[POCKETOME]
 

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ACT3_STRCO_2_261 [text] Putative ketoacyl reductase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 345. Å3; shape: 0.78; buriedness: 0.78

negative: 0.; positive: 0.; polar: 0.34; backbone: 0.27; hydrophobic: 0.4

PDB: 1w4z, 1x7g, 1x7h, 1xr3, 2rh4, 2rhc, 2rhr, 3csd, 3qrw, 3ri3, 4dbz, 4dc0, 4dc1

HET: emo, isz

BPHB_COMTE_1_281 [text] Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 115. Å3; shape: 0.55; buriedness: 0.85

negative: 0.; positive: 0.; polar: 0.49; backbone: 0.26; hydrophobic: 0.25

PDB: 2y93, 2y99, 3zv3, 3zv4, 3zv5, 3zv6

HET: 4hb, bpy

CBR1_HUMAN_2_277 [text] Carbonyl reductase [NADPH] 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 539. Å3; shape: 0.73; buriedness: 0.75

negative: 0.; positive: 0.09; polar: 0.15; backbone: 0.39; hydrophobic: 0.37

Domains/regions: [R] Glutathione binding

PDB: 1wma, 2pfg, 3bhi, 3bhj, 3bhm, 4z3d

HET: ab3, ahe, ddd, gsh, pe5

DHB14_HUMAN_1_270 [text] 17-beta-hydroxysteroid dehydrogenase 14 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 236. Å3; shape: 0.62; buriedness: 0.8

negative: 0.; positive: 0.14; polar: 0.54; backbone: 0.14; hydrophobic: 0.18

PDB: 1yde, 5en4, 5hs6, 5icm, 5ics, 5js6, 5jsf

HET: 5q6, f45, j3z

DHB1_HUMAN_2_290 [text] Estradiol 17-beta-dehydrogenase 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 554. Å3; shape: 0.24; buriedness: 0.89

negative: 0.04; positive: 0.06; polar: 0.18; backbone: 0.3; hydrophobic: 0.42

PDB: 1a27, 1bhs, 1dht, 1equ, 1fds, 1fdt, 1fdu, 1fdv, 1fdw, 1i5r, 1iol, 1jtv, 1qyv, 1qyw, 1qyx, 3dey, 3dhe, 3hb4, 3hb5, 3klm, 3klp, 3km0

HET: 5sd, and, aom, asd, b81, dht, e2b, eqi, est, hyc, nad, nap, tes

DHI1_CAVPO_25_296 [text] Corticosteroid 11-beta-dehydrogenase isozyme 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 240. Å3; shape: 0.58; buriedness: 0.9

negative: 0.; positive: 0.; polar: 0.36; backbone: 0.4; hydrophobic: 0.24

PDB: 1xse, 3dwf, 3g49, 3lz6

HET: 3g4, a0d

DHI1_HUMAN_22_291 [text] Corticosteroid 11-beta-dehydrogenase isozyme 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 494. Å3; shape: 0.65; buriedness: 0.89

negative: 0.; positive: 0.; polar: 0.24; backbone: 0.34; hydrophobic: 0.42

PDB: 1xu7, 1xu9, 2bel, 2ilt, 2irw, 2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3fco, 3frj, 3h6k, 3hfg, 3oq1, 3pdj, 3qqp, 3tfq, 4bb5, 4bb6, 4c7j, 4c7k, 4hfr, 4hx5, 4iju, 4ijv, 4ijw, 4k1l, 4p38, 4yyz

HET: 07m, 14m, 17r, 19v, 1en, 1eo, 1eq, 21t, 311, 33t, 352, 3cz, 3oq, 3pj, 4jx, 4yq, a21, a49, cbo, cps, d3e, d4n, dzl, h11, hd1, hd2, iig, nn1, nn4, s05, sff, t30, zmg

DHI1_MOUSE_25_291 [text] Corticosteroid 11-beta-dehydrogenase isozyme 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 279. Å3; shape: 0.53; buriedness: 0.88

negative: 0.02; positive: 0.; polar: 0.38; backbone: 0.31; hydrophobic: 0.29

PDB: 1y5m, 1y5r, 3gmd, 4k26, 4nmh

HET: 2kg, 2m3, c0r, oct, sff

FABG_PSEAE_1_247 [text] 3-oxoacyl-[acyl-carrier-protein] reductase FabG [Short-chain dehydrogenases/reductases (SDR) family]

volume: 220. Å3; shape: 0.64; buriedness: 1.

negative: 0.; positive: 0.; polar: 0.08; backbone: 0.56; hydrophobic: 0.37

PDB: 4afn, 4ag3, 4bnt, 4bnu, 4bnv, 4bnw, 4bnx, 4bny, 4bnz, 4bo0, 4bo1, 4bo2, 4bo3, 4bo4, 4bo5, 4bo6, 4bo7, 4bo8, 4bo9

HET: 34x, 36e, 36g, 36i, 36k, 36p, 3x3, 8m5, 9kq, fxe, j2t, nkh, o74, q7u, u98, wi4

FABI_BACCR_1_256 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 320. Å3; shape: 0.59; buriedness: 0.85

negative: 0.; positive: 0.03; polar: 0.2; backbone: 0.34; hydrophobic: 0.44

PDB: 2qio, 3oje, 3ojf

HET: imj, tcl

FABI_BACSU_1_258 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 282. Å3; shape: 0.59; buriedness: 0.83

negative: 0.; positive: 0.; polar: 0.23; backbone: 0.37; hydrophobic: 0.4

PDB: 3oif, 3oig

HET: imj, tcl

FABI_BRANA_80_382 [text] Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 590. Å3; shape: 0.54; buriedness: 0.86

negative: 0.03; positive: 0.03; polar: 0.16; backbone: 0.52; hydrophobic: 0.26

PDB: 1cwu, 1d7o, 1eno, 1enp

HET: nad, tcl, tdb

FABI_ECOLI_1_262 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 781. Å3; shape: 0.58; buriedness: 0.85

negative: 0.03; positive: 0.03; polar: 0.15; backbone: 0.44; hydrophobic: 0.36

PDB: 1c14, 1d8a, 1dfg, 1dfh, 1dfi, 1i2z, 1i30, 1lx6, 1lxc, 1mfp, 1qg6, 1qsg, 2fhs, 3pjd, 3pje, 3pjf, 4cv2, 4cv3, 4d46, 4jqc, 4jx8, 5cfz, 5cg1, 5cg2

HET: 0we, 654, 826, ae6, aym, bbn, cj3, idn, j47, nad, nai, ndt, pt6, tcl, tdb, vt4, zam

FABI_HELPY_1_275 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 170. Å3; shape: 0.48; buriedness: 0.82

negative: 0.; positive: 0.; polar: 0.24; backbone: 0.26; hydrophobic: 0.5

PDB: 2pd3, 2pd4

HET: dcn, tcl

FABI_PSEAE_1_265 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 156. Å3; shape: 0.52; buriedness: 0.83

negative: 0.; positive: 0.; polar: 0.23; backbone: 0.45; hydrophobic: 0.32

PDB: 4nqz, 4nr0

HET: tcl

FABI_STAAR_1_256 [text] Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 264. Å3; shape: 0.57; buriedness: 0.88

negative: 0.; positive: 0.; polar: 0.2; backbone: 0.37; hydrophobic: 0.42

PDB: 3gns, 3gnt, 3gr6, 4ali, 4alj, 4alk, 4all, 4alm, 4aln, 4bnf, 4bng, 4bnh, 4bni, 4bnj, 4bnk, 4bnl, 4bnm, 4bnn, 4cuz, 4cv0, 4cv1, 4d41, 4d42, 4d43, 4d44, 4d45, 4fs3, 4nz9

HET: 0we, 1jt, 5pp, 6pn, 9w7, aew, ch8, e9p, fpl, j47, ja1, ja3, jus, mj5, p1f, pt6, pv4, tcl, tcu, w0i, w1g

FABL_BACSU_1_250 [text] Enoyl-[acyl-carrier-protein] reductase [NADPH] FabL [Short-chain dehydrogenases/reductases (SDR) family]

volume: 165. Å3; shape: 0.52; buriedness: 0.83

negative: 0.; positive: 0.1; polar: 0.23; backbone: 0.36; hydrophobic: 0.31

PDB: 3oic, 3oid

HET: tcl

HCD2_RAT_1_261 [text] 3-hydroxyacyl-CoA dehydrogenase type-2 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 156. Å3; shape: 0.49; buriedness: 0.67

negative: 0.; positive: 0.; polar: 0.63; backbone: 0.; hydrophobic: 0.37

PDB: 1e3s, 1e3w, 1e6w

HET: aae, est

HDHA_ECOLI_1_255 [text] 7-alpha-hydroxysteroid dehydrogenase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 281. Å3; shape: 0.42; buriedness: 0.78

negative: 0.; positive: 0.; polar: 0.26; backbone: 0.52; hydrophobic: 0.21

PDB: 1ahh, 1ahi, 1fmc

HET: cho

HSD_MYCTU_1_260 [text] 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 200. Å3; shape: 0.51; buriedness: 0.76

negative: 0.16; positive: 0.; polar: 0.; backbone: 0.16; hydrophobic: 0.67

PDB: 1nff, 1nfq, 1nfr

HET: aoi

HSD_STREX_2_255 [text] 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 881. Å3; shape: 0.49; buriedness: 0.79

negative: 0.05; positive: 0.05; polar: 0.21; backbone: 0.45; hydrophobic: 0.25

PDB: 1hdc, 2hsd

HET: cbo, nad

INHA_MYCTU_1_269 [text] Enoyl-[acyl-carrier-protein] reductase [NADH] [Short-chain dehydrogenases/reductases (SDR) family. FabI subfamily]

volume: 778. Å3; shape: 0.93; buriedness: 0.89

negative: 0.; positive: 0.05; polar: 0.09; backbone: 0.33; hydrophobic: 0.52

PDB: 1bvr, 1eny, 1enz, 1p44, 1p45, 1zid, 2aq8, 2aqh, 2aqi, 2aqk, 2b35, 2b36, 2b37, 2h9i, 2idz, 2ie0, 2ieb, 2ied, 2nsd, 2ntj, 2ntv, 2nv6, 2pr2, 2x22, 2x23, 3fne, 3fnf, 3fng, 3fnh, 3oew, 3oey, 3of2, 4bge, 4bgi, 4bii, 4bqp, 4bqr, 4cod, 4d0r, 4d0s, 4dqu, 4dre, 4dti, 4ohu, 4oim, 4oxk, 4oxn, 4oxy, 4oyr, 4qxm, 4r9r, 4r9s, 4trj, 4trm, 4trn, 4tro, 4tzk, 4tzt, 4u0j, 4u0k, 4uvd, 4uve, 4uvg, 4uvh, 4uvi, 5coq, 5cp8, 5cpb, 5cpf, 5g0s, 5g0t, 5g0u, 5g0v, 5g0w, 5jfo

HET: 1s5, 1tn, 1us, 2nv, 2tk, 3kx, 3ky, 41i, 468, 4pi, 53k, 566, 5pp, 641, 665, 6ka, 713, 744, 8pc, 8ps, 9cv, 9g4, 9nu, a0c, dg1, ead, eeh, ete, geq, hrw, i4i, ibh, jdd, jpj, jpl, jpm, jus, ki5, kv1, kxu, nad, nai, p1h, pyw, s72, tcl, tcu, tht, uud, vmy, zid

IPIPR_MENPI_1_314 [text] (-)-isopiperitenone reductase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 111. Å3; shape: 0.91; buriedness: 0.88

negative: 0.18; positive: 0.; polar: 0.24; backbone: 0.; hydrophobic: 0.59

PDB: 5l4s, 5lcx, 5ldg

HET: 6kx, it9

IRIS_CATRO_24_388 [text] Iridoid synthase [Short-chain dehydrogenases/reductases (SDR) family. Highly divergent]

volume: 150. Å3; shape: 0.47; buriedness: 0.9

negative: 0.; positive: 0.08; polar: 0.16; backbone: 0.31; hydrophobic: 0.45

PDB: 5coa, 5cob, 5dbf, 5dbg, 5dbi, 5dcu, 5dcw, 5dcy, 5df1, 5emh

HET: 58x, teg, xog

PLDH_RHILO_2_248 [text] Pyridoxal 4-dehydrogenase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 97. Å3; shape: 0.79; buriedness: 0.92

negative: 0.; positive: 0.12; polar: 0.46; backbone: 0.12; hydrophobic: 0.31

PDB: 3ndr, 3nug, 3rwb

HET: 4pl

PTR1_LEIMA_1_288 [text] Pteridine reductase 1 [Short-chain dehydrogenases/reductases (SDR) family]

volume: 451. Å3; shape: 0.61; buriedness: 0.63

negative: 0.09; positive: 0.16; polar: 0.25; backbone: 0.17; hydrophobic: 0.33

PDB: 1e7w, 1e92, 1w0c, 2bf7, 2bfa, 2bfm, 2bfo, 2bfp, 2qhx, 2xox, 3h4v

HET: cb3, dvp, fe1, h4b, hbi, mtx, taq, top

SILD_PODPE_1_278 [text] Secoisolariciresinol dehydrogenase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 445. Å3; shape: 0.47; buriedness: 0.81

negative: 0.06; positive: 0.03; polar: 0.14; backbone: 0.56; hydrophobic: 0.21

PDB: 2bgk, 2bgl, 2bgm

HET: naj

T4HR_MAGO7_1_283 [text] Tetrahydroxynaphthalene reductase [Short-chain dehydrogenases/reductases (SDR) family]

volume: 118. Å3; shape: 0.83; buriedness: 0.95

negative: 0.; positive: 0.; polar: 0.58; backbone: 0.31; hydrophobic: 0.1

PDB: 1doh, 1g0n, 1g0o, 1ybv

HET: bea, nid, phh, pyq