3, 3ot8, 3pa3, 3pa4, 3pa5, 3tkh, 3tki, 3u9n, 4fsm, 4fsn, 4fsq, 4fsr, 4fst, 4fsu, 4fsw, 4fsy, 4fsz, 4ft0, 4ft3, 4ft5, 4ft7, 4ft9, 4fta, 4ftc, 4fti, 4ftj, 4ftk, 4ftl, 4ftm, 4ftn, 4fto, 4ftq, 4ftr, 4ftt, 4ftu, 4gh2, 4hyh, 4hyi, 4jik, 4qye, 4qyf, 4qyg, 4qyh, 4rvk, 4rvl, 4rvm, 5dls, 5f4n

HET: 07s, 09h, 12c, 199, 1am, 1ao, 1hk, 1ko, 22k, 2hk, 306, 373, 3a3, 3dl, 3dv, 3dw, 3dx, 3hk, 3x7, 3xk, 422, 43a, 4hk, 4ym, 582, 5be, 5hk, 5uy, 6hk, 710, 76a, 77a, 7hk, 85a, a25, a42, a53, a58, abo, c70, c72, c73, df1, df2, dfw, dfy, dfz, h0k, h2k, h3k, h5k, h6k, h7k, h8k, h9k, hk0, hk1, hk3, hk4, hk5, hk7, hk9, hkc, m54, mi5, pfp, pfq, s25, ucm, ydi, ydj, ydk, ym5, ym7, ym8, yvq, zy6

CHK2_HUMAN_210_526 [text] Serine/threonine-protein kinase Chk2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily]

volume: 470. Å3; shape: 0.43; buriedness: 0.84

negative: 0.14; positive: 0.04; polar: 0.05; backbone: 0.4; hydrophobic: 0.36

Domains/regions: [D] Protein kinase, [R] T-loop/activation segment

PDB: 2cn5, 2cn8, 2w0j, 2w7x, 2wtc, 2wtd, 2wti, 2wtj, 2xbj, 2xk9, 2xm8, 2xm9, 2ycf, 2ycq, 2ycr, 2ycs, 2yiq, 2yir, 2yit, 3i6u, 3i6w, 4a9r, 4a9s, 4a9t, 4a9u, 4bda, 4bdb, 4bdc, 4bdd, 4bde, 4bdf, 4bdg, 4bdh, 4bdi, 4bdj, 4bdk

HET: a9t, a9u, adp, b4w, cws, d1a, dbq, h3r, hau, hcw, lwh, mg, nxp, odh, odo, p3j, rqq, ru5, ru9, upx, vfb, vgm, wti, wtj, wvi, xbj, xk9, ycf, yiq, yir, yit, z0o, z2m, zat, zzk

CHKA_HUMAN_60_457_catalytic [text] Choline kinase alpha [Choline/ethanolamine kinase family]

volume: 811. Å3; shape: 0.85; buriedness: 0.77

negative: 0.16; positive: 0.07; polar: 0.27; backbone: 0.2; hydrophobic: 0.3

PDB: 2cko, 2ckp, 2ckq, 2i7q, 3f2r, 3g15, 3zm9, 4br3, 4cg8, 4cg9, 4cga, 4da5, 5afv, 5eqe, 5eqp, 5eqy, 5ftg, 5fut

HET: 0h7, 5r8, 5r9, 5ra, a4v, adp, dtt, g8s, gqg, hc6, jh5, mg, nbr, pc, pq7, qlw, qmq, u85

CHKB_HUMAN_17_395 [text] Choline/ethanolamine kinase [Choline/ethanolamine kinase family]

volume: 243. Å3; shape: 0.6; buriedness: 0.71

negative: 0.12; positive: 0.08; polar: 0.08; backbone: 0.38; hydrophobic: 0.35

PDB: 2ig7, 3feg, 3lq3

HET: adp, amp

CHLE_HUMAN_29_558 [text] Cholinesterase [Type-B carboxylesterase/lipase family]

volume: 373. Å3; shape: 0.83; buriedness: 0.85

negative: 0.06; positive: 0.06; polar: 0.1; backbone: 0.39; hydrophobic: 0.4

Domains/regions: [R] Substrate binding

PDB: 1p0i, 1p0m, 1p0p, 1p0q, 1xlu, 1xlv, 1xlw, 2j4c, 2pm8, 2wid, 2wif, 2wig, 2wij, 2wik, 2wil, 2wsl, 2xmb, 2xmc, 2xmd, 2xmg, 2xqf, 2xqg, 2xqi, 2xqj, 2xqk, 2y1k, 3djy, 3dkk, 3o9m, 4aqd, 4axb, 4b0o, 4b0p, 4bbz, 4bds, 4tpk, 4xii, 5dyt, 5k5e

HET: 15f, 3f9, 40v, 4oj, 5hb, 6qs, bal, bch, bez, bua, ca, cht, cvx, dep, efs, fp1, fpk, isp, k, mf5, mg, na, tc3, tc5, tcx, tha, tn6, tn7, tun, vr, vx

CHMU_MYCTU_16_105 [text] Intracellular chorismate mutase

volume: 121. Å3; shape: 0.75; buriedness: 0.95

negative: 0.09; positive: 0.39; polar: 0.14; backbone: 0.; hydrophobic: 0.38

Domains/regions: [D] Chorismate mutase, [R] Substrate binding

PDB: 2qbv, 2vkl, 2w19, 2w1a, 5ckx

HET: mlt, tsa

CHMU_YEAST_1_256 [text] Chorismate mutase

volume: 129. Å3; shape: 0.85; buriedness: 0.98

negative: 0.19; positive: 0.33; polar: 0.; backbone: 0.28; hydrophobic: 0.19

Domains/regions: [D] Chorismate mutase

PDB: 1csm, 2csm, 3csm, 4csm, 5csm

HET: tsa

CHOD_BREST_46_552 [text] Cholesterol oxidase [GMC oxidoreductase family]

volume: 192. Å3; shape: 0.54; buriedness: 0.96

negative: 0.09; positive: 0.; polar: 0.14; backbone: 0.32; hydrophobic: 0.45

PDB: 1coy, 3cox

HET: and

CHOMT_MEDSA_1_372 [text] Isoliquiritigenin 2'-O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 194. Å3; shape: 0.44; buriedness: 0.8

negative: 0.; positive: 0.07; polar: 0.13; backbone: 0.; hydrophobic: 0.8

PDB: 1fp1, 1fpq

HET: hcc

CHS2_MEDSA_1_389 [text] Chalcone synthase 2 [Chalcone/stilbene synthases family]

volume: 718. Å3; shape: 0.37; buriedness: 0.88

negative: 0.05; positive: 0.07; polar: 0.14; backbone: 0.45; hydrophobic: 0.29

Domains/regions: [R] Coenzyme A binding, [R] Substrate binding

PDB: 1bi5, 1bq6, 1cgk, 1cgz, 1chw, 1cml, 1d6f, 1d6h, 1d6i, 1i86, 1i88, 1i89, 1i8b, 1jwx, 1u0v, 1u0w

HET: b3p, coa, hxc, mlc, nar, stl

CHTB_VIBCH_22_124 [text] Cholera enterotoxin subunit B

volume: 654. Å3; shape: 0.87; buriedness: 0.62

negative: 0.11; positive: 0.2; polar: 0.34; backbone: 0.27; hydrophobic: 0.08

PDB: 1chp, 1chq, 1ct1, 1eei, 1fgb, 1g8z, 1jr0, 1llr, 1md2, 1pzj, 1pzk, 1rcv, 1rd9, 1rdp, 1rf2, 1s5b, 1s5c, 1s5d, 1s5e, 1s5f, 1xtc, 2chb, 3chb, 5elb, 5elc, 5eld, 5ele, 5elf

HET: 15b, 233, a24, bv1, bv2, bv3, bv4, cyn, fng, gaa, gla, j12, j15, lnq, sq

CHXA_VIBCL_459_665 [text] Cholix toxin

volume: 366. Å3; shape: 0.78; buriedness: 0.68

negative: 0.07; positive: 0.07; polar: 0.14; backbone: 0.5; hydrophobic: 0.21

PDB: 2q5t, 2q6m, 3ess, 3ki0, 3ki1, 3ki2, 3ki3, 3ki4, 3ki5, 3ki6, 3ki7, 3ny6, 3q9o

HET: 18n, g9d, g9f, g9g, g9h, g9i, g9l, g9m, g9p, nad, p34, v30

CHXR_CHLT2_1_113 [text] Atypical response regulator protein ChxR

volume: 149. Å3; shape: 0.88; buriedness: 0.54

negative: 0.12; positive: 0.24; polar: 0.; backbone: 0.35; hydrophobic: 0.29

Domains/regions: [D] Response regulatory

PDB: 3q7r, 3q7s, 3q7t

HET: i3c

CINA_CITBR_7_404 [text] 1,8-cineole 2-endo-monooxygenase [Cytochrome P450 family]

volume: 104. Å3; shape: 0.88; buriedness: 0.84

negative: 0.; positive: 0.; polar: 0.36; backbone: 0.26; hydrophobic: 0.38

PDB: 1t2b, 3bdz, 3be0, 4fb2, 4fmx, 4fyz, 4l6g, 4l77, 4lht

HET: cnl, mli

CIPKN_ARATH_22_482 [text] CBL-interacting serine/threonine-protein kinase 23 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 1572. Å3; shape: 0.53; buriedness: 0.32

negative: 0.17; positive: 0.03; polar: 0.15; backbone: 0.33; hydrophobic: 0.33

Domains/regions: [D] Protein kinase, [R] Activation loop

PDB: 4czt, 4czu

HET: cps

CKI1_SCHPO_1_298 [text] Casein kinase I homolog 1 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

volume: 334. Å3; shape: 0.63; buriedness: 0.85

negative: 0.08; positive: 0.06; polar: 0.07; backbone: 0.4; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 1csn, 1eh4, 2csn

HET: atp, cki, ic1, mg

CKX1_MAIZE_14_534 [text] Cytokinin dehydrogenase 1 [Oxygen-dependent FAD-linked oxidoreductase family]

volume: 706. Å3; shape: 0.33; buriedness: 0.95

negative: 0.04; positive: 0.02; polar: 0.26; backbone: 0.39; hydrophobic: 0.28

Domains/regions: [D] FAD-binding PCMH-type

PDB: 1w1o, 1w1q, 1w1r, 1w1s, 2qkn, 2qpm, 3bw7, 3c0p, 3dq0, 3kjm, 3s1c, 3s1d, 3s1e, 3s1f

HET: 245, 246, 301, emu, fad, ha8, mzo, zea, zip, zir

CLC4K_HUMAN_193_328 [text] C-type lectin domain family 4 member K

volume: 317. Å3; shape: 0.77; buriedness: 0.46

negative: 0.29; positive: 0.14; polar: 0.29; backbone: 0.28; hydrophobic: 0.

Domains/regions: [D] C-type lectin

PDB: 3c22, 3kqg, 3p5d, 3p5e, 3p5f, 3p5g, 3p5h, 3p5i, 3p7f, 3p7g, 3p7h, 4ak8, 4n32, 4n33, 4n34, 4n35, 4n36, 4n37, 4n38

HET: 2f8, fuc, gla, mal, mma

CLCA_RHOOP_1_257 [text] Chlorocatechol 1,2-dioxygenase [Intradiol ring-cleavage dioxygenase family]

volume: 102. Å3; shape: 0.8; buriedness: 1.

negative: 0.07; positive: 0.25; polar: 0.13; backbone: 0.19; hydrophobic: 0.36

PDB: 1s9a, 3o32, 3o5u, 3o6j, 3o6r

HET: 35c, bez, dhb, hqn, pyg

CLH1_HUMAN_1_362 [text] Clathrin heavy chain 1 [Clathrin heavy chain family]

volume: 949. Å3; shape: 0.56; buriedness: 0.52

negative: 0.; positive: 0.13; polar: 0.11; backbone: 0.41; hydrophobic: 0.35

Domains/regions: [R] Globular terminal domain, [R] WD40-like repeat 1, [R] WD40-like repeat 2

PDB: 1bpo, 1c9i, 1c9l, 1utc, 2xzg, 3gc3, 3gd1, 4g55, 5m5r, 5m5s, 5m5t, 5m5u, 5m5v, 5m61

HET: vh1, vh2

CLIC2_HUMAN_1_247 [text] Chloride intracellular channel protein 2 [Chloride channel CLIC family]

volume: 116. Å3; shape: 0.84; buriedness: 0.71

negative: 0.; positive: 0.1; polar: 0.1; backbone: 0.55; hydrophobic: 0.24

Domains/regions: [D] GST C-terminal, [R] C-terminal

PDB: 2per, 2r4v, 2r5g

HET: mnb

CLK1_HUMAN_147_484 [text] Dual specificity protein kinase CLK1 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily]

volume: 174. Å3; shape: 0.69; buriedness: 0.91

negative: 0.07; positive: 0.09; polar: 0.; backbone: 0.25; hydrophobic: 0.6

Domains/regions: [D] Protein kinase

PDB: 1z57, 2vag, 5j1v, 5j1w

HET: 6fb, 6fd, dbq, v25

CLK2_HUMAN_129_496 [text] Dual specificity protein kinase CLK2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily]

volume: 229. Å3; shape: 0.64; buriedness: 0.84

negative: 0.1; positive: 0.06; polar: 0.06; backbone: 0.27; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 3nr9

HET: nr9

CLK3_HUMAN_275_633 [text] Dual specificity protein kinase CLK3 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily]

volume: 279. Å3; shape: 0.86; buriedness: 0.92

negative: 0.11; positive: 0.04; polar: 0.07; backbone: 0.32; hydrophobic: 0.47

Domains/regions: [D] Protein kinase

PDB: 2eu9, 2exe, 2wu6, 2wu7, 3raw

HET: 3ra, dki, v25

CLOQ_STRRC_2_324 [text] 4-hydroxyphenylpyruvate 3-dimethylallyltransferase [Aromatic prenyltransferase family]

volume: 108. Å3; shape: 0.59; buriedness: 0.97

negative: 0.11; positive: 0.11; polar: 0.24; backbone: 0.; hydrophobic: 0.54

PDB: 2xlq, 2xly, 2xm5, 2xm7

HET: 34h

CLPP_BACSU_2_196 [text] ATP-dependent Clp protease proteolytic subunit [Peptidase S14 family]

volume: 117. Å3; shape: 0.58; buriedness: 0.88

negative: 0.; positive: 0.08; polar: 0.09; backbone: 0.51; hydrophobic: 0.32

PDB: 3ktg, 3kth, 3kti, 3ktj, 3ktk, 3tt6, 3tt7

HET: dfp

CLPP_ECOLI_12_207 [text] ATP-dependent Clp protease proteolytic subunit [Peptidase S14 family]

volume: 337. Å3; shape: 0.76; buriedness: 0.76

negative: 0.03; positive: 0.05; polar: 0.05; backbone: 0.52; hydrophobic: 0.34

PDB: 1tyf, 1yg6, 2fzs

HET: cmq

CLPP_STAA8_1_195 [text] ATP-dependent Clp protease proteolytic subunit [Peptidase S14 family]

volume: 250. Å3; shape: 0.45; buriedness: 0.93

negative: 0.; positive: 0.1; polar: 0.23; backbone: 0.42; hydrophobic: 0.25

PDB: 3qwd, 3st9, 3sta, 3v5e, 4emm, 4emp, 4mxi, 5c90, 5dl1

HET: 5c2

CLPS2_AGRFC_1_103 [text] ATP-dependent Clp protease adapter protein ClpS 2 [ClpS family]

volume: 116. Å3; shape: 0.47; buriedness: 0.89

negative: 0.09; positive: 0.14; polar: 0.07; backbone: 0.39; hydrophobic: 0.32

PDB: 4yjm, 4yjx, 4yka

HET: tyc

CLPS_STRNR_9_239 [text] Cyclo(L-leucyl-L-phenylalanyl) synthase [CDPS family]

volume: 218. Å3; shape: 0.47; buriedness: 0.91

negative: 0.07; positive: 0.; polar: 0.23; backbone: 0.33; hydrophobic: 0.37

Domains/regions: [R] Substrate binding

PDB: 3oqv, 4q24

HET: dtd, xve

CMA1_HUMAN_22_247 [text] Chymase [Peptidase S1 family. Granzyme subfamily]

volume: 520. Å3; shape: 0.67; buriedness: 0.65

negative: 0.04; positive: 0.09; polar: 0.16; backbone: 0.48; hydrophobic: 0.22

Domains/regions: [D] Peptidase S1

PDB: 1klt, 1nn6, 1pjp, 1t31, 2hvx, 3n7o, 3s0n, 4afq, 4afs, 4afu, 4afz, 4ag1, 4ag2, 4k2y, 4k5z, 4k60, 4k69, 4kp0

HET: 0bb, 0qe, 1p7, 1p8, 1p9, drx, es2, hph, kpk, lmr, n7o, na, ohh, pms, tar

CMAS1_MYCTU_1_287 [text] Cyclopropane mycolic acid synthase 1 [CFA/CMAS family]

volume: 305. Å3; shape: 0.66; buriedness: 0.97

negative: 0.05; positive: 0.05; polar: 0.21; backbone: 0.29; hydrophobic: 0.4

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 1kp9, 1kpg, 1kph

HET: 10a, 16a

CMAS2_MYCTU_1_302 [text] Cyclopropane mycolic acid synthase 2 [CFA/CMAS family]

volume: 251. Å3; shape: 0.7; buriedness: 0.95

negative: 0.06; positive: 0.06; polar: 0.26; backbone: 0.19; hydrophobic: 0.42

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 1kpi, 3hem

HET: 10a, d22

CNDP2_MOUSE_1_475 [text] Cytosolic non-specific dipeptidase [Peptidase M20A family]

volume: 221. Å3; shape: 0.51; buriedness: 1.

negative: 0.23; positive: 0.23; polar: 0.16; backbone: 0.23; hydrophobic: 0.16

Domains/regions: [R] Substrate binding

PDB: 2zof, 2zog

HET: bes

CNL_CLINE_2_149 [text] Ricin B-like lectin

volume: 318. Å3; shape: 0.7; buriedness: 0.39

negative: 0.11; positive: 0.11; polar: 0.47; backbone: 0.21; hydrophobic: 0.11

PDB: 3nbc, 3nbd, 3nbe

HET: dld, lat, lbt

CNO6L_HUMAN_158_555 [text] CCR4-NOT transcription complex subunit 6-like [CCR4/nocturin family]

volume: 421. Å3; shape: 0.59; buriedness: 0.77

negative: 0.12; positive: 0.19; polar: 0.22; backbone: 0.17; hydrophobic: 0.3

Domains/regions: [R] Nuclease domain

PDB: 3ngn, 3ngo, 3ngq, 5dv2, 5dv4

HET: 1ps, amp, c5p, mg, nmy

CNX1_ARATH_462_626 [text] Molybdopterin biosynthesis protein CNX1

volume: 391. Å3; shape: 0.61; buriedness: 0.75

negative: 0.14; positive: 0.03; polar: 0.22; backbone: 0.51; hydrophobic: 0.1

Domains/regions: [R] MPT adenylyltransferase, [R] Substrate binding

PDB: 1eav, 1o8n, 1o8o, 1o8q, 1uux, 1uuy

HET: amp, cu1, mte

COAA_ECOLI_2_316 [text] Pantothenate kinase [Prokaryotic pantothenate kinase family]

volume: 626. Å3; shape: 0.51; buriedness: 0.89

negative: 0.04; positive: 0.2; polar: 0.3; backbone: 0.19; hydrophobic: 0.27

PDB: 1esm, 1esn, 1sq5, 4f7w, 4gi7, 4ne2

HET: 0jr, adp, anp, coa, mg, pau, pn4, sh2

COAA_MYCTU_1_312 [text] Pantothenate kinase [Prokaryotic pantothenate kinase family]

volume: 703. Å3; shape: 0.68; buriedness: 0.84

negative: 0.03; positive: 0.14; polar: 0.18; backbone: 0.31; hydrophobic: 0.33

PDB: 2ges, 2get, 2geu, 2gev, 2zs7, 2zs8, 2zs9, 2zsa, 2zsb, 2zsd, 2zse, 2zsf, 3aez, 3af0, 3af1, 3af2, 3af3, 3af4, 3avo, 3avp, 3avq, 4bfs, 4bft, 4bfu, 4bfv, 4bfw, 4bfx, 4bfy, 4bfz

HET: acp, adp, atp, coa, cok, gcp, gdp, mv1, mv2, na, pau, paz, zvs, zvt, zvu, zvv, zvw, zvx, zvy, zvz

COAD_BURP1_1_166 [text] Phosphopantetheine adenylyltransferase [Bacterial CoaD family]

volume: 512. Å3; shape: 0.33; buriedness: 0.8

negative: 0.03; positive: 0.13; polar: 0.15; backbone: 0.4; hydrophobic: 0.28

PDB: 3k9w, 3pxu

HET: 4ps, ade, cod

COAD_ECOLI_1_159 [text] Phosphopantetheine adenylyltransferase [Bacterial CoaD family]

volume: 706. Å3; shape: 0.52; buriedness: 0.77

negative: 0.02; positive: 0.11; polar: 0.17; backbone: 0.41; hydrophobic: 0.29

Domains/regions: [R] Product-binding (3'-dephospho-CoA)

PDB: 1b6t, 1gn8, 1h1t, 1qjc, 5jbn

HET: atp, coa, cod, pns

COAD_ENTFA_1_163 [text] Phosphopantetheine adenylyltransferase [Bacterial CoaD family]

volume: 202. Å3; shape: 0.67; buriedness: 0.84

negative: 0.06; positive: 0.06; polar: 0.23; backbone: 0.23; hydrophobic: 0.41

PDB: 3nd5, 3nd6, 3nd7

HET: pny

COAD_MYCTU_2_157 [text] Phosphopantetheine adenylyltransferase [Bacterial CoaD family]

volume: 861. Å3; shape: 0.66; buriedness: 0.64

negative: 0.04; positive: 0.09; polar: 0.2; backbone: 0.49; hydrophobic: 0.19

PDB: 1tfu, 3lcj, 3nba, 3nbk, 3pnb, 3rba, 3rff, 3rhs, 3uc5, 4e1a, 4r0n

HET: apc, atp, coa, cod, mg, pns

COAD_STAAW_1_160 [text] Phosphopantetheine adenylyltransferase [Bacterial CoaD family]

volume: 897. Å3; shape: 0.58; buriedness: 0.78

negative: 0.04; positive: 0.08; polar: 0.16; backbone: 0.42; hydrophobic: 0.29

PDB: 3f3m, 4nah, 4nat, 4nau

HET: 2vj, 2w3, 2w5, adp, ags, pps

COAW_STAA8_1_267 [text] Type II pantothenate kinase [Type II pantothenate kinase family]

volume: 721. Å3; shape: 0.4; buriedness: 0.9

negative: 0.04; positive: 0.06; polar: 0.23; backbone: 0.47; hydrophobic: 0.19

PDB: 2ews, 4m7x, 4m7y, 4nb4, 5elz, 5jic

HET: 27q, 2gh, 3v9, adp, anp, n7e, sh3

COAX_THEMA_1_246 [text] Type III pantothenate kinase [Type III pantothenate kinase family]

volume: 168. Å3; shape: 0.46; buriedness: 0.94

negative: 0.08; positive: 0.16; polar: 0.2; backbone: 0.24; hydrophobic: 0.32

Domains/regions: [R] Substrate binding

PDB: 2gtd, 3bex, 3bf1, 3bf3

HET: pau, paz

COBD_SALTY_1_364 [text] Threonine-phosphate decarboxylase [Class-II pyridoxal-phosphate-dependent aminotransferase family]

volume: 257. Å3; shape: 0.7; buriedness: 0.92

negative: 0.09; positive: 0.22; polar: 0.28; backbone: 0.22; hydrophobic: 0.2

PDB: 1lc5, 1lc7, 1lc8, 1lkc

HET: 33p, plp, tpo

COBT_SALTY_1_356 [text] Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [CobT family]

volume: 212. Å3; shape: 0.61; buriedness: 0.87

negative: 0.13; positive: 0.; polar: 0.26; backbone: 0.32; hydrophobic: 0.29

PDB: 1d0s, 1d0v, 1jh8, 1jha, 1jhm, 1jho, 1jhp, 1jhq, 1jhr, 1jhu, 1jhv, 1jhx, 1jhy, 1l4b, 1l4e, 1l4f, 1l4g, 1l4h, 1l4k, 1l4l, 1l4m, 1l4n, 1l5f, 1l5k, 1l5l, 1l5m, 1l5n, 1l5o, 4kqf, 4kqg, 4kqh, 4kqi, 4kqj, 4kqk

HET: 150, 1rb, 2ac, 2af, 2mp, 34a, 5mb, 5ob, 7ra, 7rp, aam, ade, bzi, dmd, ind, iph, mct, ncn, nio, p2p, pcr, pmo, rbz, rmb, xyd

COCE_RHOSM_1_574 [text] Cocaine esterase [CocE/NonD hydrolase family]

volume: 97. Å3; shape: 0.79; buriedness: 0.94

negative: 0.; positive: 0.09; polar: 0.26; backbone: 0.16; hydrophobic: 0.49

Domains/regions: [R] 1A, [R] 1B, [R] 2, [R] 3

PDB: 1ju3, 1ju4, 1l7q, 1l7r, 3i2f, 3i2g, 3i2h, 3i2i, 3i2j, 3i2k, 3ida, 3puh, 3pui, 4p08

HET: bez, dbc, pbc

CODA_ECOLI_2_427 [text] Cytosine deaminase [Cytosine deaminase family]

volume: 89. Å3; shape: 0.87; buriedness: 1.

negative: 0.27; positive: 0.34; polar: 0.13; backbone: 0.; hydrophobic: 0.26

PDB: 1k6w, 1k70, 1r9x, 1r9y, 1r9z, 1ra0, 1ra5, 1rak, 3g77, 3o7u, 3r0d, 3rn6

HET: fpy, hpy, iga, o7u, zn

COFD_METMA_1_303 [text] 2-phospho-L-lactate transferase [CofD family]

volume: 281. Å3; shape: 0.45; buriedness: 0.93

negative: 0.; positive: 0.04; polar: 0.22; backbone: 0.59; hydrophobic: 0.15

PDB: 3c3d, 3c3e, 3cgw

HET: gdp

COMP_HUMAN_28_72 [text] Cartilage oligomeric matrix protein [Thrombospondin family]

volume: 382. Å3; shape: 0.3; buriedness: 0.94

negative: 0.; positive: 0.; polar: 0.; backbone: 0.02; hydrophobic: 0.98

Domains/regions: [R] COMP N-terminal

PDB: 1fbm, 1mz9, 1vdf, 3v2n, 3v2p, 3v2q, 3v2r

HET: vdy

COMT1_MEDSA_1_365 [text] Caffeic acid 3-O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 173. Å3; shape: 0.6; buriedness: 0.88

negative: 0.06; positive: 0.11; polar: 0.11; backbone: 0.; hydrophobic: 0.72

Domains/regions: [R] Substrate binding

PDB: 1kyw, 1kyz

HET: fer, hfl

COMT_HUMAN_51_267 [text] Catechol O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family]

volume: 293. Å3; shape: 0.62; buriedness: 0.76

negative: 0.2; positive: 0.08; polar: 0.08; backbone: 0.24; hydrophobic: 0.41

PDB: 3a7e, 3bwm, 3bwy, 4pyi, 4pyj, 4pyk, 4xuc, 4xud, 4xue, 5lsa

HET: 43g, 43h, 43j, dnc

COMT_MOUSE_45_263 [text] Catechol O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family]

volume: 621. Å3; shape: 0.4; buriedness: 0.83

negative: 0.1; positive: 0.1; polar: 0.18; backbone: 0.42; hydrophobic: 0.21

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 1h1d, 1jr4, 1vid, 2cl5, 2zlb, 2zth, 2zvj, 3a7d, 3hvh, 3hvi, 3hvj, 3hvk, 3nw9, 3nwb, 3nwe, 3oe4, 3oe5, 3ozr, 3ozs, 3ozt, 3r6t, 3s68, 3u81, 4p58, 4p7f, 4p7g, 4p7j, 4p7k, 4pyl, 4pym, 4pyn, 4pyo, 4pyq, 5fhq, 5fhr, 5k01, 5k03, 5k05, 5k0b, 5k0c, 5k0e, 5k0f, 5k0g, 5k0j, 5k0l, 5k0n, 5lqa, 5lqc, 5lqj, 5lqk, 5lqn, 5lqr, 5lqu, 5lr6, 5p8w

HET: 2f6, 542, 610, 611, 619, 637, 659, 662, 6ow, 6oz, 6p0, 6p1, 6p2, 6p4, 6p5, 6pm, 6ps, 705, 719, 72m, 72o, 72w, 731, bia, bie, cl4, dnc, fbn, kom, lu1, mg, o01, ozr, ozs, ozz, sah, sam, sfg, tcw

CONA_CANBR_1_237 [text] Concanavalin-Br [Leguminous lectin family]

volume: 1394. Å3; shape: 0.7; buriedness: 0.56

negative: 0.07; positive: 0.08; polar: 0.25; backbone: 0.37; hydrophobic: 0.22

Domains/regions: [R] Carbohydrate binding

PDB: 1apn, 1azd, 1bxh, 1c57, 1ces, 1cjp, 1cn1, 1con, 1cvn, 1dq0, 1dq1, 1dq2, 1dq4, 1dq5, 1dq6, 1enq, 1enr, 1ens, 1gic, 1gkb, 1hqw, 1i3h, 1jbc, 1jn2, 1joj, 1jui, 1jw6, 1jyc, 1jyi, 1nls, 1nxd, 1ona, 1qdc, 1qdo, 1qgl, 1qny, 1scr, 1scs, 1tei, 1val, 1vam, 1vln, 1xqn, 2a7a, 2cna, 2ctv, 2enr, 2g4i, 2uu8, 2yz4, 3cna, 3d4k, 3enr, 3ju9, 3nwk, 3qlq, 4czs, 4h55, 4p14, 4p9w, 4p9x, 4p9y, 4pcr, 4pf5, 5cna

HET: 2ko, 8lr, amg, bdr, ejt, gyp, h1m, m3n, man, mma, mug, pna, png, r3g, r3m, sfp, xsn

CONA_CANCT_1_237 [text] Concanavalin-A [Leguminous lectin family]

volume: 251. Å3; shape: 0.77; buriedness: 0.67

negative: 0.07; positive: 0.07; polar: 0.33; backbone: 0.37; hydrophobic: 0.15

Domains/regions: [R] Carbohydrate binding

PDB: 1wuv, 2d7f, 2ef6, 2ovu, 2p2k, 4l8q, 5f5q

HET: man, mdm, mma, xmm

CONA_CANLI_1_237 [text] Concanavalin-A [Leguminous lectin family]

volume: 325. Å3; shape: 0.8; buriedness: 0.54

negative: 0.07; positive: 0.07; polar: 0.31; backbone: 0.43; hydrophobic: 0.13

Domains/regions: [R] Carbohydrate binding

PDB: 2cwm, 2cy6, 2cyf, 2ow4, 2p34, 2p37, 3snm, 4dpn, 4i30, 4tys, 4tzd, 5byn

HET: m13, mal, man, mma, tre

COTA_BACSU_1_513 [text] Spore coat protein A

volume: 419. Å3; shape: 0.61; buriedness: 0.56

negative: 0.; positive: 0.2; polar: 0.1; backbone: 0.3; hydrophobic: 0.4

PDB: 1gsk, 1of0, 1w6l, 1w6w, 1w8e, 2bhf, 2wsd, 2x87, 2x88, 3zdw, 4a66, 4a67, 4a68, 4ako, 4akp, 4akq, 4q89, 4q8b, 4yvn, 4yvu

HET: ebs, sxx

COX1_RHOSH_7_560 [text] Cytochrome c oxidase subunit 1 [Heme-copper respiratory oxidase family]

volume: 369. Å3; shape: 0.31; buriedness: 0.7

negative: 0.; positive: 0.; polar: 0.09; backbone: 0.28; hydrophobic: 0.63

PDB: 1m56, 1m57, 2gsm, 3dtu, 3fye, 3fyi, 3om3, 3oma, 3omi, 3omn

HET: dmu, trd

COX2_RHOSH_28_283 [text] Cytochrome c oxidase subunit 2 [Cytochrome c oxidase subunit 2 family]

volume: 134. Å3; shape: 0.61; buriedness: 0.66

negative: 0.; positive: 0.; polar: 0.; backbone: 0.14; hydrophobic: 0.86

Multimer with: Cytochrome c oxidase subunit 1 (COX1_RHOSH) [Heme-copper respiratory oxidase family]

PDB: 1m56, 1m57, 2gsm, 3dtu, 3fye, 3fyi, 3om3, 3oma, 3omi, 3omn

HET: trd

CP119_SULAC_1_368 [text] Cytochrome P450 119 [Cytochrome P450 family]

volume: 113. Å3; shape: 0.56; buriedness: 0.78

negative: 0.; positive: 0.; polar: 0.16; backbone: 0.37; hydrophobic: 0.47

PDB: 1f4t, 1f4u, 1io7, 1io8, 1io9, 4tt5, 4tuv, 4wpd, 4wqj, 5bv5

HET: 36y, 3sq, cpz, pim

CP11A_BOVIN_40_520 [text] Cholesterol side-chain cleavage enzyme, mitochondrial [Cytochrome P450 family]

volume: 313. Å3; shape: 0.43; buriedness: 0.85

negative: 0.; positive: 0.; polar: 0.24; backbone: 0.43; hydrophobic: 0.33

PDB: 3mzs

HET: hc9

CP11A_HUMAN_42_519 [text] Cholesterol side-chain cleavage enzyme, mitochondrial [Cytochrome P450 family]

volume: 323. Å3; shape: 0.44; buriedness: 0.86

negative: 0.; positive: 0.04; polar: 0.18; backbone: 0.27; hydrophobic: 0.5

PDB: 3n9y, 3n9z, 3na0, 3na1

HET: 2dc, clr, hc9, hcd

CP120_SYNY3_1_444 [text] Putative cytochrome P450 120 [Cytochrome P450 family]

volume: 269. Å3; shape: 0.38; buriedness: 0.83

negative: 0.; positive: 0.; polar: 0.12; backbone: 0.29; hydrophobic: 0.58

PDB: 2ve3, 2ve4

HET: rea

CP121_MYCTU_1_396 [text] Mycocyclosin synthase [Cytochrome P450 family]

volume: 409. Å3; shape: 0.62; buriedness: 0.76

negative: 0.; positive: 0.06; polar: 0.28; backbone: 0.27; hydrophobic: 0.39

Domains/regions: [R] Substrate binding

PDB: 1n40, 1n4g, 2ij5, 2ij7, 3cxv, 3cxx, 3cxy, 3cxz, 3cy0, 3cy1, 3g5f, 3g5h, 4g1x, 4g2g, 4g44, 4g45, 4g46, 4g47, 4g48, 4ict, 4ips, 4ipw, 4iq7, 4iq9, 4ktf, 4ktj, 4ktk, 4ktl, 5edt, 5ibd, 5ibe, 5ibf, 5ibg, 5ibh, 5ibi, 5ibj

HET: 1cq, 1ed, 1g4, 1g7, 1g9, 1gb, 1tm, 5mk, 69m, 69r, 69s, 69t, 69u, 69w, ggj, ktj, ktk, mqn, pyz, pzb, tdh, tpf, tqu, tty, tzf, tzm, ytt

CP124_MYCTU_1_428 [text] Methyl-branched lipid omega-hydroxylase [Cytochrome P450 family]

volume: 311. Å3; shape: 0.46; buriedness: 0.88

negative: 0.; positive: 0.; polar: 0.23; backbone: 0.2; hydrophobic: 0.57

PDB: 2wm4, 2wm5

HET: vgj

CP125_MYCTU_7_433 [text] Steroid C26-monooxygenase [Cytochrome P450 family]

volume: 387. Å3; shape: 0.65; buriedness: 0.9

negative: 0.03; positive: 0.04; polar: 0.11; backbone: 0.3; hydrophobic: 0.52

Domains/regions: [R] Substrate binding

PDB: 2x5l, 2x5w, 2xc3, 2xn8, 3ivy, 3iw0, 3iw1, 3iw2

HET: asd, eko, k2b, rt8

CP130_MYCTU_2_405 [text] Cytochrome P450 130 [Cytochrome P450 family]

volume: 406. Å3; shape: 0.53; buriedness: 0.72

negative: 0.; positive: 0.; polar: 0.19; backbone: 0.36; hydrophobic: 0.45

PDB: 2uuq, 2uvn, 2wgy, 2wh8, 2whf

HET: ecn, ii2, ii4

CP142_MYCTU_1_398_catalytic [text] Putative cytochrome P450 142 [Cytochrome P450 family]

volume: 82. Å3; shape: 0.45; buriedness: 0.85

negative: 0.; positive: 0.; polar: 0.; backbone: 0.14; hydrophobic: 0.86

PDB: 2xkr

HET: pg4

CP17A_HUMAN_22_508_catalytic [text] Steroid 17-alpha-hydroxylase/17,20 lyase [Cytochrome P450 family]

volume: 246. Å3; shape: 0.49; buriedness: 0.89

negative: 0.07; positive: 0.; polar: 0.16; backbone: 0.22; hydrophobic: 0.55

PDB: 3ruk, 3swz, 4nkv, 4nkw, 4nkx, 4nky, 4nkz

HET: 3qz, aer, lzz, plo, str, tok

CP19A_HUMAN_41_503 [text] Aromatase [Cytochrome P450 family]

volume: 224. Å3; shape: 0.63; buriedness: 0.89

negative: 0.06; positive: 0.06; polar: 0.1; backbone: 0.3; hydrophobic: 0.47

PDB: 3eqm, 3s79, 3s7s, 4gl5, 4kq8

HET: asd, exm, g29

CP1A1_HUMAN_28_512 [text] Cytochrome P450 1A1 [Cytochrome P450 family]

volume: 204. Å3; shape: 0.66; buriedness: 0.91

negative: 0.11; positive: 0.; polar: 0.22; backbone: 0.27; hydrophobic: 0.4

PDB: 4i8v

HET: bhf

CP1A2_HUMAN_26_515 [text] Cytochrome P450 1A2 [Cytochrome P450 family]

volume: 183. Å3; shape: 0.65; buriedness: 0.94

negative: 0.14; positive: 0.; polar: 0.14; backbone: 0.29; hydrophobic: 0.43

PDB: 2hi4

HET: bhf

CP1B1_HUMAN_42_543 [text] Cytochrome P450 1B1 [Cytochrome P450 family]

volume: 174. Å3; shape: 0.62; buriedness: 0.92

negative: 0.17; positive: 0.; polar: 0.17; backbone: 0.25; hydrophobic: 0.42

PDB: 3pm0

HET: bhf

CP21A_BOVIN_1_496_catalytic [text] Steroid 21-hydroxylase [Cytochrome P450 family]

volume: 214. Å3; shape: 0.5; buriedness: 0.83

negative: 0.07; positive: 0.14; polar: 0.29; backbone: 0.14; hydrophobic: 0.36

PDB: 3qz1

HET: 3qz

CP21A_BOVIN_1_496_peripheral3QZ [text] Steroid 21-hydroxylase [Cytochrome P450 family]

volume: 253. Å3; shape: 0.52; buriedness: 0.84

negative: 0.; positive: 0.; polar: 0.19; backbone: 0.19; hydrophobic: 0.62

PDB: 3qz1

HET: 3qz

CP21A_HUMAN_27_494 [text] Steroid 21-hydroxylase [Cytochrome P450 family]

volume: 194. Å3; shape: 0.49; buriedness: 0.92

negative: 0.1; positive: 0.1; polar: 0.1; backbone: 0.1; hydrophobic: 0.59

PDB: 4y8w

HET: str

CP24A_RAT_33_514_catalytic [text] 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [Cytochrome P450 family]

volume: 814. Å3; shape: 0.92; buriedness: 0.63

negative: 0.06; positive: 0.08; polar: 0.11; backbone: 0.35; hydrophobic: 0.39

PDB: 3k9v, 3k9y

HET: cm5, cps

CP24A_RAT_33_514_peripheralCPS [text] 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [Cytochrome P450 family]

volume: 981. Å3; shape: 0.72; buriedness: 0.51

negative: 0.; positive: 0.03; polar: 0.06; backbone: 0.31; hydrophobic: 0.59

PDB: 3k9v, 3k9y

HET: cm5, cps

CP2A6_HUMAN_24_494 [text] Cytochrome P450 2A6 [Cytochrome P450 family]

volume: 160. Å3; shape: 0.61; buriedness: 0.89

negative: 0.; positive: 0.; polar: 0.19; backbone: 0.2; hydrophobic: 0.61

PDB: 1z10, 1z11, 2fdu, 2fdv, 2fdw, 2fdy, 2pg5, 2pg6, 2pg7, 3ebs, 3t3q, 3t3r, 4ejj, 4rui

HET: 8mo, 9pl, cou, d1g, d2g, d3g, d4g, n4e, nct, sne

CP2AD_HUMAN_24_494_catalytic [text] Cytochrome P450 2A13 [Cytochrome P450 family]

volume: 148. Å3; shape: 0.59; buriedness: 0.9

negative: 0.; positive: 0.; polar: 0.23; backbone: 0.21; hydrophobic: 0.56

PDB: 2p85, 3t3s, 4ejg, 4ejh, 4eji

HET: 0qa, 9pl, ind, nct

CP2B4_RABIT_22_491_catalytic [text] Cytochrome P450 2B4 [Cytochrome P450 family]

volume: 1466. Å3; shape: 0.34; buriedness: 0.84

negative: 0.05; positive: 0.02; polar: 0.07; backbone: 0.5; hydrophobic: 0.37

PDB: 1po5, 1suo, 2bdm, 2q6n, 3g5n, 3g93, 3kw4, 3me6, 3mvr, 3r1a, 3r1b, 3tk3, 3tmz, 3uas, 4h1n, 4jlt, 4mgj, 5em4, 5iut, 5iuz

HET: 06x, 0bv, 1ci, 32m, 8pr, cge, cm5, cpz, pb2, tb2, tic, tmi

CP2B4_RABIT_22_491_peripheralTMI [text] Cytochrome P450 2B4 [Cytochrome P450 family]

volume: 202. Å3; shape: 0.56; buriedness: 0.81

negative: 0.; positive: 0.; polar: 0.05; backbone: 0.39; hydrophobic: 0.56

PDB: 1po5, 1suo, 2bdm, 2q6n, 3g5n, 3g93, 3kw4, 3me6, 3mvr, 3r1a, 3r1b, 3tk3, 3tmz, 3uas, 4h1n, 4jlt, 4mgj, 5em4, 5iut, 5iuz

HET: tmi

CP2B6_HUMAN_20_491_catalytic [text] Cytochrome P450 2B6 [Cytochrome P450 family]

volume: 211. Å3; shape: 0.7; buriedness: 0.9

negative: 0.; positive: 0.; polar: 0.12; backbone: 0.12; hydrophobic: 0.76

PDB: 3ibd, 3qoa, 3qu8, 3ua5, 4i91, 4rql, 4rrt, 4zv8

HET: 06x, 3qo, 3qu, 3v4, cpz, sne, tmh

CP2B6_HUMAN_20_491_peripheralAmlodipine [text] Cytochrome P450 2B6 [Cytochrome P450 family]

volume: 251. Å3; shape: 0.66; buriedness: 0.89

negative: 0.05; positive: 0.05; polar: 0.05; backbone: 0.46; hydrophobic: 0.4

PDB: 3ibd, 3qoa, 3qu8, 3ua5, 4i91, 4rql, 4rrt, 4zv8

HET: 06x

CP2B6_HUMAN_20_491_peripheralCM52 [text] Cytochrome P450 2B6 [Cytochrome P450 family]

volume: 239. Å3; shape: 0.34; buriedness: 0.73

negative: 0.; positive: 0.06; polar: 0.07; backbone: 0.47; hydrophobic: 0.4

PDB: 3ibd, 3qoa, 3qu8, 3ua5, 4i91, 4rql, 4rrt, 4zv8

HET: cm5

CP2B6_HUMAN_20_491_peripheralCM5 [text] Cytochrome P450 2B6 [Cytochrome P450 family]

volume: 372. Å3; shape: 0.39; buriedness: 0.55

negative: 0.; positive: 0.; polar: 0.; backbone: 0.33; hydrophobic: 0.67

PDB: 3ibd, 3qoa, 3qu8, 3ua5, 4i91, 4rql, 4rrt, 4zv8

HET: cm5

CP2C5_RABIT_20_487 [text] Cytochrome P450 2C5 [Cytochrome P450 family]

volume: 221. Å3; shape: 0.49; buriedness: 0.88

negative: 0.; positive: 0.; polar: 0.15; backbone: 0.21; hydrophobic: 0.64

PDB: 1dt6, 1n6b, 1nr6

HET: dif, dmz

CP2C8_HUMAN_20_490 [text] Cytochrome P450 2C8 [Cytochrome P450 family]

volume: 659. Å3; shape: 0.8; buriedness: 0.9

negative: 0.03; positive: 0.02; polar: 0.28; backbone: 0.24; hydrophobic: 0.44

PDB: 1pq2, 2nnh, 2nni, 2nnj, 2vn0

HET: 225, mtk, rea, tdz

CP2C9_HUMAN_20_490_catalytic [text] Cytochrome P450 2C9 [Cytochrome P450 family]

volume: 358. Å3; shape: 0.59; buriedness: 0.88

negative: 0.08; positive: 0.; polar: 0.21; backbone: 0.31; hydrophobic: 0.41

PDB: 1og2, 1og5, 1r9o, 4nz2, 5a5i, 5a5j

HET: 2qj, 6yf, flp, xi1

CP2C9_HUMAN_20_490_peripheralWarfarin [text] Cytochrome P450 2C9 [Cytochrome P450 family]

volume: 221. Å3; shape: 0.77; buriedness: 0.9

negative: 0.; positive: 0.07; polar: 0.11; backbone: 0.28; hydrophobic: 0.54

PDB: 1og2, 1og5, 1r9o, 4nz2, 5a5i, 5a5j

HET: swf

CP2CJ_HUMAN_20_490 [text] Cytochrome P450 2C19 [Cytochrome P450 family]

volume: 190. Å3; shape: 0.62; buriedness: 0.83

negative: 0.1; positive: 0.; polar: 0.1; backbone: 0.17; hydrophobic: 0.64

PDB: 4gqs

HET: 0xv

CP2D6_HUMAN_23_497_catalytic [text] Cytochrome P450 2D6 [Cytochrome P450 family]

volume: 381. Å3; shape: 0.6; buriedness: 0.89

negative: 0.14; positive: 0.; polar: 0.22; backbone: 0.34; hydrophobic: 0.3

PDB: 2f9q, 3qm4, 3tbg, 3tda, 4wnt, 4wnu, 4wnv, 4wnw, 4xry, 4xrz

HET: ajn, pn0, qdn, qi9, rtz, si5, si6

CP2E1_HUMAN_22_493 [text] Cytochrome P450 2E1 [Cytochrome P450 family]

volume: 221. Å3; shape: 0.56; buriedness: 0.91

negative: 0.; positive: 0.; polar: 0.22; backbone: 0.11; hydrophobic: 0.68

Domains/regions: [R] Substrate binding

PDB: 3e4e, 3e6i, 3gph, 3koh, 3lc4, 3t3z

HET: 4pz, 9pl, lc4, lz1, oid, oio

CP2R1_HUMAN_31_501 [text] Vitamin D 25-hydroxylase [Cytochrome P450 family]

volume: 330. Å3; shape: 0.47; buriedness: 0.97

negative: 0.; positive: 0.; polar: 0.27; backbone: 0.17; hydrophobic: 0.56

PDB: 3c6g, 3czh, 3dl9

HET: d2v, v2h, vd3

CP3A4_HUMAN_23_503_catalytic [text] Cytochrome P450 3A4 [Cytochrome P450 family]

volume: 900. Å3; shape: 0.63; buriedness: 0.82

negative: 0.09; positive: 0.1; polar: 0.14; backbone: 0.21; hydrophobic: 0.47

PDB: 1tqn, 1w0e, 1w0f, 1w0g, 2j0d, 2v0m, 3nxu, 3tjs, 3ua1, 4d6z, 4d75, 4d78, 4d7d, 4i3q, 4i4g, 4i4h, 4k9t, 4k9u, 4k9v, 4k9w, 4k9x, 4ny4, 5a1p, 5a1r

HET: 08y, 1rd, 2qh, 5aw, 6aw, 7aw, 8aw, d0r, ery, j9k, kln, myt, pk9, pkt, rit, str, z8z, z9z

CP46A_HUMAN_50_500 [text] Cholesterol 24-hydroxylase [Cytochrome P450 family]

volume: 593. Å3; shape: 0.34; buriedness: 0.85

negative: 0.; positive: 0.1; polar: 0.12; backbone: 0.31; hydrophobic: 0.47

PDB: 2q9f, 2q9g, 3mdm, 3mdr, 3mdt, 3mdv, 4enh, 4fia, 4j14

HET: 0u9, 198, c3s, cl6, fjz, fvx, gjz, vor, x2n

CP51A_HUMAN_57_503 [text] Lanosterol 14-alpha demethylase [Cytochrome P450 family]

volume: 867. Å3; shape: 0.35; buriedness: 0.81

negative: 0.; positive: 0.03; polar: 0.19; backbone: 0.21; hydrophobic: 0.58

PDB: 3jus, 3juv, 3ld6, 4uhi, 4uhl

HET: ecl, ecn, kkk, vfv

CP51_CANGA_20_533 [text] Lanosterol 14-alpha demethylase [Cytochrome P450 family]

volume: 562. Å3; shape: 0.24; buriedness: 0.78

negative: 0.; positive: 0.04; polar: 0.2; backbone: 0.4; hydrophobic: 0.36

PDB: 5jlc

HET: 1yn

CP51_MYCTU_1_451 [text] Lanosterol 14-alpha demethylase [Cytochrome P450 family]

volume: 295. Å3; shape: 0.81; buriedness: 0.77

negative: 0.; positive: 0.09; polar: 0.25; backbone: 0.26; hydrophobic: 0.4

PDB: 1e9x, 1ea1, 1h5z, 1u13, 1x8v, 2bz9, 2ci0, 2cib, 2vku, 2w09, 2w0a, 2w0b

HET: 1cm, cii, cm6, cm9, cmw, dbe, esl, pim, tpf

CP51_TRYCC_26_481 [text] Sterol 14-alpha demethylase [Cytochrome P450 family]

volume: 666. Å3; shape: 0.4; buriedness: 0.8

negative: 0.; positive: 0.; polar: 0.14; backbone: 0.2; hydrophobic: 0.65

PDB: 2wuz, 2wx2, 3k1o, 3khm, 3ksw, 3zg2, 3zg3, 4bmm, 4by0, 4c0c, 4c27, 4c28, 4ck8, 4ck9, 4cka, 4coh, 4h6o, 4uqh, 4uvr, 5ajr

HET: 25s, 26n, 5ps, j5y, lfd, lfs, lft, nee, poz, t9h, tpf, tu1, tw5, udd, udo, vnf, vt1, wvh

CP51_YEAST_1_530 [text] Lanosterol 14-alpha demethylase [Cytochrome P450 family]

volume: 482. Å3; shape: 0.29; buriedness: 0.79

negative: 0.; positive: 0.06; polar: 0.2; backbone: 0.39; hydrophobic: 0.36

PDB: 4lxj, 4wmz, 4zdy, 4zdz, 4ze0, 4ze1, 4ze2, 4ze3, 5eab, 5eac, 5ead, 5eae, 5eaf, 5eag, 5eah, 5eqb, 5ese, 5esf, 5esg, 5esh, 5esi, 5esj, 5esk, 5esl, 5esm, 5esn, 5hs1

HET: 1yn, 5l8, 5l9, 5lu, 5lw, 5ly, 5lz, fqc, lan, tbq, tbx, tpf, vor, x2n

CP74A_ARATH_31_518 [text] Allene oxide synthase, chloroplastic [Cytochrome P450 family]

volume: 252. Å3; shape: 0.69; buriedness: 0.85

negative: 0.; positive: 0.; polar: 0.14; backbone: 0.48; hydrophobic: 0.38

PDB: 2rch, 2rcl, 2rcm, 3cli, 3dsi, 3dsj, 3dsk

HET: 243, t24, t25

CP7A1_HUMAN_24_502 [text] Cholesterol 7-alpha-monooxygenase [Cytochrome P450 family]

volume: 323. Å3; shape: 0.36; buriedness: 0.86

negative: 0.; positive: 0.1; polar: 0.2; backbone: 0.33; hydrophobic: 0.36

PDB: 3dax, 3sn5, 3v8d

HET: 0gv, k2b

CPCT_NOSS1_1_199 [text] Phycocyanobilin lyase CpcT [CpcT/CpeT biliprotein lyase family]

volume: 406. Å3; shape: 0.8; buriedness: 0.86

negative: 0.07; positive: 0.18; polar: 0.2; backbone: 0.07; hydrophobic: 0.49

PDB: 4o4o, 4o4s

HET: cyc, mg

CPNS1_HUMAN_93_267 [text] Calpain small subunit 1

volume: 910. Å3; shape: 0.55; buriedness: 0.69

negative: 0.; positive: 0.31; polar: 0.11; backbone: 0.06; hydrophobic: 0.51

Domains/regions: [D] EF-hand 1; atypical, [D] EF-hand 2, [D] EF-hand 3, [D] EF-hand 4

PDB: 1aj5, 1alv, 1alw, 1df0, 1dvi, 1kfu, 1kfx, 1np8, 1nx0, 1nx1, 1nx2, 1nx3, 1u5i, 3bow, 3df0, 4phj, 4phk, 4phm, 4phn, 4wq2, 4wq3, 5d69

HET: 2ub, 2ud, 3su, 57t, isa

CPT2_RAT_28_658 [text] Carnitine O-palmitoyltransferase 2, mitochondrial [Carnitine/choline acetyltransferase family]

volume: 506. Å3; shape: 0.77; buriedness: 0.69

negative: 0.11; positive: 0.03; polar: 0.38; backbone: 0.38; hydrophobic: 0.09

Domains/regions: [R] Coenzyme A binding

PDB: 2deb, 2fw3, 2fyo, 2h4t, 2rcu, 4ep9, 4eph, 4eyw

HET: 0rd, 0rk, d12, l0r

CPT_STRVP_1_178 [text] Chloramphenicol 3-O phosphotransferase

volume: 239. Å3; shape: 0.75; buriedness: 0.89

negative: 0.13; positive: 0.11; polar: 0.18; backbone: 0.12; hydrophobic: 0.47

PDB: 1grq, 1grr, 1qhn, 1qhs, 1qhx, 1qhy

HET: clc, clk, clm, mg

CPVDH_PSEAH_1_403 [text] Vitamin D(3) 25-hydroxylase [Cytochrome P450 family]

volume: 359. Å3; shape: 0.35; buriedness: 0.78

negative: 0.; positive: 0.05; polar: 0.19; backbone: 0.09; hydrophobic: 0.66

PDB: 3a4g, 3a4h, 3a4z, 3a50, 3a51, 3vrm

HET: pg0, vd3, vdy

CPXA_PSEPU_2_415 [text] Camphor 5-monooxygenase [Cytochrome P450 family]

volume: 449. Å3; shape: 0.32; buriedness: 0.82

negative: 0.05; positive: 0.; polar: 0.22; backbone: 0.27; hydrophobic: 0.46

PDB: 1akd, 1c8j, 1cp4, 1dz4, 1dz6, 1dz8, 1dz9, 1geb, 1gek, 1gem, 1gjm, 1iwi, 1iwj, 1iwk, 1j51, 1k2o, 1lwl, 1mpw, 1noo, 1o76, 1p2y, 1p7r, 1pha, 1phb, 1phc, 1phd, 1phe, 1phf, 1phg, 1qmq, 1re9, 1rf9, 1t85, 1t86, 1t87, 1t88, 1uyu, 1yrc, 1yrd, 2a1m, 2a1n, 2a1o, 2cp4, 2cpp, 2fe6, 2fer, 2feu, 2frz, 2gqx, 2gr6, 2h7q, 2h7r, 2h7s, 2qbl, 2qbm, 2qbn, 2qbo, 2z97, 2zaw, 2zax, 2zuh, 2zui, 2zuj, 2zwt, 2zwu, 3cp4, 3cpp, 3fwf, 3fwg, 3fwi, 3fwj, 3l61, 3l62, 3l63, 3oia, 3ol5, 3p6m, 3p6n, 3p6o, 3p6p, 3p6q, 3p6r, 3p6s, 3p6t, 3p6u, 3p6v, 3p6w, 3p6x, 3w9c, 3wrh, 3wri, 3wrj, 3wrk, 3wrl, 3wrm, 4cp4, 4cpp, 4ek1, 4g3r, 4jws, 4jwu, 4jx1, 4kky, 4l49, 4l4a, 4l4b, 4l4c, 4l4d, 4l4e, 4l4f, 4l4g, 5cp4, 5cpp, 5ik1, 6cp4, 6cpp, 7cpp, 8cpp

HET: 1mz, 5cl, a31, a6b, adm, ado, bnz, c3q, cae, cah, cam, dbr, drb, dso, etg, fe, fem, lrb, myt, nct, pfz, pim, piw, piy, rfa, rfb, saw, sbf, tcm, tcz, tmh

CPXB_BACMB_2_464 [text] Bifunctional cytochrome P450/NADPH--P450 reductase

volume: 173. Å3; shape: 0.84; buriedness: 0.3

negative: 0.34; positive: 0.; polar: 0.49; backbone: 0.; hydrophobic: 0.17

PDB: 1bu7, 1bvy, 1fag, 1fah, 1jme, 1jpz, 1p0v, 1p0w, 1p0x, 1smi, 1smj, 1yqo, 1yqp, 1zo4, 1zo9, 1zoa, 2bmh, 2hpd, 2ij2, 2ij3, 2ij4, 2j1m, 2j4s, 2nnb, 2uwh, 2x7y, 2x80, 3ben, 3cbd, 3dgi, 3ekb, 3ekd, 3ekf, 3hf2, 3kx3, 3kx4, 3kx5, 3m4v, 3npl, 3psx, 3qi8, 3wsp, 4dtw, 4dty, 4dtz, 4du2, 4dua, 4dub, 4duc, 4dud, 4due, 4duf, 4h23, 4h24, 4hgf, 4hgg, 4hgh, 4hgi, 4hgj, 4kew, 4key, 4kf0, 4kf2, 4kpa, 4kpb, 4o4p, 4rsn, 4wg2, 4zf6, 4zf8, 4zfa, 4zfb, 5dyp, 5dyz, 5e78, 5e9z, 5jq2, 5jqu, 5jqv, 5jtd

HET: 5kk, co

CPXE_STRGO_1_406 [text] Vitamin D3 dihydroxylase [Cytochrome P450 family]

volume: 357. Å3; shape: 0.51; buriedness: 0.9

negative: 0.; positive: 0.07; polar: 0.07; backbone: 0.49; hydrophobic: 0.38

PDB: 2zbx, 2zby, 2zbz, 3cv8, 3cv9

HET: vdx

CPXJ_SACEN_2_404 [text] 6-deoxyerythronolide B hydroxylase [Cytochrome P450 family]

volume: 437. Å3; shape: 0.93; buriedness: 0.78

negative: 0.05; positive: 0.04; polar: 0.2; backbone: 0.16; hydrophobic: 0.55

PDB: 1egy, 1eup, 1jin, 1jio, 1jip, 1oxa, 1z8o, 1z8p, 1z8q

HET: 9ap, asd, deb, ktn

CPXM_BACME_1_410 [text] Cytochrome P450(MEG) [Cytochrome P450 family]

volume: 192. Å3; shape: 0.53; buriedness: 0.81

negative: 0.; positive: 0.; polar: 0.32; backbone: 0.43; hydrophobic: 0.25

PDB: 4yt3, 5iki

HET: a9h

CQSA_VIBCH_1_389 [text] CAI-1 autoinducer synthase [Class-II pyridoxal-phosphate-dependent aminotransferase family]

volume: 315. Å3; shape: 0.46; buriedness: 0.95

negative: 0.06; positive: 0.15; polar: 0.25; backbone: 0.35; hydrophobic: 0.19

PDB: 2wk7, 2wk8, 2wk9, 2wka, 3hqt, 3kki

HET: dtt, mg, p89, plg, plp

CRA1_HOMGA_1_181 [text] Crustacyanin-A1 subunit [Calycin superfamily. Lipocalin family]

volume: 671. Å3; shape: 0.24; buriedness: 0.75

negative: 0.; positive: 0.; polar: 0.41; backbone: 0.17; hydrophobic: 0.42

PDB: 1gka, 1h91, 1s2p, 1s44, 4alo

HET: axt

CRAX_BACCE_241_471 [text] Putative ADP-ribosyltransferase Certhrax

volume: 228. Å3; shape: 0.59; buriedness: 0.76

negative: 0.09; positive: 0.09; polar: 0.34; backbone: 0.48; hydrophobic: 0.

PDB: 4fk7, 4fxq, 4gf1

HET: g9l, p34

CRBN_CHICK_320_432 [text] Protein cereblon [CRBN family]

volume: 166. Å3; shape: 0.5; buriedness: 0.8

negative: 0.; positive: 0.18; polar: 0.09; backbone: 0.27; hydrophobic: 0.45

Domains/regions: [D] CULT, [R] Thalidomide binding

PDB: 4ci1, 4ci2, 4ci3

HET: ef2, lvy, y70

CRBN_HUMAN_318_430 [text] Protein cereblon [CRBN family]

volume: 179. Å3; shape: 0.51; buriedness: 0.58

negative: 0.; positive: 0.07; polar: 0.; backbone: 0.4; hydrophobic: 0.53

Domains/regions: [D] CULT, [R] Thalidomide binding

PDB: 3wx1, 3wx2, 4tz4, 4tzc, 4tzu, 5fqd

HET: ef2, lvy, y70

CRFR1_HUMAN_112_401_TM [text] Corticotropin-releasing factor receptor 1 [G-protein coupled receptor 2 family]

volume: 216. Å3; shape: 0.44; buriedness: 0.98

negative: 0.; positive: 0.; polar: 0.24; backbone: 0.26; hydrophobic: 0.5

Domains/regions: [R] Important for antagonist binding

PDB: 4k5y, 4z9g

HET: 1q5

CRFR1_HUMAN_24_112_ECD [text] Corticotropin-releasing factor receptor 1 [G-protein coupled receptor 2 family]

volume: 1394. Å3; shape: 0.62; buriedness: 0.32

negative: 0.05; positive: 0.07; polar: 0.2; backbone: 0.28; hydrophobic: 0.4

Domains/regions: [R] Important for peptide agonist binding

PDB: 3ehs, 3eht, 3ehu

HET: nh2

CRFR2_HUMAN_3_104_ECD [text] Corticotropin-releasing factor receptor 2 [G-protein coupled receptor 2 family]

volume: 1324. Å3; shape: 0.46; buriedness: 0.35

negative: 0.; positive: 0.06; polar: 0.26; backbone: 0.37; hydrophobic: 0.32

PDB: 3n93, 3n95, 3n96

HET: nh2

CRP_HUMAN_19_224 [text] C-reactive protein [Pentaxin family]

volume: 127. Å3; shape: 0.54; buriedness: 0.65

negative: 0.52; positive: 0.; polar: 0.29; backbone: 0.; hydrophobic: 0.19

Domains/regions: [D] Pentaxin

PDB: 1b09, 1gnh, 1lj7, 3l2y, 3pvn, 3pvo

HET: ope, pc

CRTM_STAAU_1_287 [text] Dehydrosqualene synthase [Phytoene/squalene synthase family. CrtM subfamily]

volume: 721. Å3; shape: 0.61; buriedness: 0.89

negative: 0.03; positive: 0.06; polar: 0.15; backbone: 0.38; hydrophobic: 0.38

Domains/regions: [R] Farnesyl diphosphate 1 binding, [R] Farnesyl diphosphate 2 binding

PDB: 2zco, 2zcq, 2zcr, 2zcs, 2zy1, 3acw, 3acx, 3acy, 3adz, 3ae0, 3lgz, 3npr, 3nri, 3tfn, 3tfp, 3tfv, 3vjd, 3vje, 3w7f, 4e9u, 4e9z, 4ea0, 4ea1, 4ea2, 4f6v, 4f6x

HET: 03l, 2cj, 2cn, 3rx, 651, 673, 702, 830, b65, b69, b70, dh7, fjp, fps, ggs, mg, ps7, rwy, rwz, srt, tar, zga, zyl, zym

CRY2_MOUSE_6_512 [text] Cryptochrome-2 [DNA photolyase class-1 family]

volume: 673. Å3; shape: 0.75; buriedness: 0.91

negative: 0.03; positive: 0.14; polar: 0.14; backbone: 0.3; hydrophobic: 0.38

Domains/regions: [R] Required for inhibition of CLOCK-ARNTL- mediated transcription

PDB: 4i6e, 4i6g, 4i6j, 4mlp, 4u8h

HET: 2cx, fad

CRYM_MOUSE_1_313 [text] Ketimine reductase mu-crystallin [Ornithine cyclodeaminase/mu-crystallin family]

volume: 248. Å3; shape: 0.52; buriedness: 0.9

negative: 0.; positive: 0.39; polar: 0.17; backbone: 0.21; hydrophobic: 0.23

PDB: 4bv8, 4bv9, 4bva

HET: pyr, t3

CSF1R_HUMAN_539_921 [text] Macrophage colony-stimulating factor 1 receptor [Protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily]

volume: 581. Å3; shape: 0.39; buriedness: 0.86

negative: 0.08; positive: 0.04; polar: 0.08; backbone: 0.41; hydrophobic: 0.39

Domains/regions: [D] Protein kinase, [R] Activation loop

PDB: 2i0v, 2i0y, 2i1m, 2ogv, 3bea, 3dpk, 3krj, 3krl, 3lcd, 3lco, 4hw7, 4r7h, 4r7i

HET: 5cn, 64m, 6c3, 8c5, bdy, ixh, krj, krl, lc0, p31, sti

CSID_ECOLI_8_325 [text] Protein CsiD [CsiD family]

volume: 97. Å3; shape: 0.74; buriedness: 0.69

negative: 0.13; positive: 0.53; polar: 0.; backbone: 0.; hydrophobic: 0.33

PDB: 1jr7, 2r6s

HET: bcn

CSK21_HUMAN_1_335_ATPsite [text] Casein kinase II subunit alpha [Protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily]

volume: 626. Å3; shape: 0.57; buriedness: 0.86

negative: 0.04; positive: 0.04; polar: 0.09; backbone: 0.38; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 1jwh, 1na7, 1pjk, 2pvr, 2r7i, 2zjw, 3amy, 3at2, 3at3, 3at4, 3axw, 3bqc, 3c13, 3fwq, 3h30, 3juh, 3mb6, 3mb7, 3nga, 3nsz, 3owj, 3owk, 3owl, 3pe1, 3pe2, 3q04, 3q9w, 3q9x, 3q9y, 3q9z, 3qa0, 3r0t, 3rps, 3u4u, 3u87, 3u9c, 3w8l, 3war, 3wik, 3wil, 3wow, 4dgl, 4fbx, 4grb, 4gub, 4ib5, 4kwp, 4md7, 4md8, 4md9, 4nh1, 4rll, 4ub7, 4uba, 5b0x, 5clp, 5cqu, 5cqw, 5cs6, 5csh, 5csp, 5csv, 5ct0, 5ctp, 5cu0, 5cu2, 5cu3, 5cu4, 5cu6, 5cvf, 5cvg, 5cvh, 5cx9, 5h8b, 5h8e, 5h8g

HET: 01i, 04g, 0tj, 0xg, 0y4, 14i, 18e, 19e, 1el, 3g5, 3ng, 42j, 4b0, 54e, 54g, 54p, 54r, 54s, 54z, 551, 5y2, 5y3, 5y4, acp, adp, agi, anp, atk, atp, cck, e1b, e91, emo, exx, fu9, gab, hck, jrj, k82, lcd, lct, lnh, mg, nio, ref, rfz, tid, txq

CSK21_HUMAN_1_335_beta [text] Casein kinase II subunit alpha [Protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily]

volume: 389. Å3; shape: 0.6; buriedness: 0.52

negative: 0.06; positive: 0.; polar: 0.17; backbone: 0.46; hydrophobic: 0.31

Domains/regions: [D] Protein kinase, [R] Interaction with beta subunit

PDB: 1jwh, 1na7, 1pjk, 2pvr, 2r7i, 2zjw, 3amy, 3at2, 3at3, 3at4, 3axw, 3bqc, 3c13, 3fwq, 3h30, 3juh, 3mb6, 3mb7, 3nga, 3nsz, 3owj, 3owk, 3owl, 3pe1, 3pe2, 3q04, 3q9w, 3q9x, 3q9y, 3q9z, 3qa0, 3r0t, 3rps, 3u4u, 3u87, 3u9c, 3w8l, 3war, 3wik, 3wil, 3wow, 4dgl, 4fbx, 4grb, 4gub, 4ib5, 4kwp, 4md7, 4md8, 4md9, 4nh1, 4rll, 4ub7, 4uba, 5b0x, 5clp, 5cqu, 5cqw, 5cs6, 5csh, 5csp, 5csv, 5ct0, 5ctp, 5cu0, 5cu2, 5cu3, 5cu4, 5cu6, 5cvf, 5cvg, 5cvh, 5cx9, 5h8b, 5h8e, 5h8g

HET: 42j, 54e, 54r, 551, rfz

CSK22_HUMAN_1_342 [text] Casein kinase II subunit alpha' [Protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily]

volume: 236. Å3; shape: 0.75; buriedness: 0.84

negative: 0.08; positive: 0.08; polar: 0.08; backbone: 0.24; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 3e3b, 3ofm

HET: 4b0, cck

CSK2A_MAIZE_1_331 [text] Casein kinase II subunit alpha [Protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily]

volume: 366. Å3; shape: 0.79; buriedness: 0.88

negative: 0.06; positive: 0.06; polar: 0.06; backbone: 0.33; hydrophobic: 0.49

Domains/regions: [D] Protein kinase

PDB: 1daw, 1day, 1ds5, 1f0q, 1j91, 1jam, 1lp4, 1lpu, 1lr4, 1m2p, 1m2q, 1m2r, 1om1, 1zoe, 1zog, 1zoh, 2oxd, 2oxx, 2oxy, 2pvh, 2pvj, 2pvk, 2pvl, 2pvm, 2pvn, 2qc6, 3be9, 3fl5, 3kxg, 3kxh, 3kxm, 3kxn, 3pvg, 3pwd, 3pzh, 4anm, 4dgm, 4dgn, 4dgo, 4rlk

HET: 0jw, agi, amp, anp, ben, cz0, e91, emo, g12, gnp, hna, iqa, k17, k22, k25, k32, k37, k44, k66, k68, k6x, k74, k8x, lu2, mg, mnx, mny, na, p04, p19, p29, p44, p45, p55, p63, tbs, txq, wul

CSK_HUMAN_180_450 [text] Tyrosine-protein kinase CSK [Protein kinase superfamily. Tyr protein kinase family. CSK subfamily]

volume: 291. Å3; shape: 0.93; buriedness: 0.78

negative: 0.05; positive: 0.05; polar: 0.14; backbone: 0.35; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 1byg, 1k9a, 3d7t

HET: stu

CSKP_HUMAN_1_338 [text] Peripheral plasma membrane protein CASK [MAGUK family]

volume: 327. Å3; shape: 0.73; buriedness: 0.79

negative: 0.; positive: 0.09; polar: 0.; backbone: 0.3; hydrophobic: 0.61

Domains/regions: [D] Protein kinase

PDB: 3c0g, 3c0h, 3c0i, 3mfr, 3mfs, 3mft, 3mfu, 3tac

HET: 3am, amp, anp

CSN5_HUMAN_10_250 [text] COP9 signalosome complex subunit 5 [Peptidase M67A family. CSN5 subfamily]

volume: 313. Å3; shape: 0.52; buriedness: 0.6

negative: 0.13; positive: 0.17; polar: 0.23; backbone: 0.3; hydrophobic: 0.17

Domains/regions: [D] MPN

PDB: 4f7o, 5jog, 5joh

HET: 6lt, 6m3

CTBP1_HUMAN_20_357 [text] C-terminal-binding protein 1 [D-isomer specific 2-hydroxyacid dehydrogenase family]

volume: 121. Å3; shape: 0.62; buriedness: 0.91

negative: 0.; positive: 0.34; polar: 0.16; backbone: 0.34; hydrophobic: 0.17

Domains/regions: [R] Interaction with GLIS2 2

PDB: 1hku, 1hl3, 1mx3, 2hu2, 3ga0, 4lce, 4u6q, 4u6s

HET: 3cr, kmt, ppy

CTDS1_HUMAN_76_258 [text] Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

volume: 568. Å3; shape: 0.56; buriedness: 0.6

negative: 0.09; positive: 0.14; polar: 0.21; backbone: 0.28; hydrophobic: 0.28

Domains/regions: [D] FCP1 homology

PDB: 1t9z, 1ta0, 2ghq, 2ght, 3l0b, 3l0c, 3l0y, 3pgl, 4ygy, 4yh1

HET: 1pg, 4cg, rzx, sep

CTR1_ARATH_537_821 [text] Serine/threonine-protein kinase CTR1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily]

volume: 281. Å3; shape: 0.89; buriedness: 0.85

negative: 0.04; positive: 0.08; polar: 0.08; backbone: 0.43; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 3p86, 3ppz

HET: stu

CTRA_BOVIN_9_245 [text] Chymotrypsinogen A [Peptidase S1 family]

volume: 1080. Å3; shape: 0.79; buriedness: 0.47

negative: 0.; positive: 0.07; polar: 0.12; backbone: 0.49; hydrophobic: 0.32

Domains/regions: [D] Peptidase S1

PDB: 1ab9, 1acb, 1afq, 1ca0, 1cbw, 1cgi, 1cgj, 1chg, 1cho, 1dlk, 1ex3, 1gcd, 1gct, 1gg6, 1ggd, 1gha, 1ghb, 1gl0, 1gl1, 1gmc, 1gmd, 1gmh, 1hja, 1k2i, 1mtn, 1n8o, 1oxg, 1p2m, 1p2n, 1p2o, 1p2q, 1t7c, 1t8l, 1t8m, 1t8n, 1t8o, 1vgc, 1yph, 2cga, 2cha, 2gch, 2gct, 2gmt, 2p8o, 2vgc, 2y6t, 3bg4, 3gch, 3gct, 3ru4, 3t62, 3vgc, 4cha, 4gch, 4q2k, 4vgc, 5cha, 5gch, 6cha, 6gch, 7gch, 8gch

HET: 0fg, 0qe, 5bf, ace, apf, bva, dep, dmc, faf, hin, hph, isp, lpf, oac, pba, phq, sn1, srb, srd, tsu, unk, v35, v36

CUCM1_CUCME_111_731 [text] Cucumisin [Peptidase S8 family]

volume: 112. Å3; shape: 0.57; buriedness: 0.66

negative: 0.; positive: 0.1; polar: 0.4; backbone: 0.5; hydrophobic: 0.

Domains/regions: [D] Peptidase S8

PDB: 3vta, 4yn3

HET: dfp

CUSC_ECOLI_18_457 [text] Cation efflux system protein CusC [Outer membrane factor (OMF) (TC 1.B.17) family]

volume: 216. Å3; shape: 0.76; buriedness: 0.7

negative: 0.; positive: 0.; polar: 0.; backbone: 0.24; hydrophobic: 0.76

PDB: 3pik, 4k34, 4k7k, 4k7r

HET: 3pk, unl

CUTI1_COLGL_24_224 [text] Cutinase 1 [Cutinase family]

volume: 168. Å3; shape: 0.58; buriedness: 0.78

negative: 0.; positive: 0.; polar: 0.34; backbone: 0.42; hydrophobic: 0.25

PDB: 3dcn, 3dd5, 3dea

HET: dep, hzh

CUTI1_FUSSO_19_230 [text] Cutinase 1 [Cutinase family]

volume: 761. Å3; shape: 0.74; buriedness: 0.59

negative: 0.; positive: 0.05; polar: 0.31; backbone: 0.4; hydrophobic: 0.23

PDB: 1agy, 1cex, 1cua, 1cub, 1cuc, 1cud, 1cue, 1cuf, 1cug, 1cuh, 1cui, 1cuj, 1cus, 1cuu, 1cuv, 1cuw, 1cux, 1cuy, 1cuz, 1ffa, 1ffb, 1ffc, 1ffd, 1ffe, 1oxm, 1xza, 1xzb, 1xzc, 1xzd, 1xze, 1xzf, 1xzg, 1xzh, 1xzi, 1xzj, 1xzk, 1xzl, 1xzm, 2cut, 3ef3, 3esa, 3esb, 3esc, 3esd, 3qpa, 3qpc

HET: dep, dfp, dpe, hee, nxc, sxc, tc4

CXCR4_HUMAN_1_319_TM [text] C-X-C chemokine receptor type 4 [G-protein coupled receptor 1 family]

volume: 2417. Å3; shape: 0.82; buriedness: 0.71

negative: 0.13; positive: 0.08; polar: 0.13; backbone: 0.35; hydrophobic: 0.31

Domains/regions: [R] Chemokine binding, [R] Chemokine binding, important for signaling and HIV-1 coreceptor activity, [R] Involved in dimerization

PDB: 3odu, 3oe0, 3oe6, 3oe8, 3oe9, 4rws

HET: aln, cir, dpr, itd, ola, olc

CYAA_BACAN_291_800 [text] Calmodulin-sensitive adenylate cyclase [Adenylyl cyclase class-2 family]

volume: 392. Å3; shape: 0.63; buriedness: 0.86

negative: 0.08; positive: 0.31; polar: 0.11; backbone: 0.4; hydrophobic: 0.09

Domains/regions: [R] Catalytic CA1, [R] Catalytic CA2, [R] Catalytic CB

PDB: 1k8t, 1k90, 1k93, 1pk0, 1s26, 1sk6

HET: 3at, apc, cmp, ema, yb

CYAA_BORPE_4_364 [text] Bifunctional hemolysin/adenylate cyclase

volume: 262. Å3; shape: 0.39; buriedness: 0.71

negative: 0.17; positive: 0.17; polar: 0.09; backbone: 0.49; hydrophobic: 0.09

Domains/regions: [R] A, catalytic

PDB: 1yrt, 1yru, 1zot, 2col

HET: ema

CYB2_YEAST_181_591 [text] Cytochrome b2, mitochondrial

volume: 970. Å3; shape: 0.38; buriedness: 0.97

negative: 0.03; positive: 0.18; polar: 0.28; backbone: 0.35; hydrophobic: 0.16

Domains/regions: [D] FMN hydroxy acid dehydrogenase

PDB: 1fcb, 1kbi, 1kbj, 1lco, 1ldc, 1ltd, 1qcw, 1sze, 1szf, 1szg, 2oz0

HET: 173, fe, fmn, fns, hem, ppy, pyr, res, so3

CYC1_STRCO_1_361 [text] Epi-isozizaene synthase [Terpene synthase family]

volume: 149. Å3; shape: 0.66; buriedness: 0.95

negative: 0.08; positive: 0.08; polar: 0.17; backbone: 0.19; hydrophobic: 0.49

PDB: 3kb9, 3kbk, 3lg5, 3lgk, 4ltv, 4ltz, 4luu, 4lxw, 4lz0, 4lz3, 4lzc

HET: btm

CYC2_STRCO_1_338 [text] Germacradienol/geosmin synthase [Terpene synthase family]

volume: 135. Å3; shape: 0.74; buriedness: 0.84

negative: 0.17; positive: 0.25; polar: 0.29; backbone: 0.08; hydrophobic: 0.21

Domains/regions: [R] Germacradienol/germacrene D synthase

PDB: 5dw7, 5dz2

HET: 212

CYCP_ALCXX_1_127 [text] Cytochrome c'

volume: 99. Å3; shape: 0.66; buriedness: 0.54

negative: 0.; positive: 0.18; polar: 0.; backbone: 0.24; hydrophobic: 0.58

PDB: 1cgn, 1cgo, 1e83, 1e84, 1e85, 1e86, 2xl6, 2xl8, 2xld, 2xle, 2xlh, 2xlm, 2xlo, 2xlv, 2xlw, 2xm0, 2xm4, 2ykz, 2yl0, 2yl1, 2yl3, 2yl7, 2yld, 2ylg, 2yli, 3zqv, 3zqy, 3ztm, 3ztz, 3zwi, 4cda, 4cdv, 4cdy, 4cip, 4cjg, 4cjo, 4d4n, 4d4x, 4wgy, 4wgz, 5agf

HET: asc

CYH2_HUMAN_252_378 [text] Cytohesin-2

volume: 258. Å3; shape: 0.84; buriedness: 0.65

negative: 0.; positive: 0.63; polar: 0.16; backbone: 0.21; hydrophobic: 0.

Domains/regions: [D] PH, [R] Phosphatidylinositol 1,4,5-trisphosphate binding

PDB: 1u27, 1u29

HET: 4ip, i3p

CYH2_HUMAN_53_252 [text] Cytohesin-2

volume: 270. Å3; shape: 0.91; buriedness: 0.78

negative: 0.; positive: 0.; polar: 0.2; backbone: 0.39; hydrophobic: 0.41

Domains/regions: [D] SEC7

PDB: 1pbv, 1r8m, 1r8q, 1r8s, 1s9d, 4jmi, 4jmo, 4jwl, 4jxh, 4l5m, 4z21

HET: hrc, jaf

CYH3_HUMAN_258_394 [text] Cytohesin-3

volume: 278. Å3; shape: 0.91; buriedness: 0.78

negative: 0.; positive: 0.51; polar: 0.19; backbone: 0.24; hydrophobic: 0.06

Domains/regions: [D] PH, [R] Phosphatidylinositol 3,4,5-trisphosphate binding

PDB: 1fgy, 1fgz, 1fhw, 1fhx, 1u2b, 2r09, 2r0d, 4kax

HET: 4ip, i5p

CYH3_HUMAN_63_258 [text] Cytohesin-3

volume: 287. Å3; shape: 0.77; buriedness: 0.76

negative: 0.04; positive: 0.12; polar: 0.16; backbone: 0.29; hydrophobic: 0.39

Domains/regions: [D] SEC7, [R] C-terminal autoinhibitory region

PDB: 2r09, 2r0d

HET: pe5

CYP28_STRAW_10_402 [text] Pentalenic acid synthase [Cytochrome P450 family]

volume: 168. Å3; shape: 0.7; buriedness: 0.79

negative: 0.; positive: 0.12; polar: 0.12; backbone: 0.12; hydrophobic: 0.62

PDB: 4ubs

HET: dif

CYPA2_RHOPA_1_412 [text] Cytochrome p450 CYP199A2 [Cytochrome P450 family]

volume: 96. Å3; shape: 0.6; buriedness: 0.86

negative: 0.; positive: 0.06; polar: 0.28; backbone: 0.11; hydrophobic: 0.56

Domains/regions: [R] Substrate binding

PDB: 2fr7, 4dnj

HET: ann

CYPC_BACSU_1_417 [text] Fatty-acid peroxygenase [Cytochrome P450 family]

volume: 257. Å3; shape: 0.37; buriedness: 0.84

negative: 0.; positive: 0.06; polar: 0.; backbone: 0.3; hydrophobic: 0.63

PDB: 1izo, 2zqj, 2zqx

HET: pam

CYPC_STRCO_1_159 [text] Putative polyketide cyclase

volume: 160. Å3; shape: 0.61; buriedness: 0.93

negative: 0.; positive: 0.1; polar: 0.27; backbone: 0.; hydrophobic: 0.63

PDB: 3tl1, 3tvr

HET: jro

CYPX_BACSU_1_405 [text] Pulcherriminic acid synthase [Cytochrome P450 family]

volume: 94. Å3; shape: 0.58; buriedness: 0.82

negative: 0.17; positive: 0.; polar: 0.38; backbone: 0.17; hydrophobic: 0.28

PDB: 3nc3, 3nc5, 3nc6, 3nc7

HET: piw, piy

CYSK1_ARATH_2_322 [text] Cysteine synthase 1 [Cysteine synthase/cystathionine beta- synthase family]

volume: 902. Å3; shape: 0.38; buriedness: 0.88

negative: 0.; positive: 0.03; polar: 0.27; backbone: 0.51; hydrophobic: 0.19

Domains/regions: [R] Pyridoxal phosphate binding, [R] SAT1 binding, [R] SUTR1;2 binding

PDB: 1z7w, 1z7y, 2isq

HET: aa5, plp

CYSK_HAEIN_1_316 [text] Cysteine synthase [Cysteine synthase/cystathionine beta- synthase family]

volume: 990. Å3; shape: 0.64; buriedness: 0.79

negative: 0.; positive: 0.06; polar: 0.25; backbone: 0.48; hydrophobic: 0.21

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 1y7l, 3iqg, 3iqh, 3iqi, 4ho1, 4li3, 4nu8, 4ore, 4zu1, 4zu6, 5dbe, 5dbh

HET: oas, p1t, plp

CYSK_MYCTU_2_310 [text] O-acetylserine sulfhydrylase [Cysteine synthase/cystathionine beta- synthase family]

volume: 629. Å3; shape: 0.62; buriedness: 0.91

negative: 0.03; positive: 0.04; polar: 0.26; backbone: 0.46; hydrophobic: 0.21

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 2q3b, 2q3c, 2q3d, 3zei

HET: awh, pda, plp

CYSM_MYCTU_2_323 [text] O-phosphoserine sulfhydrylase [Cysteine synthase/cystathionine beta- synthase family]

volume: 241. Å3; shape: 0.38; buriedness: 0.8

negative: 0.; positive: 0.05; polar: 0.31; backbone: 0.52; hydrophobic: 0.12

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 3dki, 3dwg, 3dwi, 3fgp, 5i6d, 5i7a, 5i7h, 5i7o, 5i7r, 5iw8, 5iwc

HET: 68q, 68v, 68w, 6ec, 6eq, au6, s16

CYSO_AERPE_1_389 [text] Protein CysO [Cysteine synthase/cystathionine beta- synthase family]

volume: 252. Å3; shape: 0.95; buriedness: 0.97

negative: 0.03; positive: 0.06; polar: 0.3; backbone: 0.47; hydrophobic: 0.14

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 1wkv, 3vsa, 3vsc, 3vsd, 5b36, 5b3a

HET: oas, p1t, plp, sep

CYSP_TRYCR_123_337 [text] Cruzipain [Peptidase C1 family]

volume: 628. Å3; shape: 0.68; buriedness: 0.63

negative: 0.06; positive: 0.04; polar: 0.08; backbone: 0.53; hydrophobic: 0.29

PDB: 1aim, 1ewl, 1ewm, 1ewo, 1ewp, 1f29, 1f2a, 1f2b, 1f2c, 1me3, 1me4, 1u9q, 2aim, 2oz2, 3hd3, 3i06, 3iut, 3kku, 3lxs, 4klb, 4pi3, 4qh6, 4w5b, 4w5c, 4xui

HET: 0i5, 186, 1rv, 25b, 2v5, 2vc, 33l, 3h5, 3h6, 3h7, 4mc, b95, d1r, kb2, p10, ql2, r99, rl2, t10, vs1, vs2, vs3, vs4, vsc, z22, zra, zya

D14_ORYSJ_50_318 [text] Strigolactone esterase D14 [AB hydrolase superfamily]

volume: 216. Å3; shape: 0.42; buriedness: 0.96

negative: 0.; positive: 0.07; polar: 0.22; backbone: 0.22; hydrophobic: 0.48

PDB: 3vxk, 3w04, 3w05, 3wio, 4ih9, 4iha, 5dj5

HET: gr2, h3m, opl, pms

DAAA_BACYM_2_281 [text] D-alanine aminotransferase [Class-IV pyridoxal-phosphate-dependent aminotransferase family]

volume: 266. Å3; shape: 0.91; buriedness: 0.91

negative: 0.03; positive: 0.2; polar: 0.26; backbone: 0.41; hydrophobic: 0.11

PDB: 1a0g, 1daa, 1g2w, 2daa, 2dab, 3daa, 3lqs, 4daa, 5daa

HET: dcs, pdd, plp, pmp, psz

DAB1_MOUSE_24_178 [text] Disabled homolog 1

volume: 229. Å3; shape: 0.74; buriedness: 0.49

negative: 0.; positive: 0.75; polar: 0.; backbone: 0.25; hydrophobic: 0.

Domains/regions: [D] PID

PDB: 1ntv, 1nu2, 1oqn

HET: i3p

DAC_ACTSP_50_523 [text] D-alanyl-D-alanine carboxypeptidase [Peptidase S13 family]

volume: 324. Å3; shape: 0.57; buriedness: 0.74

negative: 0.05; positive: 0.1; polar: 0.3; backbone: 0.4; hydrophobic: 0.14

Domains/regions: [R] Absent in class-A beta-lactamases

PDB: 1w79, 1w8q, 1w8y, 2vgj, 2vgk, 2wke, 2xdm, 2xk1, 2xln, 2y4a, 2y55, 2y59, 3zcz, 3zvt, 3zvw, 4b4x, 4b4z, 4ben

HET: 33d, b07, bh6, biy, bo8, bsf, ewa, ewb, fp5, hqz, im2, ncf, rec, rez, tfr, za3

DACA_ECOLI_30_392 [text] D-alanyl-D-alanine carboxypeptidase DacA [Peptidase S11 family]

volume: 247. Å3; shape: 0.79; buriedness: 0.73

negative: 0.; positive: 0.19; polar: 0.31; backbone: 0.37; hydrophobic: 0.13

PDB: 1hd8, 1nj4, 1nzo, 1nzu, 1sdn, 1z6f, 3beb, 3bec, 3mzd, 3mze, 3mzf, 4drt, 5j8x

HET: bo9, cfx, cxv, hj2, hj3, im2, ok3

DACB_ECOLI_20_477 [text] D-alanyl-D-alanine carboxypeptidase DacB [Peptidase S13 family]

volume: 343. Å3; shape: 0.82; buriedness: 0.64

negative: 0.; positive: 0.07; polar: 0.27; backbone: 0.37; hydrophobic: 0.28

Domains/regions: [R] Absent in class-A beta-lactamases

PDB: 2ex2, 2ex6, 2ex8, 2ex9, 2exa, 2exb

HET: aic, fpm, fxm, pnm, pnv

DACB_HAEIN_27_479 [text] D-alanyl-D-alanine carboxypeptidase DacB [Peptidase S13 family]

volume: 307. Å3; shape: 0.64; buriedness: 0.7

negative: 0.05; positive: 0.06; polar: 0.35; backbone: 0.31; hydrophobic: 0.23

PDB: 3a3d, 3a3e, 3a3f, 3a3i

HET: aix, cmv, fmz

DACC_BACSU_30_491 [text] D-alanyl-D-alanine carboxypeptidase DacC [Peptidase S13 family]

volume: 165. Å3; shape: 0.46; buriedness: 0.82

negative: 0.06; positive: 0.1; polar: 0.24; backbone: 0.43; hydrophobic: 0.18

Domains/regions: [R] Substrate binding

PDB: 1w5d, 2j9p

HET: rez

DACC_ECOLI_27_378 [text] D-alanyl-D-alanine carboxypeptidase DacC [Peptidase S11 family]

volume: 872. Å3; shape: 0.49; buriedness: 0.39

negative: 0.; positive: 0.12; polar: 0.34; backbone: 0.44; hydrophobic: 0.09

PDB: 3it9, 3ita, 3itb

HET: aix, amv, dal, fga

DAC_STRSR_32_380 [text] D-alanyl-D-alanine carboxypeptidase [Peptidase S12 family]

volume: 455. Å3; shape: 0.59; buriedness: 0.71

negative: 0.; positive: 0.13; polar: 0.38; backbone: 0.35; hydrophobic: 0.14

Domains/regions: [R] Substrate binding

PDB: 1cef, 1ceg, 1hvb, 1ikg, 1iki, 1mpl, 1pw1, 1pw8, 1pwc, 1pwd, 1pwg, 1scw, 1sde, 1yqs, 3pte

HET: 2pb, bsa, cef, ceh, cep, cp5, csc, dal, h2a, he0, hel, pnm, re1, rex, rey

DAPAT_ARATH_36_461 [text] LL-diaminopimelate aminotransferase, chloroplastic [Class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily]

volume: 269. Å3; shape: 0.84; buriedness: 0.98

negative: 0.04; positive: 0.15; polar: 0.38; backbone: 0.21; hydrophobic: 0.21

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 2z1z, 2z20, 3ei5, 3ei6, 3ei7, 3ei8, 3ei9, 3eia, 3eib

HET: mlt, pgu, pl4, pl5, pl6, plp

DAPB_ECOLI_1_273 [text] 4-hydroxy-tetrahydrodipicolinate reductase [DapB family]

volume: 106. Å3; shape: 0.73; buriedness: 0.82

negative: 0.; positive: 0.38; polar: 0.24; backbone: 0.38; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 1arz, 1dih, 1dru, 1drv, 1drw

HET: pdc

DAPB_MYCTU_1_245 [text] 4-hydroxy-tetrahydrodipicolinate reductase [DapB family]

volume: 91. Å3; shape: 0.7; buriedness: 0.85

negative: 0.; positive: 0.29; polar: 0.25; backbone: 0.37; hydrophobic: 0.09

Domains/regions: [R] Substrate binding

PDB: 1c3v, 1p9l, 1yl5, 1yl6, 1yl7

HET: pdc

DAPDH_CORGL_1_320 [text] Meso-diaminopimelate D-dehydrogenase [Diaminopimelate dehydrogenase family]

volume: 131. Å3; shape: 0.62; buriedness: 0.88

negative: 0.09; positive: 0.16; polar: 0.28; backbone: 0.26; hydrophobic: 0.21

PDB: 1dap, 1f06, 2dap, 3dap

HET: 2np, api, da3

DAPDH_URETH_1_326 [text] Meso-diaminopimelate D-dehydrogenase [Diaminopimelate dehydrogenase family]

volume: 128. Å3; shape: 0.62; buriedness: 0.73

negative: 0.; positive: 0.33; polar: 0.27; backbone: 0.13; hydrophobic: 0.27

PDB: 3wyb, 3wyc

HET: nes

DAPD_YERPE_1_270 [text] 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [Transferase hexapeptide repeat family]

volume: 129. Å3; shape: 0.48; buriedness: 0.95

negative: 0.11; positive: 0.23; polar: 0.21; backbone: 0.18; hydrophobic: 0.26

PDB: 1kgq, 1kgt, 1tdt, 2tdt, 3gos, 3tdt

HET: 26p, npi, pml

DAPE_NEIMB_1_381 [text] Succinyl-diaminopimelate desuccinylase [Peptidase M20A family. DapE subfamily]

volume: 125. Å3; shape: 0.68; buriedness: 0.73

negative: 0.49; positive: 0.; polar: 0.11; backbone: 0.27; hydrophobic: 0.13

PDB: 1vgy, 4o23, 4ppz, 4pqa

HET: x8z

DAPF_ARATH_52_362 [text] Diaminopimelate epimerase, chloroplastic [Diaminopimelate epimerase family]

volume: 141. Å3; shape: 0.49; buriedness: 0.99

negative: 0.05; positive: 0.05; polar: 0.3; backbone: 0.4; hydrophobic: 0.2

Domains/regions: [R] Substrate binding

PDB: 3ejx, 3ekm

HET: zdp, zdr

DAPF_HAEIN_1_274 [text] Diaminopimelate epimerase [Diaminopimelate epimerase family]

volume: 137. Å3; shape: 0.49; buriedness: 1.

negative: 0.06; positive: 0.06; polar: 0.31; backbone: 0.47; hydrophobic: 0.1

Domains/regions: [R] Substrate binding

PDB: 1bwz, 1gqz, 2gke, 2gkj, 2q9h, 2q9j

HET: zdp, zdr

DAPK1_HUMAN_1_289 [text] Death-associated protein kinase 1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily]

volume: 395. Å3; shape: 0.94; buriedness: 0.88

negative: 0.13; positive: 0.05; polar: 0.; backbone: 0.4; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 1ig1, 1jkk, 1jkl, 1jks, 1jkt, 1p4f, 1wvw, 1wvx, 1wvy, 2w4j, 2w4k, 2x0g, 2xuu, 2xzs, 2y0a, 2y4p, 2yak, 3dfc, 3dgk, 3eh9, 3eha, 3f5g, 3f5u, 3gu4, 3gu5, 3gu6, 3gu7, 3gu8, 3gub, 3zxt, 4b4l, 4pf4, 4tl0, 4txc, 4uv0, 4yo4, 4ypd, 5aut, 5auu, 5auv, 5auw, 5aux, 5auy, 5auz, 5av0, 5av1, 5av2, 5av3, 5av4

HET: 1pe, 2an, 38g, 3gu, 47x, 4ft, acp, adp, agi, anp, bd4, dkg, drg, gen, gub, kmp, lu2, mg, mn, mri, osv, pge, que, stu

DAPK2_HUMAN_10_297 [text] Death-associated protein kinase 2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily]

volume: 234. Å3; shape: 0.61; buriedness: 0.82

negative: 0.08; positive: 0.; polar: 0.; backbone: 0.39; hydrophobic: 0.53

Domains/regions: [D] Protein kinase

PDB: 1zws, 2a27, 2a2a, 2cke, 2ya9, 2yaa, 2yab

HET: amp, atp, iqu

DAPK3_HUMAN_7_287 [text] Death-associated protein kinase 3 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily]

volume: 286. Å3; shape: 0.82; buriedness: 0.85

negative: 0.; positive: 0.07; polar: 0.; backbone: 0.41; hydrophobic: 0.52

Domains/regions: [D] Protein kinase, [R] Activation segment

PDB: 1yrp, 2j90, 3bhy, 3bqr, 5a6n, 5a6o

HET: 4rb, 7cp, cl, iza, u7e

DAPP1_HUMAN_148_273 [text] Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

volume: 264. Å3; shape: 0.9; buriedness: 0.67

negative: 0.; positive: 0.38; polar: 0.15; backbone: 0.31; hydrophobic: 0.15

Domains/regions: [D] PH

PDB: 1fao, 1fb8

HET: 4ip

DBP5_YEAST_295_482 [text] ATP-dependent RNA helicase DBP5 [DEAD box helicase family. DDX19/DBP5 subfamily]

volume: 403. Å3; shape: 0.79; buriedness: 0.82

negative: 0.05; positive: 0.13; polar: 0.13; backbone: 0.45; hydrophobic: 0.24

Domains/regions: [D] Helicase ATP-binding, [D] Helicase C-terminal

PDB: 3gfp, 3peu, 3pev, 3pew, 3pey, 3rrm, 5elx

HET: adp, m2a, mg

DBR2_ARTAN_1_387 [text] Artemisinic aldehyde Delta(11(13)) reductase [NADH:flavin oxidoreductase/NADH oxidase family]

volume: 281. Å3; shape: 0.7; buriedness: 0.87

negative: 0.; positive: 0.2; polar: 0.15; backbone: 0.4; hydrophobic: 0.25

Domains/regions: [R] Substrate-binding

PDB: 5dxx, 5dxy, 5dy2, 5dy3

HET: fmn

DBR_TOBAC_1_343 [text] 2-alkenal reductase (NADP(+)-dependent) [NADP-dependent oxidoreductase L4BD family]

volume: 121. Å3; shape: 0.61; buriedness: 0.75

negative: 0.; positive: 0.; polar: 0.38; backbone: 0.; hydrophobic: 0.62

PDB: 4hfj, 4hfm, 4hfn

HET: ciy

DCAM_HUMAN_1_332 [text] S-adenosylmethionine decarboxylase proenzyme [Eukaryotic AdoMetDC family]

volume: 297. Å3; shape: 0.77; buriedness: 0.66

negative: 0.07; positive: 0.06; polar: 0.14; backbone: 0.5; hydrophobic: 0.22

PDB: 1i72, 1i79, 1i7b, 1i7c, 1i7m, 1jen, 1jl0, 1msv, 3dz2, 3dz3, 3dz4, 3dz5, 3dz6, 3dz7, 3ep3, 3ep4, 3ep5, 3ep6, 3ep7, 3ep8, 3ep9, 3epa, 3epb, 3h0v, 3h0w

HET: a8m, c8m, cg, m2t, m8e, m8m, mao, mgb, mhz, n8m, o8m, pyr, smm

DCAS_RHIRD_1_304 [text] N-carbamoyl-D-amino acid hydrolase

volume: 398. Å3; shape: 0.17; buriedness: 0.91

negative: 0.12; positive: 0.24; polar: 0.18; backbone: 0.24; hydrophobic: 0.23

Domains/regions: [D] CN hydrolase

PDB: 1erz, 1fo6, 1uf4, 1uf5, 1uf7, 1uf8, 2ggk, 2ggl

HET: cdt, cdv, ing

DCE1_HUMAN_92_594 [text] Glutamate decarboxylase 1 [Group II decarboxylase family]

volume: 258. Å3; shape: 0.73; buriedness: 0.99

negative: 0.04; positive: 0.16; polar: 0.19; backbone: 0.35; hydrophobic: 0.26

Domains/regions: [R] Substrate binding

PDB: 2okj, 3vp6

HET: abu, hld, plp, plz

DCIP_AZOBR_2_545_allosteric [text] Indole-3-pyruvate decarboxylase [TPP enzyme family]

volume: 140. Å3; shape: 0.58; buriedness: 0.98

negative: 0.; positive: 0.26; polar: 0.; backbone: 0.5; hydrophobic: 0.24

Domains/regions: [R] Thiamine pyrophosphate binding

PDB: 2nxw, 2q5j, 2q5l, 2q5o, 2q5q

HET: kpv, ppy

DCIP_AZOBR_2_545_catalytic [text] Indole-3-pyruvate decarboxylase [TPP enzyme family]

volume: 448. Å3; shape: 0.79; buriedness: 0.97

negative: 0.14; positive: 0.; polar: 0.07; backbone: 0.51; hydrophobic: 0.28

Domains/regions: [R] Thiamine pyrophosphate binding

PDB: 2nxw, 2q5j, 2q5l, 2q5o, 2q5q

HET: kpv, ppy, r1t, s1t, tpp, tpw

DCK_HUMAN_3_260 [text] Deoxycytidine kinase [DCK/DGK family]

volume: 715. Å3; shape: 0.67; buriedness: 0.93

negative: 0.13; positive: 0.09; polar: 0.14; backbone: 0.24; hydrophobic: 0.4

PDB: 1p5z, 1p60, 1p61, 1p62, 2a2z, 2a30, 2a7q, 2no0, 2no1, 2no6, 2no7, 2no9, 2noa, 2qrn, 2qro, 2zi3, 2zi4, 2zi5, 2zi6, 2zi7, 2zi9, 2zia, 3hp1, 3ipx, 3ipy, 3kfx, 3mjr, 3qej, 3qen, 3qeo, 4jlj, 4jlk, 4jlm, 4jln, 4kcg, 4l5b, 4q18, 4q19, 4q1a, 4q1b, 4q1c, 4q1d, 4q1e, 4q1f

HET: 18v, 1nm, 1nn, 1no, 1qc, 1ux, 2xj, 2xl, 2xm, 2xn, 2xz, 2y0, 2y1, 2y7, 2y8, 3d1, 3l1, 3tc, 5bt, ac2, ar3, b86, b87, cfb, cl9, d5m, dcm, dcz, etv, geo, gng, ldc, llt, ltt, mcy, mg, mlt

DCLK1_HUMAN_370_649 [text] Serine/threonine-protein kinase DCLK1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 449. Å3; shape: 0.67; buriedness: 0.77

negative: 0.13; positive: 0.05; polar: 0.05; backbone: 0.4; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 5jzj, 5jzn

HET: an2, gui

DCMC_HUMAN_38_492 [text] Malonyl-CoA decarboxylase, mitochondrial

volume: 253. Å3; shape: 0.43; buriedness: 0.83

negative: 0.; positive: 0.08; polar: 0.11; backbone: 0.43; hydrophobic: 0.38

Domains/regions: [R] Catalytic domain, [R] Malonyl-CoA binding

PDB: 2ygw, 4f0x

HET: 0or

DCOR_TRYBB_1_423 [text] Ornithine decarboxylase [Orn/Lys/Arg decarboxylase class-II family]

volume: 247. Å3; shape: 0.84; buriedness: 0.93

negative: 0.21; positive: 0.23; polar: 0.1; backbone: 0.34; hydrophobic: 0.12

PDB: 1f3t, 1njj, 1qu4, 1szr, 2tod

HET: dmo, orx, plg, plp, put, pxp

DCPS_HUMAN_37_337 [text] m7GpppX diphosphatase [HIT family]

volume: 549. Å3; shape: 0.71; buriedness: 0.78

negative: 0.1; positive: 0.27; polar: 0.11; backbone: 0.27; hydrophobic: 0.26

Domains/regions: [R] Substrate binding

PDB: 1st0, 1st4, 1xml, 1xmm, 3bl7, 3bl9, 3bla, 4qde, 4qdv, 4qeb

HET: 30s, 30u, 31g, dd1, dd2, dd3, g7m, gta, gtg, m7g, po4

DCS1_GOSAR_1_554 [text] (+)-delta-cadinene synthase isozyme XC1 [Terpene synthase family]

volume: 271. Å3; shape: 0.45; buriedness: 0.78

negative: 0.38; positive: 0.08; polar: 0.18; backbone: 0.18; hydrophobic: 0.18

PDB: 3g4d, 3g4f

HET: fpf

DCSD_STRLA_1_324 [text] O-ureido-L-serine synthase [Cysteine synthase/cystathionine beta- synthase family]

volume: 237. Å3; shape: 0.89; buriedness: 0.95

negative: 0.05; positive: 0.03; polar: 0.32; backbone: 0.41; hydrophobic: 0.2

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 3x43, 3x44

HET: plp, pus

DCTP_DESAG_28_340 [text] Solute-binding protein Dde_0634 [Bacterial solute-binding protein 7 family]

volume: 128. Å3; shape: 0.74; buriedness: 1.

negative: 0.07; positive: 0.07; polar: 0.48; backbone: 0.; hydrophobic: 0.38

Domains/regions: [R] Indole-3-acetate binding

PDB: 4nap, 4pgn, 4pgp

HET: 3io, dtr, iac

DCUP_HUMAN_2_367 [text] Uroporphyrinogen decarboxylase [Uroporphyrinogen decarboxylase family]

volume: 547. Å3; shape: 0.84; buriedness: 0.83

negative: 0.03; positive: 0.11; polar: 0.09; backbone: 0.38; hydrophobic: 0.4

Domains/regions: [R] Substrate binding

PDB: 1jph, 1jpi, 1jpk, 1r3q, 1r3r, 1r3s, 1r3t, 1r3v, 1r3w, 1r3y, 1uro, 2q6z, 2q71, 3gvq, 3gvr, 3gvv, 3gvw, 3gw0, 3gw3

HET: 1cp, cp3

DCYD_SALTY_1_328 [text] D-cysteine desulfhydrase [ACC deaminase/D-cysteine desulfhydrase family]

volume: 227. Å3; shape: 0.93; buriedness: 0.96

negative: 0.; positive: 0.1; polar: 0.34; backbone: 0.51; hydrophobic: 0.04

PDB: 4d8t, 4d8u, 4d8w, 4d92, 4d96, 4d97, 4d99, 4d9b, 4d9c, 4d9e, 4d9f

HET: 5pa, dcs, dsn, lcs, pmp

DDAH1_HUMAN_2_285 [text] N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [DDAH family]

volume: 166. Å3; shape: 0.49; buriedness: 0.97

negative: 0.23; positive: 0.23; polar: 0.06; backbone: 0.27; hydrophobic: 0.21

Domains/regions: [R] Substrate binding

PDB: 2c6z, 2ci1, 2ci3, 2ci4, 2ci5, 2ci6, 2ci7, 2jai, 2jaj, 3i2e, 3i4a, 3p8e, 3p8p

HET: cir, d20, hcs, ln5, ln6, ln7, zn

DDAH_PSEAE_1_254 [text] N(G),N(G)-dimethylarginine dimethylaminohydrolase [DDAH family]

volume: 147. Å3; shape: 0.53; buriedness: 0.89

negative: 0.25; positive: 0.16; polar: 0.01; backbone: 0.38; hydrophobic: 0.19

Domains/regions: [R] Substrate binding

PDB: 1h70, 3bpb, 3rhy

HET: cir, hm3, smz

DDLB_ECOLI_1_306 [text] D-alanine--D-alanine ligase B [D-alanine--D-alanine ligase family]

volume: 345. Å3; shape: 0.41; buriedness: 0.98

negative: 0.18; positive: 0.18; polar: 0.18; backbone: 0.31; hydrophobic: 0.17

Domains/regions: [D] ATP-grasp

PDB: 1iov, 1iow, 2dln, 4c5a, 4c5b, 4c5c

HET: adp, atp, dal, ds0, phy, pob

DDL_STAAC_1_356 [text] D-alanine--D-alanine ligase [D-alanine--D-alanine ligase family]

volume: 139. Å3; shape: 0.44; buriedness: 0.97

negative: 0.; positive: 0.; polar: 0.; backbone: 0.48; hydrophobic: 0.52

Domains/regions: [D] ATP-grasp

PDB: 2i80, 2i87, 2i8c, 3n8d

HET: g1l

DDR1_HUMAN_598_913 [text] Epithelial discoidin domain-containing receptor 1 [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 590. Å3; shape: 0.43; buriedness: 0.9

negative: 0.07; positive: 0.07; polar: 0.07; backbone: 0.33; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 3zos, 4bkj, 4ckr, 5bvk, 5bvn, 5bvo, 5bvw, 5fdp, 5fdx

HET: 0li, 1n1, 4vc, 4vd, 4ve, 5wr, 5x1, di1, sti

DEF1A_ARATH_78_268 [text] Peptide deformylase 1A, chloroplastic/mitochondrial [Polypeptide deformylase family]

volume: 268. Å3; shape: 0.68; buriedness: 0.83

negative: 0.12; positive: 0.23; polar: 0.05; backbone: 0.38; hydrophobic: 0.22

Domains/regions: [R] Dimerization, [R] Substrate binding

PDB: 1zxz, 1zy0, 1zy1, 4je6, 4je7, 4je8

HET: bb2

DEF1_BACCR_1_156 [text] Peptide deformylase 1 [Polypeptide deformylase family]

volume: 266. Å3; shape: 0.64; buriedness: 0.81

negative: 0.1; positive: 0.15; polar: 0.1; backbone: 0.45; hydrophobic: 0.2

PDB: 1ws0, 1ws1

HET: bb2

DEF1B_ARATH_80_272_actinonin [text] Peptide deformylase 1B, chloroplastic/mitochondrial [Polypeptide deformylase family]

volume: 293. Å3; shape: 0.65; buriedness: 0.84

negative: 0.11; positive: 0.16; polar: 0.09; backbone: 0.45; hydrophobic: 0.2

PDB: 3cpm, 3m6o, 3m6p, 3m6q, 3m6r, 3o3j, 3pn2, 3pn3, 3pn4, 3pn5, 3pn6

HET: bb2, bb4, zn

DEF1B_ARATH_80_272_pn3 [text] Peptide deformylase 1B, chloroplastic/mitochondrial [Polypeptide deformylase family]

volume: 181. Å3; shape: 0.86; buriedness: 0.44

negative: 0.; positive: 0.18; polar: 0.17; backbone: 0.34; hydrophobic: 0.31

PDB: 3cpm, 3m6o, 3m6p, 3m6q, 3m6r, 3o3j, 3pn2, 3pn3, 3pn4, 3pn5, 3pn6

HET: pn3

DEF_ECOLI_2_168 [text] Peptide deformylase [Polypeptide deformylase family]

volume: 373. Å3; shape: 0.8; buriedness: 0.78

negative: 0.1; positive: 0.14; polar: 0.05; backbone: 0.47; hydrophobic: 0.24

PDB: 1bs4, 1bs5, 1bs6, 1bs7, 1bs8, 1bsj, 1bsk, 1bsz, 1dff, 1g27, 1g2a, 1icj, 1lru, 1xem, 1xen, 1xeo, 2ai8, 2w3t, 2w3u, 3k6l, 4al2, 4al3, 4az4

HET: 2bb, 2pe, bb1, bb2, mln, sb7

DEF_ENTFA_1_187 [text] Peptide deformylase [Polypeptide deformylase family]

volume: 249. Å3; shape: 0.72; buriedness: 0.82

negative: 0.11; positive: 0.13; polar: 0.09; backbone: 0.4; hydrophobic: 0.27

PDB: 2os0, 2os1

HET: bb2

DEF_HAEI8_1_169 [text] Peptide deformylase [Polypeptide deformylase family]

volume: 303. Å3; shape: 0.8; buriedness: 0.81

negative: 0.09; positive: 0.14; polar: 0.05; backbone: 0.51; hydrophobic: 0.21

PDB: 4wxk, 4wxl

HET: bb2

DEF_LEPIN_2_178 [text] Peptide deformylase [Polypeptide deformylase family]

volume: 268. Å3; shape: 0.79; buriedness: 0.9

negative: 0.09; positive: 0.15; polar: 0.16; backbone: 0.4; hydrophobic: 0.2

PDB: 1sv2, 1szz, 1vev, 1vey, 1vez, 1y6h

HET: bb2, dtt

DEFM_HUMAN_62_243 [text] Peptide deformylase, mitochondrial [Polypeptide deformylase family]

volume: 293. Å3; shape: 0.62; buriedness: 0.8

negative: 0.14; positive: 0.17; polar: 0.05; backbone: 0.39; hydrophobic: 0.25

Domains/regions: [R] Hydrophobic dimerization interface

PDB: 3g5k, 3g5p

HET: bb2

DEF_PSEAE_1_168 [text] Peptide deformylase [Polypeptide deformylase family]

volume: 250. Å3; shape: 0.67; buriedness: 0.82

negative: 0.11; positive: 0.11; polar: 0.13; backbone: 0.41; hydrophobic: 0.24

PDB: 1ix1, 1lry, 1n5n, 1s17

HET: bb2, gnr

DEF_STAAU_1_183 [text] Peptide deformylase [Polypeptide deformylase family]

volume: 327. Å3; shape: 0.59; buriedness: 0.8

negative: 0.11; positive: 0.16; polar: 0.17; backbone: 0.39; hydrophobic: 0.17

PDB: 1lm4, 1lmh, 1lqw, 1q1y, 2ai9, 3u7k, 3u7l, 3u7m, 3u7n

HET: bb2, fhf, mdb, udb, uhf

DEF_STRPN_1_203 [text] Peptide deformylase [Polypeptide deformylase family]

volume: 377. Å3; shape: 0.79; buriedness: 0.84

negative: 0.13; positive: 0.09; polar: 0.09; backbone: 0.44; hydrophobic: 0.25

PDB: 1lm6, 2ai7, 2aia, 2aie, 3str, 3svj, 3sw8, 4eox

HET: 0s5, 3li, 4li, 5li, sb7, sb8, sb9

DEOC_ECOLI_1_258 [text] Deoxyribose-phosphate aldolase [DeoC/FbaB aldolase family. DeoC type 2 subfamily]

volume: 173. Å3; shape: 0.4; buriedness: 0.92

negative: 0.09; positive: 0.14; polar: 0.06; backbone: 0.31; hydrophobic: 0.41

PDB: 1jcj, 1jcl, 1ktn, 1p1x, 3npu, 3npv, 3npw, 3npx, 3nq2, 3nq8, 3nqv, 3nr0, 3q2d, 5eky, 5el1, 5emu

HET: 3ny, ben, bu2, hpd

DEOD1_VIBCH_1_241 [text] Purine nucleoside phosphorylase DeoD-type 1 [PNP/UDP phosphorylase family]

volume: 163. Å3; shape: 0.61; buriedness: 0.91

negative: 0.07; positive: 0.22; polar: 0.05; backbone: 0.37; hydrophobic: 0.29

Domains/regions: [R] Phosphate binding, [R] Purine nucleoside binding

PDB: 1vhj, 1vhw, 3of3

HET: adn, dih

DEOD_BACSU_2_233 [text] Purine nucleoside phosphorylase DeoD-type [PNP/UDP phosphorylase family]

volume: 191. Å3; shape: 0.68; buriedness: 0.82

negative: 0.17; positive: 0.06; polar: 0.12; backbone: 0.38; hydrophobic: 0.28

Domains/regions: [R] Phosphate binding, [R] Purine nucleoside binding

PDB: 4d8v, 4d8x, 4d8y, 4d98, 4d9h, 4da0, 4da6, 4da7, 4da8, 4dab, 4dae, 4dan, 4dao, 4dar

HET: 2fa, 6cr, ac2, ade, adn, bg2, ga2, gng, hpa, tbn

DEOD_ECOLI_2_238 [text] Purine nucleoside phosphorylase DeoD-type [PNP/UDP phosphorylase family]

volume: 202. Å3; shape: 0.62; buriedness: 0.9

negative: 0.16; positive: 0.17; polar: 0.09; backbone: 0.35; hydrophobic: 0.22

Domains/regions: [R] Phosphate binding, [R] Purine nucleoside binding

PDB: 1a69, 1ecp, 1k9s, 1otx, 1oty, 1ou4, 1oum, 1ov6, 1ovg, 1pk7, 1pk9, 1pke, 1pr0, 1pr1, 1pr2, 1pr4, 1pr5, 1pr6, 1pw7, 3occ, 3onv, 3ooe, 3ooh, 3opv, 3ut6, 4rj2, 4ts3, 4ts9, 4tta, 4tti, 4ttj

HET: 2fa, 2fd, 6mp, adn, dbm, dih, fm1, fm2, fmb, fmc, mdr, mtp, nos, rab, tal, tbn, xya

DEOR_BACSU_55_313 [text] Deoxyribonucleoside regulator [SorC transcriptional regulatory family]

volume: 168. Å3; shape: 0.7; buriedness: 0.78

negative: 0.06; positive: 0.17; polar: 0.34; backbone: 0.38; hydrophobic: 0.04

PDB: 4oqp, 4oqq

HET: bcn, ped

DESV_STRVZ_1_379 [text] dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase [DegT/dnrJ/eryC1 family]

volume: 199. Å3; shape: 0.83; buriedness: 0.96

negative: 0.07; positive: 0.14; polar: 0.47; backbone: 0.19; hydrophobic: 0.14

Domains/regions: [R] Pyridoxal phosphate binding

PDB: 2oga, 2oge

HET: pgu, plp

DFPA_LOLVU_2_314 [text] Diisopropyl-fluorophosphatase

volume: 138. Å3; shape: 0.6; buriedness: 0.86

negative: 0.27; positive: 0.11; polar: 0.23; backbone: 0.; hydrophobic: 0.38

PDB: 1e1a, 1pjx, 2gvu, 2gvv, 2gvw, 2gvx, 2iao, 2iap, 2iaq, 2iar, 2ias, 2iat, 2iau, 2iav, 2iaw, 2iax, 3byc, 3hlh, 3hli, 3i1c, 3kgg, 3li3, 3li4, 3li5, 3o4p, 3u0s

HET: di9

DFRA_VITVI_1_337 [text] Dihydroflavonol 4-reductase [NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily]

volume: 197. Å3; shape: 0.51; buriedness: 0.8

negative: 0.; positive: 0.; polar: 0.38; backbone: 0.39; hydrophobic: 0.24

PDB: 2c29, 2iod, 2nnl, 3bxx, 3c1t

HET: dqh, erd, myc, que

DGDA_BURCE_1_433 [text] 2,2-dialkylglycine decarboxylase [Class-III pyridoxal-phosphate-dependent aminotransferase family]

volume: 245. Å3; shape: 0.89; buriedness: 0.8

negative: 0.12; positive: 0.12; polar: 0.28; backbone: 0.3; hydrophobic: 0.18

PDB: 1d7r, 1d7s, 1d7u, 1d7v, 1dgd, 1dge, 1dka, 1m0n, 1m0o, 1m0p, 1m0q, 1z3z, 1zc9, 1zob, 1zod, 2dkb

HET: 5pa, dcs, elp, epc, hcp, lcs, mpm, nma, plp, pmp

DGOA_ECOLI_1_205 [text] 2-dehydro-3-deoxy-6-phosphogalactonate aldolase [KHG/KDPG aldolase family]

volume: 122. Å3; shape: 0.39; buriedness: 0.86

negative: 0.; positive: 0.11; polar: 0.11; backbone: 0.52; hydrophobic: 0.26

Domains/regions: [R] Substrate binding

PDB: 2v81, 2v82

HET: kdp

DHAA_RHORH_1_293 [text] Haloalkane dehalogenase [Haloalkane dehalogenase family. Type 2 subfamily]

volume: 197. Å3; shape: 0.64; buriedness: 1.

negative: 0.06; positive: 0.04; polar: 0.12; backbone: 0.23; hydrophobic: 0.55

Domains/regions: [D] AB hydrolase-1

PDB: 1bn6, 1bn7, 1cqw, 2v9z, 3fbw, 3fwh, 3g9x, 3rk4, 3sk0, 4e46, 4f5z, 4f60, 4fwb, 4hzg, 4kaa, 4kac, 4kaf, 4kaj, 4kyv, 4wcv

HET: 1q9, 3kp, bez, cl, na, pge

DHAK_ECOLI_1_356 [text] PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK

volume: 99. Å3; shape: 0.61; buriedness: 0.93

negative: 0.09; positive: 0.23; polar: 0.11; backbone: 0.57; hydrophobic: 0.

Domains/regions: [D] DhaK, [R] Substrate binding

PDB: 1oi2, 1oi3, 1uod, 1uoe, 3pnk, 3pnl, 3pnm, 3pno, 3pnq, 4lrx, 4lry

HET: 2ha, g3h

DHAS1_VIBCH_1_370 [text] Aspartate-semialdehyde dehydrogenase 1 [Aspartate-semialdehyde dehydrogenase family]

volume: 867. Å3; shape: 0.42; buriedness: 0.69

negative: 0.03; positive: 0.13; polar: 0.2; backbone: 0.47; hydrophobic: 0.17

PDB: 1mb4, 1mc4, 3pzr, 3q0e, 4r5m

HET: 4no, nap, ndp

DHB14_HUMAN_1_270 [text] 17-beta-hydroxysteroid dehydrogenase 14 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 236. Å3; shape: 0.62; buriedness: 0.8

negative: 0.; positive: 0.14; polar: 0.54; backbone: 0.14; hydrophobic: 0.18

PDB: 1yde, 5en4, 5hs6, 5icm, 5ics, 5js6, 5jsf

HET: 5q6, f45, j3z

DHB1_HUMAN_2_290 [text] Estradiol 17-beta-dehydrogenase 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 554. Å3; shape: 0.24; buriedness: 0.89

negative: 0.04; positive: 0.06; polar: 0.18; backbone: 0.3; hydrophobic: 0.42

PDB: 1a27, 1bhs, 1dht, 1equ, 1fds, 1fdt, 1fdu, 1fdv, 1fdw, 1i5r, 1iol, 1jtv, 1qyv, 1qyw, 1qyx, 3dey, 3dhe, 3hb4, 3hb5, 3klm, 3klp, 3km0

HET: 5sd, and, aom, asd, b81, dht, e2b, eqi, est, hyc, nad, nap, tes

DHBE_BACSU_1_539 [text] 2,3-dihydroxybenzoate-AMP ligase [ATP-dependent AMP-binding enzyme family]

volume: 313. Å3; shape: 0.86; buriedness: 0.94

negative: 0.04; positive: 0.17; polar: 0.16; backbone: 0.45; hydrophobic: 0.17

Domains/regions: [R] Substrate binding

PDB: 1md9, 1mdb, 1mdf

HET: amp, dbh

DHDH_MACFA_1_334 [text] Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [Gfo/Idh/MocA family]

volume: 104. Å3; shape: 0.62; buriedness: 0.73

negative: 0.15; positive: 0.15; polar: 0.; backbone: 0.31; hydrophobic: 0.38

PDB: 2o48, 2o4u, 2poq, 3ohs

HET: 2ha, ac6, isd

DHE3_HUMAN_59_558 [text] Glutamate dehydrogenase 1, mitochondrial [Glu/Leu/Phe/Val dehydrogenases family]

volume: 445. Å3; shape: 0.74; buriedness: 0.41

negative: 0.22; positive: 0.52; polar: 0.; backbone: 0.; hydrophobic: 0.26

PDB: 1hwy, 1hwz, 1l1f, 1nr1, 3etd, 3ete, 3etg, 3jcz, 3jd0, 3jd1, 3jd2, 3jd4, 3mvo, 3mvq, 3mw9, 5k12

HET: b1t, gwd

DHGB_ACICA_25_478 [text] Quinoprotein glucose dehydrogenase B [PQQ oxidoreductase GdhB family]

volume: 233. Å3; shape: 0.71; buriedness: 0.86

negative: 0.; positive: 0.31; polar: 0.35; backbone: 0.16; hydrophobic: 0.18

Domains/regions: [R] PQQ

PDB: 1c9u, 1cq1, 1cru, 1qbi

HET: hdn, pqq

DHI1_CAVPO_25_296 [text] Corticosteroid 11-beta-dehydrogenase isozyme 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 240. Å3; shape: 0.58; buriedness: 0.9

negative: 0.; positive: 0.; polar: 0.36; backbone: 0.4; hydrophobic: 0.24

PDB: 1xse, 3dwf, 3g49, 3lz6

HET: 3g4, a0d

DHI1_HUMAN_22_291 [text] Corticosteroid 11-beta-dehydrogenase isozyme 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 494. Å3; shape: 0.65; buriedness: 0.89

negative: 0.; positive: 0.; polar: 0.24; backbone: 0.34; hydrophobic: 0.42

PDB: 1xu7, 1xu9, 2bel, 2ilt, 2irw, 2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3fco, 3frj, 3h6k, 3hfg, 3oq1, 3pdj, 3qqp, 3tfq, 4bb5, 4bb6, 4c7j, 4c7k, 4hfr, 4hx5, 4iju, 4ijv, 4ijw, 4k1l, 4p38, 4yyz

HET: 07m, 14m, 17r, 19v, 1en, 1eo, 1eq, 21t, 311, 33t, 352, 3cz, 3oq, 3pj, 4jx, 4yq, a21, a49, cbo, cps, d3e, d4n, dzl, h11, hd1, hd2, iig, nn1, nn4, s05, sff, t30, zmg

DHI1_MOUSE_25_291 [text] Corticosteroid 11-beta-dehydrogenase isozyme 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 279. Å3; shape: 0.53; buriedness: 0.88

negative: 0.02; positive: 0.; polar: 0.38; backbone: 0.31; hydrophobic: 0.29

PDB: 1y5m, 1y5r, 3gmd, 4k26, 4nmh

HET: 2kg, 2m3, c0r, oct, sff

DHOM_YEAST_2_359 [text] Homoserine dehydrogenase [Homoserine dehydrogenase family]

volume: 631. Å3; shape: 0.38; buriedness: 0.68

negative: 0.11; positive: 0.05; polar: 0.14; backbone: 0.52; hydrophobic: 0.17

PDB: 1ebf, 1ebu, 1q7g, 1tve

HET: 178, hse, nad, nda, nho

DHPH_RHOSO_2_356 [text] Phenylalanine dehydrogenase [Glu/Leu/Phe/Val dehydrogenases family]

volume: 117. Å3; shape: 0.6; buriedness: 0.93

negative: 0.; positive: 0.17; polar: 0.04; backbone: 0.42; hydrophobic: 0.37

Domains/regions: [R] Substrate binding

PDB: 1bw9, 1bxg, 1c1d, 1c1x

HET: hci, hfa, ppy

DHPS_ECOLI_1_282 [text] Dihydropteroate synthase [DHPS family]

volume: 178. Å3; shape: 0.48; buriedness: 0.91

negative: 0.13; positive: 0.27; polar: 0.2; backbone: 0.13; hydrophobic: 0.27

Domains/regions: [D] Pterin-binding, [R] 6-hydroxymethyl-7,8-dihydropterin diphosphate binding

PDB: 1aj0, 1aj2, 1ajz

HET: 2ph, ph2

DHPS_STAAU_2_267 [text] Dihydropteroate synthase [DHPS family]

volume: 213. Å3; shape: 0.5; buriedness: 0.88

negative: 0.17; positive: 0.3; polar: 0.19; backbone: 0.09; hydrophobic: 0.26

Domains/regions: [D] Pterin-binding, [R] 6-hydroxymethyl-7,8-dihydropterin diphosphate binding

PDB: 1ad1, 1ad4

HET: hh2, mn

DHPS_STRR6_1_314 [text] Dihydropteroate synthase [DHPS family]

volume: 169. Å3; shape: 0.52; buriedness: 0.8

negative: 0.17; positive: 0.26; polar: 0.13; backbone: 0.09; hydrophobic: 0.36

Domains/regions: [D] Pterin-binding, [R] 6-hydroxymethyl-7,8-dihydropterin diphosphate binding

PDB: 2vef, 2veg

HET: pmm

DHQSD_ARATH_90_603_DHQ [text] Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic

volume: 103. Å3; shape: 0.69; buriedness: 0.97

negative: 0.1; positive: 0.4; polar: 0.2; backbone: 0.; hydrophobic: 0.3

Domains/regions: [R] 3-dehydroquinate dehydratase

PDB: 2gpt, 2o7q, 2o7s

HET: dhk

DHQSD_ARATH_90_603_SDH [text] Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic

volume: 107. Å3; shape: 0.74; buriedness: 0.94

negative: 0.08; positive: 0.08; polar: 0.62; backbone: 0.08; hydrophobic: 0.15

Domains/regions: [R] Shikimate dehydrogenase

PDB: 2gpt, 2o7q, 2o7s

HET: dhk, skm

DHSO_HUMAN_6_357 [text] Sorbitol dehydrogenase [Zinc-containing alcohol dehydrogenase family]

volume: 169. Å3; shape: 0.5; buriedness: 0.75

negative: 0.11; positive: 0.11; polar: 0.22; backbone: 0.06; hydrophobic: 0.5

PDB: 1pl6, 1pl7, 1pl8

HET: 572

DHYS_HUMAN_2_369 [text] Deoxyhypusine synthase [Deoxyhypusine synthase family]

volume: 174. Å3; shape: 0.34; buriedness: 0.91

negative: 0.18; positive: 0.12; polar: 0.09; backbone: 0.37; hydrophobic: 0.23

Domains/regions: [R] Spermidine binding

PDB: 1dhs, 1rlz, 1roz, 1rqd

HET: gc7

DIDH_RAT_1_319 [text] 3-alpha-hydroxysteroid dehydrogenase [Aldo/keto reductase family]

volume: 151. Å3; shape: 0.53; buriedness: 0.69

negative: 0.; positive: 0.22; polar: 0.39; backbone: 0.09; hydrophobic: 0.3

PDB: 1afs, 1lwi, 1ral

HET: tes

DLDH_MYCTU_1_464 [text] Dihydrolipoyl dehydrogenase [Class-I pyridine nucleotide-disulfide oxidoreductase family]

volume: 295. Å3; shape: 0.36; buriedness: 0.84

negative: 0.13; positive: 0.13; polar: 0.13; backbone: 0.3; hydrophobic: 0.32

PDB: 2a8x, 3ii4, 4m52

HET: m52

DMAW_ASPFU_1_459 [text] Tryptophan dimethylallyltransferase [Tryptophan dimethylallyltransferase family]

volume: 159. Å3; shape: 0.43; buriedness: 0.92

negative: 0.; positive: 0.37; polar: 0.58; backbone: 0.; hydrophobic: 0.05

PDB: 3i4x, 3i4z

HET: dst

DMDA_PELUB_1_369 [text] Dimethylsulfonioproprionate demethylase DmdA [GcvT family. DmdA subfamily]

volume: 314. Å3; shape: 0.51; buriedness: 0.83

negative: 0.15; positive: 0.04; polar: 0.26; backbone: 0.31; hydrophobic: 0.24

PDB: 3tfh, 3tfi, 3tfj

HET: thg

DMGD_CHRSD_1_403 [text] D-galactonate dehydratase family member ManD [Mandelate racemase/muconate lactonizing enzyme family. GalD subfamily]

volume: 123. Å3; shape: 0.55; buriedness: 0.93

negative: 0.33; positive: 0.29; polar: 0.13; backbone: 0.; hydrophobic: 0.25

PDB: 3bsm, 3ow1, 3p93, 3pk7, 3qke, 3rgt, 4f4r, 4k2s, 4kpl, 4kt2, 4kws

HET: cs2, ez4, gco, kdg

DMGO_ARTGO_2_830 [text] Dimethylglycine oxidase [GcvT family]

volume: 429. Å3; shape: 0.49; buriedness: 0.83

negative: 0.11; positive: 0.; polar: 0.43; backbone: 0.21; hydrophobic: 0.25

Domains/regions: [R] Tetrahydrofolate binding

PDB: 1pj5, 1pj6, 1pj7, 3gsi

HET: ffo, fol, thg

DMPK_HUMAN_9_420 [text] Myotonin-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily]

volume: 251. Å3; shape: 0.86; buriedness: 0.78

negative: 0.06; positive: 0.06; polar: 0.15; backbone: 0.36; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 2vd5

HET: bi8

DNAK_ECOLI_388_507 [text] Chaperone protein DnaK [Heat shock protein 70 family]

volume: 268. Å3; shape: 0.74; buriedness: 0.57

negative: 0.11; positive: 0.; polar: 0.32; backbone: 0.27; hydrophobic: 0.31

PDB: 1dkx, 1dky, 1dkz, 3dpo, 3dpp, 3dpq, 3qnj, 4b9q, 4e81, 4ezn, 4ezo, 4ezp, 4ezq, 4ezr, 4ezs, 4ezt, 4ezu, 4ezv, 4ezw, 4ezx, 4ezy, 4ezz, 4f00, 4f01, 4hy9, 4hyb, 4jn4, 4jne, 4jnf, 4jwc, 4jwd, 4jwe, 4jwi, 4r5g, 4r5i, 4r5j, 4r5k, 4r5l

HET: 3je

DNK_DROME_1_233 [text] Deoxynucleoside kinase [DCK/DGK family]

volume: 274. Å3; shape: 0.6; buriedness: 0.96

negative: 0.11; positive: 0.12; polar: 0.15; backbone: 0.14; hydrophobic: 0.48

PDB: 1j90, 1oe0, 1ot3, 1zm7, 1zmx, 2jcs, 2jj8, 2vp0, 2vp2, 2vp4, 2vp5, 2vp6, 2vp9, 2vpp, 2vqs

HET: 5fu, azz, bvd, dcp, dcz, dgt, doc, geo, mg, thm, ttp

DNLJ_ECOLI_1_586 [text] DNA ligase [NAD-dependent DNA ligase family. LigA subfamily]

volume: 255. Å3; shape: 0.76; buriedness: 0.86

negative: 0.13; positive: 0.19; polar: 0.13; backbone: 0.32; hydrophobic: 0.23

PDB: 2owo, 4glx

HET: 0xs, amp

DNLJ_ENTFA_1_325 [text] DNA ligase [NAD-dependent DNA ligase family. LigA subfamily]

volume: 404. Å3; shape: 0.74; buriedness: 0.89

negative: 0.11; positive: 0.14; polar: 0.13; backbone: 0.28; hydrophobic: 0.33

PDB: 1ta8, 1tae, 3ba8, 3ba9, 3baa, 3bab, 4eeq, 4efb, 4efe, 4lh6, 4lh7

HET: 0ov, 0ow, 0ox, 1x7, 1x8, 3b8, 3b9, 3ba, 3bd, nad

DNLJ_HAEIN_1_64 [text] DNA ligase [NAD-dependent DNA ligase family. LigA subfamily]

volume: 409. Å3; shape: 0.55; buriedness: 0.69

negative: 0.11; positive: 0.23; polar: 0.17; backbone: 0.33; hydrophobic: 0.16

PDB: 3pn1, 3uq8, 4uco, 4ucr, 4ucs, 4uct, 4ucu, 4ucv, 4ufz

HET: iwh, nad

DNLJ_HAEIN_64_324 [text] DNA ligase [NAD-dependent DNA ligase family. LigA subfamily]

volume: 304. Å3; shape: 0.83; buriedness: 0.79

negative: 0.16; positive: 0.2; polar: 0.08; backbone: 0.33; hydrophobic: 0.23

PDB: 3bac, 3pn1, 3uq8, 4uco, 4ucr, 4ucs, 4uct, 4ucu, 4ucv, 4ufz

HET: 3b9, 5u1, 8hc, 9mj, amp, d41, i6g, ia7, ivh, jcf

DNLJ_STAAU_1_312 [text] DNA ligase [NAD-dependent DNA ligase family. LigA subfamily]

volume: 171. Å3; shape: 0.82; buriedness: 0.89

negative: 0.1; positive: 0.16; polar: 0.1; backbone: 0.36; hydrophobic: 0.29

PDB: 3jsl, 3jsn, 4cc5, 4cc6, 5fpo, 5fpr

HET: 10l, l5v, l5y

DNMT1_HUMAN_1129_1600_catalytic [text] DNA (cytosine-5)-methyltransferase 1 [Class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family]

volume: 283. Å3; shape: 0.42; buriedness: 0.88

negative: 0.07; positive: 0.; polar: 0.04; backbone: 0.53; hydrophobic: 0.36

Domains/regions: [D] SAM-dependent MTase C5-type, [R] Catalytic

PDB: 3swr, 4wxx, 4yoc

HET: sah, sfg

DNMT1_MOUSE_730_1609 [text] DNA (cytosine-5)-methyltransferase 1 [Class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family]

volume: 569. Å3; shape: 0.54; buriedness: 0.89

negative: 0.09; positive: 0.06; polar: 0.06; backbone: 0.49; hydrophobic: 0.29

Domains/regions: [D] SAM-dependent MTase C5-type, [R] Catalytic

PDB: 3av4, 3av5, 3av6, 3pt6, 3pt9, 4da4

HET: c49, sah, sam

DNPH1_RAT_9_152 [text] 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [2'-deoxynucleoside 5'-phosphate N- hydrolase 1 family]

volume: 327. Å3; shape: 0.74; buriedness: 0.79

negative: 0.05; positive: 0.05; polar: 0.21; backbone: 0.43; hydrophobic: 0.26

Domains/regions: [R] Substrate binding, [R] Substrate binding; shared with homodimeric partner

PDB: 4fyh, 4fyi, 4fyk, 4kxl, 4kxm, 4kxn, 4p5d

HET: 6c6, 6ia, 6k6, n6p, sra, tr5

DNRD_STRGJ_1_144 [text] Aklanonic acid methyl ester cyclase AcmA [Polyketide cyclase DnrD family]

volume: 304. Å3; shape: 0.62; buriedness: 0.92

negative: 0.08; positive: 0.; polar: 0.29; backbone: 0.08; hydrophobic: 0.55

PDB: 2f98, 2f99

HET: akv, ngv

DNRK_STRPE_3_355 [text] Carminomycin 4-O-methyltransferase DnrK [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family]

volume: 763. Å3; shape: 0.5; buriedness: 0.92

negative: 0.08; positive: 0.07; polar: 0.12; backbone: 0.3; hydrophobic: 0.44

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 1tw2, 1tw3, 4wxh, 5eeg, 5eeh, 5jr3

HET: 3vl, 4mu, ert, p9p, s8m, sah

DODEC_HALS3_1_67 [text] Dodecin [Dodecin family]

volume: 277. Å3; shape: 0.83; buriedness: 0.67

negative: 0.17; positive: 0.; polar: 0.15; backbone: 0.49; hydrophobic: 0.2

PDB: 1mog, 2cc6, 2cc7, 2cc8, 2cc9, 2ccb, 2ccc, 2cie, 2cif, 2cjc, 2vkf, 2vkg, 2vx9, 4b2h, 4b2j, 4b2k, 4b2m

HET: c3f, cf2, cf4, fad, lfn, lum, rbf

DOHH_HUMAN_1_289 [text] Deoxyhypusine hydroxylase [Deoxyhypusine hydroxylase family]

volume: 171. Å3; shape: 0.64; buriedness: 0.45

negative: 0.42; positive: 0.; polar: 0.17; backbone: 0.12; hydrophobic: 0.29

PDB: 4d4z, 4d50

HET: b3p

DOIS_BACCI_1_368 [text] 2-deoxy-scyllo-inosose synthase [Dehydroquinate synthase family. DOI synthase subfamily]

volume: 142. Å3; shape: 0.64; buriedness: 0.81

negative: 0.36; positive: 0.45; polar: 0.; backbone: 0.1; hydrophobic: 0.1

PDB: 2d2x, 2gru

HET: cak, exo

DOT1L_HUMAN_1_335 [text] Histone-lysine N-methyltransferase, H3 lysine-79 specific [Class I-like SAM-binding methyltransferase superfamily. DOT1 family]

volume: 726. Å3; shape: 0.47; buriedness: 0.9

negative: 0.09; positive: 0.03; polar: 0.14; backbone: 0.5; hydrophobic: 0.24

Domains/regions: [D] DOT1, [R] S-adenosyl-L-methionine binding

PDB: 1nw3, 3qow, 3qox, 3sr4, 3sx0, 3uwp, 4ek9, 4ekg, 4eki, 4eqz, 4er0, 4er3, 4er5, 4er6, 4er7, 4hra, 4wvl, 5drt, 5dry, 5dsx, 5dt2, 5dtm, 5dtq, 5dtr, 5juw

HET: 0qj, 0qk, 3us, 5eg, 5ek, 5ev, 5ew, 5f4, 5f6, 5f7, 5id, 6nr, aw0, aw1, aw2, aw3, ep4, ep6, sah, sam, sx0, tt8

DPAL_ECOLI_1_398 [text] Diaminopropionate ammonia-lyase [Diaminopropionate ammonia-lyase family]

volume: 225. Å3; shape: 0.91; buriedness: 0.98

negative: 0.14; positive: 0.07; polar: 0.18; backbone: 0.43; hydrophobic: 0.19

PDB: 4d9g, 4d9i, 4d9k, 4d9m, 4d9n

HET: 0jo, dsn

DPDS_MYCTU_13_296 [text] Decaprenyl diphosphate synthase [UPP synthase family]

volume: 532. Å3; shape: 0.4; buriedness: 0.85

negative: 0.05; positive: 0.25; polar: 0.21; backbone: 0.44; hydrophobic: 0.05

Domains/regions: [R] Substrate binding

PDB: 2vg2, 2vg3, 2vg4, 4onc

HET: 40b, dpo, gpp, mg

DPEP1_HUMAN_17_385 [text] Dipeptidase 1 [Peptidase M19 family]

volume: 166. Å3; shape: 0.78; buriedness: 0.77

negative: 0.2; positive: 0.33; polar: 0.24; backbone: 0.08; hydrophobic: 0.14

PDB: 1itq, 1itu

HET: cil

DPES_AGRFC_1_289 [text] D-psicose 3-epimerase [Hyi family]

volume: 113. Å3; shape: 0.6; buriedness: 0.94

negative: 0.38; positive: 0.28; polar: 0.; backbone: 0.34; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 2hk0, 2hk1

HET: fud

DPES_CLOCE_1_293 [text] D-psicose 3-epimerase [Hyi family]

volume: 121. Å3; shape: 0.66; buriedness: 0.98

negative: 0.35; positive: 0.25; polar: 0.09; backbone: 0.15; hydrophobic: 0.16

Domains/regions: [R] Substrate binding

PDB: 3vni, 3vnj, 3vnk, 3vnl, 3vnm

HET: fud, psj, sdd, tag

DPO1_BACCA_292_877 [text] DNA polymerase I [DNA polymerase type-A family]

volume: 5352. Å3; shape: 0.47; buriedness: 0.42

negative: 0.05; positive: 0.14; polar: 0.34; backbone: 0.38; hydrophobic: 0.1

Domains/regions: [D] 3'-5' exonuclease, [R] Polymerase

PDB: 1l3s, 1l3t, 1l3u, 1l3v, 1l5u, 1lv5, 1njw, 1njx, 1njy, 1njz, 1nk0, 1nk4, 1nk5, 1nk6, 1nk7, 1nk8, 1nk9, 1nkb, 1nkc, 1nke, 1u45, 1u47, 1u48, 1u49, 1u4b, 1ua0, 1ua1, 1xc9, 1xwl, 2bdp, 2hhq, 2hhs, 2hht, 2hhu, 2hhv, 2hhw, 2hhx, 2hvh, 2hvi, 2hw3, 2xo7, 2xy5, 2xy6, 2xy7, 2y1i, 2y1j, 3bdp, 3eyz, 3ez5, 3hp6, 3hpo, 3ht3, 3pv8, 3px0, 3px4, 3px6, 3tan, 3tap, 3taq, 3tar, 3thv, 3ti0, 4b9l, 4b9m, 4b9n, 4b9s, 4b9t, 4b9u, 4b9v, 4bdp, 4dqi, 4dqp, 4dqq, 4dqr, 4dqs, 4ds4, 4ds5, 4dse, 4dsf, 4dsi, 4dsj, 4dsk, 4dsl, 4dwi, 4e0d, 4ez6, 4ez9, 4f2r, 4f2s, 4f3o, 4f4k, 4f8r, 4o0i, 4uqg, 4yfu

HET: 23t, 2da, 2dt, 47c, 6og, 8og, bap, ca, ctp, d3t, dad, dcp, dct, ddg, dds, dg3, dgt, doc, fax, fox, mg, pbt, qbt, say, t0t, thm, ttp

DPO1_THEAQ_292_832 [text] DNA polymerase I, thermostable [DNA polymerase type-A family]

volume: 4769. Å3; shape: 0.45; buriedness: 0.39

negative: 0.08; positive: 0.22; polar: 0.22; backbone: 0.4; hydrophobic: 0.08

Domains/regions: [R] Polymerase

PDB: 1bgx, 1jxe, 1ktq, 1qss, 1qsy, 1qtm, 1taq, 1tau, 2ktq, 3ktq, 3lwl, 3lwm, 3m8r, 3m8s, 3ojs, 3oju, 3po4, 3po5, 3py8, 3rr7, 3rr8, 3rrg, 3rrh, 3rtv, 3sv3, 3sv4, 3syz, 3sz2, 3t3f, 4bwj, 4bwm, 4c8k, 4c8l, 4c8m, 4c8n, 4c8o, 4cch, 4df4, 4df8, 4dfj, 4dfk, 4dfm, 4dfp, 4dle, 4dlg, 4elt, 4elu, 4elv, 4ktq, 4n56, 4n5s, 4xiu, 5ktq

HET: 0kl, 0l3, 0l4, 0l5, 0l6, 0l7, 0r5, 0r6, 0r7, 0r8, 3dr, 5si, bmn, bmr, dcp, dct, dds, dg3, doc, hxb, hxz, lho, mg, n5p, pge, ssj, ttp, xjs

DPO3B_ECOLI_1_366 [text] DNA polymerase III subunit beta

volume: 946. Å3; shape: 0.47; buriedness: 0.61

negative: 0.; positive: 0.09; polar: 0.18; backbone: 0.37; hydrophobic: 0.36

Domains/regions: [R] II, [R] III

PDB: 1jqj, 1jql, 1mmi, 1ok7, 1unn, 2pol, 2xur, 3bep, 3d1e, 3d1f, 3d1g, 3f1v, 3pwe, 3q4j, 3q4k, 3q4l, 3qsb, 4k3k, 4k3l, 4k3m, 4k3o, 4k3p, 4k3q, 4k3r, 4k3s, 4k74, 4mjp, 4mjq, 4mjr, 4n94, 4n95, 4n96, 4n97, 4n98, 4n99, 4n9a, 4ovf, 4ovg, 4ovh, 4pnu, 4pnv, 4pnw

HET: 0la, 200, 27o, 27r, 2ho, 2hq, 2hu, 2j1, 2j2, 2vd, 2ve, 2vf, 2vg, 2vm, 322, 323, 4fc, 6ni, 743, ace, alc, sfk, zcl

DPO4_SULSO_1_347 [text] DNA polymerase IV [DNA polymerase type-Y family]

volume: 1740. Å3; shape: 0.61; buriedness: 0.56

negative: 0.07; positive: 0.19; polar: 0.14; backbone: 0.44; hydrophobic: 0.16

Domains/regions: [D] UmuC

PDB: 1jx4, 1jxl, 1n48, 1n56, 1ryr, 1rys, 1s0m, 1s0n, 1s0o, 1s10, 1s97, 1s9f, 2ago, 2agp, 2agq, 2asd, 2asj, 2asl, 2atl, 2au0, 2bq3, 2bqr, 2bqu, 2br0, 2c22, 2c28, 2c2d, 2c2e, 2c2r, 2ia6, 2ibk, 2imw, 2j6s, 2j6t, 2j6u, 2jef, 2jeg, 2jei, 2jej, 2r8g, 2r8h, 2r8i, 2rdi, 2rdj, 2uvr, 2uvu, 2uvv, 2uvw, 2v4q, 2v4r, 2v9w, 2va2, 2va3, 2w8k, 2w8l, 2w9a, 2w9b, 2w9c, 2xc9, 2xca, 2xcp, 3fds, 3gii, 3gij, 3gik, 3gil, 3gim, 3khg, 3khh, 3khl, 3khr, 3m9m, 3m9n, 3m9o, 3pr4, 3pr5, 3pvx, 3pw0, 3pw2, 3pw4, 3pw5, 3pw7, 3qz7, 3qz8, 3raq, 3rax, 3rb0, 3rb3, 3rb4, 3rb6, 3rbd, 3rbe, 3t5h, 3t5j, 3t5k, 3t5l, 3v6h, 3v6j, 4fbt, 4fbu, 4g3i, 4gc6, 4gc7, 4juz, 4jv0, 4jv1, 4jv2, 4qw8, 4qw9, 4qwa, 4qwb, 4qwc, 4qwd, 4qwe, 4rua, 4ruc, 4rzr, 4tqr, 4tqs, 5edw

HET: 0g4, 0g8, 0oh, 0oj, 2da, 2dt, 2jv, 3tt, 6og, 8og, adi, atp, bap, bzg, ca, dad, dcp, dct, ddg, dds, ddy, dft, dg3, dg8, dgt, doc, dtp, efg, ftd, gne, gtp, hn0, hn1, kag, m1g, me6, mf7, mg, mg1, n2g, o2g, p, pvx, tmp, ttp, x, yyy

DPOG1_HUMAN_70_1239 [text] DNA polymerase subunit gamma-1 [DNA polymerase type-A family]

volume: 265. Å3; shape: 0.53; buriedness: 0.74

negative: 0.26; positive: 0.14; polar: 0.23; backbone: 0.31; hydrophobic: 0.06

PDB: 3ikm, 4ztu, 4ztz, 5c51

HET: 1ry, dcp, dct

DPOLA_HUMAN_337_1259 [text] DNA polymerase alpha catalytic subunit [DNA polymerase type-B family]

volume: 545. Å3; shape: 0.35; buriedness: 0.53

negative: 0.06; positive: 0.05; polar: 0.21; backbone: 0.58; hydrophobic: 0.1

PDB: 4q5v, 4qcl, 5iud

HET: 2ze, dcp, mg

DPOLB_HUMAN_142_335 [text] DNA polymerase beta [DNA polymerase type-X family]

volume: 1055. Å3; shape: 0.45; buriedness: 0.57

negative: 0.14; positive: 0.16; polar: 0.19; backbone: 0.45; hydrophobic: 0.07

Domains/regions: [R] DNA binding

PDB: 1bpb, 1bpe, 1bpx, 1bpy, 1bpz, 1huo, 1huz, 1jn3, 1mq2, 1mq3, 1nom, 1rpl, 1tv9, 1tva, 1zjm, 1zjn, 1zqa, 1zqb, 1zqc, 1zqd, 1zqf, 1zqg, 1zqh, 1zqi, 1zqj, 1zqk, 1zql, 1zqm, 1zqn, 1zqo, 1zqp, 1zqq, 1zqs, 1zqt, 1zqu, 1zqv, 1zqw, 1zqx, 1zqy, 1zqz, 2bpc, 2bpf, 2fmp, 2fmq, 2fms, 2i9g, 2iso, 2isp, 2p66, 2pxi, 2van, 3c2k, 3c2l, 3c2m, 3gdx, 3isb, 3isc, 3isd, 3jpn, 3jpo, 3jpp, 3jpq, 3jpr, 3jps, 3jpt, 3k75, 3lk9, 3lqc, 3mby, 3ogu, 3rh4, 3rh5, 3rh6, 3rje, 3rjf, 3rjg, 3rjh, 3rji, 3rjj, 3rjk, 3tfr, 3tfs, 3uxn, 3uxo, 3uxp, 3v72, 3v7j, 3v7k, 3v7l, 4do9, 4doa, 4dob, 4doc, 4f5n, 4f5o, 4f5p, 4f5q, 4f5r, 4gxi, 4gxj, 4gxk, 4jwm, 4jwn, 4kld, 4kle, 4klf, 4klg, 4klh, 4kli, 4klj, 4kll, 4klm, 4klo, 4klq, 4kls, 4klt, 4klu, 4lvs, 4m2y, 4m47, 4m9g, 4m9h, 4m9j, 4m9l, 4m9n, 4mf2, 4mf8, 4mfa, 4mfc, 4mff, 4nlk, 4nln, 4nlz, 4nm1, 4nm2, 4nxz, 4ny8, 4o5c, 4o5e, 4o5k, 4o9m, 4p2h, 4pgq, 4pgx, 4pgy, 4ph5, 4pha, 4phd, 4phe, 4php, 4ppx, 4r63, 4r64, 4r65, 4r66, 4rpx, 4rpy, 4rpz, 4rq0, 4rq1, 4rq2, 4rq3, 4rq4, 4rq5, 4rq6, 4rq7, 4rq8, 4rt2, 4rt3, 4tup, 4tuq, 4tur, 4tus, 4uaw, 4uay, 4uaz, 4ub1, 4ub2, 4ub3, 4ub4, 4ub5, 4ubb, 4ubc, 4ymm, 4ymn, 4ymo, 4yn4, 4z6c, 4z6d, 4z6e, 4z6f, 5bol, 5bom, 5bpc, 5db6, 5db7, 5db8, 5db9, 5dba, 5dbb, 5dbc, 5eoz, 5j0o, 5j0p, 5j0q, 5j0r, 5j0s, 5j0t, 5j0u, 5j0v, 5j0w, 5j0x, 5j0y, 5j29, 5j2a, 5j2b, 5j2c, 5j2d, 5j2e, 5j2f, 5j2g, 5j2h, 5j2i, 5j2j, 5j2k, 7ice, 7icf, 7icg, 7ich, 7ici, 7icj, 7ick, 7icl, 7icm, 7icn, 7ico, 7icp, 7icq, 7icr, 7ics, 7ict, 7icu, 7icv, 8ica, 8icb, 8icc, 8ice, 8icf, 8icg, 8ich, 8ici, 8icj, 8ick, 8icl, 8icm, 8icn, 8ico, 8icp, 8icq, 8icr, 8ics, 8ict, 8icu, 8icv, 8icw, 8icx, 8icy, 8icz, 9ica, 9icb, 9icc, 9ice, 9icf, 9icg, 9ich, 9ici, 9icj, 9ick, 9icl, 9icm, 9icn, 9ico, 9icp, 9icq, 9icr, 9ics, 9ict, 9icu, 9icv, 9icw, 9icx, 9icy

HET: 0kx, 1fz, 1gc, 4bd, 4u3, 6cf, 6og, 7bg, 8dg, 8og, azt, bgm, bpi, c6t, ctp, dad, dcp, dct, ddg, dgt, doc, dtp, dup, f2a, f3a, fha, fmg, g1c, g1m, g2c, g2m, gbr, gfc, gff, gfh, gfl, gfm, ggh, grc, mdn, mn, n6t, na, ppv, sdh, stp, tff, tte, ttp, xg4

DPOL_BPR69_1_903 [text] DNA-directed DNA polymerase [DNA polymerase type-B family]

volume: 539. Å3; shape: 0.59; buriedness: 0.29

negative: 0.13; positive: 0.29; polar: 0.24; backbone: 0.27; hydrophobic: 0.07

PDB: 1clq, 1ig9, 1ih7, 1q9x, 1q9y, 1waf, 1waj, 2atq, 2dtu, 2dy4, 2oyq, 2ozm, 2ozs, 2p5g, 2p5o, 3cfo, 3cfp, 3cfr, 3cq8, 3kd1, 3kd5, 3l8b, 3lds, 3lzi, 3lzj, 3nae, 3nci, 3ndk, 3ne6, 3ngi, 3nhg, 3qei, 3qep, 3qer, 3qes, 3qet, 3qev, 3qew, 3qex, 3qnn, 3qno, 3rma, 3rmb, 3rmc, 3rmd, 3rwu, 3s9h, 3scx, 3si6, 3sjj, 3snn, 3spy, 3spz, 3sq0, 3sq1, 3sq2, 3sq4, 3sun, 3suo, 3sup, 3suq, 3tab, 3tae, 3taf, 3tag, 3uiq, 4dtj, 4dtm, 4dtn, 4dto, 4dtp, 4dtr, 4dts, 4dtu, 4dtx, 4du1, 4du3, 4du4, 4e3s, 4fj5, 4fj7, 4fj8, 4fj9, 4fjg, 4fjh, 4fji, 4fjj, 4fjk, 4fjl, 4fjm, 4fjn, 4fjx, 4fk0, 4fk2, 4fk4, 4i9l, 4i9q, 4j2a, 4j2b, 4j2d, 4j2e, 4khn, 4khq, 4khs, 4khu, 4khw, 4khy, 4ki4, 4ki6, 4m3r, 4m3t, 4m3u, 4m3w, 4m3x, 4m3y, 4m3z, 4m41, 4m42, 4m45

HET: dgp, n5p

DPOL_BPT7_1_704 [text] DNA-directed DNA polymerase [DNA polymerase type-A family]

volume: 706. Å3; shape: 0.4; buriedness: 0.68

negative: 0.17; positive: 0.1; polar: 0.1; backbone: 0.57; hydrophobic: 0.06

Domains/regions: [R] Polymerase

PDB: 1skr, 1sks, 1skw, 1sl0, 1sl1, 1sl2, 1t7p, 1t8e, 1tk0, 1tk5, 1tk8, 1tkd, 1x9m, 1x9s, 1x9w, 1zyq, 2ajq

HET: 8og, d3t, dad, dct, dg3, mg, ttd

DPOLL_HUMAN_327_575 [text] DNA polymerase lambda [DNA polymerase type-X family]

volume: 1603. Å3; shape: 0.64; buriedness: 0.45

negative: 0.08; positive: 0.15; polar: 0.16; backbone: 0.52; hydrophobic: 0.1

Domains/regions: [R] DNA binding, [R] Involved in primer binding

PDB: 1rzt, 1xsl, 1xsn, 1xsp, 2bcq, 2bcr, 2bcs, 2bcu, 2bcv, 2gws, 2pfn, 2pfo, 2pfp, 2pfq, 3c5f, 3c5g, 3hw8, 3hwt, 3hx0, 3mda, 3mdc, 3mgh, 3mgi, 3pml, 3pmn, 3pnc, 3upq, 3uq0, 3uq2, 4fo6, 4k4g, 4k4h, 4k4i, 4x5v, 4xa5, 4xq8, 4xrh, 4xus, 5ca7, 5cb1, 5chg, 5cj7, 5cp2, 5cr0, 5cwr, 5ddm, 5ddy, 5dkw, 5iii, 5iij, 5iik, 5iil, 5iim, 5iin, 5iio

HET: 1gc, 1ry, 1rz, 1s0, 2dt, 8dg, 8og, ca, car, d3t, dcp, dct, dgt, doc, dtp, dup, f2a, gtf, mg, mn, na, o2c, ppv, ttp, zan

DPP2_HUMAN_27_492 [text] Dipeptidyl peptidase 2 [Peptidase S28 family]

volume: 132. Å3; shape: 0.6; buriedness: 0.89

negative: 0.18; positive: 0.05; polar: 0.23; backbone: 0.21; hydrophobic: 0.32

PDB: 3jyh, 3n0t, 4ebb

HET: opy

DPP4_HUMAN_38_766 [text] Dipeptidyl peptidase 4 [Peptidase S9B family. DPPIV subfamily]

volume: 602. Å3; shape: 0.67; buriedness: 0.74

negative: 0.11; positive: 0.15; polar: 0.37; backbone: 0.16; hydrophobic: 0.21

PDB: 1j2e, 1n1m, 1nu6, 1nu8, 1pfq, 1r9m, 1r9n, 1rwq, 1tk3, 1tkr, 1u8e, 1w1i, 1wcy, 1x70, 2ajl, 2bgn, 2bgr, 2bub, 2fjp, 2g5p, 2g5t, 2g63, 2hha, 2i03, 2i78, 2iit, 2iiv, 2jid, 2oag, 2ogz, 2ole, 2onc, 2oph, 2oqi, 2oqv, 2p8s, 2qjr, 2qky, 2qoe, 2qt9, 2qtb, 2rgu, 2rip, 3bjm, 3c43, 3c45, 3ccb, 3ccc, 3d4l, 3eio, 3f8s, 3g0b, 3g0c, 3g0d, 3g0g, 3h0c, 3hab, 3hac, 3kwf, 3kwj, 3nox, 3o95, 3o9v, 3oc0, 3opm, 3q0t, 3qbj, 3sww, 3sx4, 3vjk, 3vjl, 3vjm, 3w2t, 3wqh, 4a5s, 4dsa, 4dsz, 4dtc, 4g1f, 4j3j, 4jh0, 4kr0, 4l72, 4lko, 4n8d, 4n8e, 4pnz, 4pv7, 4qzv, 5i7u, 5ism, 5kby, 5t4b, 5t4e, 5t4f, 5t4h

HET: 01t, 0wg, 10t, 13z, 1md, 1wh, 23q, 277, 2ks, 2kv, 2vh, 315, 317, 34q, 356, 361, 3tp, 417, 448, 474, 524, 565, 5ap, 605, 677, 6a5, 6aj, 6dg, 6rl, 715, 75j, 75l, 75m, 75n, 7ac, 872, a3m, acf, adf, ajh, b1q, b2q, b2y, bjm, cjp, d1c, d3c, d5c, dc3, fpb, gvb, jnh, kr2, kxa, kxb, lf7, lge, lui, m51, ma9, n7f, nxz, pf2, ps4, pzf, ruf, rum, s14, skk, sy1, t22, u1n, w61, w94, xih

DPP4_PIG_39_766 [text] Dipeptidyl peptidase 4 [Peptidase S9B family. DPPIV subfamily]

volume: 285. Å3; shape: 0.79; buriedness: 0.82

negative: 0.11; positive: 0.16; polar: 0.39; backbone: 0.17; hydrophobic: 0.17

PDB: 1orv, 1orw, 2aj8, 2ajb, 2ajc, 2ajd, 2bua, 2buc, 5lls

HET: 007, 008, 0qg, 6z8, aes, bpr, p2y, phi, sc3

DPP4_RAT_38_767 [text] Dipeptidyl peptidase 4 [Peptidase S9B family. DPPIV subfamily]

volume: 365. Å3; shape: 0.6; buriedness: 0.8

negative: 0.11; positive: 0.13; polar: 0.34; backbone: 0.26; hydrophobic: 0.16

PDB: 2gbc, 2gbf, 2gbg, 2gbi, 2i3z, 2oae, 4ffv, 4ffw

HET: 1ad, 715, aia, ail, lir, xih

DPRE1_MYCS2_58_460 [text] FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase

volume: 245. Å3; shape: 0.4; buriedness: 0.63

negative: 0.; positive: 0.32; polar: 0.17; backbone: 0.22; hydrophobic: 0.29

Domains/regions: [D] FAD-binding PCMH-type, [R] Substrate binding

PDB: 4aut, 4f4q, 4g3t, 4g3u

HET: 0sk

DPRE1_MYCTU_2_461 [text] FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase

volume: 377. Å3; shape: 0.54; buriedness: 0.72

negative: 0.; positive: 0.26; polar: 0.26; backbone: 0.26; hydrophobic: 0.22

Domains/regions: [D] FAD-binding PCMH-type, [R] Substrate binding

PDB: 4fdn, 4fdo, 4fdp, 4feh, 4ff6, 4kw5, 4ncr, 4p8c, 4p8h, 4p8k, 4p8l, 4p8m, 4p8n, 4p8p, 4p8t, 4p8y, 4pfa, 4pfd

HET: 0t4, 0t5, 1w6, 26j, 2r2, 36c, 38c, n77, o95, r26, r57, r58, rg2, y22

DPSS_PINSY_2_393 [text] Pinosylvin synthase [Chalcone/stilbene synthases family]

volume: 125. Å3; shape: 0.58; buriedness: 0.94

negative: 0.; positive: 0.12; polar: 0.12; backbone: 0.23; hydrophobic: 0.54

Domains/regions: [R] Substrate binding

PDB: 1u0u, 1xes, 1xet

HET: 3io

DPYD_PIG_1_1025_NADPH [text] Dihydropyrimidine dehydrogenase [NADP(+)] [Dihydropyrimidine dehydrogenase family]

volume: 558. Å3; shape: 0.39; buriedness: 0.74

negative: 0.1; positive: 0.19; polar: 0.1; backbone: 0.47; hydrophobic: 0.14

PDB: 1gt8, 1gte, 1gth, 1h7w, 1h7x

HET: ndp

DPYD_PIG_1_1025_uracil [text] Dihydropyrimidine dehydrogenase [NADP(+)] [Dihydropyrimidine dehydrogenase family]

volume: 106. Å3; shape: 0.83; buriedness: 0.8

negative: 0.; positive: 0.; polar: 0.71; backbone: 0.29; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 1gt8, 1gte, 1gth, 1h7w, 1h7x

HET: idh, iur, uaa, ura, urf

DRAA_ECOLX_22_160 [text] Dr hemagglutinin structural subunit [Dr-adhesin family]

volume: 213. Å3; shape: 0.76; buriedness: 0.55

negative: 0.; positive: 0.; polar: 0.13; backbone: 0.51; hydrophobic: 0.36

Domains/regions: [R] Receptor-binding

PDB: 1usq, 1ut1, 2jkj, 2jkl, 2jkn, 2w5p

HET: brx, cl8, clm

DRD3_HUMAN_1_400 [text] D(3) dopamine receptor [G-protein coupled receptor 1 family]

volume: 211. Å3; shape: 0.55; buriedness: 0.96

negative: 0.08; positive: 0.08; polar: 0.25; backbone: 0.17; hydrophobic: 0.42

Domains/regions: [R] Agonist binding

PDB: 3pbl

HET: etq

DRTS_PLAFK_1_608 [text] Bifunctional dihydrofolate reductase-thymidylate synthase

volume: 304. Å3; shape: 0.59; buriedness: 0.87

negative: 0.07; positive: 0.; polar: 0.2; backbone: 0.29; hydrophobic: 0.44

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 1j3i, 1j3j, 1j3k, 3dg8, 3dga, 3jsu, 3qg2, 3qgt, 3um5, 3um6, 3um8, 4dp3, 4dpd, 4dph

HET: 1cy, cp6, dhf, ka5, mmv, p65, rj1, rj6, wra

DRTS_PLAVI_1_238 [text] Bifunctional dihydrofolate reductase-thymidylate synthase

volume: 166. Å3; shape: 0.64; buriedness: 0.87

negative: 0.09; positive: 0.; polar: 0.14; backbone: 0.37; hydrophobic: 0.4

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 2bl9, 2bla, 2blb, 2blc

HET: cp6, cp7

DRTS_TOXGO_1_610 [text] Bifunctional dihydrofolate reductase-thymidylate synthase

volume: 359. Å3; shape: 0.65; buriedness: 0.83

negative: 0.06; positive: 0.06; polar: 0.12; backbone: 0.28; hydrophobic: 0.49

Domains/regions: [D] DHFR

PDB: 4eil, 4ky4, 4kya, 5t0l

HET: 04j, 73x, fol

DRTS_TRYBB_1_240 [text] Bifunctional dihydrofolate reductase-thymidylate synthase

volume: 257. Å3; shape: 0.6; buriedness: 0.87

negative: 0.06; positive: 0.; polar: 0.24; backbone: 0.24; hydrophobic: 0.46

Domains/regions: [D] DHFR

PDB: 3qfx, 3rg9

HET: cp6, wra

DRTS_TRYCR_1_521 [text] Bifunctional dihydrofolate reductase-thymidylate synthase

volume: 922. Å3; shape: 0.15; buriedness: 0.83

negative: 0.03; positive: 0.09; polar: 0.2; backbone: 0.38; hydrophobic: 0.3

Domains/regions: [D] DHFR, [R] Thymidylate synthase

PDB: 2h2q, 3cl9, 3clb, 3hbb, 3inv, 3irm, 3irn, 3iro, 3kjs

HET: 1cy, 2cy, c50, dq1, mtx, tmq, ump

DSBA_ECOLI_20_208 [text] Thiol:disulfide interchange protein DsbA [Thioredoxin family. DsbA subfamily]

volume: 1868. Å3; shape: 0.93; buriedness: 0.53

negative: 0.04; positive: 0.06; polar: 0.17; backbone: 0.39; hydrophobic: 0.34

Domains/regions: [D] Thioredoxin

PDB: 1a2j, 1a2l, 1a2m, 1ac1, 1acv, 1bq7, 1dsb, 1fvj, 1fvk, 1ti1, 1u3a, 2b3s, 2b6m, 3dks, 4tky, 4wet, 4wey, 4wf4, 4wf5, 4zij

HET: ace, d12, eg6, hse, pe5, sfq, wef, wf4

DSBA_PSEAE_21_211 [text] Thiol:disulfide interchange protein DsbA [Thioredoxin family. DsbA subfamily]

volume: 144. Å3; shape: 0.53; buriedness: 0.81

negative: 0.07; positive: 0.07; polar: 0.22; backbone: 0.34; hydrophobic: 0.29

Domains/regions: [D] Thioredoxin

PDB: 3h93, 4zl7, 4zl8, 4zl9, 5dch

HET: 1yo

DT3E_PSECI_1_290 [text] D-tagatose 3-epimerase [Hyi family]

volume: 124. Å3; shape: 0.67; buriedness: 0.98

negative: 0.35; positive: 0.26; polar: 0.01; backbone: 0.17; hydrophobic: 0.2

Domains/regions: [R] Substrate binding

PDB: 2ou4, 2qul, 2qum, 2qun, 4pfh, 4pgl, 4q7i, 4xsl, 4xsm, 4ytq, 4ytr, 4yts, 4ytt, 4ytu, 5j8l

HET: fud, ler, ltg, psj, pud, sol, tag, tgd, tgj, tgs, tlz

DUS22_HUMAN_1_163 [text] Dual specificity protein phosphatase 22 [Protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily]

volume: 125. Å3; shape: 0.51; buriedness: 0.93

negative: 0.06; positive: 0.11; polar: 0.09; backbone: 0.51; hydrophobic: 0.23

Domains/regions: [D] Tyrosine-protein phosphatase

PDB: 1wrm, 4woh

HET: 4np

DUS3_HUMAN_2_185 [text] Dual specificity protein phosphatase 3 [Protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily]

volume: 1169. Å3; shape: 0.34; buriedness: 0.66

negative: 0.1; positive: 0.07; polar: 0.24; backbone: 0.46; hydrophobic: 0.12

Domains/regions: [D] Tyrosine-protein phosphatase

PDB: 1j4x, 1vhr, 3f81

HET: ahp, ptr, stt, tpo

DUT_HUMAN_98_252 [text] Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [DUTPase family]

volume: 388. Å3; shape: 0.9; buriedness: 0.72

negative: 0.04; positive: 0.04; polar: 0.12; backbone: 0.52; hydrophobic: 0.28

Domains/regions: [R] Substrate binding

PDB: 1q5h, 1q5u, 2hqu, 3ara, 3arn, 3ehw

HET: dud, dup, mg, mkh, msj

DXO_MOUSE_26_389_RNA [text] Decapping and exoribonuclease protein [DXO/Dom3Z family]

volume: 1293. Å3; shape: 0.45; buriedness: 0.62

negative: 0.11; positive: 0.28; polar: 0.14; backbone: 0.29; hydrophobic: 0.19

PDB: 3fqi, 3fqj, 4j7l, 4j7m, 4j7n

HET: 9mg, gdp, gtg, u37

DXR_ECOLI_1_398 [text] 1-deoxy-D-xylulose 5-phosphate reductoisomerase [DXR family]

volume: 273. Å3; shape: 0.82; buriedness: 0.89

negative: 0.18; positive: 0.1; polar: 0.37; backbone: 0.27; hydrophobic: 0.07

Domains/regions: [R] Binding to substrate phosphate group

PDB: 1jvs, 1k5h, 1onn, 1ono, 1onp, 1q0h, 1q0l, 1q0q, 1t1r, 1t1s, 2egh, 3anl, 3anm, 3ann, 3r0i

HET: c0k, cbq, dxp, fom, imb, mg, mn, syc, syd, sye

DXR_MYCTU_1_390 [text] 1-deoxy-D-xylulose 5-phosphate reductoisomerase [DXR family]

volume: 928. Å3; shape: 0.33; buriedness: 0.83

negative: 0.07; positive: 0.07; polar: 0.19; backbone: 0.47; hydrophobic: 0.21

PDB: 2c82, 2jcv, 2jcx, 2jcy, 2jd0, 2jd1, 2jd2, 2y1c, 2y1d, 2y1e, 2y1f, 2y1g, 3ras, 3zhx, 3zhy, 3zhz, 3zi0, 4a03, 4aic, 4ooe, 4oof, 4rcv

HET: 34f, dcv, de2, f98, fm5, fm6, fm7, fm8, fom, ndp

DXR_PLAF7_75_488 [text] 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic [DXR family]

volume: 272. Å3; shape: 0.74; buriedness: 0.94

negative: 0.14; positive: 0.09; polar: 0.24; backbone: 0.27; hydrophobic: 0.26

Domains/regions: [R] Binding to substrate phosphate group, [R] Substrate binding

PDB: 3au8, 3au9, 3aua, 3wqq, 3wqr, 3wqs, 4gae, 4kp7, 4y67, 4y6p, 4y6r, 4y6s, 5jaz, 5jbi, 5jc1, 5jmp, 5jmw, 5jnl, 5jo0

HET: 1uq, 48s, 6j8, 6jb, f98, fob, fom, foq, ib3, kbk, l50, l54, l56, lc5, lc7, lsx, r77, rc5, rf7

DXR_THEMA_1_376 [text] 1-deoxy-D-xylulose 5-phosphate reductoisomerase [DXR family]

volume: 56. Å3; shape: 0.98; buriedness: 0.93

negative: 0.07; positive: 0.14; polar: 0.43; backbone: 0.29; hydrophobic: 0.07

PDB: 3a06, 3a14

HET: fom

DYR1A_HUMAN_124_488 [text] Dual specificity tyrosine-phosphorylation-regulated kinase 1A [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily]

volume: 380. Å3; shape: 0.75; buriedness: 0.83

negative: 0.06; positive: 0.05; polar: 0.; backbone: 0.32; hydrophobic: 0.57

Domains/regions: [D] Protein kinase

PDB: 2vx3, 2wo6, 3anq, 3anr, 4aze, 4mq1, 4mq2, 4nct, 4ylj, 4ylk, 4yll, 4yu2, 5a3x, 5a4e, 5a4l, 5a4q, 5a4t, 5a54, 5aik

HET: 2c3, 2c4, 2k2, 3ra, 4e1, 4e2, 4e3, 4h5, 5pw, 7qq, ajg, awr, d15, ehb, hrm, qiv, y3l, zc3

DYR21_ECOLX_17_78 [text] Dihydrofolate reductase type 2

volume: 500. Å3; shape: 0.42; buriedness: 0.55

negative: 0.; positive: 0.15; polar: 0.18; backbone: 0.34; hydrophobic: 0.32

PDB: 1vie, 1vif, 2gqv, 2p4t, 2rh2, 2rk1, 2rk2, 3sfm

HET: fol, nap

DYRA_STAAU_1_161 [text] Dihydrofolate reductase type 1 from Tn4003 [Dihydrofolate reductase family]

volume: 195. Å3; shape: 0.58; buriedness: 0.79

negative: 0.08; positive: 0.; polar: 0.14; backbone: 0.3; hydrophobic: 0.49

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 2w9s, 2w9t

HET: top

DYR_CANAX_1_192 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 317. Å3; shape: 0.61; buriedness: 0.82

negative: 0.07; positive: 0.; polar: 0.24; backbone: 0.27; hydrophobic: 0.43

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 1ai9, 1aoe, 1ia1, 1ia2, 1ia3, 1ia4, 1m78, 1m79, 1m7a, 3qlr, 3qls, 3qlw, 4h95, 4h96, 4h97, 4hoe, 4hof

HET: 06u, 14q, 18g, 18h, 53s, 55v, clz, gw3, mq1, mqu, n22, qlr, tq3, tq4

DYR_CHICK_1_189 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 147. Å3; shape: 0.58; buriedness: 0.87

negative: 0.11; positive: 0.; polar: 0.11; backbone: 0.44; hydrophobic: 0.33

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 1dr1, 1dr2, 1dr3, 1dr4, 1dr5, 1dr6, 1dr7, 8dfr

HET: hbi

DYR_ECOLI_1_159 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 796. Å3; shape: 0.48; buriedness: 0.76

negative: 0.04; positive: 0.12; polar: 0.17; backbone: 0.31; hydrophobic: 0.36

Domains/regions: [D] DHFR

PDB: 1ddr, 1dds, 1dhi, 1dhj, 1dra, 1drb, 1dre, 1drh, 1dyh, 1dyi, 1dyj, 1jol, 1jom, 1ra1, 1ra2, 1ra3, 1ra8, 1ra9, 1rb2, 1rb3, 1rc4, 1rd7, 1re7, 1rf7, 1rg7, 1rh3, 1rx1, 1rx2, 1rx3, 1rx4, 1rx5, 1rx6, 1rx7, 1rx8, 1rx9, 1tdr, 2ano, 2anq, 2d0k, 2drc, 2inq, 3dau, 3drc, 3k74, 3kfy, 3och, 3ql0, 3ql3, 3qyl, 3qyo, 3r33, 4dfr, 4eig, 4eiz, 4ej1, 4fhb, 4gh8, 4i13, 4i1n, 4kjj, 4kjk, 4kjl, 4nx6, 4nx7, 4or7, 4osg, 4p3q, 4p3r, 4p66, 4p68, 4pdj, 4pss, 4pst, 4psy, 4pth, 4ptj, 4qle, 4qlf, 4qlg, 4rgc, 4x5f, 4x5g, 4x5h, 4x5i, 4x5j, 5cc9, 5ccc, 5dfr, 5dxv, 5e8q, 5eaj, 6dfr, 7dfr

HET: 06u, 25u, 2mx, 6me, 7me, 817, c1a, ca, ddf, dhf, dzf, ffo, fol, jzm, mtx, q24, te

DYR_HUMAN_2_187 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 623. Å3; shape: 0.78; buriedness: 0.85

negative: 0.08; positive: 0.05; polar: 0.24; backbone: 0.27; hydrophobic: 0.37

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 1boz, 1dhf, 1dlr, 1dls, 1drf, 1hfp, 1hfq, 1hfr, 1kms, 1kmv, 1mvs, 1mvt, 1ohj, 1ohk, 1pd8, 1pd9, 1pdb, 1s3u, 1s3v, 1s3w, 1u71, 1u72, 2c2s, 2c2t, 2dhf, 2w3a, 2w3b, 2w3m, 3eig, 3f8y, 3f8z, 3f91, 3fs6, 3ghc, 3ghv, 3ghw, 3gi2, 3gyf, 3l3r, 3n0h, 3ntz, 3nu0, 3nxo, 3nxr, 3nxt, 3nxv, 3nxx, 3nxy, 3nzd, 3oaf, 3s3v, 3s7a, 4ddr, 4g95, 4kak, 4kbn, 4kd7, 4keb, 4kfj, 4m6j, 4m6k, 4m6l, 4qhv, 4qjc

HET: 06u, 1qz, 1r0, 21v, 25u, 34b, 39b, 39e, 3tu, 3tz, 51p, 684, 9dr, co4, cop, d2b, d2d, d2e, d2f, d2h, d2q, dh1, dtm, dzf, fol, ghc, ghw, ixe, ixf, lih, lii, mg, mmv, mot, mtx, mxa, ndp, oag, prd, top, tqd, tqt, vg9

DYRK2_HUMAN_145_550 [text] Dual specificity tyrosine-phosphorylation-regulated kinase 2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily]

volume: 302. Å3; shape: 0.86; buriedness: 0.82

negative: 0.06; positive: 0.06; polar: 0.; backbone: 0.35; hydrophobic: 0.53

Domains/regions: [D] Protein kinase

PDB: 3k2l, 3kvw, 4azf, 5lxc, 5lxd

HET: 3ra, 7a7, 7aa, irb

DYR_MOUSE_2_187 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 351. Å3; shape: 0.8; buriedness: 0.87

negative: 0.05; positive: 0.09; polar: 0.18; backbone: 0.28; hydrophobic: 0.4

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 1u70, 2fzj, 3d80, 3d84, 3k45, 3k47

HET: 51p, d09, dh3, mtx, q22

DYR_MYCTU_4_161 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 356. Å3; shape: 0.69; buriedness: 0.85

negative: 0.07; positive: 0.; polar: 0.21; backbone: 0.27; hydrophobic: 0.46

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 1df7, 1dg5, 1dg7, 1dg8, 2cig, 4kl9, 4klx, 4km0, 4km2, 4kne, 4m2x, 5ja3

HET: 1cy, cp6, mtx, tmq, top, u06, wrb

DYR_PNECA_1_206 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 452. Å3; shape: 0.71; buriedness: 0.85

negative: 0.05; positive: 0.09; polar: 0.14; backbone: 0.26; hydrophobic: 0.46

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 1cd2, 1daj, 1dyr, 1e26, 1klk, 1ly3, 1ly4, 1s3y, 1vj3, 2cd2, 2fzh, 2fzi, 3cd2, 3nz6, 3nz9, 3nza, 3nzb, 3nzc, 3td8, 4cd2, 4g8z, 4ixe, 4ixf, 4ixg, 4qjz

HET: 33m, cog, coq, d2j, d2k, d2n, d2o, d2r, dh1, dh3, fol, gpb, ixe, ixf, ixg, mot, mtx, pmd, tab, top, tqt

DYR_STAAU_2_158 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 389. Å3; shape: 0.81; buriedness: 0.8

negative: 0.07; positive: 0.; polar: 0.16; backbone: 0.26; hydrophobic: 0.51

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 2w9g, 2w9h, 3f0b, 3f0q, 3f0s, 3f0u, 3f0v, 3f0x, 3fq0, 3fqc, 3fqf, 3fqo, 3fqv, 3fqz, 3fra, 3frb, 3frd, 3fre, 3frf, 3fy8, 3fy9, 3fyv, 3fyw, 3i8a, 3lg4, 3m08, 3m09, 3sgy, 3sh2, 3sqy, 3sr5, 3srq, 3srr, 3srs, 3sru, 3srw, 4fgg, 4fgh, 4lae, 4lag, 4lah, 4lek, 4q67, 4q6a, 4tu5, 4xe6, 4xec

HET: 06u, 06w, 0u5, 0u6, 11f, 1dn, 1vm, 1vn, 1vo, 52v, 53r, 53t, 55v, 5dr, dhf, i2h, m23, n22, q11, q12, q19, q20, q26, q27, rar, top, xcf

DYR_THEMA_2_169 [text] Dihydrofolate reductase [Dihydrofolate reductase family]

volume: 333. Å3; shape: 0.6; buriedness: 0.79

negative: 0.1; positive: 0.21; polar: 0.; backbone: 0.32; hydrophobic: 0.38

Domains/regions: [D] DHFR, [R] Substrate binding

PDB: 1cz3, 1d1g

HET: mtx

E2AK2_HUMAN_255_551_ATPsite [text] Interferon-induced, double-stranded RNA-activated protein kinase [Protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily]

volume: 376. Å3; shape: 0.58; buriedness: 0.67

negative: 0.06; positive: 0.06; polar: 0.17; backbone: 0.36; hydrophobic: 0.36

Domains/regions: [D] Protein kinase, [R] Interaction with TRAF5

PDB: 2a19, 2a1a, 3uiu

HET: anp, mg

E2AK3_HUMAN_581_1092 [text] Eukaryotic translation initiation factor 2-alpha kinase 3 [Protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily]

volume: 466. Å3; shape: 0.49; buriedness: 0.92

negative: 0.07; positive: 0.03; polar: 0.; backbone: 0.4; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 4g31, 4g34, 4m7i, 4x7h, 4x7j, 4x7k, 4x7l, 4x7n, 4x7o

HET: 3z1, 3z2, 3z3, 3z4, 3z5

EBDG_AMYOR_1_906 [text] Exo-beta-D-glucosaminidase [Glycosyl hydrolase 2 family]

volume: 214. Å3; shape: 0.69; buriedness: 0.92

negative: 0.25; positive: 0.; polar: 0.14; backbone: 0.07; hydrophobic: 0.55

PDB: 2vzo, 2vzs, 2vzt, 2vzu, 2vzv, 2x05, 2x09

HET: cd, gcs, pnj, x05, x09

EBDG_AMYOR_906_1032 [text] Exo-beta-D-glucosaminidase [Glycosyl hydrolase 2 family]

volume: 207. Å3; shape: 0.75; buriedness: 0.5

negative: 0.; positive: 0.34; polar: 0.49; backbone: 0.; hydrophobic: 0.17

Domains/regions: [D] CBM6

PDB: 2vzo, 2vzp, 2vzq, 2vzr, 2vzs, 2vzt, 2vzu, 2vzv, 2x05, 2x09

HET: unf

ECHA6_MYCTU_2_243 [text] Probable enoyl-CoA hydratase echA6 [Enoyl-CoA hydratase/isomerase family]

volume: 976. Å3; shape: 0.34; buriedness: 0.73

negative: 0.1; positive: 0.15; polar: 0.08; backbone: 0.37; hydrophobic: 0.29

PDB: 3he2, 5dtp, 5dtw, 5du4, 5du6, 5du8, 5duc, 5duf

HET: 5f9, 5ff, 5fk, g51, g59, g7a, pge

ECR_HELVI_304_550 [text] Ecdysone receptor [Nuclear hormone receptor family. NR1 subfamily]

volume: 512. Å3; shape: 0.57; buriedness: 0.99

negative: 0.03; positive: 0.03; polar: 0.23; backbone: 0.26; hydrophobic: 0.45

Domains/regions: [R] Hormone-binding

PDB: 1r1k, 1r20, 2r40, 3ixp

HET: 20e, 834, hwg, p1a

EDNRB_HUMAN_64_407_TM [text] Endothelin B receptor [G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily]

volume: 1857. Å3; shape: 0.66; buriedness: 0.72

negative: 0.06; positive: 0.13; polar: 0.13; backbone: 0.24; hydrophobic: 0.44

PDB: 5glh, 5gli

EED_HUMAN_77_441 [text] Polycomb protein EED [WD repeat ESC family]

volume: 930. Å3; shape: 0.75; buriedness: 0.44

negative: 0.07; positive: 0.07; polar: 0.36; backbone: 0.22; hydrophobic: 0.28

Domains/regions: [R] Interaction with EZH2, [R] Required for interaction with the matrix protein MA of HIV-1

PDB: 2qxv, 3iiw, 3iiy, 3ij0, 3ij1, 3ijc, 3jpx, 3jzg, 3jzh, 3jzn, 3k26, 3k27, 4x3e, 5hyn, 5ij7, 5ij8

HET: m3l, nds

EF2_YEAST_1_842 [text] Elongation factor 2 [TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily]

volume: 470. Å3; shape: 0.74; buriedness: 0.78

negative: 0.03; positive: 0.; polar: 0.08; backbone: 0.51; hydrophobic: 0.38

PDB: 1n0u, 1n0v, 1u2r, 1zm2, 1zm3, 1zm4, 1zm9, 2e1r, 2npf, 2zit, 3b78, 3b82, 3b8h

HET: mou, so1, sod

EFEB_ECOLI_35_423 [text] Deferrochelatase/peroxidase EfeB [DyP-type peroxidase family. EfeB subfamily]

volume: 410. Å3; shape: 0.82; buriedness: 0.95

negative: 0.04; positive: 0.14; polar: 0.18; backbone: 0.18; hydrophobic: 0.46

Domains/regions: [R] Heme binding

PDB: 2y4d, 2y4e, 2y4f, 3o72

HET: hem, pg4, pp9

EFTU1_ECOLI_3_394 [text] Elongation factor Tu 1 [TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily]

volume: 382. Å3; shape: 0.65; buriedness: 0.74

negative: 0.05; positive: 0.11; polar: 0.21; backbone: 0.52; hydrophobic: 0.12

Domains/regions: [D] tr-type G, [R] G1, [R] G4, [R] G5

PDB: 1d8t, 1etu, 2fx3, 2hcj, 2hdn, 3u2q, 3u6b, 3u6k, 4g5g, 4p3y, 4pc1, 4pc2, 4pc3, 4pc6, 4q7j, 5jbq

HET: gdp, gnp

EFTU1_THET8_2_406 [text] Elongation factor Tu-A [TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily]

volume: 200. Å3; shape: 0.63; buriedness: 0.75

negative: 0.11; positive: 0.09; polar: 0.; backbone: 0.49; hydrophobic: 0.31

PDB: 1aip, 1b23, 1ob5, 1ttt, 1tui, 2c78, 4h9g, 4lbv, 4lbw, 4lby, 4lbz, 4lc0

HET: 14j, mg

EFTU2_ECOLI_3_394 [text] Elongation factor Tu 2 [TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily]

volume: 206. Å3; shape: 0.75; buriedness: 0.64

negative: 0.26; positive: 0.34; polar: 0.; backbone: 0.4; hydrophobic: 0.

Domains/regions: [D] tr-type G

PDB: 1dg1, 1efc, 1efm, 1efu, 1ob2, 2bvn

HET: suc

EGFR_HUMAN_721_983 [text] Epidermal growth factor receptor [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 731. Å3; shape: 0.6; buriedness: 0.79

negative: 0.09; positive: 0.04; polar: 0.08; backbone: 0.42; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 1m14, 1m17, 1xkk, 2eb2, 2eb3, 2gs2, 2gs6, 2gs7, 2itn, 2ito, 2itp, 2itq, 2itt, 2itu, 2itv, 2itw, 2itx, 2ity, 2itz, 2j5e, 2j5f, 2j6m, 2jit, 2jiu, 2jiv, 2rf9, 2rfe, 2rgp, 3bel, 3gop, 3gt8, 3ika, 3lzb, 3poz, 3ug1, 3ug2, 3vjn, 3vjo, 3w2o, 3w2p, 3w2q, 3w2r, 3w2s, 3w32, 3w33, 4g5j, 4g5p, 4hjo, 4i1z, 4i20, 4i21, 4i22, 4i23, 4i24, 4jq7, 4jq8, 4jr3, 4jrv, 4li5, 4lqm, 4r3p, 4r3r, 4r5s, 4riw, 4rix, 4riy, 4rj4, 4rj5, 4rj6, 4rj7, 4rj8, 4tks, 4wd5, 4wkq, 4wrg, 4zau, 4zjv, 4zse, 5c8k, 5c8m, 5c8n, 5cal, 5can, 5cao, 5cap, 5caq, 5cas, 5cau, 5cav, 5cnn, 5cno, 5czh, 5czi, 5d41, 5edp, 5edq, 5edr, 5em5, 5em6, 5em7, 5em8, 5fed, 5fee, 5feq, 5hcx, 5hcy, 5hcz, 5hg5, 5hg7, 5hg8, 5hg9, 5hib, 5hic, 5j9y, 5j9z, 5jeb

HET: 03p, 0un, 0wn, 112, 1c9, 1wy, 3lh, 3qs, 3qw, 3qy, 3r0, 3r1, 4yv, 4yw, 4yx, 4z8, 4zb, 4zg, 4zh, 4zj, 4zq, 4zr, 57n, 5n3, 5n4, 5q2, 5q3, 5q4, 5x4, 5xh, 60b, 60d, 60e, 630, 633, 634, 63a, 63m, 63n, 6hj, 6hl, 6js, adp, aee, anp, aq4, djk, fi3, fmm, hki, hyz, ire, iti, itq, kj8, kjq, kjr, kjv, mg, pox, w19, w2p, w2r, w32, yy3

EGFR_HUMAN_983_1022 [text] Epidermal growth factor receptor [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 320. Å3; shape: 0.7; buriedness: 0.32

negative: 0.; positive: 0.37; polar: 0.16; backbone: 0.48; hydrophobic: 0.

PDB: 1m14, 1m17, 1xkk, 2eb2, 2eb3, 2gs2, 2gs6, 2gs7, 2itn, 2ito, 2itp, 2itq, 2itt, 2itu, 2itv, 2itw, 2itx, 2ity, 2itz, 2j5e, 2j5f, 2j6m, 2jit, 2jiu, 2jiv, 2rf9, 2rfe, 2rgp, 3bel, 3gop, 3gt8, 3ika, 3poz, 3ug1, 3ug2, 3vjn, 3vjo, 3w2o, 3w2p, 3w2q, 3w2r, 3w2s, 3w32, 3w33, 4g5j, 4g5p, 4hjo, 4i1z, 4i20, 4i21, 4i22, 4i23, 4i24, 4jq7, 4jq8, 4jr3, 4jrv, 4li5, 4lqm, 4r3p, 4r3r, 4r5s, 4riw, 4rix, 4riy, 4rj4, 4rj5, 4rj6, 4rj7, 4rj8, 4tks, 4wd5, 4wkq, 4wrg, 4zau, 4zjv, 4zse, 5c8k, 5c8m, 5c8n, 5cal, 5can, 5cao, 5cap, 5caq, 5cas, 5cau, 5cav, 5cnn, 5cno, 5czh, 5czi, 5d41, 5edp, 5edq, 5edr, 5em5, 5em6, 5em7, 5em8, 5fed, 5fee, 5feq, 5hcx, 5hcy, 5hcz, 5hg5, 5hg7, 5hg8, 5hg9, 5hib, 5hic, 5j9y, 5j9z, 5jeb

HET: 0wm

EGLN1_HUMAN_181_396 [text] Egl nine homolog 1

volume: 1268. Å3; shape: 0.6; buriedness: 0.84

negative: 0.11; positive: 0.25; polar: 0.18; backbone: 0.15; hydrophobic: 0.3

Domains/regions: [D] Fe2OG dioxygenase

PDB: 2g19, 2g1m, 2hbt, 2hbu, 2y33, 2y34, 3hqr, 3hqu, 3ouh, 3oui, 3ouj, 4bqw, 4bqx, 4bqy, 4jzr, 4kbz, 4uwd, 5a3u, 5l9b, 5l9r, 5l9v, 5la9, 5las, 5lat, 5lb6, 5lbb, 5lbc, 5lbe, 5lbf

HET: 014, 1qa, 42z, 4hg, 4jr, fnt, oga, pg4, qnm, r8j, un9

EGS1_OCIBA_1_314 [text] Eugenol synthase 1 [NmrA-type oxidoreductase family]

volume: 166. Å3; shape: 0.55; buriedness: 0.9

negative: 0.; positive: 0.; polar: 0.07; backbone: 0.28; hydrophobic: 0.65

PDB: 2qw8, 2qx7, 2qys, 2qzz, 2r2g, 2r6j, 3c3x

HET: emf

EGTB_MYCT3_2_446 [text] Hercynine oxygenase [EgtB family]

volume: 123. Å3; shape: 0.61; buriedness: 0.73

negative: 0.; positive: 0.31; polar: 0.62; backbone: 0.; hydrophobic: 0.08

PDB: 4x8b, 4x8d, 4x8e

HET: avi, avj

EGTC_MYCS2_1_227 [text] Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase

volume: 318. Å3; shape: 0.54; buriedness: 0.92

negative: 0.05; positive: 0.1; polar: 0.2; backbone: 0.47; hydrophobic: 0.18

Domains/regions: [D] Glutamine amidotransferase type-2

PDB: 4zfj, 4zfk, 4zfl

HET: 4nk

EGTD_MYCS2_1_321 [text] Histidine N-alpha-methyltransferase [Methyltransferase superfamily. EgtD family]

volume: 321. Å3; shape: 0.58; buriedness: 0.95

negative: 0.07; positive: 0.03; polar: 0.37; backbone: 0.25; hydrophobic: 0.28

Domains/regions: [R] L-histidine binding, [R] S-adenosyl-L-methionine binding

PDB: 4pim, 4pin, 4pio, 4pip, 4uy5, 4uy6, 4uy7

HET: avi, sah

EHMT1_HUMAN_986_1266 [text] Histone-lysine N-methyltransferase EHMT1 [Class V-like SAM-binding methyltransferase superfamily]

volume: 1037. Å3; shape: 0.55; buriedness: 0.71

negative: 0.14; positive: 0.07; polar: 0.07; backbone: 0.5; hydrophobic: 0.23

Domains/regions: [D] SET, [R] Interaction with histone H3, [R] S-adenosyl-L-methionine binding

PDB: 2igq, 2rfi, 3fpd, 3hna, 3mo0, 3mo2, 3mo5, 3sw9, 3swc, 4i51

HET: e11, e67, e72, ldh, mly, mlz, q4a

EHMT2_HUMAN_914_1192 [text] Histone-lysine N-methyltransferase EHMT2 [Class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily]

volume: 674. Å3; shape: 0.59; buriedness: 0.69

negative: 0.16; positive: 0.04; polar: 0.08; backbone: 0.45; hydrophobic: 0.27

Domains/regions: [D] SET, [R] Interaction with histone H3

PDB: 2o8j, 3k5k, 3rjw, 4nvq, 5jhn, 5jin, 5jiy, 5jj0, 5t0k, 5t0m

HET: 2od, ciq, dxq, nle

EHPR_ENTAG_2_129 [text] Phenazine antibiotic resistance protein EhpR

volume: 165. Å3; shape: 0.81; buriedness: 0.85

negative: 0.07; positive: 0.; polar: 0.2; backbone: 0.24; hydrophobic: 0.49

Domains/regions: [R] Phenazine antibiotic binding

PDB: 3sk1, 3sk2

HET: gri

EIS_MYCTU_2_408 [text] Enhanced intracellular survival protein [UPF0256 (eis) family]

volume: 1035. Å3; shape: 0.4; buriedness: 0.72

negative: 0.07; positive: 0.11; polar: 0.07; backbone: 0.45; hydrophobic: 0.29

Domains/regions: [D] N-acetyltransferase

PDB: 3r1k, 3ryo, 3sxo, 3uy5, 4jd6, 5ebv, 5ec4

HET: 5lq, 5lr, aco, coa, toy

EIZFM_STRCO_1_461 [text] Epi-isozizaene 5-monooxygenase/(E)-beta-farnesene synthase [Cytochrome P450 family]

volume: 132. Å3; shape: 0.8; buriedness: 0.68

negative: 0.; positive: 0.; polar: 0.; backbone: 0.22; hydrophobic: 0.78

PDB: 3dbg, 3el3

HET: el3

ELAS_PSEAE_198_498 [text] Elastase [Peptidase M4 family]

volume: 408. Å3; shape: 0.78; buriedness: 0.69

negative: 0.16; positive: 0.33; polar: 0.12; backbone: 0.08; hydrophobic: 0.31

PDB: 1ezm, 1u4g, 3dbk, 4k89

HET: hpi, rdf

ELBP_ECOLX_22_124 [text] Heat-labile enterotoxin B chain

volume: 314. Å3; shape: 0.62; buriedness: 0.64

negative: 0.1; positive: 0.21; polar: 0.4; backbone: 0.19; hydrophobic: 0.1

PDB: 1djr, 1eef, 1efi, 1fd7, 1htl, 1jqy, 1lt3, 1lt4, 1lt5, 1lt6, 1lta, 1ltb, 1ltg, 1lti, 1lts, 1ltt, 1pzi, 2xrq, 2xrs

HET: 1dm, a32, ai1, bez, gaa, gat, gla, i06, tdg

ELIB_PHYCI_1_98 [text] Beta-elicitin cinnamomin [Elicitin family]

volume: 328. Å3; shape: 0.37; buriedness: 0.95

negative: 0.; positive: 0.; polar: 0.17; backbone: 0.31; hydrophobic: 0.51

PDB: 1ljp, 2a8f, 2aib

HET: erg

ELIB_PHYCR_21_118 [text] Beta-elicitin cryptogein [Elicitin family]

volume: 302. Å3; shape: 0.35; buriedness: 0.95

negative: 0.; positive: 0.; polar: 0.2; backbone: 0.24; hydrophobic: 0.57

PDB: 1beo, 1bxm, 1lri

HET: clr, erg

ELIC_DICCH_5_319 [text] Cys-loop ligand-gated ion channel [Ligand-gated ion channel (TC 1.A.9) family]

volume: 253. Å3; shape: 0.77; buriedness: 0.91

negative: 0.14; positive: 0.05; polar: 0.24; backbone: 0.29; hydrophobic: 0.29

PDB: 2vl0, 2yks, 2yn6, 3rqu, 3rqw, 3uq4, 4a97, 4twd, 4z90, 4z91, 5hej, 5heo, 5heu

HET: 377, 4lj, ach, zpc

ELNE_HUMAN_30_247 [text] Neutrophil elastase [Peptidase S1 family. Elastase subfamily]

volume: 843. Å3; shape: 0.62; buriedness: 0.64

negative: 0.07; positive: 0.1; polar: 0.11; backbone: 0.47; hydrophobic: 0.25

Domains/regions: [D] Peptidase S1

PDB: 1b0f, 1h1b, 1hne, 1ppf, 1ppg, 2rg3, 2z7f, 3q76, 3q77, 4nzl, 4wvp, 5a09, 5a0a, 5a0b, 5a0c, 5a8x, 5a8y, 5a8z, 5abw

HET: 0qe, 151, 2hy, 3v2, 3v3, alv, btn, hmb, iul, iuy, jjd, jjs, jjv, jjx, mli, msu, nlb, oic, omt, sei, vai, vbm, wqq

END4_THEMA_1_286 [text] Probable endonuclease 4 [AP endonuclease 2 family]

volume: 104. Å3; shape: 0.72; buriedness: 0.55

negative: 0.16; positive: 0.32; polar: 0.05; backbone: 0.47; hydrophobic: 0.

PDB: 2x7v, 2x7w, 4hno

HET: bcn

ENO1_YEAST_2_437 [text] Enolase 1 [Enolase family]

volume: 127. Å3; shape: 0.67; buriedness: 0.97

negative: 0.32; positive: 0.21; polar: 0.13; backbone: 0.24; hydrophobic: 0.11

Domains/regions: [R] Substrate binding

PDB: 1ebg, 1ebh, 1els, 1l8p, 1nel, 1one, 1p43, 1p48, 2al1, 2al2, 2one, 2xgz, 2xh0, 2xh2, 2xh4, 2xh7, 3enl, 4enl, 5enl, 6enl, 7enl

HET: 2pg, li, mg, mn, pah, pep, pga

ENO_CHLAA_1_426 [text] Enolase [Enolase family]

volume: 111. Å3; shape: 0.72; buriedness: 0.84

negative: 0.38; positive: 0.3; polar: 0.16; backbone: 0.16; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 4yws, 4z17, 4z1y

HET: 2pg, pep

ENOG_HUMAN_2_434 [text] Gamma-enolase [Enolase family]

volume: 114. Å3; shape: 0.75; buriedness: 0.98

negative: 0.25; positive: 0.23; polar: 0.15; backbone: 0.29; hydrophobic: 0.08

Domains/regions: [R] Substrate binding

PDB: 1te6, 2akm, 2akz, 3ucc, 3ucd, 3uje, 3ujf, 3ujr, 3ujs, 4za0, 4zcw, 5eu9

HET: 0v5, 2pg, 4ng, 5tx, pah, pep, xsp

ENOPH_HUMAN_1_261 [text] Enolase-phosphatase E1 [HAD-like hydrolase superfamily. MasA/MtnC family]

volume: 124. Å3; shape: 0.47; buriedness: 0.84

negative: 0.08; positive: 0.08; polar: 0.17; backbone: 0.29; hydrophobic: 0.38

Domains/regions: [R] Substrate binding

PDB: 1yns, 1zs9

HET: hpo

ENO_STAAU_1_434 [text] Enolase [Enolase family]

volume: 94. Å3; shape: 0.68; buriedness: 0.87

negative: 0.32; positive: 0.36; polar: 0.05; backbone: 0.27; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 5boe, 5bof

HET: pep

ENO_SYNP6_4_429 [text] Enolase [Enolase family]

volume: 95. Å3; shape: 0.67; buriedness: 0.89

negative: 0.27; positive: 0.32; polar: 0.08; backbone: 0.32; hydrophobic: 0.

Domains/regions: [R] Substrate binding

PDB: 4rop, 5j04

HET: pep

ENPL_HUMAN_70_337 [text] Endoplasmin [Heat shock protein 90 family]

volume: 473. Å3; shape: 0.86; buriedness: 0.79

negative: 0.1; positive: 0.05; polar: 0.17; backbone: 0.34; hydrophobic: 0.33

PDB: 1qy5, 1qy8, 1qye, 1tbw, 1tc0, 1tc6, 1u0y, 1u0z, 1u2o, 1ysz, 1yt0, 1yt1, 1yt2, 2esa, 2exl, 2fyp, 2gfd, 2gqp, 2h8m, 2hch, 2hg1, 2o1u, 2o1v, 2o1w, 3o2f, 4nh9, 5in9

HET: 2lc, 6c0, adp, amp, anp, atp, cdy, gdm, mg, n5a, n5o, nec, nei, p54, pa7, pg4, rda, rdc, rde, rdi

ENPP2_HUMAN_40_863 [text] Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 [Nucleotide pyrophosphatase/phosphodiesterase family]

volume: 1152. Å3; shape: 0.6; buriedness: 0.82

negative: 0.05; positive: 0.12; polar: 0.16; backbone: 0.25; hydrophobic: 0.41

Domains/regions: [D] SMB 1, [R] Substrate binding

PDB: 2xr9, 2xrg, 3nkm, 3nkn, 3nko, 3nkp, 3nkq, 3nkr, 3wav, 3waw, 3wax, 3way, 4zg6, 4zg7, 4zg9, 4zga, 5dlt, 5dlv, 5dlw, 5hrt, 5ijq, 5ijs, 5kxa, 5l0b, 5l0e, 5l0k, 5lia

HET: 4ny, 4o0, 4o2, 4o3, 5d5, 5jk, 6xn, 6y7, 6zm, 6zn, 6zo, acd, dwv, dww, dwx, dwy, nkn, nko, nkp, nkq, nkr, swh

ENPP6_MOUSE_1_422 [text] Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 [Nucleotide pyrophosphatase/phosphodiesterase family]

volume: 115. Å3; shape: 0.52; buriedness: 0.87

negative: 0.23; positive: 0.23; polar: 0.46; backbone: 0.08; hydrophobic: 0.

PDB: 5ege, 5egh

HET: pc

ENTC_ECOLI_1_391 [text] Isochorismate synthase EntC [Isochorismate synthase family]

volume: 161. Å3; shape: 0.65; buriedness: 1.

negative: 0.18; positive: 0.18; polar: 0.06; backbone: 0.42; hydrophobic: 0.16

Domains/regions: [R] Substrate

PDB: 3hwo, 5jxz, 5jy4, 5jy8, 5jzd

HET: isc, isj

ENTP2_RAT_27_462 [text] Ectonucleoside triphosphate diphosphohydrolase 2 [GDA1/CD39 NTPase family]

volume: 277. Å3; shape: 0.7; buriedness: 0.63

negative: 0.2; positive: 0.26; polar: 0.23; backbone: 0.2; hydrophobic: 0.1

PDB: 3cj1, 3cj7, 3cj9, 3cja, 4bqz, 4br0, 4br2, 4br5, 4cd1, 4cd3

HET: 8e9

ENV_HV1Y2_326_479 [text] Envelope glycoprotein gp160

volume: 547. Å3; shape: 0.52; buriedness: 0.68

negative: 0.12; positive: 0.02; polar: 0.15; backbone: 0.37; hydrophobic: 0.34

Domains/regions: [R] CD4-binding loop

PDB: 1g9n, 1rzk, 1yyl, 1yym, 2i5y, 2i60, 2qad, 3hi1, 3tgq, 4dvr, 4jzw, 4jzz, 4k0a, 4ka2, 4laj, 4rwy

HET: 0ly, 1op, bif, dpr, u2x, u3x

EP300_HUMAN_1043_1161 [text] Histone acetyltransferase p300

volume: 341. Å3; shape: 0.65; buriedness: 0.62

negative: 0.; positive: 0.08; polar: 0.31; backbone: 0.14; hydrophobic: 0.47

Domains/regions: [D] Bromo

PDB: 3i3j, 4bhw, 5bt3, 5lkt, 5lku, 5lkx, 5lkz

HET: 2lo

EPAS1_HUMAN_238_353 [text] Endothelial PAS domain-containing protein 1

volume: 210. Å3; shape: 0.59; buriedness: 1.

negative: 0.; positive: 0.06; polar: 0.45; backbone: 0.05; hydrophobic: 0.44

Domains/regions: [D] PAC, [D] PAS 2

PDB: 3f1n, 3f1o, 3f1p, 3h7w, 3h82, 4ghi, 4gs9, 4pky, 4xt2, 4zp4, 4zph, 4zqd, 5t0t, 5tbm

HET: 018, 020, 0x3, 0xb, 2xy, 72q, 79a

EPHA2_HUMAN_594_903_ATPsite [text] Ephrin type-A receptor 2 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 660. Å3; shape: 0.43; buriedness: 0.75

negative: 0.06; positive: 0.06; polar: 0.12; backbone: 0.43; hydrophobic: 0.32

Domains/regions: [D] Protein kinase, [R] Mediates interaction with ARHGEF16 and ELMO2

PDB: 1mqb, 4p2k, 4pdo, 4trl, 5ek7, 5i9u, 5i9v, 5i9w, 5i9x, 5i9y, 5i9z, 5ia0, 5ia1, 5ia2, 5ia3, 5ia4, 5ia5

HET: 1n1, 627, 88z, a5b, ags, anp, db8, gv0, l66, p17, zzl

EPHA3_HUMAN_604_947 [text] Ephrin type-A receptor 3 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 502. Å3; shape: 0.46; buriedness: 0.83

negative: 0.04; positive: 0.04; polar: 0.12; backbone: 0.49; hydrophobic: 0.3

Domains/regions: [D] Protein kinase

PDB: 2gsf, 2qo2, 2qo7, 2qo9, 2qob, 2qoc, 2qod, 2qof, 2qoi, 2qok, 2qol, 2qon, 2qoo, 2qoq, 3dzq, 3fxx, 3fy2, 4g2f, 4gk2, 4gk3, 4gk4, 4p4c, 4p5q, 4p5z, 4twn, 4two

HET: 25q, 37w, anp, b96, c07, ifc, l66, l87, l90, mg, q0b, q7m

EPHA4_HUMAN_604_894 [text] Ephrin type-A receptor 4 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 342. Å3; shape: 0.34; buriedness: 0.78

negative: 0.05; positive: 0.05; polar: 0.11; backbone: 0.4; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 2hel, 2xyu, 2y6m, 2y6o

HET: 1n1, q9g

EPHA7_HUMAN_589_908 [text] Ephrin type-A receptor 7 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 259. Å3; shape: 0.39; buriedness: 0.92

negative: 0.12; positive: 0.03; polar: 0.06; backbone: 0.29; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 2rei, 3dko

HET: ihz

EPHB2_HUMAN_604_902 [text] Ephrin type-B receptor 2 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 232. Å3; shape: 0.56; buriedness: 0.78

negative: 0.; positive: 0.08; polar: 0.16; backbone: 0.25; hydrophobic: 0.51

Domains/regions: [D] Protein kinase

PDB: 1jpa, 2hen, 3zfm

HET: adp, anp

EPHB3_HUMAN_614_910 [text] Ephrin type-B receptor 3 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 212. Å3; shape: 0.45; buriedness: 0.9

negative: 0.; positive: 0.05; polar: 0.14; backbone: 0.39; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 3zfy, 5l6o, 5l6p

HET: 6p6, 6p8

EPHB4_HUMAN_598_896 [text] Ephrin type-B receptor 4 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 439. Å3; shape: 0.52; buriedness: 0.79

negative: 0.05; positive: 0.05; polar: 0.09; backbone: 0.45; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 2vwu, 2vwv, 2vww, 2vwx, 2vwy, 2vwz, 2vx0, 2vx1, 2x9f, 2xvd, 2yn8, 3zew, 4aw5, 4bb4

HET: 30k, 32w, 7x1, 7x2, 7x3, 7x4, 7x5, 7x6, 7x7, 7x8, as6, stu, x9f

EPHB_MYCTO_1_356 [text] Epoxide hydrolase B [AB hydrolase superfamily. Epoxide hydrolase family]

volume: 106. Å3; shape: 0.37; buriedness: 0.99

negative: 0.13; positive: 0.13; polar: 0.33; backbone: 0.; hydrophobic: 0.4

Domains/regions: [D] AB hydrolase-1

PDB: 2e3j, 2zjf

HET: bsu

EPMA_ECOLI_2_325 [text] Elongation factor P--(R)-beta-lysine ligase [Class-II aminoacyl-tRNA synthetase family. EpmA subfamily]

volume: 321. Å3; shape: 0.44; buriedness: 0.9

negative: 0.16; positive: 0.14; polar: 0.09; backbone: 0.4; hydrophobic: 0.21

Domains/regions: [R] Substrate binding

PDB: 3a5y, 3a5z, 3g1z

HET: amp, kaa

EPN1_HUMAN_12_156 [text] Epsin-1 [Epsin family]

volume: 209. Å3; shape: 0.74; buriedness: 0.64

negative: 0.; positive: 0.46; polar: 0.28; backbone: 0.26; hydrophobic: 0.

Domains/regions: [D] ENTH

PDB: 1edu, 1eyh, 1h0a, 5lp0

HET: i3p

ERAP1_HUMAN_39_529 [text] Endoplasmic reticulum aminopeptidase 1 [Peptidase M1 family]

volume: 238. Å3; shape: 0.49; buriedness: 0.76

negative: 0.34; positive: 0.17; polar: 0.14; backbone: 0.26; hydrophobic: 0.1

Domains/regions: [R] Substrate binding

PDB: 2yd0, 3mdj, 3qnf

HET: bes

ERAP2_HUMAN_1_960 [text] Endoplasmic reticulum aminopeptidase 2 [Peptidase M1 family]

volume: 1034. Å3; shape: 0.41; buriedness: 0.82

negative: 0.19; positive: 0.14; polar: 0.15; backbone: 0.3; hydrophobic: 0.22

Domains/regions: [R] Substrate binding

PDB: 3se6, 4e36, 4jbs, 5ab0, 5ab2, 5cu5

HET: 2x0, 7ga, lyn, p52

ERBB2_HUMAN_697_1029 [text] Receptor tyrosine-protein kinase erbB-2 [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 389. Å3; shape: 0.57; buriedness: 0.89

negative: 0.04; positive: 0.03; polar: 0.14; backbone: 0.39; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 3pp0, 3rcd

HET: 03p, 03q

ERBB3_HUMAN_683_1020_ATPsite [text] Receptor tyrosine-protein kinase erbB-3 [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 579. Å3; shape: 0.66; buriedness: 0.83

negative: 0.04; positive: 0.07; polar: 0.14; backbone: 0.45; hydrophobic: 0.3

Domains/regions: [D] Protein kinase

PDB: 3kex, 3lmg, 4otw, 4riw, 4rix, 4riy

HET: anp, db8

ERBB4_HUMAN_695_999 [text] Receptor tyrosine-protein kinase erbB-4 [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 332. Å3; shape: 0.39; buriedness: 0.92

negative: 0.05; positive: 0.04; polar: 0.08; backbone: 0.45; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 2r4b, 3bbt, 3bce

HET: fmm, gw7

ERG7_HUMAN_1_732 [text] Lanosterol synthase [Terpene cyclase/mutase family]

volume: 383. Å3; shape: 0.45; buriedness: 0.98

negative: 0.05; positive: 0.05; polar: 0.26; backbone: 0.16; hydrophobic: 0.47

PDB: 1w6j, 1w6k

HET: lan, r71

ERN1_HUMAN_554_974 [text] Serine/threonine-protein kinase/endoribonuclease IRE1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 617. Å3; shape: 0.51; buriedness: 0.85

negative: 0.04; positive: 0.09; polar: 0.11; backbone: 0.38; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 3p23, 4pl3, 4pl4, 4pl5, 4u6r, 4yz9, 4yzc, 4yzd, 4z7g, 4z7h, 5hgi

HET: 3e4, 4k7, 4l5, adp, mg, stu

ERR1_HUMAN_192_423 [text] Steroid hormone receptor ERR1 [Nuclear hormone receptor family. NR3 subfamily]

volume: 351. Å3; shape: 0.53; buriedness: 0.95

negative: 0.05; positive: 0.; polar: 0.; backbone: 0.33; hydrophobic: 0.61

Domains/regions: [R] Ligand binding domain

PDB: 1xb7, 2pjl, 3d24, 3k6p

HET: 047, 5fb

ERR3_HUMAN_228_458 [text] Estrogen-related receptor gamma [Nuclear hormone receptor family. NR3 subfamily]

volume: 358. Å3; shape: 0.56; buriedness: 0.96

negative: 0.04; positive: 0.07; polar: 0.08; backbone: 0.33; hydrophobic: 0.48

PDB: 1kv6, 1s9p, 1s9q, 1tfc, 1vjb, 2e2r, 2ewp, 2gp7, 2gpo, 2gpp, 2gpu, 2gpv, 2p7a, 2p7g, 2p7z, 2zas, 2zbs, 2zkc

HET: 1ba, 1oh, 2oh, 43m, bpz, des, oht, txf

ERYK_SACEN_1_397 [text] Erythromycin C-12 hydroxylase [Cytochrome P450 family]

volume: 586. Å3; shape: 0.68; buriedness: 0.75

negative: 0.06; positive: 0.08; polar: 0.2; backbone: 0.19; hydrophobic: 0.47

Domains/regions: [R] Substrate binding

PDB: 2jjn, 2jjo, 2jjp, 2wio, 2xfh, 3zkp

HET: cl6, erb, ey5, kln

ESR1_HUMAN_300_553 [text] Estrogen receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 463. Å3; shape: 0.91; buriedness: 0.99

negative: 0.04; positive: 0.08; polar: 0.04; backbone: 0.26; hydrophobic: 0.59

Domains/regions: [R] Interaction with AKAP13, [R] Transactivation AF-2

PDB: 1a52, 1ere, 1err, 1g50, 1gwq, 1gwr, 1l2i, 1pcg, 1qkt, 1qku, 1r5k, 1sj0, 1uom, 1x7e, 1x7r, 1xp1, 1xp6, 1xp9, 1xpc, 1xqc, 1yim, 1yin, 1zky, 2ayr, 2b1v, 2b1z, 2b23, 2bj4, 2fai, 2g44, 2g5o, 2i0j, 2iog, 2iok, 2jf9, 2jfa, 2ocf, 2ouz, 2p15, 2pog, 2q6j, 2q70, 2qa6, 2qa8, 2qab, 2qe4, 2qgt, 2qgw, 2qh6, 2qr9, 2qse, 2qxm, 2qxs, 2qzo, 2r6w, 2r6y, 2yat, 2yja, 3dt3, 3erd, 3ert, 3hlv, 3hm1, 3l03, 3os8, 3os9, 3osa, 3q95, 3q97, 3uu7, 3uua, 3uuc, 3uud, 4dma, 4iu7, 4iui, 4iv2, 4iv4, 4ivw, 4ivy, 4iw6, 4iw8, 4iwc, 4iwf, 4mg5, 4mg6, 4mg7, 4mg8, 4mg9, 4mga, 4mgb, 4mgc, 4mgd, 4pp6, 4ppp, 4pps, 4pxm, 4q13, 4q50, 4tuz, 4tv1, 4xi3, 4zn7, 4zn9, 4znh, 4zns, 4znt, 4znu, 4znv, 4znw, 5aau, 5aav, 5acc, 5ak2, 5di7, 5did, 5die, 5dig, 5dk9, 5dkb, 5dke, 5dkg, 5dks, 5dl4, 5dlr, 5dmc, 5dmf, 5dp0, 5drj, 5drm, 5dtv, 5du5, 5due, 5dug, 5duh, 5dvs, 5dvv, 5dwe, 5dwg, 5dwi, 5dwj, 5dx3, 5dxb, 5dxe, 5dxg, 5dxk, 5dxm, 5dxp, 5dxq, 5dxr, 5dy8, 5dyb, 5dyd, 5dz0, 5dz1, 5dz3, 5dzh, 5dzi, 5e0w, 5e0x, 5e14, 5e15, 5e19, 5e1c, 5egv, 5ehj, 5ei1, 5eit, 5fqp, 5fqr, 5fqs, 5fqt, 5fqv, 5hyr, 5kcc, 5kcd, 5kce, 5kcf, 5kct, 5kcu, 5kcw, 5kd9

HET: 0cz, 1gj, 1gm, 1gq, 1gr, 1gs, 1gt, 1gu, 27g, 27h, 29s, 369, 4q7, 4q9, 5c4, 5c6, 5c7, 5c8, 5c9, 5cc, 5dg, 5dh, 5es, 5ft, 5fv, 5fy, 5g3, 5g4, 5hz, 5j0, 5j1, 5j2, 5k2, 5k5, 5k7, 5k8, 5ka, 5kb, 5kd, 5ke, 5kf, 5kg, 7qn, 85z, aej, aih, aij, c3d, cm3, cm4, drq, e4d, ezt, gqd, gw5, hz3, iok, j0w, ke9, kn0, kn3, llb, llc, ob1, ob2, ob3, ob5, ob7, ob9, obb, obc, obh, obm, ode, ofb, pti, q97, qhg, srr, vqi, xbr

ESR2_HUMAN_260_502 [text] Estrogen receptor beta [Nuclear hormone receptor family. NR3 subfamily]

volume: 1500. Å3; shape: 0.44; buriedness: 0.58

negative: 0.07; positive: 0.08; polar: 0.05; backbone: 0.27; hydrophobic: 0.53

Domains/regions: [R] Steroid-binding

PDB: 1hj1, 1l2j, 1nde, 1qkm, 1qkn, 1u3q, 1u3r, 1u3s, 1u9e, 1x76, 1x78, 1x7b, 1x7j, 1yy4, 1yye, 1zaf, 2fsz, 2giu, 2i0g, 2j7x, 2j7y, 2jj3, 2nv7, 2qtu, 2yjd, 2yly, 2z4b, 3oll, 3ols, 3omo, 3omp, 3omq, 4j24, 4j26, 4zi1

HET: 041, 196, 244, 272, 338, 397, 3as, 4na, 555, 697, 789, 797, ace, aoe, dc8, e3o, est, etc, fbr, gen, i0g, jj3, kb0, mk8, mon, oht, ral, su4, w14, w23, wv7, yjd

EST1_HUMAN_20_559 [text] Liver carboxylesterase 1 [Type-B carboxylesterase/lipase family]

volume: 459. Å3; shape: 0.47; buriedness: 0.88

negative: 0.; positive: 0.05; polar: 0.09; backbone: 0.26; hydrophobic: 0.6

PDB: 1mx1, 1mx5, 1ya4, 1ya8, 1yah, 2dqy, 2dqz, 2dr0, 2h7c, 2hrq, 2hrr, 3k9b, 4ab1, 5a7f, 5a7g, 5a7h

HET: coa, ctx, eee, gd7, htq, ntj, plm, smb, tch, tha, ww2

EST2_PSEFL_1_218 [text] Carboxylesterase 2 [AB hydrolase superfamily. AB hydrolase 2 family]

volume: 119. Å3; shape: 0.72; buriedness: 0.81

negative: 0.; positive: 0.1; polar: 0.2; backbone: 0.27; hydrophobic: 0.44

PDB: 1auo, 1aur

HET: pms

ESTA_BACSU_33_212 [text] Lipase EstA [AB hydrolase superfamily]

volume: 366. Å3; shape: 0.28; buriedness: 0.72

negative: 0.; positive: 0.1; polar: 0.1; backbone: 0.34; hydrophobic: 0.45

PDB: 1i6w, 1isp, 1r4z, 1r50, 1t2n, 1t4m, 2qxt, 2qxu, 3d2a, 3d2b, 3d2c, 3qmm, 3qzu, 5cri, 5ct4, 5ct5, 5ct6, 5ct8, 5ct9, 5cta, 5cur

HET: bm0, ril, sil

ESTB_BURGA_1_392 [text] Esterase EstB [Class-A beta-lactamase family]

volume: 107. Å3; shape: 0.6; buriedness: 0.92

negative: 0.; positive: 0.; polar: 0.23; backbone: 0.34; hydrophobic: 0.43

PDB: 1ci8, 1ci9

HET: dfp

ETFD_PIG_34_617 [text] Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

volume: 531. Å3; shape: 0.33; buriedness: 0.76

negative: 0.; positive: 0.05; polar: 0.1; backbone: 0.4; hydrophobic: 0.45

PDB: 2gmh, 2gmj

HET: uq5

ETHR_MYCTU_1_216 [text] HTH-type transcriptional regulator EthR

volume: 510. Å3; shape: 0.29; buriedness: 0.97

negative: 0.03; positive: 0.02; polar: 0.18; backbone: 0.32; hydrophobic: 0.45

Domains/regions: [D] HTH tetR-type

PDB: 1t56, 1u9n, 1u9o, 3g1l, 3g1m, 3g1o, 3o8g, 3o8h, 3q0u, 3q0v, 3q0w, 3q3s, 3qpl, 3sdg, 3sfi, 3tp0, 3tp3, 4dw6, 4m3b, 4m3d, 4m3e, 4m3f, 4m3g, 5eyr, 5ezg, 5ezh, 5f04, 5f08, 5f0c, 5f0f, 5f0h, 5f1j, 5f27

HET: 0mn, 2b2, 2b3, 2d1, 2g1, 2h2, 3se, 3sf, 5t0, 5t4, 5tb, 5tc, 5td, 5te, 5tg, 5to, 5tt, 841, cns, dio, fo5, ll3, ll4, ll5, o8b, o8g, o8h, rf1, rf2, rf3

EX1_ECOLI_1_475 [text] Exodeoxyribonuclease I

volume: 353. Å3; shape: 0.89; buriedness: 0.63

negative: 0.; positive: 0.13; polar: 0.06; backbone: 0.34; hydrophobic: 0.47

Domains/regions: [D] ExoI SH3-like

PDB: 1fxx, 2qxf, 3c94, 3c95, 3hl8, 3hp9, 4hcb, 4hcc, 4jrp, 4jrq, 4js4, 4js5

HET: bbp, cf1

EXG1_CANAL_41_438 [text] Glucan 1,3-beta-glucosidase [Glycosyl hydrolase 5 (cellulase A) family]

volume: 352. Å3; shape: 0.47; buriedness: 0.77

negative: 0.17; positive: 0.07; polar: 0.31; backbone: 0.; hydrophobic: 0.45

PDB: 1cz1, 1eqc, 1eqp, 2pb1, 2pbo, 2pc8, 2pf0, 3n9k, 3o6a, 4m80, 4m81, 4m82

HET: cts, g2f, glf, nfg, ngb, pnw

EXO5_BPT5_10_291 [text] T5 flap endonuclease

volume: 202. Å3; shape: 0.45; buriedness: 0.35

negative: 0.16; positive: 0.14; polar: 0.2; backbone: 0.39; hydrophobic: 0.11

Domains/regions: [D] 5'-3' exonuclease

PDB: 1exn, 1ut5, 1ut8, 1xo1, 5hml, 5hmm, 5hnk, 5hp4

HET: b3p

EZH2_HUMAN_519_746 [text] Histone-lysine N-methyltransferase EZH2 [Class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily]

volume: 559. Å3; shape: 0.43; buriedness: 0.76

negative: 0.; positive: 0.07; polar: 0.21; backbone: 0.51; hydrophobic: 0.21

Domains/regions: [D] SET, [R] Interaction with DNMT1, DNMT3A and DNMT3B

PDB: 4mi0, 4mi5, 5hyn, 5ij7, 5ij8

HET: 6bn, sah

F16P1_HUMAN_1_338 [text] Fructose-1,6-bisphosphatase 1 [FBPase class 1 family]

volume: 898. Å3; shape: 0.34; buriedness: 0.84

negative: 0.07; positive: 0.11; polar: 0.13; backbone: 0.46; hydrophobic: 0.24

PDB: 1bk4, 1fta, 2fhy, 2fie, 2fix, 2jjk, 2vt5, 2wbb, 2wbd, 2y5k, 2y5l, 3a29, 3kbz, 3kc0, 3kc1, 4mjo, 5ldz

HET: 2c1, 2t0, 2t4, 2t5, 2t6, 870, a37, a74, amp, r15, ro3, ro5, ro8, rok, ycu

F16P1_PIG_2_337_allosteric2 [text] Fructose-1,6-bisphosphatase 1 [FBPase class 1 family]

volume: 596. Å3; shape: 0.6; buriedness: 0.34

negative: 0.; positive: 0.1; polar: 0.; backbone: 0.56; hydrophobic: 0.34

PDB: 1cnq, 1eyi, 1eyj, 1eyk, 1fbc, 1fbd, 1fbe, 1fbf, 1fbg, 1fbh, 1fbp, 1fj6, 1fj9, 1fpb, 1fpd, 1fpe, 1fpf, 1fpg, 1fpi, 1fpj, 1fpk, 1fpl, 1frp, 1fsa, 1kz8, 1lev, 1nuw, 1nux, 1nuy, 1nuz, 1nv0, 1nv1, 1nv2, 1nv3, 1nv4, 1nv5, 1nv6, 1nv7, 1q9d, 1rdx, 1rdy, 1rdz, 1yxi, 1yyz, 1yz0, 2f3b, 2f3d, 2fbp, 2qvu, 2qvv, 3fbp, 4fbp, 4gbv, 4gbw, 4gws, 4gwu, 4gww, 4gwx, 4gwy, 4gwz, 4gx3, 4gx4, 4gx6, 4h45, 4h46, 4kxp, 5fbp

HET: oi1, pfe

F16P1_PIG_2_337_allosteric [text] Fructose-1,6-bisphosphatase 1 [FBPase class 1 family]

volume: 269. Å3; shape: 0.75; buriedness: 0.82

negative: 0.06; positive: 0.09; polar: 0.17; backbone: 0.46; hydrophobic: 0.22

PDB: 1cnq, 1eyi, 1eyj, 1eyk, 1fbc, 1fbd, 1fbe, 1fbf, 1fbg, 1fbh, 1fbp, 1fj6, 1fj9, 1fpb, 1fpd, 1fpe, 1fpf, 1fpg, 1fpi, 1fpj, 1fpk, 1fpl, 1frp, 1fsa, 1kz8, 1lev, 1nuw, 1nux, 1nuy, 1nuz, 1nv0, 1nv1, 1nv2, 1nv3, 1nv4, 1nv5, 1nv6, 1nv7, 1q9d, 1rdx, 1rdy, 1rdz, 1yxi, 1yyz, 1yz0, 2f3b, 2f3d, 2fbp, 2qvu, 2qvv, 3fbp, 4fbp, 4gbv, 4gbw, 4gws, 4gwu, 4gww, 4gwx, 4gwy, 4gwz, 4gx3, 4gx4, 4gx6, 4h45, 4h46, 4kxp, 5fbp

HET: amp, cli, f6p, fdp

F16P1_PIG_2_337_catalytic [text] Fructose-1,6-bisphosphatase 1 [FBPase class 1 family]

volume: 247. Å3; shape: 0.65; buriedness: 0.88

negative: 0.14; positive: 0.13; polar: 0.27; backbone: 0.32; hydrophobic: 0.14

Domains/regions: [R] Substrate binding

PDB: 1cnq, 1eyi, 1eyj, 1eyk, 1fbc, 1fbd, 1fbe, 1fbf, 1fbg, 1fbh, 1fbp, 1fj6, 1fj9, 1fpb, 1fpd, 1fpe, 1fpf, 1fpg, 1fpi, 1fpj, 1fpk, 1fpl, 1frp, 1fsa, 1kz8, 1lev, 1nuw, 1nux, 1nuy, 1nuz, 1nv0, 1nv1, 1nv2, 1nv3, 1nv4, 1nv5, 1nv6, 1nv7, 1q9d, 1rdx, 1rdy, 1rdz, 1yxi, 1yyz, 1yz0, 2f3b, 2f3d, 2fbp, 2qvu, 2qvv, 3fbp, 4fbp, 4gbv, 4gbw, 4gws, 4gwu, 4gww, 4gwx, 4gwy, 4gwz, 4gx3, 4gx4, 4gx6, 4h45, 4h46, 4kxp, 5fbp

HET: afp, ahg, ahm, f6p, fbp, fdp, k, mg, mn, tl, zn

F16PA_ECOLI_1_332 [text] Fructose-1,6-bisphosphatase class 1 [FBPase class 1 family]

volume: 188. Å3; shape: 0.65; buriedness: 0.81

negative: 0.14; positive: 0.07; polar: 0.31; backbone: 0.33; hydrophobic: 0.14

Domains/regions: [R] Substrate binding

PDB: 2gq1, 2owz, 2ox3, 2q8m, 2qvr

HET: f6p, fbp, fdp, mg

F17AG_ECOLX_23_199 [text] F17a-G fimbrial adhesin [Fimbrial protein family]

volume: 250. Å3; shape: 0.79; buriedness: 0.59

negative: 0.08; positive: 0.; polar: 0.38; backbone: 0.31; hydrophobic: 0.23

Domains/regions: [R] Carbohydrate binding, [R] Receptor-binding lectin domain

PDB: 1o9v, 1o9w, 1o9z, 1zpl, 2bsc, 3f64, 3f6j

HET: lec, mag, mbg, nag, sng

F261_HUMAN_251_441 [text] 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

volume: 366. Å3; shape: 0.63; buriedness: 0.81

negative: 0.06; positive: 0.36; polar: 0.2; backbone: 0.16; hydrophobic: 0.23

Domains/regions: [R] Fructose-2,6-bisphosphatase

PDB: 1c7z, 1c80, 1c81, 1fbt, 1k6m, 1tip

HET: f6p, fdq, g3h, gtp

F263_HUMAN_1_449 [text] 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

volume: 426. Å3; shape: 0.49; buriedness: 0.93

negative: 0.03; positive: 0.; polar: 0.16; backbone: 0.42; hydrophobic: 0.38

Domains/regions: [R] 6-phosphofructo-2-kinase, [R] Fructose-2,6-bisphosphatase

PDB: 2axn, 2dwo, 2dwp, 2i1v, 3qpu, 3qpv, 3qpw, 4d4j, 4d4k, 4d4l, 4d4m, 4ma4, 5ajv, 5ajw, 5ajx, 5ajy, 5ajz, 5ak0

HET: 87t, 8r2, 8v1, acp, adp, bke, bki, bks, bkv, fd9, mg, mjp, s6l

FA10_HUMAN_126_476 [text] Coagulation factor X [Peptidase S1 family]

volume: 535. Å3; shape: 0.69; buriedness: 0.77

negative: 0.04; positive: 0.; polar: 0.18; backbone: 0.56; hydrophobic: 0.22

Domains/regions: [D] Peptidase S1

PDB: 1c5m, 1ezq, 1f0r, 1f0s, 1fax, 1fjs, 1g2l, 1g2m, 1hcg, 1ioe, 1iqe, 1iqf, 1iqg, 1iqh, 1iqi, 1iqj, 1iqk, 1iql, 1iqm, 1iqn, 1ksn, 1lpg, 1lpk, 1lpz, 1lqd, 1mq5, 1mq6, 1nfu, 1nfw, 1nfx, 1nfy, 1p0s, 1v3x, 1wu1, 1xka, 1xkb, 1z6e, 2bmg, 2boh, 2bok, 2bq6, 2bq7, 2bqw, 2cji, 2d1j, 2ei6, 2ei7, 2ei8, 2fzz, 2g00, 2gd4, 2h9e, 2j2u, 2j34, 2j38, 2j4i, 2j94, 2j95, 2jkh, 2p16, 2p3f, 2p3t, 2p3u, 2p93, 2p94, 2p95, 2phb, 2pr3, 2q1j, 2ra0, 2uwl, 2uwo, 2uwp, 2vh0, 2vh6, 2vvc, 2vvu, 2vvv, 2vwl, 2vwm, 2vwn, 2vwo, 2w26, 2w3i, 2w3k, 2wyg, 2wyj, 2xbv, 2xbw, 2xbx, 2xby, 2xc0, 2xc4, 2xc5, 2y5f, 2y5g, 2y5h, 2y7x, 2y7z, 2y80, 2y81, 2y82, 3cen, 3cs7, 3ens, 3ffg, 3hpt, 3iit, 3k9x, 3kl6, 3kqb, 3kqc, 3kqd, 3kqe, 3liw, 3m36, 3m37, 3q3k, 3sw2, 3tk5, 3tk6, 4a7i, 4bti, 4btt, 4btu, 4y6d, 4y71, 4y76, 4y79, 4y7a, 4y7b, 4zh8, 4zha, 5k0h

HET: 230, 443, 455, 461, 48u, 48w, 4o4, 4o5, 4o6, 4pp, 663, 701, 784, 815, 894, 895, 931, 987, 993, a7i, bi7, c0z, cbb, cmb, cmi, d01, d1q, d46, d76, d90, d92, dx9, ens, fjd, fxa, fxv, g15, gg2, gs5, gs6, gsi, gsj, gsk, gsq, gsv, gsx, h21, h22, h25, i1h, iib, iid, iie, lzf, lzg, lzh, me1, me4, me5, mza, pr2, rdr, riv, rpr, rr8, rrp, rrr, rtr, rup, xbv, xlc, xld, xmf, xmg, xmi, xmj, xmk, xwg, y5h, yet

FA11_HUMAN_387_625 [text] Coagulation factor XI [Peptidase S1 family. Plasma kallikrein subfamily]

volume: 760. Å3; shape: 0.6; buriedness: 0.74

negative: 0.08; positive: 0.09; polar: 0.1; backbone: 0.53; hydrophobic: 0.2

Domains/regions: [D] Peptidase S1, [R] Heparin-binding

PDB: 1xx9, 1xxd, 1xxf, 1zhm, 1zhp, 1zhr, 1zjd, 1zlr, 1zmj, 1zml, 1zmn, 1zom, 1zpb, 1zpc, 1zpz, 1zrk, 1zsj, 1zsk, 1zsl, 1ztj, 1ztk, 1ztl, 2f83, 2fda, 3bg8, 3sor, 3sos, 4cr5, 4cr9, 4cra, 4crb, 4crc, 4crd, 4cre, 4crf, 4crg, 4d76, 4d7f, 4d7g, 4na7, 4na8, 4ty6, 4ty7, 4wxi, 4x6m, 4x6n, 4x6o, 4x6p, 4y8x, 4y8y, 4y8z, 5e2o, 5e2p, 5eod, 5eok, 5exl, 5exm, 5exn, 5i25

HET: 0tu, 1t5, 1t6, 339, 367, 368, 39d, 39f, 3vm, 3y3, 3y4, 3y5, 3yu, 412, 421, 427, 4ce, 4d5, 4gr, 5jm, 5ss, 5st, 5su, 624, 62a, 632, 682, 709, 716, 737, 7p0, 995, ben, buk, e6u, hdb, inh, ixa, j1j, j4x, mvn, o58, o61, otj, otm, otw, r9b, xj8

FA7_HUMAN_149_466 [text] Coagulation factor VII [Peptidase S1 family]

volume: 757. Å3; shape: 0.84; buriedness: 0.75

negative: 0.11; positive: 0.07; polar: 0.14; backbone: 0.5; hydrophobic: 0.17

Domains/regions: [D] Peptidase S1

PDB: 1cvw, 1dan, 1dva, 1fak, 1j9c, 1jbu, 1kli, 1klj, 1o5d, 1qfk, 1w0y, 1w2k, 1w7x, 1w8b, 1wqv, 1wss, 1wtg, 1wun, 1wv7, 1ygc, 1z6j, 2a2q, 2aei, 2aer, 2b7d, 2b8o, 2bz6, 2c4f, 2ec9, 2f9b, 2fir, 2flb, 2flr, 2puq, 2zp0, 2zwl, 2zzu, 3ela, 3th2, 3th3, 3th4, 4ibl, 4ish, 4isi, 4jyu, 4jyv, 4jzd, 4jze, 4jzf, 4na9, 4ng9, 4nga, 4x8s, 4x8t, 4x8u, 4x8v, 4ylq, 4yt6, 4yt7, 4z6a, 4zma, 4zxx, 4zxy, 5i46, 5l2y, 5l2z, 5l30

HET: 03r, 0g7, 0ge, 0gj, 0qe, 0z6, 0z7, 1ge, 1gg, 1nj, 1nk, 1nl, 1oj, 1ok, 1t7, 24x, 2ke, 2kf, 346, 359, 380, 3bp, 3cb, 3z7, 3z8, 3z9, 3zb, 413, 4jy, 4k1, 4t0, 4t1, 567, 5pi, 67o, 6nh, 70a, 70c, 70d, 771, 7nh, 905, ar7, ben, c1b, cr9, gil, n1h, p5b, pbz, pi0, psm, py3

FA8_HUMAN_2190_2349 [text] Coagulation factor VIII [Multicopper oxidase family]

volume: 313. Å3; shape: 0.46; buriedness: 0.34

negative: 0.; positive: 0.17; polar: 0.11; backbone: 0.54; hydrophobic: 0.19

Domains/regions: [D] F5/8 type C 2

PDB: 1d7p, 1iqd, 3hnb, 3hny, 3hob, 4ki5, 4pt6, 4xzu

HET: 768

FA9_HUMAN_131_461 [text] Coagulation factor IX [Peptidase S1 family]

volume: 506. Å3; shape: 0.71; buriedness: 0.73

negative: 0.05; positive: 0.07; polar: 0.18; backbone: 0.53; hydrophobic: 0.17

Domains/regions: [D] Peptidase S1

PDB: 1rfn, 2wph, 2wpi, 2wpj, 2wpk, 2wpl, 2wpm, 3kcg, 3lc3, 3lc5, 4yzu, 4z0k, 4zae, 5egm, 5jb8, 5jb9, 5jba, 5jbb, 5jbc

HET: 0g6, 0gj, 4k6, 4ln, 4m1, 5ny, dpn, iyx, izx, pbz

FA9_PIG_48_409 [text] Coagulation factor IX [Peptidase S1 family]

volume: 488. Å3; shape: 0.61; buriedness: 0.75

negative: 0.06; positive: 0.08; polar: 0.2; backbone: 0.5; hydrophobic: 0.16

Domains/regions: [D] Peptidase S1

PDB: 1pfx, 1x7a

HET: 0g6, 187

FAAA_MOUSE_1_419 [text] Fumarylacetoacetase [FAH family]

volume: 172. Å3; shape: 0.51; buriedness: 0.98

negative: 0.22; positive: 0.17; polar: 0.23; backbone: 0.23; hydrophobic: 0.16

PDB: 1hyo, 1qcn, 1qco, 1qqj, 2hzy

HET: aae, dhj, fum, hbu

FAAH1_RAT_32_577 [text] Fatty-acid amide hydrolase 1 [Amidase family]

volume: 509. Å3; shape: 0.41; buriedness: 0.94

negative: 0.; positive: 0.03; polar: 0.17; backbone: 0.38; hydrophobic: 0.42

Domains/regions: [R] Substrate binding

PDB: 2vya, 2wap, 2wj1, 2wj2, 3k7f, 3k83, 3k84, 3lj6, 3lj7, 3oj8, 3ppm, 3pr0, 3qj8, 3qj9, 3qk5, 3qkv, 4do3, 4hbp, 4j5p

HET: 0la, 17j, br1, f27, f2c, jg1, jg2, k84, na, oho, oj8, ol1, pf7, pix, qj9, qk5, qkv, s99

FAB1_MYCTU_1_416 [text] 3-oxoacyl-[acyl-carrier-protein] synthase 1 [Beta-ketoacyl-ACP synthases family]

volume: 180. Å3; shape: 0.55; buriedness: 0.95

negative: 0.; positive: 0.13; polar: 0.17; backbone: 0.45; hydrophobic: 0.25

PDB: 2wgd, 2wge, 2wgf, 2wgg, 4c6u, 4c6v, 4c6w, 4c6x, 4c6z, 4c70, 4c71, 4c72, 4c73, 5ld8

HET: 7rd, tle, tlg, tlh, tlj, tlm

FABA_ECOLI_2_172 [text] 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase [Thioester dehydratase family. FabA subfamily]

volume: 416. Å3; shape: 0.57; buriedness: 0.93

negative: 0.04; positive: 0.07; polar: 0.07; backbone: 0.56; hydrophobic: 0.26

PDB: 1mka, 1mkb, 4keh

HET: 1r3, dac

FABA_PSEAE_1_171 [text] 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase [Thioester dehydratase family. FabA subfamily]

volume: 358. Å3; shape: 0.53; buriedness: 0.98

negative: 0.04; positive: 0.06; polar: 0.08; backbone: 0.55; hydrophobic: 0.27

PDB: 4b0b, 4b0c, 4b0i, 4b0j, 4b8u, 4cl6, 4fq9

HET: 3mq, 54f, 7sb, c9h, ibk, kbp

FABA_YERPE_1_172 [text] 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase [Thioester dehydratase family. FabA subfamily]

volume: 159. Å3; shape: 0.44; buriedness: 0.88

negative: 0.; positive: 0.12; polar: 0.07; backbone: 0.57; hydrophobic: 0.24

PDB: 3q62, 5f6r, 5hd6

HET: 5vo

FABB_ECOLI_1_406 [text] 3-oxoacyl-[acyl-carrier-protein] synthase 1 [Beta-ketoacyl-ACP synthases family]

volume: 379. Å3; shape: 0.42; buriedness: 0.98

negative: 0.04; positive: 0.06; polar: 0.06; backbone: 0.42; hydrophobic: 0.42

PDB: 1dd8, 1ek4, 1f91, 1fj4, 1fj8, 1g5x, 1h4f, 2aq7, 2aqb, 2buh, 2bui, 2byw, 2byx, 2byy, 2byz, 2bz3, 2bz4, 2vb7, 2vb8, 2vb9, 2vba

HET: cer, dao, dka, oca, p4t, tl5, tl6, tlm

FABF_BACSU_1_413 [text] 3-oxoacyl-[acyl-carrier-protein] synthase 2 [Beta-ketoacyl-ACP synthases family]

volume: 204. Å3; shape: 0.4; buriedness: 0.96

negative: 0.05; positive: 0.11; polar: 0.09; backbone: 0.37; hydrophobic: 0.37

PDB: 4ls5, 4ls6, 4ls7, 4ls8

HET: 1x9, 1xg

FABF_ECOLI_1_413 [text] 3-oxoacyl-[acyl-carrier-protein] synthase 2 [Beta-ketoacyl-ACP synthases family]

volume: 467. Å3; shape: 0.55; buriedness: 0.8

negative: 0.; positive: 0.1; polar: 0.15; backbone: 0.46; hydrophobic: 0.29

PDB: 1b3n, 1kas, 2gfv, 2gfw, 2gfx, 2gfy, 3g0y, 3g11, 3hnz, 3ho2, 3ho9, 3i8p

HET: 840, cer, dao, n32, n3a, p9a, p9c, pmn

FABG_PSEAE_1_247 [text] 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Short-chain dehydrogenases/reductases (SDR) family]

volume: 220. Å3; shape: 0.64; buriedness: 1.

negative: 0.; positive: 0.; polar: 0.08; backbone: 0.56; hydrophobic: 0.37

PDB: 4afn, 4ag3, 4bnt, 4bnu, 4bnv, 4bnw, 4bnx, 4bny, 4bnz, 4bo0, 4bo1, 4bo2, 4bo3, 4bo4, 4bo5, 4bo6, 4bo7, 4bo8, 4bo9

HET: 34x, 36e, 36g, 36i, 36k, 36p, 3x3, 8m5, 9kq, fxe, j2t, nkh, o74, q7u, u98, wi4

FABH_ECOLI_1_317 [text] 3-oxoacyl-[acyl-carrier-protein] synthase 3 [FabH family]

volume: 533. Å3; shape: 0.38; buriedness: 0.82

negative: 0.; positive: 0.12; polar: 0.16; backbone: 0.26; hydrophobic: 0.45

Domains/regions: [R] ACP-binding

PDB: 1ebl, 1hn9, 1hnd, 1hnh, 1hnj, 1hnk, 1mzs, 2eft, 2gyo, 3il9, 4z8d, 5bnm, 5bnr, 5bns

HET: 4lb, 4vk, 4vl, 4vm, 669, coa, mlc, pg4

FABH_ENTFA_2_321 [text] 3-oxoacyl-[acyl-carrier-protein] synthase 3 [FabH family]

volume: 603. Å3; shape: 0.51; buriedness: 0.82

negative: 0.; positive: 0.15; polar: 0.11; backbone: 0.35; hydrophobic: 0.39

Domains/regions: [R] ACP-binding

PDB: 3il4, 3il5, 3il6

HET: aco, b82, b83

FABH_MYCTU_1_335 [text] 3-oxoacyl-[acyl-carrier-protein] synthase 3 [FabH family]

volume: 830. Å3; shape: 0.5; buriedness: 0.93

negative: 0.; positive: 0.04; polar: 0.23; backbone: 0.39; hydrophobic: 0.33

Domains/regions: [R] ACP-binding

PDB: 1hzp, 1m1m, 1u6e, 1u6s, 2ahb, 2aj9, 2qnx, 2qny, 2qnz, 2qo0, 2qo1, 2qx1

HET: coa, d1t, dao, dcc, dfd, mdx, udt, vzz

FABI_BACCR_1_256 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 320. Å3; shape: 0.59; buriedness: 0.85

negative: 0.; positive: 0.03; polar: 0.2; backbone: 0.34; hydrophobic: 0.44

PDB: 2qio, 3oje, 3ojf

HET: imj, tcl

FABI_BACSU_1_258 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 282. Å3; shape: 0.59; buriedness: 0.83

negative: 0.; positive: 0.; polar: 0.23; backbone: 0.37; hydrophobic: 0.4

PDB: 3oif, 3oig

HET: imj, tcl

FABI_BRANA_80_382 [text] Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 590. Å3; shape: 0.54; buriedness: 0.86

negative: 0.03; positive: 0.03; polar: 0.16; backbone: 0.52; hydrophobic: 0.26

PDB: 1cwu, 1d7o, 1eno, 1enp

HET: nad, tcl, tdb

FABI_ECOLI_1_262 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 781. Å3; shape: 0.58; buriedness: 0.85

negative: 0.03; positive: 0.03; polar: 0.15; backbone: 0.44; hydrophobic: 0.36

PDB: 1c14, 1d8a, 1dfg, 1dfh, 1dfi, 1i2z, 1i30, 1lx6, 1lxc, 1mfp, 1qg6, 1qsg, 2fhs, 3pjd, 3pje, 3pjf, 4cv2, 4cv3, 4d46, 4jqc, 4jx8, 5cfz, 5cg1, 5cg2

HET: 0we, 654, 826, ae6, aym, bbn, cj3, idn, j47, nad, nai, ndt, pt6, tcl, tdb, vt4, zam

FABI_HELPY_1_275 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 170. Å3; shape: 0.48; buriedness: 0.82

negative: 0.; positive: 0.; polar: 0.24; backbone: 0.26; hydrophobic: 0.5

PDB: 2pd3, 2pd4