[POCKETOME]
 

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275 entries [expand]
Show only: ⁠Human; ⁠Other mammals; ⁠Gram-positive bacteria; ⁠Gram-negative bacteria; ⁠Archaea; ⁠Virus; ⁠Other.

AAK1_HUMAN_28_358 [text] AP2-associated protein kinase 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 452. Å3; shape: 0.51; buriedness: 0.8

negative: 0.09; positive: 0.05; polar: 0.1; backbone: 0.33; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 4wsq, 5l4q, 5te0

HET: ksa, lkb, xin

AAPK1_HUMAN_15_295 [text] 5'-AMP-activated protein kinase catalytic subunit alpha-1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 357. Å3; shape: 0.65; buriedness: 0.53

negative: 0.1; positive: 0.25; polar: 0.08; backbone: 0.19; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 4cfh, 4qfg, 4qfr, 4red, 5kq5

HET: 32j, 6vt

AAPK2_HUMAN_2_280_ATPsite [text] 5'-AMP-activated protein kinase catalytic subunit alpha-2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 413. Å3; shape: 0.57; buriedness: 0.87

negative: 0.09; positive: 0.04; polar: 0.08; backbone: 0.42; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 2h6d, 2yza, 3aqv, 4cfe, 4zhx, 5ezv

HET: 4o7, stu, tak

AAPK2_HUMAN_2_280_beta [text] 5'-AMP-activated protein kinase catalytic subunit alpha-2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 289. Å3; shape: 0.48; buriedness: 0.54

negative: 0.12; positive: 0.19; polar: 0.12; backbone: 0.23; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 2h6d, 2yza, 3aqv, 4cfe, 4zhx, 5ezv

HET: 992, c1v

ABL1_HUMAN_228_509_allosteric [text] Tyrosine-protein kinase ABL1 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

volume: 438. Å3; shape: 0.63; buriedness: 0.74

negative: 0.03; positive: 0.; polar: 0.07; backbone: 0.41; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 1fpu, 1iep, 1m52, 1opj, 1opk, 1opl, 2e2b, 2f4j, 2fo0, 2g1t, 2g2f, 2g2h, 2g2i, 2gqg, 2hiw, 2hyy, 2hz0, 2hz4, 2hzi, 2hzn, 2qoh, 2v7a, 2z60, 3cs9, 3dk3, 3dk6, 3dk7, 3ik3, 3k5v, 3kf4, 3kfa, 3ms9, 3mss, 3oxz, 3oy3, 3pyy, 3qri, 3qrj, 3qrk, 3ue4, 4twp, 4wa9, 4xey, 4yc8, 4zog, 5hu9

HET: 3yy, ms7, ms9, myr, stj

ABL1_HUMAN_228_509_ATPsite [text] Tyrosine-protein kinase ABL1 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

volume: 777. Å3; shape: 0.35; buriedness: 0.88

negative: 0.05; positive: 0.05; polar: 0.06; backbone: 0.47; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 1fpu, 1iep, 1m52, 1opj, 1opk, 1opl, 2e2b, 2f4j, 2fo0, 2g1t, 2g2f, 2g2h, 2g2i, 2gqg, 2hiw, 2hyy, 2hz0, 2hz4, 2hzi, 2hzn, 2qoh, 2v7a, 2z60, 3cs9, 3dk3, 3dk6, 3dk7, 3ik3, 3k5v, 3kf4, 3kfa, 3ms9, 3mss, 3oxz, 3oy3, 3pyy, 3qri, 3qrj, 3qrk, 3ue4, 4twp, 4wa9, 4xey, 4yc8, 4zog, 5hu9

HET: 0li, 112, 1n1, 406, 4b7, 4st, 627, 66k, 7mp, 919, 9dp, adp, ags, axi, b90, b91, db8, gin, jin, kin, mg, nil, p16, p17, p3y, prc, sti, sx7, vx6, xy3

ABL1_HUMAN_61_120_SH3 [text] Tyrosine-protein kinase ABL1 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

volume: 912. Å3; shape: 0.39; buriedness: 0.39

negative: 0.12; positive: 0.; polar: 0.42; backbone: 0.13; hydrophobic: 0.33

Domains/regions: [D] SH3

PDB: 1abo, 1abq, 1bbz, 1opk, 1opl, 2abl, 2fo0, 2o88, 3eg0, 3eg1, 3eg2, 3eg3, 3egu, 4j9b, 4j9c, 4j9d, 4j9e, 4j9f, 4j9g, 4j9h, 4j9i, 4jjb, 4jjc, 4jjd

HET: ace

ABL2_HUMAN_274_551 [text] Abelson tyrosine-protein kinase 2 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

volume: 614. Å3; shape: 0.35; buriedness: 0.78

negative: 0.05; positive: 0.03; polar: 0.12; backbone: 0.49; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 2xyn, 3gvu, 3hmi, 4xli

HET: 1n1, dki, sti, vx6

ACK1_HUMAN_113_392 [text] Activated CDC42 kinase 1 [Protein kinase superfamily. Tyr protein kinase family]

volume: 624. Å3; shape: 0.58; buriedness: 0.74

negative: 0.07; positive: 0.04; polar: 0.07; backbone: 0.44; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 1u46, 1u4d, 1u54, 3eqp, 3eqr, 4ewh, 4hzr, 4hzs, 4id7

HET: 1g0, acp, dbq, mg, t74, t77, t95

ACVR1_HUMAN_199_499 [text] Activin receptor type-1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 343. Å3; shape: 0.44; buriedness: 0.78

negative: 0.04; positive: 0.09; polar: 0.15; backbone: 0.4; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 3h9r, 3mtf, 3oom, 3q4u, 4bgg, 4c02, 4dym

HET: 507, 844, a3f, iyz, ldn, tak

AKT1_HUMAN_1_137 [text] RAC-alpha serine/threonine-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily]

volume: 554. Å3; shape: 0.74; buriedness: 0.83

negative: 0.; positive: 0.11; polar: 0.25; backbone: 0.31; hydrophobic: 0.33

Domains/regions: [D] PH

PDB: 1h10, 1unp, 1unq, 1unr, 2uvm, 2uzr, 2uzs, 3o96, 4ejn, 5kcv

HET: 0r4, 6s1, iqo

AKT1_HUMAN_137_445 [text] RAC-alpha serine/threonine-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily]

volume: 671. Å3; shape: 0.72; buriedness: 0.6

negative: 0.09; positive: 0.03; polar: 0.14; backbone: 0.44; hydrophobic: 0.3

Domains/regions: [D] AGC-kinase C-terminal, [D] Protein kinase, [R] Inhibitor binding

PDB: 3cqu, 3cqw, 3mv5, 3mvh, 3o96, 3ocb, 3ow4, 3qkk, 3qkl, 3qkm, 4ejn, 4ekk, 4ekl, 4gv1, 5kcv

HET: 0rf, 0xz, anp, cqu, cqw, mn, sm9, smh, smr, smy, wfe, xfe, xm1

AKT2_HUMAN_145_478 [text] RAC-beta serine/threonine-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily]

volume: 380. Å3; shape: 0.71; buriedness: 0.89

negative: 0.11; positive: 0.03; polar: 0.14; backbone: 0.4; hydrophobic: 0.32

Domains/regions: [D] Protein kinase, [R] Inhibitor binding

PDB: 1gzk, 1gzn, 1gzo, 1mrv, 1mry, 1o6k, 1o6l, 2jdo, 2jdr, 2uw9, 2x39, 2xh5, 3d0e, 3e87, 3e88, 3e8d

HET: anp, g93, g95, g96, g98, gvp, i5s, l20, mn, x37, x39

ALK_HUMAN_1090_1410 [text] ALK tyrosine kinase receptor [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 630. Å3; shape: 0.5; buriedness: 0.77

negative: 0.07; positive: 0.03; polar: 0.; backbone: 0.51; hydrophobic: 0.38

Domains/regions: [D] Protein kinase, [R] Inhibitor binding

PDB: 2xb7, 2xba, 2xp2, 2yfx, 2yhv, 2yjr, 2yjs, 3aox, 3l9p, 3lcs, 3lct, 4anl, 4anq, 4ans, 4ccb, 4ccu, 4cd0, 4cli, 4clj, 4cmo, 4cmt, 4cmu, 4cnh, 4ctb, 4ctc, 4dce, 4fnw, 4fnx, 4fny, 4fnz, 4fob, 4foc, 4fod, 4joa, 4mkc, 4tt7, 4z55, 5a9u, 5aa8, 5aa9, 5aaa, 5aab, 5aac, 5fto, 5ftq, 5imx, 5iug, 5iuh, 5iui, 5j7h, 5kz0

HET: 0jf, 0us, 0uu, 0uv, 34y, 3dk, 3u9, 45q, 4lo, 4mk, 53p, 571, 5p8, 6gy, 6yl, 729, adp, awf, awj, cz4, emh, gui, gwh, i3k, iv7, j99, kvc, nzf, ofg, qb4, stu, u4w, vgh, ymx, ypw

AUKBA_XENLA_78_360 [text] Aurora kinase B-A [Protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily]

volume: 601. Å3; shape: 0.4; buriedness: 0.73

negative: 0.09; positive: 0.04; polar: 0.04; backbone: 0.39; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 2bfx, 2bfy, 2vgo, 2vgp, 2vrx, 3ztx, 4b8l, 4b8m, 4c2v, 4c2w, 5eyk, 5k3y

HET: 447, 5u5, 6q4, a0p, ad5, ad6, anp, h1n, vx6, yja, ztx

AURKA_HUMAN_122_398 [text] Aurora kinase A [Protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily]

volume: 816. Å3; shape: 0.42; buriedness: 0.81

negative: 0.04; positive: 0.07; polar: 0.09; backbone: 0.45; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 1mq4, 1muo, 1ol5, 1ol6, 1ol7, 2bmc, 2c6d, 2c6e, 2dwb, 2j4z, 2j50, 2np8, 2w1c, 2w1d, 2w1e, 2w1f, 2w1g, 2wqe, 2wtv, 2wtw, 2x6d, 2x6e, 2x81, 2xne, 2xng, 2xru, 3coh, 3d14, 3d15, 3d2i, 3d2k, 3daj, 3dj5, 3dj6, 3dj7, 3e5a, 3efw, 3fdn, 3h0y, 3h0z, 3h10, 3ha6, 3k5u, 3lau, 3m11, 3myg, 3nrm, 3o50, 3o51, 3p9j, 3qbn, 3r21, 3r22, 3unz, 3uo4, 3uo5, 3uo6, 3uod, 3uoh, 3uoj, 3uok, 3uol, 3up2, 3up7, 3vap, 3w10, 3w16, 3w18, 3w2c, 4b0g, 4bn1, 4byi, 4byj, 4c3p, 4c3r, 4ceg, 4dea, 4deb, 4ded, 4dee, 4dhf, 4j8m, 4j8n, 4jai, 4jaj, 4jbo, 4jbp, 4jbq, 4o0s, 4o0u, 4o0w, 4prj, 4utd, 4uyn, 4uzd, 4uzh, 4zs0, 4ztq, 4ztr, 4zts, 5aad, 5aae, 5aaf, 5aag, 5dn3, 5dnr, 5dos, 5dpv, 5dr2, 5dr6, 5dr9, 5drd, 5dt0, 5dt3, 5dt4, 5ew9, 5g1x, 5l8j, 5l8k, 5l8l, 5lxm

HET: 0bx, 0by, 0bz, 0c0, 0c3, 0c4, 0c5, 0c6, 0c7, 0c8, 0c9, 0fy, 0k6, 2jz, 2vu, 400, 48b, 4qv, 4rj, 4rk, 4rm, 5gx, 5vc, 626, 627, 6f2, 7hd, 83h, 97b, a0h, ak1, ak2, ak3, ak4, ak5, ak6, ak7, ak8, aki, ash, cc3, cj5, d36, d37, e9z, eml, fh3, fh5, fxg, hpm, jve, l0c, l0e, l0f, l0g, lje, ljf, mg, mmh, mpy, n13, n15, nhi, nhj, nhu, nl4, nrm, ofi, p9j, pfq, qmn, ro9, ske, vek, wph, x6d, xu2, y3m, ym4, zzl

AURKB_HUMAN_54_344 [text] Aurora kinase B [Protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily]

volume: 332. Å3; shape: 0.45; buriedness: 0.77

negative: 0.; positive: 0.06; polar: 0.06; backbone: 0.44; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 4af3

HET: vx6

AVR2A_HUMAN_190_488 [text] Activin receptor type-2A [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 339. Å3; shape: 0.47; buriedness: 0.9

negative: 0.09; positive: 0.11; polar: 0.11; backbone: 0.39; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 3q4t, 3soc, 4asx

HET: 6oj, gvd, tak

AVR2B_HUMAN_188_487_ATPsite [text] Activin receptor type-2B [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 75. Å3; shape: 0.83; buriedness: 0.9

negative: 0.; positive: 0.; polar: 0.11; backbone: 0.33; hydrophobic: 0.56

Domains/regions: [D] Protein kinase

PDB: 2qlu

HET: ade

BAK1_ARATH_253_588_ATPsite [text] BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 379. Å3; shape: 0.37; buriedness: 0.53

negative: 0.05; positive: 0.08; polar: 0.15; backbone: 0.26; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 3tl8, 3uim, 3ulz

HET: anp

BMP2K_HUMAN_40_344 [text] BMP-2-inducible protein kinase [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 341. Å3; shape: 0.54; buriedness: 0.89

negative: 0.07; positive: 0.; polar: 0.17; backbone: 0.4; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4w9w, 4w9x, 5i3o, 5i3r, 5ikw

HET: 3jw, 6bu, idk, idv, ydj

BMPR2_HUMAN_189_518 [text] Bone morphogenetic protein receptor type-2 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 244. Å3; shape: 0.54; buriedness: 0.91

negative: 0.05; positive: 0.05; polar: 0.18; backbone: 0.46; hydrophobic: 0.26

Domains/regions: [D] Protein kinase

PDB: 3g2f

HET: adp

BMR1B_HUMAN_167_502 [text] Bone morphogenetic protein receptor type-1B [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 290. Å3; shape: 0.38; buriedness: 0.75

negative: 0.11; positive: 0.; polar: 0.16; backbone: 0.42; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 3mdy

HET: ldn

BMX_HUMAN_404_675 [text] Cytoplasmic tyrosine-protein kinase BMX [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

volume: 344. Å3; shape: 0.35; buriedness: 0.69

negative: 0.; positive: 0.05; polar: 0.15; backbone: 0.38; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 3sxr, 3sxs

HET: 1n1, pp2

BRAF_HUMAN_438_724 [text] Serine/threonine-protein kinase B-raf [Protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily]

volume: 892. Å3; shape: 0.46; buriedness: 0.88

negative: 0.05; positive: 0.06; polar: 0.03; backbone: 0.44; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 1uwh, 1uwj, 2fb8, 3c4c, 3d4q, 3idp, 3ii5, 3og7, 3ppk, 3prf, 3pri, 3psb, 3q4c, 3q96, 3skc, 3tv4, 3tv6, 4cqe, 4dbn, 4e26, 4ehe, 4ehg, 4fc0, 4fk3, 4g9c, 4g9r, 4h58, 4jvg, 4ksp, 4ksq, 4mne, 4mnf, 4pp7, 4r5y, 4rzv, 4rzw, 4wo5, 4xv1, 4xv2, 4xv3, 4xv9, 4yht, 5c9c, 5csw, 5csx, 5ct7, 5fd2, 5hi2, 5hid, 5hie, 5ita, 5jrq, 5jsm, 5jt2

HET: 032, 0ja, 0nf, 0t2, 0wp, 10z, 1oo, 1su, 1sw, 215, 29l, 2vx, 324, 325, 3k3, 4ef, 4z5, 54j, 55j, 5xj, 6dc, 6n9, 6nb, 6nc, 734, 831, 904, b0r, b1e, b96, bax, br2, cqe, fni, fp3, fp4, glc, l1e, p02, p06, ri8, ri9, rsw, sm5, sm6, tv4

BRI1_ARATH_26_786 [text] Protein BRASSINOSTEROID INSENSITIVE 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 327. Å3; shape: 0.39; buriedness: 0.8

negative: 0.; positive: 0.11; polar: 0.55; backbone: 0.1; hydrophobic: 0.24

PDB: 3rgx, 3rgz, 3riz, 3rj0, 4lsa, 4lsx

HET: bld

BRI1_ARATH_864_1168 [text] Protein BRASSINOSTEROID INSENSITIVE 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 266. Å3; shape: 0.52; buriedness: 0.83

negative: 0.1; positive: 0.03; polar: 0.2; backbone: 0.35; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 4oh4, 4q5j, 5lpb, 5lpv, 5lpw, 5lpy, 5lpz

HET: adp, anp, atp, mn

BTK_HUMAN_2_170 [text] Tyrosine-protein kinase BTK [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

volume: 435. Å3; shape: 0.67; buriedness: 0.59

negative: 0.; positive: 0.29; polar: 0.31; backbone: 0.36; hydrophobic: 0.04

Domains/regions: [D] PH, [R] Inositol-(1,3,4,5)-tetrakisphosphate 1- binding

PDB: 1b55, 1btk, 1bwn, 2z0p, 4y93, 4y94

HET: 4ip, 4pt, ihp

BTK_HUMAN_387_659 [text] Tyrosine-protein kinase BTK [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

volume: 734. Å3; shape: 0.52; buriedness: 0.74

negative: 0.04; positive: 0.04; polar: 0.18; backbone: 0.46; hydrophobic: 0.28

Domains/regions: [D] Protein kinase, [R] Inhibitor-binding

PDB: 1k2p, 3gen, 3k54, 3ocs, 3oct, 3p08, 3pix, 3piy, 3piz, 3pj1, 3pj2, 3pj3, 4nwm, 4ot5, 4ot6, 4otf, 4otq, 4otr, 4rfy, 4rfz, 4rg0, 4rx5, 4xi2, 4y93, 4y95, 4yhf, 4z3v, 4zly, 4zlz, 5bpy, 5bq0, 5fbn, 5fbo, 5jrs, 5kup

HET: 027, 03c, 04k, 04l, 1n1, 2p5, 2v1, 2v2, 2v3, 2vl, 3ou, 3ov, 3p0, 3yo, 481, 4c9, 4l6, 4ru, 4rv, 4uq, 4us, 585, 5wf, 5wh, 6mv, 6xl, 746, b43, ca, lhl

BUD32_YEAST_1_261 [text] EKC/KEOPS complex subunit BUD32 [Protein kinase superfamily. BUD32 family]

volume: 263. Å3; shape: 0.58; buriedness: 0.81

negative: 0.08; positive: 0.06; polar: 0.08; backbone: 0.25; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 4ww5, 4ww7, 4ww9, 4wwa

HET: adp, amp, anp, mg

CDC2H_PLAFK_1_288 [text] Cell division control protein 2 homolog [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 334. Å3; shape: 0.61; buriedness: 0.86

negative: 0.09; positive: 0.13; polar: 0.03; backbone: 0.41; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 1ob3, 1v0b, 1v0o, 1v0p

HET: inr, pvb

CDC7_HUMAN_36_574 [text] Cell division cycle 7-related protein kinase [Protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily]

volume: 217. Å3; shape: 0.56; buriedness: 0.88

negative: 0.06; positive: 0.12; polar: 0.18; backbone: 0.23; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 4f99, 4f9a, 4f9b, 4f9c

HET: 0sx, 0sy, adp

CDK12_HUMAN_714_1051 [text] Cyclin-dependent kinase 12 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 605. Å3; shape: 0.71; buriedness: 0.87

negative: 0.12; positive: 0.03; polar: 0.13; backbone: 0.46; hydrophobic: 0.27

Domains/regions: [D] Protein kinase

PDB: 4cxa, 4nst, 4un0, 5acb

HET: 5i1, adp, al, anp, mg

CDK13_HUMAN_692_1029 [text] Cyclin-dependent kinase 13 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 235. Å3; shape: 0.53; buriedness: 0.89

negative: 0.13; positive: 0.13; polar: 0.13; backbone: 0.29; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 5efq

HET: adp

CDK16_HUMAN_162_479 [text] Cyclin-dependent kinase 16 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 549. Å3; shape: 0.49; buriedness: 0.9

negative: 0.08; positive: 0.06; polar: 0.08; backbone: 0.39; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 3mtl, 5g6v

HET: 919, fef

CDK1_HUMAN_1_297 [text] Cyclin-dependent kinase 1 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 257. Å3; shape: 0.62; buriedness: 0.9

negative: 0.11; positive: 0.07; polar: 0.07; backbone: 0.35; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 4y72, 4yc3, 5hq0

HET: lz9

CDK2_HUMAN_1_298 [text] Cyclin-dependent kinase 2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 511. Å3; shape: 0.71; buriedness: 0.84

negative: 0.08; positive: 0.07; polar: 0.06; backbone: 0.42; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 1aq1, 1b38, 1b39, 1buh, 1ckp, 1di8, 1dm2, 1e1v, 1e1x, 1e9h, 1f5q, 1fin, 1fq1, 1fvt, 1fvv, 1g5s, 1gih, 1gii, 1gij, 1gy3, 1gz8, 1h00, 1h01, 1h07, 1h08, 1h0v, 1h0w, 1h1p, 1h1q, 1h1r, 1h1s, 1h24, 1h25, 1h26, 1h27, 1h28, 1hck, 1hcl, 1jst, 1jsu, 1jsv, 1jvp, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1ogu, 1oi9, 1oiq, 1oir, 1oit, 1oiu, 1oiy, 1okv, 1okw, 1ol1, 1ol2, 1p2a, 1p5e, 1pf8, 1pkd, 1pw2, 1pxi, 1pxj, 1pxk, 1pxl, 1pxm, 1pxn, 1pxo, 1pxp, 1pye, 1qmz, 1r78, 1urc, 1urw, 1v1k, 1vyw, 1vyz, 1w0x, 1w8c, 1w98, 1wcc, 1y8y, 1y91, 1ykr, 2a0c, 2a4l, 2b52, 2b53, 2b54, 2b55, 2bhe, 2bhh, 2bkz, 2bpm, 2btr, 2bts, 2c4g, 2c5n, 2c5o, 2c5v, 2c5x, 2c5y, 2c68, 2c69, 2c6i, 2c6k, 2c6l, 2c6m, 2c6o, 2c6t, 2cch, 2cci, 2cjm, 2clx, 2ds1, 2duv, 2exm, 2fvd, 2g9x, 2i40, 2iw6, 2iw8, 2iw9, 2j9m, 2jgz, 2r3f, 2r3g, 2r3h, 2r3i, 2r3j, 2r3k, 2r3l, 2r3m, 2r3n, 2r3o, 2r3p, 2r3q, 2r3r, 2r64, 2uue, 2uzb, 2uzd, 2uze, 2uzl, 2uzn, 2uzo, 2v0d, 2v22, 2vta, 2vth, 2vti, 2vtj, 2vtl, 2vtm, 2vtn, 2vto, 2vtp, 2vtq, 2vtr, 2vts, 2vtt, 2vu3, 2vv9, 2w05, 2w06, 2w17, 2w1h, 2wev, 2wfy, 2whb, 2wih, 2wip, 2wma, 2wmb, 2wpa, 2wxv, 2x1n, 2xmy, 2xnb, 3bht, 3bhu, 3bhv, 3ddp, 3ddq, 3dog, 3eid, 3ej1, 3eoc, 3ezr, 3ezv, 3f5x, 3fz1, 3ig7, 3igg, 3le6, 3lfn, 3lfq, 3lfs, 3my5, 3ns9, 3pj8, 3pxf, 3pxq, 3pxr, 3pxy, 3pxz, 3py0, 3py1, 3qhr, 3qhw, 3ql8, 3qqf, 3qqg, 3qqh, 3qqj, 3qqk, 3qql, 3qrt, 3qru, 3qtq, 3qtr, 3qts, 3qtu, 3qtw, 3qtx, 3qtz, 3qu0, 3qwj, 3qwk, 3qx2, 3qx4, 3qxo, 3qxp, 3qzf, 3qzg, 3qzh, 3qzi, 3r1q, 3r1s, 3r1y, 3r28, 3r6x, 3r71, 3r73, 3r7e, 3r7i, 3r7u, 3r7v, 3r7y, 3r83, 3r8l, 3r8m, 3r8p, 3r8u, 3r8v, 3r8z, 3r9d, 3r9h, 3r9n, 3r9o, 3rah, 3rai, 3rak, 3ral, 3rjc, 3rk5, 3rk7, 3rk9, 3rkb, 3rm6, 3rm7, 3rmf, 3rni, 3roy, 3rpo, 3rpr, 3rpv, 3rpy, 3rzb, 3s00, 3s0o, 3s1h, 3s2p, 3sqq, 3sw4, 3sw7, 3ti1, 3tiy, 3tiz, 3tnw, 3uli, 3unj, 3unk, 3wbl, 4acm, 4bck, 4bcm, 4bcn, 4bco, 4bcp, 4bcq, 4bgh, 4bzd, 4cfm, 4cfn, 4cfu, 4cfv, 4cfw, 4cfx, 4d1x, 4d1z, 4ek3, 4ek4, 4ek5, 4ek6, 4ek8, 4eoi, 4eoj, 4eok, 4eol, 4eom, 4eon, 4eoo, 4eop, 4eoq, 4eor, 4eos, 4erw, 4ez3, 4ez7, 4fkg, 4fki, 4fkj, 4fkl, 4fko, 4fkp, 4fkq, 4fkr, 4fks, 4fkt, 4fku, 4fkv, 4fkw, 4fx3, 4gcj, 4i3z, 4ii5, 4kd1, 4lyn, 4nj3, 4rj3, 5a14, 5and, 5ane, 5ang, 5ani, 5anj, 5ank, 5ano, 5cyi, 5d1j, 5fp5, 5fp6, 5iev, 5iex, 5iey, 5if1, 5k4j, 5l2w

HET: 04z, 107, 11k, 18z, 19k, 1cd, 1n3, 1yg, 20z, 22z, 24z, 26z, 2pu, 2wc, 371, 3fp, 3sc, 404, 45k, 46k, 48k, 55s, 56z, 5sc, 61k, 628, 62k, 6af, 740, 75x, 889, 99z, a27, blz, c94, cdk, ck9, ct9, d05, d23, d31, d42, d6i, dt1, dt2, dt4, ezr, fmd, frt, frv, g6t, hdt, hdy, i17, i19, i1p, im9, lia, ls2, ls3, ls4, mtz, n41, n76, nnn, ns9, nu5, p48, pm1, qq2, r0n, ryu, scx, scz, sq9, st8, t2a, tjf, wxv, x14

CDK5_HUMAN_1_292 [text] Cyclin-dependent-like kinase 5 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 262. Å3; shape: 0.63; buriedness: 0.89

negative: 0.09; positive: 0.09; polar: 0.03; backbone: 0.39; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 1h4l, 1ung, 1unh, 1unl, 3o0g, 4au8

HET: 3o0, alh, ixm, rrc, z3r

CDK6_HUMAN_1_312 [text] Cyclin-dependent kinase 6 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 548. Å3; shape: 0.61; buriedness: 0.73

negative: 0.08; positive: 0.07; polar: 0.09; backbone: 0.43; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 1bi7, 1bi8, 1blx, 1g3n, 1jow, 1xo2, 2euf, 2f2c, 3nup, 3nux, 4aua, 4ez5, 4tth, 5l2i, 5l2s, 5l2t

HET: 0rs, 24v, 3nu, 3nv, 4au, 6zv, 6zz, ap9, fse, lqq

CDK7_HUMAN_1_346_ATPsite [text] Cyclin-dependent kinase 7 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 302. Å3; shape: 0.61; buriedness: 0.84

negative: 0.; positive: 0.05; polar: 0.16; backbone: 0.47; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 1ua2

HET: atp

CDK8_HUMAN_1_363 [text] Cyclin-dependent kinase 8 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 641. Å3; shape: 0.52; buriedness: 0.88

negative: 0.09; positive: 0.12; polar: 0.05; backbone: 0.36; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 3rgf, 4crl, 4f6s, 4f6u, 4f6w, 4f70, 4f7j, 4f7l, 4f7n, 4f7s, 4g6l, 5bnj, 5cei, 5fgk, 5hbe, 5hbh, 5hbj, 5hnb, 5hvy, 5i5z

HET: 0so, 0sq, 0sr, 0ss, 0st, 0su, 0sv, 0sw, 4tv, 50r, 5xg, 5y6, 5y7, 5y8, 62m, 66x, 68u, bax, c1i

CDK9_HUMAN_1_331 [text] Cyclin-dependent kinase 9 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 399. Å3; shape: 0.88; buriedness: 0.84

negative: 0.13; positive: 0.04; polar: 0.07; backbone: 0.3; hydrophobic: 0.47

Domains/regions: [D] Protein kinase, [R] T-loop

PDB: 3blh, 3blq, 3blr, 3lq5, 3mi9, 3mia, 3my1, 3tn8, 3tnh, 3tni, 4bcf, 4bcg, 4bch, 4bci, 4bcj, 4ec9, 4imy, 4ogr, 4or5

HET: adn, amp, anp, atp, cpb, f18, mg, rfz, slq, t3c, t3e, t6q, t7z, t9n, yt3

CDKL1_HUMAN_1_304 [text] Cyclin-dependent kinase-like 1 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 347. Å3; shape: 0.59; buriedness: 0.82

negative: 0.06; positive: 0.09; polar: 0.13; backbone: 0.39; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 4agu

HET: d15

CDKL2_HUMAN_1_308 [text] Cyclin-dependent kinase-like 2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 391. Å3; shape: 0.44; buriedness: 0.81

negative: 0.12; positive: 0.; polar: 0.1; backbone: 0.37; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 4aaa, 4bbm

HET: dki, tc0

CDKL3_HUMAN_1_324 [text] Cyclin-dependent kinase-like 3 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 245. Å3; shape: 0.83; buriedness: 0.95

negative: 0.15; positive: 0.05; polar: 0.1; backbone: 0.35; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 3zdu

HET: 38r

CDKL5_HUMAN_1_303 [text] Cyclin-dependent kinase-like 5 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 234. Å3; shape: 0.84; buriedness: 0.95

negative: 0.07; positive: 0.; polar: 0.14; backbone: 0.43; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4bgq

HET: 38r

CDPK2_PLAFK_25_334 [text] Calcium-dependent protein kinase 2 [Protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily]

volume: 274. Å3; shape: 0.93; buriedness: 0.79

negative: 0.07; positive: 0.07; polar: 0.; backbone: 0.5; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4mvf

HET: stu

CDPK4_PLAF7_9_528 [text] Calcium-dependent protein kinase 4 [Protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily]

volume: 183. Å3; shape: 0.59; buriedness: 0.91

negative: 0.04; positive: 0.08; polar: 0.17; backbone: 0.46; hydrophobic: 0.25

Domains/regions: [D] Protein kinase

PDB: 4qox, 4rgj

HET: dxr

CHK1_HUMAN_1_283_allosteric [text] Serine/threonine-protein kinase Chk1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily]

volume: 602. Å3; shape: 0.51; buriedness: 0.62

negative: 0.2; positive: 0.; polar: 0.05; backbone: 0.45; hydrophobic: 0.3

Domains/regions: [D] Protein kinase, [R] Interaction with CLSPN

PDB: 1ia8, 1nvq, 1nvr, 1nvs, 1zlt, 1zys, 2ayp, 2br1, 2brb, 2brg, 2brh, 2brm, 2brn, 2bro, 2c3j, 2c3k, 2c3l, 2cgu, 2cgv, 2cgw, 2cgx, 2e9n, 2e9o, 2e9p, 2e9u, 2e9v, 2gdo, 2ghg, 2hog, 2hxl, 2hxq, 2hy0, 2qhm, 2qhn, 2r0u, 2wmq, 2wmr, 2wms, 2wmt, 2wmu, 2wmv, 2wmw, 2wmx, 2x8d, 2x8e, 2x8i, 2xey, 2xez, 2xf0, 2ydi, 2ydj, 2ydk, 2yer, 2yex, 2ym3, 2ym4, 2ym5, 2ym6, 2ym7, 2ym8, 2ywp, 3f9n, 3jvr, 3jvs, 3nlb, 3ot3, 3ot8, 3pa3, 3pa4, 3pa5, 3tkh, 3tki, 3u9n, 4fsm, 4fsn, 4fsq, 4fsr, 4fst, 4fsu, 4fsw, 4fsy, 4fsz, 4ft0, 4ft3, 4ft5, 4ft7, 4ft9, 4fta, 4ftc, 4fti, 4ftj, 4ftk, 4ftl, 4ftm, 4ftn, 4fto, 4ftq, 4ftr, 4ftt, 4ftu, 4gh2, 4hyh, 4hyi, 4jik, 4qye, 4qyf, 4qyg, 4qyh, 4rvk, 4rvl, 4rvm, 5dls, 5f4n

HET: 38m, agx, agy

CHK1_HUMAN_1_283_ATPsite [text] Serine/threonine-protein kinase Chk1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily]

volume: 559. Å3; shape: 0.57; buriedness: 0.79

negative: 0.14; positive: 0.05; polar: 0.09; backbone: 0.41; hydrophobic: 0.32

Domains/regions: [D] Protein kinase, [R] Interaction with CLSPN

PDB: 1ia8, 1nvq, 1nvr, 1nvs, 1zlt, 1zys, 2ayp, 2br1, 2brb, 2brg, 2brh, 2brm, 2brn, 2bro, 2c3j, 2c3k, 2c3l, 2cgu, 2cgv, 2cgw, 2cgx, 2e9n, 2e9o, 2e9p, 2e9u, 2e9v, 2gdo, 2ghg, 2hog, 2hxl, 2hxq, 2hy0, 2qhm, 2qhn, 2r0u, 2wmq, 2wmr, 2wms, 2wmt, 2wmu, 2wmv, 2wmw, 2wmx, 2x8d, 2x8e, 2x8i, 2xey, 2xez, 2xf0, 2ydi, 2ydj, 2ydk, 2yer, 2yex, 2ym3, 2ym4, 2ym5, 2ym6, 2ym7, 2ym8, 2ywp, 3f9n, 3jvr, 3jvs, 3nlb, 3ot3, 3ot8, 3pa3, 3pa4, 3pa5, 3tkh, 3tki, 3u9n, 4fsm, 4fsn, 4fsq, 4fsr, 4fst, 4fsu, 4fsw, 4fsy, 4fsz, 4ft0, 4ft3, 4ft5, 4ft7, 4ft9, 4fta, 4ftc, 4fti, 4ftj, 4ftk, 4ftl, 4ftm, 4ftn, 4fto, 4ftq, 4ftr, 4ftt, 4ftu, 4gh2, 4hyh, 4hyi, 4jik, 4qye, 4qyf, 4qyg, 4qyh, 4rvk, 4rvl, 4rvm, 5dls, 5f4n

HET: 07s, 09h, 12c, 199, 1am, 1ao, 1hk, 1ko, 22k, 2hk, 306, 373, 3a3, 3dl, 3dv, 3dw, 3dx, 3hk, 3x7, 3xk, 422, 43a, 4hk, 4ym, 582, 5be, 5hk, 5uy, 6hk, 710, 76a, 77a, 7hk, 85a, a25, a42, a53, a58, abo, c70, c72, c73, df1, df2, dfw, dfy, dfz, h0k, h2k, h3k, h5k, h6k, h7k, h8k, h9k, hk0, hk1, hk3, hk4, hk5, hk7, hk9, hkc, m54, mi5, pfp, pfq, s25, ucm, ydi, ydj, ydk, ym5, ym7, ym8, yvq, zy6

CHK2_HUMAN_210_526 [text] Serine/threonine-protein kinase Chk2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily]

volume: 470. Å3; shape: 0.43; buriedness: 0.84

negative: 0.14; positive: 0.04; polar: 0.05; backbone: 0.4; hydrophobic: 0.36

Domains/regions: [D] Protein kinase, [R] T-loop/activation segment

PDB: 2cn5, 2cn8, 2w0j, 2w7x, 2wtc, 2wtd, 2wti, 2wtj, 2xbj, 2xk9, 2xm8, 2xm9, 2ycf, 2ycq, 2ycr, 2ycs, 2yiq, 2yir, 2yit, 3i6u, 3i6w, 4a9r, 4a9s, 4a9t, 4a9u, 4bda, 4bdb, 4bdc, 4bdd, 4bde, 4bdf, 4bdg, 4bdh, 4bdi, 4bdj, 4bdk

HET: a9t, a9u, adp, b4w, cws, d1a, dbq, h3r, hau, hcw, lwh, mg, nxp, odh, odo, p3j, rqq, ru5, ru9, upx, vfb, vgm, wti, wtj, wvi, xbj, xk9, ycf, yiq, yir, yit, z0o, z2m, zat, zzk

CIPKN_ARATH_22_482 [text] CBL-interacting serine/threonine-protein kinase 23 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 1572. Å3; shape: 0.53; buriedness: 0.32

negative: 0.17; positive: 0.03; polar: 0.15; backbone: 0.33; hydrophobic: 0.33

Domains/regions: [D] Protein kinase, [R] Activation loop

PDB: 4czt, 4czu

HET: cps

CKI1_SCHPO_1_298 [text] Casein kinase I homolog 1 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

volume: 334. Å3; shape: 0.63; buriedness: 0.85

negative: 0.08; positive: 0.06; polar: 0.07; backbone: 0.4; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 1csn, 1eh4, 2csn

HET: atp, cki, ic1, mg

CLK1_HUMAN_147_484 [text] Dual specificity protein kinase CLK1 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily]

volume: 174. Å3; shape: 0.69; buriedness: 0.91

negative: 0.07; positive: 0.09; polar: 0.; backbone: 0.25; hydrophobic: 0.6

Domains/regions: [D] Protein kinase

PDB: 1z57, 2vag, 5j1v, 5j1w

HET: 6fb, 6fd, dbq, v25

CLK2_HUMAN_129_496 [text] Dual specificity protein kinase CLK2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily]

volume: 229. Å3; shape: 0.64; buriedness: 0.84

negative: 0.1; positive: 0.06; polar: 0.06; backbone: 0.27; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 3nr9

HET: nr9

CLK3_HUMAN_275_633 [text] Dual specificity protein kinase CLK3 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily]

volume: 279. Å3; shape: 0.86; buriedness: 0.92

negative: 0.11; positive: 0.04; polar: 0.07; backbone: 0.32; hydrophobic: 0.47

Domains/regions: [D] Protein kinase

PDB: 2eu9, 2exe, 2wu6, 2wu7, 3raw

HET: 3ra, dki, v25

CSF1R_HUMAN_539_921 [text] Macrophage colony-stimulating factor 1 receptor [Protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily]

volume: 581. Å3; shape: 0.39; buriedness: 0.86

negative: 0.08; positive: 0.04; polar: 0.08; backbone: 0.41; hydrophobic: 0.39

Domains/regions: [D] Protein kinase, [R] Activation loop

PDB: 2i0v, 2i0y, 2i1m, 2ogv, 3bea, 3dpk, 3krj, 3krl, 3lcd, 3lco, 4hw7, 4r7h, 4r7i

HET: 5cn, 64m, 6c3, 8c5, bdy, ixh, krj, krl, lc0, p31, sti

CSK21_HUMAN_1_335_ATPsite [text] Casein kinase II subunit alpha [Protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily]

volume: 626. Å3; shape: 0.57; buriedness: 0.86

negative: 0.04; positive: 0.04; polar: 0.09; backbone: 0.38; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 1jwh, 1na7, 1pjk, 2pvr, 2r7i, 2zjw, 3amy, 3at2, 3at3, 3at4, 3axw, 3bqc, 3c13, 3fwq, 3h30, 3juh, 3mb6, 3mb7, 3nga, 3nsz, 3owj, 3owk, 3owl, 3pe1, 3pe2, 3q04, 3q9w, 3q9x, 3q9y, 3q9z, 3qa0, 3r0t, 3rps, 3u4u, 3u87, 3u9c, 3w8l, 3war, 3wik, 3wil, 3wow, 4dgl, 4fbx, 4grb, 4gub, 4ib5, 4kwp, 4md7, 4md8, 4md9, 4nh1, 4rll, 4ub7, 4uba, 5b0x, 5clp, 5cqu, 5cqw, 5cs6, 5csh, 5csp, 5csv, 5ct0, 5ctp, 5cu0, 5cu2, 5cu3, 5cu4, 5cu6, 5cvf, 5cvg, 5cvh, 5cx9, 5h8b, 5h8e, 5h8g

HET: 01i, 04g, 0tj, 0xg, 0y4, 14i, 18e, 19e, 1el, 3g5, 3ng, 42j, 4b0, 54e, 54g, 54p, 54r, 54s, 54z, 551, 5y2, 5y3, 5y4, acp, adp, agi, anp, atk, atp, cck, e1b, e91, emo, exx, fu9, gab, hck, jrj, k82, lcd, lct, lnh, mg, nio, ref, rfz, tid, txq

CSK21_HUMAN_1_335_beta [text] Casein kinase II subunit alpha [Protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily]

volume: 389. Å3; shape: 0.6; buriedness: 0.52

negative: 0.06; positive: 0.; polar: 0.17; backbone: 0.46; hydrophobic: 0.31

Domains/regions: [D] Protein kinase, [R] Interaction with beta subunit

PDB: 1jwh, 1na7, 1pjk, 2pvr, 2r7i, 2zjw, 3amy, 3at2, 3at3, 3at4, 3axw, 3bqc, 3c13, 3fwq, 3h30, 3juh, 3mb6, 3mb7, 3nga, 3nsz, 3owj, 3owk, 3owl, 3pe1, 3pe2, 3q04, 3q9w, 3q9x, 3q9y, 3q9z, 3qa0, 3r0t, 3rps, 3u4u, 3u87, 3u9c, 3w8l, 3war, 3wik, 3wil, 3wow, 4dgl, 4fbx, 4grb, 4gub, 4ib5, 4kwp, 4md7, 4md8, 4md9, 4nh1, 4rll, 4ub7, 4uba, 5b0x, 5clp, 5cqu, 5cqw, 5cs6, 5csh, 5csp, 5csv, 5ct0, 5ctp, 5cu0, 5cu2, 5cu3, 5cu4, 5cu6, 5cvf, 5cvg, 5cvh, 5cx9, 5h8b, 5h8e, 5h8g

HET: 42j, 54e, 54r, 551, rfz

CSK22_HUMAN_1_342 [text] Casein kinase II subunit alpha' [Protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily]

volume: 236. Å3; shape: 0.75; buriedness: 0.84

negative: 0.08; positive: 0.08; polar: 0.08; backbone: 0.24; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 3e3b, 3ofm

HET: 4b0, cck

CSK2A_MAIZE_1_331 [text] Casein kinase II subunit alpha [Protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily]

volume: 366. Å3; shape: 0.79; buriedness: 0.88

negative: 0.06; positive: 0.06; polar: 0.06; backbone: 0.33; hydrophobic: 0.49

Domains/regions: [D] Protein kinase

PDB: 1daw, 1day, 1ds5, 1f0q, 1j91, 1jam, 1lp4, 1lpu, 1lr4, 1m2p, 1m2q, 1m2r, 1om1, 1zoe, 1zog, 1zoh, 2oxd, 2oxx, 2oxy, 2pvh, 2pvj, 2pvk, 2pvl, 2pvm, 2pvn, 2qc6, 3be9, 3fl5, 3kxg, 3kxh, 3kxm, 3kxn, 3pvg, 3pwd, 3pzh, 4anm, 4dgm, 4dgn, 4dgo, 4rlk

HET: 0jw, agi, amp, anp, ben, cz0, e91, emo, g12, gnp, hna, iqa, k17, k22, k25, k32, k37, k44, k66, k68, k6x, k74, k8x, lu2, mg, mnx, mny, na, p04, p19, p29, p44, p45, p55, p63, tbs, txq, wul

CSK_HUMAN_180_450 [text] Tyrosine-protein kinase CSK [Protein kinase superfamily. Tyr protein kinase family. CSK subfamily]

volume: 291. Å3; shape: 0.93; buriedness: 0.78

negative: 0.05; positive: 0.05; polar: 0.14; backbone: 0.35; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 1byg, 1k9a, 3d7t

HET: stu

CTR1_ARATH_537_821 [text] Serine/threonine-protein kinase CTR1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily]

volume: 281. Å3; shape: 0.89; buriedness: 0.85

negative: 0.04; positive: 0.08; polar: 0.08; backbone: 0.43; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 3p86, 3ppz

HET: stu

DAPK1_HUMAN_1_289 [text] Death-associated protein kinase 1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily]

volume: 395. Å3; shape: 0.94; buriedness: 0.88

negative: 0.13; positive: 0.05; polar: 0.; backbone: 0.4; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 1ig1, 1jkk, 1jkl, 1jks, 1jkt, 1p4f, 1wvw, 1wvx, 1wvy, 2w4j, 2w4k, 2x0g, 2xuu, 2xzs, 2y0a, 2y4p, 2yak, 3dfc, 3dgk, 3eh9, 3eha, 3f5g, 3f5u, 3gu4, 3gu5, 3gu6, 3gu7, 3gu8, 3gub, 3zxt, 4b4l, 4pf4, 4tl0, 4txc, 4uv0, 4yo4, 4ypd, 5aut, 5auu, 5auv, 5auw, 5aux, 5auy, 5auz, 5av0, 5av1, 5av2, 5av3, 5av4

HET: 1pe, 2an, 38g, 3gu, 47x, 4ft, acp, adp, agi, anp, bd4, dkg, drg, gen, gub, kmp, lu2, mg, mn, mri, osv, pge, que, stu

DAPK2_HUMAN_10_297 [text] Death-associated protein kinase 2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily]

volume: 234. Å3; shape: 0.61; buriedness: 0.82

negative: 0.08; positive: 0.; polar: 0.; backbone: 0.39; hydrophobic: 0.53

Domains/regions: [D] Protein kinase

PDB: 1zws, 2a27, 2a2a, 2cke, 2ya9, 2yaa, 2yab

HET: amp, atp, iqu

DAPK3_HUMAN_7_287 [text] Death-associated protein kinase 3 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily]

volume: 286. Å3; shape: 0.82; buriedness: 0.85

negative: 0.; positive: 0.07; polar: 0.; backbone: 0.41; hydrophobic: 0.52

Domains/regions: [D] Protein kinase, [R] Activation segment

PDB: 1yrp, 2j90, 3bhy, 3bqr, 5a6n, 5a6o

HET: 4rb, 7cp, cl, iza, u7e

DCLK1_HUMAN_370_649 [text] Serine/threonine-protein kinase DCLK1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 449. Å3; shape: 0.67; buriedness: 0.77

negative: 0.13; positive: 0.05; polar: 0.05; backbone: 0.4; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 5jzj, 5jzn

HET: an2, gui

DDR1_HUMAN_598_913 [text] Epithelial discoidin domain-containing receptor 1 [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 590. Å3; shape: 0.43; buriedness: 0.9

negative: 0.07; positive: 0.07; polar: 0.07; backbone: 0.33; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 3zos, 4bkj, 4ckr, 5bvk, 5bvn, 5bvo, 5bvw, 5fdp, 5fdx

HET: 0li, 1n1, 4vc, 4vd, 4ve, 5wr, 5x1, di1, sti

DMPK_HUMAN_9_420 [text] Myotonin-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily]

volume: 251. Å3; shape: 0.86; buriedness: 0.78

negative: 0.06; positive: 0.06; polar: 0.15; backbone: 0.36; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 2vd5

HET: bi8

DYR1A_HUMAN_124_488 [text] Dual specificity tyrosine-phosphorylation-regulated kinase 1A [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily]

volume: 380. Å3; shape: 0.75; buriedness: 0.83

negative: 0.06; positive: 0.05; polar: 0.; backbone: 0.32; hydrophobic: 0.57

Domains/regions: [D] Protein kinase

PDB: 2vx3, 2wo6, 3anq, 3anr, 4aze, 4mq1, 4mq2, 4nct, 4ylj, 4ylk, 4yll, 4yu2, 5a3x, 5a4e, 5a4l, 5a4q, 5a4t, 5a54, 5aik

HET: 2c3, 2c4, 2k2, 3ra, 4e1, 4e2, 4e3, 4h5, 5pw, 7qq, ajg, awr, d15, ehb, hrm, qiv, y3l, zc3

DYRK2_HUMAN_145_550 [text] Dual specificity tyrosine-phosphorylation-regulated kinase 2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily]

volume: 302. Å3; shape: 0.86; buriedness: 0.82

negative: 0.06; positive: 0.06; polar: 0.; backbone: 0.35; hydrophobic: 0.53

Domains/regions: [D] Protein kinase

PDB: 3k2l, 3kvw, 4azf, 5lxc, 5lxd

HET: 3ra, 7a7, 7aa, irb

E2AK2_HUMAN_255_551_ATPsite [text] Interferon-induced, double-stranded RNA-activated protein kinase [Protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily]

volume: 376. Å3; shape: 0.58; buriedness: 0.67

negative: 0.06; positive: 0.06; polar: 0.17; backbone: 0.36; hydrophobic: 0.36

Domains/regions: [D] Protein kinase, [R] Interaction with TRAF5

PDB: 2a19, 2a1a, 3uiu

HET: anp, mg

E2AK3_HUMAN_581_1092 [text] Eukaryotic translation initiation factor 2-alpha kinase 3 [Protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily]

volume: 466. Å3; shape: 0.49; buriedness: 0.92

negative: 0.07; positive: 0.03; polar: 0.; backbone: 0.4; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 4g31, 4g34, 4m7i, 4x7h, 4x7j, 4x7k, 4x7l, 4x7n, 4x7o

HET: 3z1, 3z2, 3z3, 3z4, 3z5

EGFR_HUMAN_721_983 [text] Epidermal growth factor receptor [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 731. Å3; shape: 0.6; buriedness: 0.79

negative: 0.09; positive: 0.04; polar: 0.08; backbone: 0.42; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 1m14, 1m17, 1xkk, 2eb2, 2eb3, 2gs2, 2gs6, 2gs7, 2itn, 2ito, 2itp, 2itq, 2itt, 2itu, 2itv, 2itw, 2itx, 2ity, 2itz, 2j5e, 2j5f, 2j6m, 2jit, 2jiu, 2jiv, 2rf9, 2rfe, 2rgp, 3bel, 3gop, 3gt8, 3ika, 3lzb, 3poz, 3ug1, 3ug2, 3vjn, 3vjo, 3w2o, 3w2p, 3w2q, 3w2r, 3w2s, 3w32, 3w33, 4g5j, 4g5p, 4hjo, 4i1z, 4i20, 4i21, 4i22, 4i23, 4i24, 4jq7, 4jq8, 4jr3, 4jrv, 4li5, 4lqm, 4r3p, 4r3r, 4r5s, 4riw, 4rix, 4riy, 4rj4, 4rj5, 4rj6, 4rj7, 4rj8, 4tks, 4wd5, 4wkq, 4wrg, 4zau, 4zjv, 4zse, 5c8k, 5c8m, 5c8n, 5cal, 5can, 5cao, 5cap, 5caq, 5cas, 5cau, 5cav, 5cnn, 5cno, 5czh, 5czi, 5d41, 5edp, 5edq, 5edr, 5em5, 5em6, 5em7, 5em8, 5fed, 5fee, 5feq, 5hcx, 5hcy, 5hcz, 5hg5, 5hg7, 5hg8, 5hg9, 5hib, 5hic, 5j9y, 5j9z, 5jeb

HET: 03p, 0un, 0wn, 112, 1c9, 1wy, 3lh, 3qs, 3qw, 3qy, 3r0, 3r1, 4yv, 4yw, 4yx, 4z8, 4zb, 4zg, 4zh, 4zj, 4zq, 4zr, 57n, 5n3, 5n4, 5q2, 5q3, 5q4, 5x4, 5xh, 60b, 60d, 60e, 630, 633, 634, 63a, 63m, 63n, 6hj, 6hl, 6js, adp, aee, anp, aq4, djk, fi3, fmm, hki, hyz, ire, iti, itq, kj8, kjq, kjr, kjv, mg, pox, w19, w2p, w2r, w32, yy3

EGFR_HUMAN_983_1022 [text] Epidermal growth factor receptor [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 320. Å3; shape: 0.7; buriedness: 0.32

negative: 0.; positive: 0.37; polar: 0.16; backbone: 0.48; hydrophobic: 0.

PDB: 1m14, 1m17, 1xkk, 2eb2, 2eb3, 2gs2, 2gs6, 2gs7, 2itn, 2ito, 2itp, 2itq, 2itt, 2itu, 2itv, 2itw, 2itx, 2ity, 2itz, 2j5e, 2j5f, 2j6m, 2jit, 2jiu, 2jiv, 2rf9, 2rfe, 2rgp, 3bel, 3gop, 3gt8, 3ika, 3poz, 3ug1, 3ug2, 3vjn, 3vjo, 3w2o, 3w2p, 3w2q, 3w2r, 3w2s, 3w32, 3w33, 4g5j, 4g5p, 4hjo, 4i1z, 4i20, 4i21, 4i22, 4i23, 4i24, 4jq7, 4jq8, 4jr3, 4jrv, 4li5, 4lqm, 4r3p, 4r3r, 4r5s, 4riw, 4rix, 4riy, 4rj4, 4rj5, 4rj6, 4rj7, 4rj8, 4tks, 4wd5, 4wkq, 4wrg, 4zau, 4zjv, 4zse, 5c8k, 5c8m, 5c8n, 5cal, 5can, 5cao, 5cap, 5caq, 5cas, 5cau, 5cav, 5cnn, 5cno, 5czh, 5czi, 5d41, 5edp, 5edq, 5edr, 5em5, 5em6, 5em7, 5em8, 5fed, 5fee, 5feq, 5hcx, 5hcy, 5hcz, 5hg5, 5hg7, 5hg8, 5hg9, 5hib, 5hic, 5j9y, 5j9z, 5jeb

HET: 0wm

EPHA2_HUMAN_594_903_ATPsite [text] Ephrin type-A receptor 2 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 660. Å3; shape: 0.43; buriedness: 0.75

negative: 0.06; positive: 0.06; polar: 0.12; backbone: 0.43; hydrophobic: 0.32

Domains/regions: [D] Protein kinase, [R] Mediates interaction with ARHGEF16 and ELMO2

PDB: 1mqb, 4p2k, 4pdo, 4trl, 5ek7, 5i9u, 5i9v, 5i9w, 5i9x, 5i9y, 5i9z, 5ia0, 5ia1, 5ia2, 5ia3, 5ia4, 5ia5

HET: 1n1, 627, 88z, a5b, ags, anp, db8, gv0, l66, p17, zzl

EPHA3_HUMAN_604_947 [text] Ephrin type-A receptor 3 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 502. Å3; shape: 0.46; buriedness: 0.83

negative: 0.04; positive: 0.04; polar: 0.12; backbone: 0.49; hydrophobic: 0.3

Domains/regions: [D] Protein kinase

PDB: 2gsf, 2qo2, 2qo7, 2qo9, 2qob, 2qoc, 2qod, 2qof, 2qoi, 2qok, 2qol, 2qon, 2qoo, 2qoq, 3dzq, 3fxx, 3fy2, 4g2f, 4gk2, 4gk3, 4gk4, 4p4c, 4p5q, 4p5z, 4twn, 4two

HET: 25q, 37w, anp, b96, c07, ifc, l66, l87, l90, mg, q0b, q7m

EPHA4_HUMAN_604_894 [text] Ephrin type-A receptor 4 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 342. Å3; shape: 0.34; buriedness: 0.78

negative: 0.05; positive: 0.05; polar: 0.11; backbone: 0.4; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 2hel, 2xyu, 2y6m, 2y6o

HET: 1n1, q9g

EPHA7_HUMAN_589_908 [text] Ephrin type-A receptor 7 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 259. Å3; shape: 0.39; buriedness: 0.92

negative: 0.12; positive: 0.03; polar: 0.06; backbone: 0.29; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 2rei, 3dko

HET: ihz

EPHB2_HUMAN_604_902 [text] Ephrin type-B receptor 2 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 232. Å3; shape: 0.56; buriedness: 0.78

negative: 0.; positive: 0.08; polar: 0.16; backbone: 0.25; hydrophobic: 0.51

Domains/regions: [D] Protein kinase

PDB: 1jpa, 2hen, 3zfm

HET: adp, anp

EPHB3_HUMAN_614_910 [text] Ephrin type-B receptor 3 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 212. Å3; shape: 0.45; buriedness: 0.9

negative: 0.; positive: 0.05; polar: 0.14; backbone: 0.39; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 3zfy, 5l6o, 5l6p

HET: 6p6, 6p8

EPHB4_HUMAN_598_896 [text] Ephrin type-B receptor 4 [Protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily]

volume: 439. Å3; shape: 0.52; buriedness: 0.79

negative: 0.05; positive: 0.05; polar: 0.09; backbone: 0.45; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 2vwu, 2vwv, 2vww, 2vwx, 2vwy, 2vwz, 2vx0, 2vx1, 2x9f, 2xvd, 2yn8, 3zew, 4aw5, 4bb4

HET: 30k, 32w, 7x1, 7x2, 7x3, 7x4, 7x5, 7x6, 7x7, 7x8, as6, stu, x9f

ERBB2_HUMAN_697_1029 [text] Receptor tyrosine-protein kinase erbB-2 [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 389. Å3; shape: 0.57; buriedness: 0.89

negative: 0.04; positive: 0.03; polar: 0.14; backbone: 0.39; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 3pp0, 3rcd

HET: 03p, 03q

ERBB3_HUMAN_683_1020_ATPsite [text] Receptor tyrosine-protein kinase erbB-3 [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 579. Å3; shape: 0.66; buriedness: 0.83

negative: 0.04; positive: 0.07; polar: 0.14; backbone: 0.45; hydrophobic: 0.3

Domains/regions: [D] Protein kinase

PDB: 3kex, 3lmg, 4otw, 4riw, 4rix, 4riy

HET: anp, db8

ERBB4_HUMAN_695_999 [text] Receptor tyrosine-protein kinase erbB-4 [Protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily]

volume: 332. Å3; shape: 0.39; buriedness: 0.92

negative: 0.05; positive: 0.04; polar: 0.08; backbone: 0.45; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 2r4b, 3bbt, 3bce

HET: fmm, gw7

ERN1_HUMAN_554_974 [text] Serine/threonine-protein kinase/endoribonuclease IRE1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 617. Å3; shape: 0.51; buriedness: 0.85

negative: 0.04; positive: 0.09; polar: 0.11; backbone: 0.38; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 3p23, 4pl3, 4pl4, 4pl5, 4u6r, 4yz9, 4yzc, 4yzd, 4z7g, 4z7h, 5hgi

HET: 3e4, 4k7, 4l5, adp, mg, stu

FAK1_HUMAN_409_687 [text] Focal adhesion kinase 1 [Protein kinase superfamily. Tyr protein kinase family. FAK subfamily]

volume: 758. Å3; shape: 0.5; buriedness: 0.85

negative: 0.1; positive: 0.05; polar: 0.03; backbone: 0.47; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 1mp8, 2etm, 2ijm, 2j0j, 2j0k, 2j0l, 2j0m, 2jkk, 2jkm, 2jko, 2jkq, 3bz3, 3pxk, 4brx, 4c7t, 4d4r, 4d4s, 4d4v, 4d4y, 4d55, 4d58, 4d5h, 4d5k, 4ebv, 4ebw, 4gu6, 4gu9, 4i4e, 4i4f, 4k8a, 4k9y, 4kab, 4kao, 4q9s

HET: 0o7, 0pf, 10n, 1bq, 1br, 30g, 4gu, 4ka, 4st, 5ri, 7py, 9rm, adp, anp, atp, bi9, bii, bij, k8a, k9y, kao, kb8, kgw, mg, pxk, vg8, yam

FAK2_HUMAN_415_692 [text] Protein-tyrosine kinase 2-beta [Protein kinase superfamily. Tyr protein kinase family. FAK subfamily]

volume: 688. Å3; shape: 0.45; buriedness: 0.82

negative: 0.11; positive: 0.07; polar: 0.03; backbone: 0.41; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 3cc6, 3et7, 3fzo, 3fzp, 3fzr, 3fzs, 3fzt, 3h3c, 4h1j, 4h1m

HET: 0yh, 0yj, 349, 3jz, 4jz, ags, b96, p1e

FES_HUMAN_552_822 [text] Tyrosine-protein kinase Fes/Fps [Protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily]

volume: 476. Å3; shape: 0.57; buriedness: 0.84

negative: 0.09; positive: 0.; polar: 0.11; backbone: 0.45; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 3bkb, 3cbl, 3cd3, 4e93

HET: gui, stu

FGFR1_HUMAN_456_766 [text] Fibroblast growth factor receptor 1 [Protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily]

volume: 574. Å3; shape: 0.42; buriedness: 0.78

negative: 0.08; positive: 0.05; polar: 0.05; backbone: 0.41; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 1agw, 1fgi, 1fgk, 2fgi, 3c4f, 3gqi, 3gql, 3js2, 3kxx, 3ky2, 3rhx, 3tt0, 4f63, 4f64, 4f65, 4nk9, 4nka, 4nks, 4rwi, 4rwj, 4rwk, 4rwl, 4uwb, 4uwc, 4uwy, 4v01, 4v04, 4v05, 4wun, 4zsa, 5a46, 5a4c, 5am6, 5am7, 5b7v, 5ew8, 5flf

HET: 07j, 0li, 0s7, 0s8, 0s9, 2k5, 2k7, 2m2, 38o, 3rh, 3zc, 4ut, 4y0, 5sf, 66t, acp, c4f, gql, jvt, lwj, mg, pd1, su1, su2, vm1, xoj

FGFR2_HUMAN_455_769 [text] Fibroblast growth factor receptor 2 [Protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily]

volume: 396. Å3; shape: 0.77; buriedness: 0.74

negative: 0.1; positive: 0.04; polar: 0.17; backbone: 0.33; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 1gjo, 1oec, 2psq, 2pvf, 2pvy, 2pwl, 2py3, 2pz5, 2pzp, 2pzr, 2q0b, 3b2t, 3cly, 3ri1, 4j95, 4j96, 4j97, 4j98, 4j99, 5eg3

HET: 3rh, aa2, acp, m33, mg

FGFR3_HUMAN_445_759 [text] Fibroblast growth factor receptor 3 [Protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily]

volume: 297. Å3; shape: 0.44; buriedness: 0.86

negative: 0.05; positive: 0.09; polar: 0.14; backbone: 0.45; hydrophobic: 0.27

Domains/regions: [D] Protein kinase

PDB: 4k33

HET: acp

FGFR4_HUMAN_444_753 [text] Fibroblast growth factor receptor 4 [Protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily]

volume: 689. Å3; shape: 0.55; buriedness: 0.82

negative: 0.07; positive: 0.04; polar: 0.; backbone: 0.45; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 4qq5, 4qqc, 4qqj, 4qqt, 4qrc, 4r6v, 4tye, 4tyg, 4tyi, 4tyj, 4uxq, 4xcu, 5jkg

HET: 0li, 37o, 38o, 40m, 6lf, fi3

FLT3_HUMAN_600_952 [text] Receptor-type tyrosine-protein kinase FLT3 [Protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily]

volume: 461. Å3; shape: 0.29; buriedness: 0.8

negative: 0.08; positive: 0.1; polar: 0.04; backbone: 0.33; hydrophobic: 0.45

Domains/regions: [D] Protein kinase

PDB: 1rjb, 4rt7, 4xuf

HET: p30

FUS3_YEAST_1_353 [text] Mitogen-activated protein kinase FUS3 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 232. Å3; shape: 0.55; buriedness: 0.86

negative: 0.09; positive: 0.12; polar: 0.19; backbone: 0.22; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 2b9f, 2b9h, 2b9i, 2b9j, 2f49, 2f9g, 2fa2

HET: adp

FYN_HUMAN_248_537 [text] Tyrosine-protein kinase Fyn [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

volume: 271. Å3; shape: 0.91; buriedness: 0.84

negative: 0.08; positive: 0.08; polar: 0.08; backbone: 0.46; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 2dq7

HET: stu

GAK_HUMAN_12_350 [text] Cyclin-G-associated kinase [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 300. Å3; shape: 0.67; buriedness: 0.85

negative: 0.; positive: 0.06; polar: 0.1; backbone: 0.41; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 4c57, 4c58, 4c59, 4o38, 4y8d

HET: 49j, 824, fef

GCN2_YEAST_593_997_ATPsite [text] eIF-2-alpha kinase GCN2 [Protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily]

volume: 335. Å3; shape: 0.49; buriedness: 0.71

negative: 0.12; positive: 0.07; polar: 0.12; backbone: 0.37; hydrophobic: 0.32

Domains/regions: [D] Protein kinase 2

PDB: 1zxe, 1zy4, 1zy5, 1zyc, 1zyd

HET: anp, atp, mg

GRK4_HUMAN_1_578 [text] G protein-coupled receptor kinase 4 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily]

volume: 244. Å3; shape: 0.55; buriedness: 0.76

negative: 0.07; positive: 0.07; polar: 0.; backbone: 0.5; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4yhj

HET: an2

GRK5_HUMAN_1_590 [text] G protein-coupled receptor kinase 5 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily]

volume: 390. Å3; shape: 0.59; buriedness: 0.85

negative: 0.08; positive: 0.07; polar: 0.08; backbone: 0.42; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 4tnb, 4tnd, 4wnk

HET: 453, anp, mg, sgv

GRK6_HUMAN_2_576 [text] G protein-coupled receptor kinase 6 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily]

volume: 274. Å3; shape: 0.59; buriedness: 0.9

negative: 0.1; positive: 0.07; polar: 0.04; backbone: 0.46; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 2acx, 3nyn, 3nyo

HET: amp, anp, mg, sgv

GSK3B_HUMAN_31_387 [text] Glycogen synthase kinase-3 beta [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily]

volume: 453. Å3; shape: 0.84; buriedness: 0.84

negative: 0.05; positive: 0.08; polar: 0.14; backbone: 0.38; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 1gng, 1h8f, 1i09, 1j1b, 1j1c, 1o9u, 1pyx, 1q3d, 1q3w, 1q41, 1q4l, 1q5k, 1r0e, 1uv5, 2jld, 2o5k, 2ow3, 3du8, 3f7z, 3f88, 3gb2, 3i4b, 3l1s, 3m1s, 3pup, 3q3b, 3say, 3sd0, 3zdi, 3zrk, 3zrl, 3zrm, 4acc, 4acd, 4acg, 4ach, 4afj, 4b7t, 4dit, 4iq6, 4j1r, 4j71, 4nm0, 4nm3, 4nm5, 4nm7, 4nu1, 4ptc, 4pte, 4ptg, 5air, 5f94, 5f95, 5hln, 5hlp, 5k5n

HET: 0kd, 1jx, 2ht, 2we, 2wf, 2wg, 34o, 3ht, 3uo, 3up, 553, 55e, 65a, 65c, 679, 6lq, 6qh, 7yg, adp, adz, ag1, al, anp, atu, bim, brw, co, cwt, dfn, dw1, g3b, gr9, hbm, i5r, iq6, ixm, kdi, mg, oft, os1, sjj, stu, tmu, tsk, ugj, z48, z92, zrk, zrl, zrm

HASP_HUMAN_462_798 [text] Serine/threonine-protein kinase haspin [Protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily]

volume: 1095. Å3; shape: 0.64; buriedness: 0.84

negative: 0.14; positive: 0.05; polar: 0.14; backbone: 0.35; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 2vuw, 2wb8, 3dlz, 3e7v, 3f2n, 3fmd, 3iq7, 4ouc, 4qtc, 5htb, 5htc

HET: 38z, 5id, 66m, 66n, 6l5, amp, dzo, iod, iqb, izz, mg

HCK_HUMAN_246_526 [text] Tyrosine-protein kinase HCK [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

volume: 444. Å3; shape: 0.54; buriedness: 0.84

negative: 0.08; positive: 0.04; polar: 0.09; backbone: 0.36; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 1ad5, 1qcf, 2c0i, 2c0o, 2c0t, 2hck, 2hk5, 3vry, 3vrz, 3vs0, 3vs1, 3vs2, 3vs3, 3vs4, 3vs5, 3vs6, 3vs7, 4lud, 4lue

HET: 1bm, anp, b43, ca, ks1, l1g, l2g, l3g, pp1, que, sk8, vrz, vs0, vsa, vsb, vse, vsf, vsg, vsh

HRR25_YEAST_1_394 [text] Casein kinase I homolog HRR25 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

volume: 174. Å3; shape: 0.61; buriedness: 0.8

negative: 0.07; positive: 0.; polar: 0.; backbone: 0.43; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 4xhl, 5cyz, 5czo

HET: cki

IGF1R_HUMAN_981_1287 [text] Insulin-like growth factor 1 receptor [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 708. Å3; shape: 0.51; buriedness: 0.76

negative: 0.06; positive: 0.04; polar: 0.; backbone: 0.5; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 1jqh, 1k3a, 1m7n, 1p4o, 2oj9, 2zm3, 3d94, 3f5p, 3i81, 3lvp, 3lw0, 3nw5, 3nw6, 3nw7, 3o23, 3qqu, 4d2r, 5fxq, 5fxr, 5fxs, 5hzn

HET: 01p, 575, 66a, 741, 8ln, acp, anp, bmi, ccx, d94, dyk, ebi, gd5, lgv, lgw, lgx, mg, mqy, ozn, pdr

IKKB_HUMAN_7_668 [text] Inhibitor of nuclear factor kappa-B kinase subunit beta [Protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily]

volume: 283. Å3; shape: 0.89; buriedness: 0.87

negative: 0.14; positive: 0.05; polar: 0.08; backbone: 0.43; hydrophobic: 0.3

Domains/regions: [D] Protein kinase

PDB: 4kik

HET: ksa

ILK_HUMAN_178_452_ATPsite [text] Integrin-linked protein kinase [Protein kinase superfamily. TKL Ser/Thr protein kinase family]

volume: 284. Å3; shape: 0.53; buriedness: 0.82

negative: 0.07; positive: 0.16; polar: 0.25; backbone: 0.23; hydrophobic: 0.3

Domains/regions: [D] Protein kinase, [R] PH-like; mediates interaction with TGFB1I1

PDB: 3kmu, 3kmw, 3rep

HET: atp

INSR_HUMAN_1004_1311 [text] Insulin receptor [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 729. Å3; shape: 0.72; buriedness: 0.77

negative: 0.11; positive: 0.06; polar: 0.05; backbone: 0.46; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 1gag, 1i44, 1ir3, 1irk, 1p14, 1rqq, 2auh, 2b4s, 2z8c, 3bu3, 3bu5, 3bu6, 3ekk, 3ekn, 3eta, 4ibm, 4xlv, 5e1s, 5hhw

HET: 112, 351, 5ja, 60o, acp, anp, atp, ca, gs2, gs3, ir1, mg, mn, ptr, s91

IRAK4_HUMAN_158_460 [text] Interleukin-1 receptor-associated kinase 4 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily]

volume: 488. Å3; shape: 0.63; buriedness: 0.86

negative: 0.07; positive: 0.03; polar: 0.18; backbone: 0.43; hydrophobic: 0.28

Domains/regions: [D] Protein kinase

PDB: 2nru, 2nry, 2o8y, 2oib, 2oic, 2oid, 4rmz, 4u97, 4u9a, 4xs2, 4y73, 4yo6, 4yp8, 4ztl, 4ztm, 4ztn, 5kx7, 5kx8

HET: 42p, 4gd, 4gf, 4s1, 4s2, 4s3, 6yd, 6ye, anp, stu, t12, unl, xpy

IRE1_YEAST_644_1115 [text] Serine/threonine-protein kinase/endoribonuclease IRE1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 321. Å3; shape: 0.62; buriedness: 0.87

negative: 0.06; positive: 0.04; polar: 0.08; backbone: 0.51; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 2rio, 3lj0, 3lj1, 3lj2

HET: adp, dki, iza

ITK_HUMAN_353_620 [text] Tyrosine-protein kinase ITK/TSK [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

volume: 729. Å3; shape: 0.4; buriedness: 0.69

negative: 0.04; positive: 0.05; polar: 0.05; backbone: 0.4; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 1sm2, 1snu, 1snx, 3miy, 3mj1, 3mj2, 3qgw, 3qgy, 3t9t, 3v5j, 3v5l, 3v8t, 3v8w, 4hct, 4hcu, 4hcv, 4kio, 4l7s, 4m0y, 4m0z, 4m12, 4m13, 4m14, 4m15, 4mf0, 4mf1, 4pp9, 4ppa, 4ppb, 4ppc, 4pqn, 4qd6, 4rfm

HET: 0f2, 0g1, 0g2, 13j, 13l, 18r, 29y, 29z, 2vt, 2vu, 2vv, 2vw, 2w6, 30t, 3p6, 477, 614, adp, b49, g5k, g6k, g7k, iaq, l7a, l7o, m0y, m0z, mjg, pqc, qws, stu

JAK1_HUMAN_854_1154 [text] Tyrosine-protein kinase JAK1 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

volume: 303. Å3; shape: 0.74; buriedness: 0.91

negative: 0.1; positive: 0.; polar: 0.05; backbone: 0.43; hydrophobic: 0.42

Domains/regions: [D] Protein kinase 2

PDB: 3eyg, 3eyh, 4e4l, 4e4n, 4e5w, 4ehz, 4ei4, 4fk6, 4i5c, 4ivb, 4ivc, 4ivd, 4k6z, 4k77, 5e1e, 5hx8, 5khw, 5khx

HET: 0nh, 0nl, 0nt, 0q2, 0uj, 15t, 1j5, 1j6, 1q3, 1q4, 5jg, 66p, 6te, adp, c5i, iza, jak, mg, mi1

JAK2_HUMAN_536_835_ATPsite [text] Tyrosine-protein kinase JAK2 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

volume: 301. Å3; shape: 0.56; buriedness: 0.86

negative: 0.; positive: 0.1; polar: 0.3; backbone: 0.33; hydrophobic: 0.27

Domains/regions: [D] Protein kinase 1

PDB: 4fvp, 4fvq, 4fvr, 5i4n

HET: atp

JAK2_HUMAN_835_1132 [text] Tyrosine-protein kinase JAK2 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

volume: 488. Å3; shape: 0.76; buriedness: 0.84

negative: 0.05; positive: 0.; polar: 0.09; backbone: 0.53; hydrophobic: 0.33

Domains/regions: [D] Protein kinase 2

PDB: 2b7a, 2w1i, 2xa4, 3e62, 3e63, 3e64, 3fup, 3io7, 3iok, 3jy9, 3kck, 3krr, 3lpb, 3q32, 3rvg, 3tjc, 3tjd, 3ugc, 3zmm, 4aqc, 4bbe, 4bbf, 4c61, 4c62, 4d0w, 4d0x, 4d1s, 4e4m, 4e6d, 4e6q, 4f08, 4f09, 4gfm, 4gmy, 4hge, 4iva, 4ji9, 4jia, 4p7e, 4ytc, 4ytf, 4yth, 4yti, 4zim, 5aep, 5cf4, 5cf5, 5cf6, 5cf8, 5hez, 5l3a

HET: 046, 0nh, 0nu, 0nv, 0tp, 0x2, 0x5, 15v, 17p, 1j5, 1k3, 1m3, 1p5, 1p6, 1rs, 2hb, 3kc, 3o4, 467, 4hw, 4hz, 4ok, 50o, 50v, 50w, 50y, 5b1, 5b2, 5b3, 6dp, 6tp, 88a, 953, az5, bjg, dqx, iza, j2i, jak, jzh, l0i, lmm, mi1, nvb, o19, qup, vjk, vvq, xww

JAK3_HUMAN_811_1112 [text] Tyrosine-protein kinase JAK3 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

volume: 446. Å3; shape: 0.99; buriedness: 0.85

negative: 0.05; positive: 0.03; polar: 0.09; backbone: 0.41; hydrophobic: 0.42

Domains/regions: [D] Protein kinase 2

PDB: 1yvj, 3lxk, 3lxl, 3pjc, 3zc6, 3zep, 4hvd, 4hvg, 4hvh, 4hvi, 4i6q, 4qps, 4qt1, 4rio, 4v0g, 4z16, 5lwm, 5lwn, 5toz

HET: 19q, 19r, 19s, 1dt, 1nx, 37q, 3c9, 3qx, 4lh, 4st, 79r, 79s, 79t, 7h4, 933, dtv, g9b, iza, mi1, pjc, vfc

KAPCA_HUMAN_8_351 [text] cAMP-dependent protein kinase catalytic subunit alpha [Protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily]

volume: 667. Å3; shape: 0.57; buriedness: 0.65

negative: 0.1; positive: 0.03; polar: 0.1; backbone: 0.46; hydrophobic: 0.31

Domains/regions: [D] AGC-kinase C-terminal, [D] Protein kinase

PDB: 1apm, 1atp, 1bkx, 1bx6, 1cdk, 1cmk, 1ctp, 1fmo, 1j3h, 1jbp, 1jlu, 1l3r, 1q24, 1q61, 1q62, 1q8t, 1q8u, 1q8w, 1rdq, 1re8, 1rej, 1rek, 1smh, 1stc, 1sve, 1svg, 1svh, 1syk, 1szm, 1veb, 1xh4, 1xh5, 1xh6, 1xh7, 1xh8, 1xh9, 1xha, 1ydr, 1yds, 1ydt, 2c1a, 2c1b, 2cpk, 2erz, 2f7e, 2f7x, 2f7z, 2gfc, 2gnf, 2gng, 2gnh, 2gni, 2gnj, 2gnl, 2gu8, 2jds, 2jdt, 2jdv, 2oh0, 2ojf, 2qcs, 2qur, 2qvs, 2uvx, 2uvy, 2uvz, 2uw0, 2uw3, 2uw4, 2uw5, 2uw6, 2uw7, 2uw8, 2uzt, 2uzu, 2uzv, 2uzw, 2vnw, 2vny, 2vo0, 2vo3, 2vo6, 2vo7, 3ag9, 3agl, 3agm, 3ama, 3amb, 3bwj, 3dnd, 3dne, 3e8c, 3e8e, 3fhi, 3fjq, 3idb, 3idc, 3kkv, 3l9l, 3l9m, 3l9n, 3mvj, 3nx8, 3o7l, 3oog, 3ovv, 3ow3, 3owp, 3oxt, 3p0m, 3poo, 3pvb, 3qal, 3qam, 3tnp, 3tnq, 3vqh, 3x2u, 3x2v, 3x2w, 3zo1, 3zo2, 3zo3, 3zo4, 4ae6, 4ae9, 4axa, 4c33, 4c34, 4c35, 4c36, 4c37, 4c38, 4dfx, 4dfy, 4dfz, 4dg0, 4dg2, 4dg3, 4dh1, 4dh3, 4dh5, 4dh7, 4dh8, 4hpt, 4hpu, 4iac, 4iad, 4iaf, 4iai, 4iak, 4iay, 4iaz, 4ib0, 4ib1, 4ib3, 4ie9, 4ij9, 4nts, 4ntt, 4o21, 4o22, 4uj1, 4uj2, 4uj9, 4uja, 4ujb, 4wb5, 4wb6, 4wb7, 4wb8, 4wbb, 4wih, 4x6q, 4x6r, 4xw4, 4xw5, 4xw6, 4yxr, 4yxs, 4z83, 4z84, 5bx6, 5bx7, 5izf, 5izj, 5j5x

HET: 15i, 1sb, 2ea, 2py, 2sb, 3sb, 4ea, 4l7, 4py, 4sb, 69p, 6ea, 796, 8bq, b1l, b8l, b99, ba1, bd2, bi4, bud, cqp, dar, g96, g98, gvi, gvj, gvk, gvn, gvp, gvq, h52, hfs, i01, i04, i05, i08, i5s, iqb, iqp, iqs, l15, l20, l9l, l9m, l9n, ll1, ll2, m01, m02, m03, m04, m05, m77, nh2, nu3, nvv, nvx, oce, ptv, pzx, qni, qwi, r55, r68, r69, r94, r96, rkd, s3n, s69, sij, ske, smy, ss3, ss4, ss5, vup, vx6, xfe, z21, zo9

KC1D_HUMAN_1_302 [text] Casein kinase I isoform delta [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

volume: 416. Å3; shape: 0.45; buriedness: 0.88

negative: 0.; positive: 0.05; polar: 0.05; backbone: 0.45; hydrophobic: 0.45

Domains/regions: [D] Protein kinase

PDB: 1cki, 1ckj, 3uys, 3uyt, 3uzp, 4hgt, 4hnf, 4jjr, 4kb8, 4kba, 4kbc, 4kbk, 4tn6, 4tw9, 4twc, 5ih4, 5ih5, 5ih6

HET: 0ck, 15g, 16w, 1qg, 1qj, 1qm, 1qn, 1qo, 37j, 386, aue, aug, na, pfo

KC1E_HUMAN_1_295 [text] Casein kinase I isoform epsilon [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

volume: 259. Å3; shape: 0.59; buriedness: 0.87

negative: 0.04; positive: 0.06; polar: 0.04; backbone: 0.48; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 4hni, 4hok

HET: 16w

KC1G1_HUMAN_43_352 [text] Casein kinase I isoform gamma-1 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

volume: 213. Å3; shape: 0.55; buriedness: 0.75

negative: 0.; positive: 0.; polar: 0.; backbone: 0.53; hydrophobic: 0.47

Domains/regions: [D] Protein kinase

PDB: 2cmw

HET: olp

KC1G2_HUMAN_41_353 [text] Casein kinase I isoform gamma-2 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

volume: 197. Å3; shape: 0.71; buriedness: 0.76

negative: 0.; positive: 0.; polar: 0.07; backbone: 0.41; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 2c47

HET: 5id

KC1G3_HUMAN_34_360 [text] Casein kinase I isoform gamma-3 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily]

volume: 330. Å3; shape: 0.61; buriedness: 0.82

negative: 0.; positive: 0.03; polar: 0.03; backbone: 0.43; hydrophobic: 0.5

Domains/regions: [D] Protein kinase, [R] Inhibitors binding

PDB: 2chl, 2izr, 2izs, 2izt, 2izu, 4g16, 4g17, 4hgl, 4hgs

HET: 0vm, 0vn, 0yo, 15g, 23d, brk, brq, dki, p01

KCC1D_HUMAN_1_333 [text] Calcium/calmodulin-dependent protein kinase type 1D [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 218. Å3; shape: 0.99; buriedness: 0.74

negative: 0.; positive: 0.; polar: 0.; backbone: 0.48; hydrophobic: 0.52

Domains/regions: [D] Protein kinase, [R] Autoinhibitory domain, [R] Calmodulin-binding

PDB: 2jc6

HET: qpp

KCC1G_HUMAN_14_316 [text] Calcium/calmodulin-dependent protein kinase type 1G [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 320. Å3; shape: 0.5; buriedness: 0.63

negative: 0.06; positive: 0.06; polar: 0.06; backbone: 0.35; hydrophobic: 0.47

Domains/regions: [D] Protein kinase

PDB: 2jam

HET: j60

KCC2A_HUMAN_8_304 [text] Calcium/calmodulin-dependent protein kinase type II subunit alpha [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 246. Å3; shape: 0.84; buriedness: 0.86

negative: 0.06; positive: 0.; polar: 0.03; backbone: 0.44; hydrophobic: 0.47

Domains/regions: [D] Protein kinase

PDB: 2vz6

HET: fef

KCC2B_HUMAN_9_306 [text] Calcium/calmodulin-dependent protein kinase type II subunit beta [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 241. Å3; shape: 0.7; buriedness: 0.82

negative: 0.08; positive: 0.; polar: 0.; backbone: 0.46; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 3bhh

HET: 5cp

KCC2D_HUMAN_9_306 [text] Calcium/calmodulin-dependent protein kinase type II subunit delta [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 270. Å3; shape: 0.58; buriedness: 0.72

negative: 0.06; positive: 0.09; polar: 0.; backbone: 0.34; hydrophobic: 0.51

Domains/regions: [D] Protein kinase

PDB: 2vn9, 2wel

HET: gvd, k88

KCC2G_HUMAN_9_306 [text] Calcium/calmodulin-dependent protein kinase type II subunit gamma [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 288. Å3; shape: 0.79; buriedness: 0.69

negative: 0.06; positive: 0.; polar: 0.06; backbone: 0.41; hydrophobic: 0.47

Domains/regions: [D] Protein kinase

PDB: 2v7o

HET: drn

KCC4_HUMAN_13_340 [text] Calcium/calmodulin-dependent protein kinase type IV [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily]

volume: 265. Å3; shape: 0.64; buriedness: 0.68

negative: 0.07; positive: 0.; polar: 0.; backbone: 0.43; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 2w4o

HET: dki

KIT_HUMAN_550_935 [text] Mast/stem cell growth factor receptor Kit [Protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily]

volume: 577. Å3; shape: 0.42; buriedness: 0.89

negative: 0.06; positive: 0.06; polar: 0.06; backbone: 0.48; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 1pkg, 1t45, 1t46, 3g0e, 3g0f, 4hvs, 4u0i

HET: 0li, 647, adp, b49, mg, sti

KKCC2_HUMAN_158_448 [text] Calcium/calmodulin-dependent protein kinase kinase 2 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 164. Å3; shape: 0.55; buriedness: 0.88

negative: 0.; positive: 0.; polar: 0.; backbone: 0.4; hydrophobic: 0.6

Domains/regions: [D] Protein kinase

PDB: 2zv2

HET: 609

KPCA_HUMAN_157_292 [text] Protein kinase C alpha type [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily]

volume: 247. Å3; shape: 0.65; buriedness: 0.86

negative: 0.22; positive: 0.05; polar: 0.17; backbone: 0.47; hydrophobic: 0.09

Domains/regions: [D] C2

PDB: 1dsy, 3gpe, 3rdj, 3twy, 4dnl, 4l1l

HET: psf

KPCA_HUMAN_319_672 [text] Protein kinase C alpha type [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily]

volume: 331. Å3; shape: 0.78; buriedness: 0.89

negative: 0.09; positive: 0.; polar: 0.12; backbone: 0.36; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 3iw4, 4ra4

HET: 3kz, lw4

KPCB_HUMAN_321_668 [text] Protein kinase C beta type [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily]

volume: 277. Å3; shape: 0.87; buriedness: 0.84

negative: 0.1; positive: 0.; polar: 0.16; backbone: 0.39; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 2i0e

HET: pds

KPCD_HUMAN_229_282 [text] Protein kinase C delta type [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily]

volume: 230. Å3; shape: 0.69; buriedness: 0.55

negative: 0.; positive: 0.; polar: 0.08; backbone: 0.67; hydrophobic: 0.25

PDB: 1ptq, 1ptr, 3uej, 3uey, 3uff, 3ugd, 3ugi, 3ugl

HET: prb

KPCI_HUMAN_244_594 [text] Protein kinase C iota type [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily]

volume: 390. Å3; shape: 0.64; buriedness: 0.85

negative: 0.09; positive: 0.04; polar: 0.09; backbone: 0.4; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 1zrz, 3a8w, 3a8x, 3zh8, 4dc2, 5li1, 5li9, 5lih

HET: acp, ade, adp, al, anp, atp, bi1, c58, mg, mn

KPCL_HUMAN_332_683 [text] Protein kinase C eta type [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily]

volume: 202. Å3; shape: 0.9; buriedness: 0.92

negative: 0.14; positive: 0.07; polar: 0.; backbone: 0.29; hydrophobic: 0.5

Domains/regions: [D] AGC-kinase C-terminal, [D] Protein kinase

PDB: 3txo

HET: 07u

KPCT_HUMAN_367_706 [text] Protein kinase C theta type [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily]

volume: 326. Å3; shape: 0.88; buriedness: 0.88

negative: 0.09; positive: 0.05; polar: 0.13; backbone: 0.3; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 1xjd, 2jed, 4q9z, 4ra5, 5f9e

HET: 3l0, 5vs, lg8, pzw, stu

KS6A1_HUMAN_33_353 [text] Ribosomal protein S6 kinase alpha-1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily]

volume: 347. Å3; shape: 0.79; buriedness: 0.79

negative: 0.1; positive: 0.06; polar: 0.1; backbone: 0.38; hydrophobic: 0.36

Domains/regions: [D] Protein kinase 1

PDB: 2z7q, 2z7r, 2z7s

HET: acp, mg, p01, stu

KS6A3_HUMAN_398_740 [text] Ribosomal protein S6 kinase alpha-3 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily]

volume: 369. Å3; shape: 0.67; buriedness: 0.81

negative: 0.06; positive: 0.06; polar: 0.13; backbone: 0.3; hydrophobic: 0.44

Domains/regions: [D] Protein kinase 2

PDB: 2qr7, 2qr8, 4d9t, 4d9u, 4jg6, 4jg7, 4jg8, 4m8t, 4mao

HET: 0jg, 0jh, 1lb, 1lc, 1le, 28d, rmm

KS6A3_HUMAN_41_357 [text] Ribosomal protein S6 kinase alpha-3 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily]

volume: 449. Å3; shape: 0.65; buriedness: 0.81

negative: 0.05; positive: 0.05; polar: 0.05; backbone: 0.39; hydrophobic: 0.46

Domains/regions: [D] Protein kinase 1

PDB: 3g51, 3ubd, 4el9, 4gue, 4nus, 4nw5, 4nw6, 5d9k, 5d9l

HET: 2nk, 2nr, 2ns, 583, 584, anp, qct

KS6A5_HUMAN_414_738_ATPsite [text] Ribosomal protein S6 kinase alpha-5 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily]

volume: 348. Å3; shape: 0.39; buriedness: 0.68

negative: 0.12; positive: 0.03; polar: 0.; backbone: 0.42; hydrophobic: 0.42

Domains/regions: [D] Protein kinase 2

PDB: 3kn5, 3kn6

HET: anp

KS6B1_HUMAN_76_373 [text] Ribosomal protein S6 kinase beta-1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily]

volume: 401. Å3; shape: 0.58; buriedness: 0.88

negative: 0.03; positive: 0.07; polar: 0.08; backbone: 0.46; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 3a60, 3a61, 3a62, 3we4, 3wf5, 3wf6, 3wf7, 3wf8, 3wf9, 4l3j, 4l3l, 4l42, 4l43, 4l44, 4l45, 4l46, 4rlo, 4rlp

HET: 3t3, 5fi, 72b, f76, fs7, fs9, fz8, fz9, stu

KSR2_HUMAN_633_950_ATPsite [text] Kinase suppressor of Ras 2 [Protein kinase superfamily. TKL Ser/Thr protein kinase family]

volume: 288. Å3; shape: 0.53; buriedness: 0.86

negative: 0.05; positive: 0.21; polar: 0.16; backbone: 0.32; hydrophobic: 0.26

Domains/regions: [D] Protein kinase

PDB: 2y4i

HET: atp

KSYK_HUMAN_354_635 [text] Tyrosine-protein kinase SYK [Protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily]

volume: 536. Å3; shape: 0.83; buriedness: 0.81

negative: 0.03; positive: 0.; polar: 0.09; backbone: 0.44; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 1xba, 1xbb, 1xbc, 3emg, 3fqe, 3fqh, 3fqs, 3srv, 3tub, 3tuc, 3tud, 3vf8, 3vf9, 4dfl, 4dfn, 4f4p, 4fl1, 4fl2, 4fl3, 4fyn, 4fyo, 4fz6, 4fz7, 4gfg, 4i0r, 4i0s, 4i0t, 4puz, 4pv0, 4px6, 4rss, 4rx7, 4rx8, 4rx9, 4wnm, 4xg2, 4xg3, 4xg4, 4xg6, 4xg7, 4xg8, 4xg9, 4yjo, 4yjp, 4yjq, 4yjr, 4yjs, 4yjt, 4yju, 4yjv, 5c26, 5c27, 5cxh, 5cxz, 5cy3, 5ghv, 5lma, 5lmb, 5t68, 5tr6, 5tt7

HET: 057, 0je, 0k0, 0k1, 0sb, 0ve, 0vf, 0vg, 0vh, 0xf, 1b4, 1b5, 1b6, 2x6, 3rt, 3yt, 3yv, 3yx, 477, 4df, 4dj, 4dk, 4dl, 4dn, 4do, 4dq, 4dt, 4mg, 50h, 50j, 55m, 55u, 55y, 585, 685, 6zf, 6zg, 77v, 7kf, 7kg, anp, cg4, cg9, fpu, fpw, fpx, mg, p5c, s19, sti, stu, x3g, x4g, x5g, x6g, x7g, x8g, x9g

LCK_HUMAN_122_227 [text] Tyrosine-protein kinase Lck [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

volume: 947. Å3; shape: 0.46; buriedness: 0.48

negative: 0.03; positive: 0.29; polar: 0.21; backbone: 0.38; hydrophobic: 0.09

Domains/regions: [D] SH2, [R] Interaction with PTPRH

PDB: 1bhf, 1bhh, 1cwd, 1cwe, 1fbz, 1ijr, 1lcj, 1lck, 1lkk, 1lkl, 1x27, 4d8k

HET: 1pa, ace, cc0, cc1, pm3, ptr

LCK_HUMAN_227_506 [text] Tyrosine-protein kinase Lck [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

volume: 662. Å3; shape: 0.44; buriedness: 0.74

negative: 0.04; positive: 0.04; polar: 0.09; backbone: 0.46; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 1qpc, 1qpd, 1qpe, 1qpj, 2of2, 2of4, 2ofu, 2ofv, 2og8, 2pl0, 2zm1, 2zm4, 2zyb, 3ac1, 3ac2, 3ac3, 3ac4, 3ac5, 3ac8, 3acj, 3ack, 3ad4, 3ad5, 3ad6, 3b2w, 3bym, 3byo, 3bys, 3byu, 3kmm, 3kxz, 3lck, 3mpm, 4c3f

HET: 1n8, 1n9, 242, 547, 5lk, 5pb, 7kw, 925, 979, 9nh, am0, am5, am6, am9, anp, kbm, ksc, kse, ksf, ksh, ksk, ksl, ksm, ksr, kss, kzi, kzl, kzm, lhl, pp2, sti, stu

LIMK1_HUMAN_328_638 [text] LIM domain kinase 1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family]

volume: 422. Å3; shape: 0.46; buriedness: 0.72

negative: 0.13; positive: 0.05; polar: 0.17; backbone: 0.33; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 3s95, 5hvj, 5hvk, 5l6w

HET: ags, anp, mg, sep, stu

LIMK2_HUMAN_330_632 [text] LIM domain kinase 2 [Protein kinase superfamily. TKL Ser/Thr protein kinase family]

volume: 344. Å3; shape: 0.48; buriedness: 0.95

negative: 0.04; positive: 0.13; polar: 0.04; backbone: 0.36; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 4tpt

HET: 35h

LYN_HUMAN_235_512 [text] Tyrosine-protein kinase Lyn [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

volume: 487. Å3; shape: 0.71; buriedness: 0.72

negative: 0.07; positive: 0.06; polar: 0.07; backbone: 0.28; hydrophobic: 0.51

Domains/regions: [D] Protein kinase

PDB: 2zv7, 2zv8, 2zv9, 2zva, 3a4o

HET: 1n1, anp, pp2, stu

M3K12_HUMAN_113_402 [text] Mitogen-activated protein kinase kinase kinase 12 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 322. Å3; shape: 0.51; buriedness: 0.69

negative: 0.; positive: 0.; polar: 0.08; backbone: 0.5; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 5cen, 5ceo, 5cep, 5ceq

HET: 50d, 50e, 50f

M3K14_HUMAN_321_678 [text] Mitogen-activated protein kinase kinase kinase 14 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 320. Å3; shape: 0.69; buriedness: 0.93

negative: 0.11; positive: 0.1; polar: 0.13; backbone: 0.39; hydrophobic: 0.27

Domains/regions: [D] Protein kinase, [R] Interaction with ZFP91

PDB: 4dn5, 4g3d, 4idt, 4idv

HET: 13v, ags, mg, t28

M3K14_MOUSE_334_675 [text] Mitogen-activated protein kinase kinase kinase 14 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 264. Å3; shape: 0.61; buriedness: 0.97

negative: 0.11; positive: 0.09; polar: 0.12; backbone: 0.31; hydrophobic: 0.36

Domains/regions: [D] Protein kinase, [R] Interaction with ZFP91

PDB: 4g3c, 4g3e, 4g3f, 4g3g

HET: 0wa, 0wb, 0wc

M3K5_HUMAN_661_945 [text] Mitogen-activated protein kinase kinase kinase 5 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 428. Å3; shape: 0.51; buriedness: 0.87

negative: 0.04; positive: 0.04; polar: 0.13; backbone: 0.46; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 2clq, 3vw6, 4bf2, 4bhn, 4bib, 4bic, 4bid, 4bie

HET: bh9, ie4, ie6, ie8, ieo, im6, stu

M3K7_HUMAN_27_330 [text] Mitogen-activated protein kinase kinase kinase 7 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 567. Å3; shape: 0.36; buriedness: 0.83

negative: 0.08; positive: 0.03; polar: 0.07; backbone: 0.44; hydrophobic: 0.39

Domains/regions: [D] Protein kinase, [R] Interaction with MAPK8IP1

PDB: 2eva, 2yiy, 4gs6, 4l3p, 4l52, 4l53, 4o91, 5e7r, 5gjd, 5gjf, 5gjg, 5jga, 5jgb, 5jgd

HET: 1fm, 1uh, 1ul, 1uo, 5kw, 6kd, 6v3, 6v4, 6v5, adn, ng2, yiy

M3K8_HUMAN_65_395 [text] Mitogen-activated protein kinase kinase kinase 8 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 320. Å3; shape: 0.72; buriedness: 0.95

negative: 0.09; positive: 0.07; polar: 0.05; backbone: 0.46; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 4y83, 4y85, 5iu2

HET: 499, 49b, 6da

M3K9_HUMAN_135_406 [text] Mitogen-activated protein kinase kinase kinase 9 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 274. Å3; shape: 0.52; buriedness: 0.9

negative: 0.06; positive: 0.06; polar: 0.06; backbone: 0.5; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 3dtc, 4uy9

HET: vin

M4K4_HUMAN_3_325 [text] Mitogen-activated protein kinase kinase kinase kinase 4 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 340. Å3; shape: 0.51; buriedness: 0.89

negative: 0.04; positive: 0.07; polar: 0.; backbone: 0.39; hydrophobic: 0.51

Domains/regions: [D] Protein kinase

PDB: 4obo, 4obp, 4obq, 4rvt, 4u3y, 4u3z, 4u40, 4u41, 4u42, 4u43, 4u44, 4u45, 4zk5, 4zp5, 5di1

HET: 2qt, 2qu, 2qv, 3c8, 3d8, 3d9, 3dc, 3xm, 4p4, 4qg, 5df, anp, mg

MAPK2_HUMAN_42_364 [text] MAP kinase-activated protein kinase 2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family]

volume: 417. Å3; shape: 0.64; buriedness: 0.82

negative: 0.08; positive: 0.05; polar: 0.12; backbone: 0.39; hydrophobic: 0.36

Domains/regions: [D] Protein kinase, [R] Staurosporine binding

PDB: 1kwp, 1nxk, 1ny3, 2jbo, 2jbp, 2oza, 2pzy, 3a2c, 3fpm, 3fyk, 3gok, 3ka0, 3kc3, 3kga, 3m2w, 3m42, 3r2b, 3r2y, 3r30, 3wi6, 4tyh

HET: 05b, 793, adp, b18, b98, cd2, hg, hgf, l8i, lx9, mk2, mk3, p4o, pdy, stu, yrz

MAPK3_HUMAN_33_349 [text] MAP kinase-activated protein kinase 3 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family]

volume: 320. Å3; shape: 0.56; buriedness: 0.85

negative: 0.1; positive: 0.05; polar: 0.09; backbone: 0.44; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 3fhr, 3fxw, 3r1n, 3she

HET: 05b, f10, i85, p4o

MARK2_HUMAN_40_364 [text] Serine/threonine-protein kinase MARK2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 282. Å3; shape: 0.61; buriedness: 0.8

negative: 0.; positive: 0.08; polar: 0.09; backbone: 0.46; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 1y8g, 1zmu, 1zmv, 1zmw, 2r0i, 2wzj, 3iec, 5eak

HET: 24r

MARK4_HUMAN_43_370 [text] MAP/microtubule affinity-regulating kinase 4 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 287. Å3; shape: 0.74; buriedness: 0.82

negative: 0.09; positive: 0.05; polar: 0.09; backbone: 0.45; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 5es1

HET: 5rc

MELK_HUMAN_2_335 [text] Maternal embryonic leucine zipper kinase [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily]

volume: 504. Å3; shape: 0.5; buriedness: 0.79

negative: 0.04; positive: 0.04; polar: 0.05; backbone: 0.33; hydrophobic: 0.54

Domains/regions: [D] Protein kinase

PDB: 4bfm, 4bky, 4bkz, 4bl1, 4cqg, 4d2p, 4d2t, 4d2v, 4d2w, 4ixp, 4ump, 4umq, 4umr, 4umt, 4umu, 5ih8, 5ih9, 5iha, 5ihc

HET: 0v0, 1ws, 3i7, 45r, 47w, 5qm, 6bb, 6be, 6bf, 6bj, 6z7, 82b, anp, b5s, nf5, ot5, qbb

MERTK_HUMAN_569_864 [text] Tyrosine-protein kinase Mer [Protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily]

volume: 428. Å3; shape: 0.67; buriedness: 0.73

negative: 0.04; positive: 0.; polar: 0.; backbone: 0.41; hydrophobic: 0.56

Domains/regions: [D] Protein kinase

PDB: 2p0c, 3bpr, 3brb, 3tcp, 4m3q, 4mh7, 4mha

HET: 24k, 4mh, adp, anp, ckj, mg, mh7, olp

MET_HUMAN_1048_1351 [text] Hepatocyte growth factor receptor [Protein kinase superfamily. Tyr protein kinase family]

volume: 730. Å3; shape: 0.47; buriedness: 0.87

negative: 0.06; positive: 0.04; polar: 0.08; backbone: 0.45; hydrophobic: 0.36

Domains/regions: [D] Protein kinase, [R] Interaction with RANBP9

PDB: 1r0p, 1r1w, 2g15, 2rfn, 2rfs, 2wd1, 2wgj, 2wkm, 3a4p, 3c1x, 3ccn, 3cd8, 3ce3, 3cth, 3ctj, 3dkc, 3dkf, 3dkg, 3efj, 3efk, 3f66, 3f82, 3i5n, 3l8v, 3lq8, 3q6u, 3q6w, 3qti, 3r7o, 3rhk, 3u6h, 3u6i, 3vw8, 3zbx, 3zc5, 3zcl, 3zxz, 3zze, 4aoi, 4ap7, 4deg, 4deh, 4dei, 4eev, 4gg5, 4gg7, 4iwd, 4knb, 4mxc, 4r1v, 4r1y, 4xmo, 4xyf, 5dg5, 5eob, 5eyc, 5eyd, 5hlw, 5hni, 5ho6, 5hoa, 5hor, 5t3q

HET: 03x, 044, 0j3, 0j8, 0jj, 0jk, 0jl, 1fn, 1jc, 1ru, 319, 320, 353, 3e8, 3eh, 3qt, 44x, 46g, 4k0, 5b4, 5qq, 5sz, 5t1, 5tf, 62e, 63b, 63k, 6xe, 6xp, 75h, 88z, am7, am8, atp, b2d, ckk, df6, dfq, dwf, f47, gbl, ihx, krw, ksa, l1x, l5g, l8v, lkg, m61, m97, mg, mt3, mt4, pfy, q6w, sx8, vgh, w9z, zzy

MHCKA_DICDI_551_809 [text] Myosin heavy chain kinase A [Protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily]

volume: 286. Å3; shape: 0.55; buriedness: 0.84

negative: 0.1; positive: 0.13; polar: 0.05; backbone: 0.32; hydrophobic: 0.4

Domains/regions: [D] Alpha-type protein kinase, [R] Catalytic

PDB: 3lkm, 3lla, 3lmh, 3lmi, 3pdt, 4zme, 4zmf, 4zs4, 5dyj, 5e4h, 5e9e

HET: acp, adn, adp, amp, anp, atp, mg

MK01_HUMAN_9_360 [text] Mitogen-activated protein kinase 1 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 1171. Å3; shape: 0.45; buriedness: 0.84

negative: 0.08; positive: 0.08; polar: 0.09; backbone: 0.46; hydrophobic: 0.28

Domains/regions: [D] Protein kinase, [R] Inhibitor-binding

PDB: 1erk, 1gol, 1pme, 1tvo, 1wzy, 2erk, 2fys, 2gph, 2ojg, 2oji, 2ojj, 2y9q, 2z7l, 3c9w, 3erk, 3i5z, 3i60, 3o71, 3qyw, 3qyz, 3r63, 3sa0, 3tei, 3w55, 3zu7, 3zuv, 4erk, 4fmq, 4fux, 4fuy, 4fv0, 4fv1, 4fv2, 4fv3, 4fv4, 4fv5, 4fv6, 4fv7, 4fv8, 4fv9, 4g6n, 4g6o, 4gsb, 4gt3, 4gva, 4h3p, 4h3q, 4i5h, 4iz5, 4iz7, 4iza, 4n0s, 4n4s, 4nif, 4o6e, 4qp1, 4qp2, 4qp3, 4qp4, 4qp6, 4qp7, 4qp8, 4qp9, 4qpa, 4qta, 4qte, 4qyy, 4s2z, 4s30, 4s31, 4s32, 4s33, 4s34, 4xj0, 4xne, 4xoy, 4xoz, 4xp0, 4xp2, 4xp3, 4xrj, 4xrl, 4zxt, 4zzm, 4zzn, 4zzo, 5ax3, 5bue, 5bui, 5buj, 5bvd, 5bve, 5bvf, 5hd4, 5hd7, 5k4i, 5ke0, 5lcj, 5lck

HET: 19a, 1fm, 2h1, 2sh, 33a, 35w, 35x, 362, 363, 36o, 36q, 36r, 38z, 390, 3g7, 41b, 42a, 4v8, 4v9, 4vb, 4vf, 4vg, 4vj, 5id, 620, 6pb, 6qb, 6s9, 6tt, 82a, adp, anp, atp, cq3, cq6, cq8, dhc, dx4, e28, e57, e63, e71, e75, e86, e94, ek0, ek2, ek3, ek4, ek5, ek6, ek7, ek9, emu, f29, frz, g17, hmy, l01, mg, ni, nra, olo, pg4, s91, sb2, sb4, tt4, z48, z8b

MK03_HUMAN_13_379 [text] Mitogen-activated protein kinase 3 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 555. Å3; shape: 0.42; buriedness: 0.91

negative: 0.09; positive: 0.09; polar: 0.13; backbone: 0.39; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 2zoq, 4qtb

HET: 38z, 5id

MK07_HUMAN_49_394 [text] Mitogen-activated protein kinase 7 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 509. Å3; shape: 0.71; buriedness: 0.79

negative: 0.09; positive: 0.03; polar: 0.09; backbone: 0.46; hydrophobic: 0.33

Domains/regions: [D] Protein kinase, [R] Necessary for oligomerization, [R] Required for binding to MAP2K5, [R] Required for cytoplasmic targeting

PDB: 4b99, 4ic7, 4ic8, 4zsg, 4zsj, 4zsl, 5byy, 5byz

HET: 4we, 4wg, anp, r4l

MK08_HUMAN_2_364_allosteric [text] Mitogen-activated protein kinase 8 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 462. Å3; shape: 0.66; buriedness: 0.51

negative: 0.; positive: 0.05; polar: 0.21; backbone: 0.38; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 1ukh, 1uki, 2g01, 2gmx, 2h96, 2no3, 2xrw, 2xs0, 3elj, 3o17, 3o2m, 3pze, 3v3v, 3vud, 3vug, 3vuh, 3vui, 3vuk, 3vul, 3vum, 4awi, 4e73, 4g1w, 4hys, 4hyu, 4izy, 4l7f, 4qtd, 4ux9, 4yr8

HET: 46a

MK08_HUMAN_2_364_ATPsite [text] Mitogen-activated protein kinase 8 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 497. Å3; shape: 0.6; buriedness: 0.79

negative: 0.; positive: 0.04; polar: 0.07; backbone: 0.49; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 1ukh, 1uki, 2g01, 2gmx, 2h96, 2no3, 2xrw, 2xs0, 3elj, 3o17, 3o2m, 3pze, 3v3v, 3vud, 3vug, 3vuh, 3vui, 3vuk, 3vul, 3vum, 4awi, 4e73, 4g1w, 4hys, 4hyu, 4izy, 4l7f, 4qtd, 4ux9, 4yr8

HET: 0nr, 1bj, 1bk, 1j2, 1v5, 38z, 537, 73q, 859, 877, 893, anp, aq2, cfk, g1w, gs7, mg, myu

MK08_HUMAN_2_364_JIP [text] Mitogen-activated protein kinase 8 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 1831. Å3; shape: 0.32; buriedness: 0.42

negative: 0.2; positive: 0.04; polar: 0.11; backbone: 0.33; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 1ukh, 1uki, 2g01, 2gmx, 2h96, 2no3, 2xrw, 2xs0, 3elj, 3o17, 3o2m, 3pze, 3v3v, 3vud, 3vug, 3vuh, 3vui, 3vuk, 3vul, 3vum, 4awi, 4e73, 4g1w, 4hys, 4hyu, 4izy, 4l7f, 4qtd, 4ux9, 4yr8

MK09_HUMAN_4_363 [text] Mitogen-activated protein kinase 9 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 567. Å3; shape: 0.34; buriedness: 0.84

negative: 0.07; positive: 0.07; polar: 0.04; backbone: 0.42; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 3e7o, 3npc

HET: 35f, b96

MK10_HUMAN_40_402 [text] Mitogen-activated protein kinase 10 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 637. Å3; shape: 0.63; buriedness: 0.8

negative: 0.; positive: 0.04; polar: 0.07; backbone: 0.48; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 1jnk, 1pmn, 1pmu, 1pmv, 2b1p, 2exc, 2o0u, 2o2u, 2ok1, 2p33, 2r9s, 2waj, 2zdt, 2zdu, 3cgf, 3cgo, 3da6, 3fi2, 3fi3, 3fv8, 3g90, 3g9l, 3g9n, 3kvx, 3oxi, 3oy1, 3ptg, 3rtp, 3tti, 3ttj, 3v6r, 3v6s, 4h36, 4h39, 4h3b, 4kke, 4kkg, 4kkh, 4u79, 4w4v, 4w4w, 4w4x, 4w4y, 4whz, 4x21, 4y46, 4y5h, 4z9l

HET: 0f0, 1rq, 255, 33a, 34i, 3el, 3h8, 3hj, 3hn, 3hq, 3nl, 3wh, 446, 46c, 4f2, 519, 537, 589, 738, 880, 932, 984, 9hp, aiz, amp, anp, bz9, c0m, cqq, fmy, j07, j67, j72, j88, jbi, jk1, jk2, jk3, jnf, jnk, jno, kbi, mg, snb, syy, tfa

MK11_HUMAN_2_361 [text] Mitogen-activated protein kinase 11 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 521. Å3; shape: 0.52; buriedness: 0.88

negative: 0.07; positive: 0.03; polar: 0.06; backbone: 0.47; hydrophobic: 0.37

Domains/regions: [D] Protein kinase, [R] Inhibitor-binding

PDB: 3gc8, 3gc9, 3gp0

HET: b45, nil

MK12_HUMAN_1_367_ATPsite [text] Mitogen-activated protein kinase 12 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 314. Å3; shape: 0.49; buriedness: 0.77

negative: 0.12; positive: 0.12; polar: 0.06; backbone: 0.25; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 1cm8

HET: anp

MK13_HUMAN_1_352 [text] Mitogen-activated protein kinase 13 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 349. Å3; shape: 0.48; buriedness: 0.91

negative: 0.11; positive: 0.09; polar: 0.; backbone: 0.34; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 3coi, 4eyj, 4eym, 4myg, 4yno, 5ekn, 5eko

HET: 0rx, n17, n58, n61

MK14_HUMAN_1_360 [text] Mitogen-activated protein kinase 14 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

volume: 745. Å3; shape: 0.48; buriedness: 0.88

negative: 0.08; positive: 0.05; polar: 0.03; backbone: 0.48; hydrophobic: 0.36

Domains/regions: [D] Protein kinase, [R] Inhibitor-binding

PDB: 1a9u, 1bl6, 1bl7, 1bmk, 1di9, 1ian, 1kv1, 1kv2, 1lew, 1lez, 1m7q, 1ouk, 1ouy, 1ove, 1oz1, 1p38, 1r39, 1r3c, 1w7h, 1w82, 1w83, 1w84, 1wbn, 1wbo, 1wbs, 1wbt, 1wbv, 1wbw, 1wfc, 1yqj, 1yw2, 1ywr, 1zyj, 1zz2, 1zzl, 2baj, 2bak, 2bal, 2baq, 2ewa, 2fsl, 2fsm, 2fso, 2fst, 2gfs, 2ghl, 2ghm, 2gtm, 2gtn, 2i0h, 2npq, 2okr, 2oza, 2puu, 2qd9, 2rg5, 2rg6, 2y8o, 2yis, 2yiw, 2yix, 2zaz, 2zb0, 2zb1, 3bv2, 3bv3, 3bx5, 3c5u, 3ctq, 3d7z, 3d83, 3ds6, 3dt1, 3e92, 3e93, 3fc1, 3fi4, 3fkl, 3fkn, 3fko, 3fl4, 3fln, 3flq, 3fls, 3flw, 3fly, 3flz, 3fmh, 3fmj, 3fmk, 3fml, 3fmm, 3fmn, 3fsf, 3fsk, 3gc7, 3gcp, 3gcq, 3gcs, 3gcu, 3gcv, 3gfe, 3gi3, 3ha8, 3hec, 3heg, 3hl7, 3hll, 3hp2, 3hp5, 3hrb, 3hub, 3huc, 3hv3, 3hv4, 3hv5, 3hv6, 3hv7, 3hvc, 3iph, 3itz, 3iw5, 3iw6, 3iw7, 3iw8, 3k3i, 3k3j, 3kf7, 3kq7, 3l8s, 3l8x, 3lfa, 3lfb, 3lfc, 3lfd, 3lfe, 3lff, 3lhj, 3mgy, 3mh0, 3mh1, 3mh2, 3mh3, 3mpa, 3mpt, 3mvl, 3mvm, 3mw1, 3new, 3nnu, 3nnv, 3nnw, 3nnx, 3nww, 3o8p, 3o8t, 3o8u, 3obg, 3obj, 3oc1, 3ocg, 3od6, 3ody, 3odz, 3oef, 3p4k, 3p5k, 3p78, 3p79, 3p7a, 3p7b, 3p7c, 3pg3, 3py3, 3qud, 3que, 3rin, 3roc, 3s3i, 3s4q, 3tg1, 3u8w, 3uvp, 3uvq, 3uvr, 3zs5, 3zsg, 3zsh, 3zsi, 3zya, 4a9y, 4aa0, 4aa4, 4aa5, 4aac, 4dli, 4dlj, 4e5a, 4e5b, 4e6a, 4e6c, 4e8a, 4eh2, 4eh3, 4eh4, 4eh5, 4eh6, 4eh7, 4eh8, 4eh9, 4ehv, 4ewq, 4f9w, 4f9y, 4fa2, 4geo, 4ka3, 4kin, 4kip, 4kiq, 4l8m, 4loo, 4lop, 4loq, 4r3c, 4tyh, 4zth, 5eta, 5etc, 5etf, 5eti, 5lar

HET: 048, 094, 09j, 0oq, 1m8, 1pp, 1r9, 1ra, 279, 287, 29a, 358, 38p, 39g, 39p, 3ff, 3fn, 3gf, 3nw, 437, 6rg, a17, aav, b11, bff, bog, cq0, dqo, edb, f4c, fi4, fkl, fkn, flw, flz, fss, g11, g6a, gk1, gk3, gk4, gk5, hiz, i2o, i45, i47, ipk, l09, l10, l11, l9g, lhj, li2, lib, lic, lid, lie, mih, mwl, n4d, nk0, nqb, ocg, p37, p40, p5k, p66, p78, p79, p7a, p7b, pgj, pp0, pqa, qc0, ro6, sb0, t75, wbt, yix, z83

MKNK2_HUMAN_70_385 [text] MAP kinase-interacting serine/threonine-protein kinase 2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family]

volume: 277. Å3; shape: 0.93; buriedness: 0.86

negative: 0.12; positive: 0.03; polar: 0.03; backbone: 0.45; hydrophobic: 0.38

Domains/regions: [D] Protein kinase, [R] Staurosporine binding

PDB: 2ac3, 2ac5, 2hw7

HET: stu

MLKL_HUMAN_185_471 [text] Mixed lineage kinase domain-like protein [Protein kinase superfamily]

volume: 504. Å3; shape: 0.57; buriedness: 0.85

negative: 0.07; positive: 0.07; polar: 0.14; backbone: 0.42; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 4m67, 4mwi, 5knj, 5ko1

HET: 6ux, 6uy

MLTK_HUMAN_3_309 [text] Mitogen-activated protein kinase kinase kinase MLT [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 318. Å3; shape: 0.37; buriedness: 0.91

negative: 0.02; positive: 0.04; polar: 0.1; backbone: 0.44; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 5hes

HET: 032

MP2K1_HUMAN_61_390 [text] Dual specificity mitogen-activated protein kinase kinase 1 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

volume: 645. Å3; shape: 0.7; buriedness: 0.91

negative: 0.06; positive: 0.03; polar: 0.04; backbone: 0.38; hydrophobic: 0.5

Domains/regions: [D] Protein kinase, [R] Inhibitor binding

PDB: 1s9j, 2p55, 2y4i, 3dv3, 3dy7, 3e8n, 3eqb, 3eqc, 3eqd, 3eqf, 3eqg, 3eqh, 3eqi, 3mbl, 3orn, 3os3, 3pp1, 3sls, 3v01, 3v04, 3vvh, 3w8q, 3wig, 3zls, 3zlw, 3zlx, 3zly, 3zm4, 4an2, 4an3, 4an9, 4anb, 4ark, 4lmn, 4mne, 4u7z, 4u80, 4u81, 5bx0, 5eym

HET: 1cx, 22t, 2p7, 3bm, 3ew, 3ex, 3ey, 3or, 3os, 3v0, 4bm, 4w5, 573, 5bm, 5ez, 5u5, 5y0, 77d, 92p, acp, adp, ags, anp, atp, bbm, chu, eui, izg, ksa, lsg, lug, m3k, mek, mg, mra, mt8, na, v04, vra, yqy, yso

MP2K2_HUMAN_55_400 [text] Dual specificity mitogen-activated protein kinase kinase 2 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

volume: 328. Å3; shape: 0.47; buriedness: 0.84

negative: 0.1; positive: 0.05; polar: 0.07; backbone: 0.33; hydrophobic: 0.45

Domains/regions: [D] Protein kinase

PDB: 1s9i

HET: 5ea

MP2K4_HUMAN_79_399_allosteric [text] Dual specificity mitogen-activated protein kinase kinase 4 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

volume: 739. Å3; shape: 0.36; buriedness: 0.48

negative: 0.06; positive: 0.03; polar: 0.11; backbone: 0.54; hydrophobic: 0.25

Domains/regions: [D] Protein kinase

PDB: 3aln, 3alo, 3vut

HET: tpo

MP2K4_HUMAN_79_399_ATPsite [text] Dual specificity mitogen-activated protein kinase kinase 4 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

volume: 332. Å3; shape: 0.51; buriedness: 0.88

negative: 0.08; positive: 0.12; polar: 0.12; backbone: 0.33; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 3aln, 3alo, 3vut

HET: anp

MP2K6_HUMAN_43_333 [text] Dual specificity mitogen-activated protein kinase kinase 6 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

volume: 354. Å3; shape: 0.66; buriedness: 0.89

negative: 0.03; positive: 0.09; polar: 0.1; backbone: 0.56; hydrophobic: 0.22

Domains/regions: [D] Protein kinase

PDB: 3enm, 3fme, 3vn9

HET: ank, mg, stu

MP2K7_HUMAN_102_417 [text] Dual specificity mitogen-activated protein kinase kinase 7 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

volume: 242. Å3; shape: 0.82; buriedness: 0.85

negative: 0.; positive: 0.12; polar: 0.08; backbone: 0.49; hydrophobic: 0.31

Domains/regions: [D] Protein kinase

PDB: 2dyl, 3wzu, 5b2k, 5b2l, 5b2m

HET: 1fm

MRCKA_RAT_2_424 [text] Serine/threonine-protein kinase MRCK alpha [Protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily]

volume: 275. Å3; shape: 0.42; buriedness: 0.73

negative: 0.21; positive: 0.21; polar: 0.14; backbone: 0.36; hydrophobic: 0.07

Domains/regions: [D] AGC-kinase C-terminal, [D] Protein kinase

PDB: 4aw2

HET: 22e

MRCKB_HUMAN_2_416 [text] Serine/threonine-protein kinase MRCK beta [Protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily]

volume: 268. Å3; shape: 0.71; buriedness: 0.86

negative: 0.05; positive: 0.; polar: 0.23; backbone: 0.4; hydrophobic: 0.33

Domains/regions: [D] AGC-kinase C-terminal, [D] Protein kinase

PDB: 3qfv, 3tku, 4uak, 4ual

HET: 3fv, adp, m77, mg, nm7

MYLK4_HUMAN_39_388 [text] Myosin light chain kinase family member 4 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family]

volume: 213. Å3; shape: 0.76; buriedness: 0.86

negative: 0.; positive: 0.; polar: 0.07; backbone: 0.46; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 2x4f

HET: 16x

NAHK_BIFL2_2_359 [text] N-acetylhexosamine 1-kinase [Protein kinase superfamily]

volume: 170. Å3; shape: 0.74; buriedness: 0.97

negative: 0.15; positive: 0.32; polar: 0.09; backbone: 0.; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 4ocj, 4ock, 4oco, 4ocp, 4ocq, 4ocu, 4ocv, 4wh1, 4wh2, 4wh3

HET: gn1, mg, ndg

NEK1_HUMAN_1_328 [text] Serine/threonine-protein kinase Nek1 [Protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily]

volume: 209. Å3; shape: 0.75; buriedness: 0.82

negative: 0.09; positive: 0.07; polar: 0.09; backbone: 0.33; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 4apc, 4b9d

HET: ck7

NEK2_HUMAN_1_273 [text] Serine/threonine-protein kinase Nek2 [Protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily]

volume: 442. Å3; shape: 0.71; buriedness: 0.76

negative: 0.09; positive: 0.05; polar: 0.06; backbone: 0.43; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 2jav, 2w5a, 2w5b, 2w5h, 2wqo, 2xk3, 2xk4, 2xk6, 2xk7, 2xk8, 2xkc, 2xkd, 2xke, 2xkf, 2xnm, 2xnn, 2xno, 2xnp, 4a4x, 4afe, 5m51, 5m53, 5m55, 5m57

HET: 30e, 430, 4sp, 4vq, 5r1, 5z5, 7gg, 7gj, adp, ags, bx1, ed8, eqh, ggy, jup, mg, nu6, ol2, t3m, vgk, wcx, wgz, wi2, xk3

NEK7_HUMAN_1_302 [text] Serine/threonine-protein kinase Nek7 [Protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily]

volume: 239. Å3; shape: 0.57; buriedness: 0.67

negative: 0.05; positive: 0.09; polar: 0.09; backbone: 0.36; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 2wqm, 2wqn, 5de2

HET: adp

NTRK1_HUMAN_491_793 [text] High affinity nerve growth factor receptor [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 508. Å3; shape: 0.47; buriedness: 0.89

negative: 0.11; positive: 0.03; polar: 0.05; backbone: 0.41; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 4aoj, 4f0i, 4gt5, 4pmm, 4pmp, 4pms, 4pmt, 4yne, 4yps

HET: 31v, 31w, 31x, 31y, 4ek, 4f6, v4z

NTRK2_HUMAN_526_822 [text] BDNF/NT-3 growth factors receptor [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 356. Å3; shape: 0.4; buriedness: 0.93

negative: 0.05; positive: 0.04; polar: 0.04; backbone: 0.38; hydrophobic: 0.49

Domains/regions: [D] Protein kinase

PDB: 4asz, 4at3, 4at4, 4at5

HET: lti, muj, t6e

NTRK3_HUMAN_526_836 [text] NT-3 growth factor receptor [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 383. Å3; shape: 0.45; buriedness: 0.88

negative: 0.09; positive: 0.05; polar: 0.05; backbone: 0.33; hydrophobic: 0.49

Domains/regions: [D] Protein kinase

PDB: 3v5q, 4ymj

HET: 0f4, 4ej

OXSR1_HUMAN_4_299_ATPsite [text] Serine/threonine-protein kinase OSR1 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 331. Å3; shape: 0.51; buriedness: 0.72

negative: 0.07; positive: 0.07; polar: 0.06; backbone: 0.3; hydrophobic: 0.5

Domains/regions: [D] Protein kinase

PDB: 2vwi, 3dak

HET: anp

PAK1_HUMAN_249_545 [text] Serine/threonine-protein kinase PAK 1 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 597. Å3; shape: 0.62; buriedness: 0.78

negative: 0.03; positive: 0.06; polar: 0.17; backbone: 0.31; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 1f3m, 1yhv, 1yhw, 2hy8, 3fxz, 3fy0, 3q4z, 3q52, 3q53, 4daw, 4eqc, 4o0r, 4o0t, 4p90, 4zji, 4zjj, 4zlo, 4zy4, 4zy5, 4zy6, 5dew, 5dey, 5dfp, 5ime, 5kbq, 5kbr

HET: 0h2, 1st, 2k0, 2ol, 4t3, 4t5, 4t6, 59n, 59t, 59u, 6bz, anp, atp, dw1, fll, ipv, ipw, mg, x4z, xr1

PAK4_HUMAN_292_591 [text] Serine/threonine-protein kinase PAK 4 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 485. Å3; shape: 0.68; buriedness: 0.84

negative: 0.08; positive: 0.05; polar: 0.04; backbone: 0.5; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 2bva, 2cdz, 2j0i, 2q0n, 2x4z, 4app, 4fie, 4fif, 4fig, 4fih, 4fii, 4fij, 4jdh, 4jdi, 4jdj, 4jdk, 4l67, 4njd, 4o0v, 4o0x, 4o0y, 4xbr, 4xbu, 5bms

HET: 23d, 2ol, 2oo, 2oq, 4t6, anp, atp, mg, n53, njd, x4z

PAK5_HUMAN_424_719 [text] Serine/threonine-protein kinase PAK 5 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 244. Å3; shape: 0.84; buriedness: 0.77

negative: 0.; positive: 0.; polar: 0.08; backbone: 0.5; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 2f57

HET: 23d

PAK6_HUMAN_383_676 [text] Serine/threonine-protein kinase PAK 6 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 447. Å3; shape: 0.6; buriedness: 0.7

negative: 0.07; positive: 0.04; polar: 0.07; backbone: 0.44; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 2c30, 4ks7, 4ks8

HET: b49, x4z

PASK_HUMAN_975_1300 [text] PAS domain-containing serine/threonine-protein kinase [Protein kinase superfamily. CAMK Ser/Thr protein kinase family]

volume: 251. Å3; shape: 0.56; buriedness: 0.81

negative: 0.13; positive: 0.07; polar: 0.; backbone: 0.4; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 3dls

HET: adp

PDPK1_HUMAN_408_556 [text] 3-phosphoinositide-dependent protein kinase 1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily]

volume: 310. Å3; shape: 0.76; buriedness: 0.49

negative: 0.02; positive: 0.83; polar: 0.15; backbone: 0.; hydrophobic: 0.

Domains/regions: [D] PH

PDB: 1w1d, 1w1g, 1w1h, 2vki

HET: 4ip, 4pt

PDPK1_HUMAN_53_359_ATPsite [text] 3-phosphoinositide-dependent protein kinase 1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily]

volume: 540. Å3; shape: 0.7; buriedness: 0.83

negative: 0.11; positive: 0.04; polar: 0.13; backbone: 0.41; hydrophobic: 0.31

Domains/regions: [D] Protein kinase, [R] PIF-pocket

PDB: 1h1w, 1oky, 1okz, 1uu3, 1uu7, 1uu8, 1uu9, 1uvr, 1z5m, 2biy, 2pe0, 2pe1, 2pe2, 2r7b, 2xch, 2xck, 3h9o, 3hrc, 3hrf, 3ion, 3iop, 3nax, 3nay, 3nun, 3nus, 3nuu, 3nuy, 3orx, 3orz, 3otu, 3pwy, 3qc4, 3qcq, 3qcs, 3qcx, 3qcy, 3qd0, 3qd3, 3qd4, 3rcj, 3rwp, 3rwq, 3sc1, 4a06, 4a07, 4aw0, 4aw1, 4ct1, 4ct2, 4rqk, 4rqv, 4rrv, 4xx9, 5ack, 5hkm, 5hng, 5ho7, 5ho8, 5lvl, 5lvm, 5lvn, 5lvo, 5lvp

HET: 253, 39z, 3q0, 3q1, 3q2, 3q3, 3q4, 3q5, 3q6, 3rc, 3rw, 3s1, 464, 517, 537, 61y, 62o, 63e, 63l, 8h1, 8i1, 9bd, abq, ade, adn, atp, bi1, bi2, bi3, bi4, bi8, ckg, jmz, jnz, joz, jpz, li8, ly4, mg, mh4, mn, mp6, mp7, na, stu, syp, ucn

PDPK1_HUMAN_53_359_PIFsite [text] 3-phosphoinositide-dependent protein kinase 1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily]

volume: 470. Å3; shape: 0.55; buriedness: 0.72

negative: 0.; positive: 0.18; polar: 0.12; backbone: 0.31; hydrophobic: 0.38

Domains/regions: [D] Protein kinase, [R] PIF-pocket

PDB: 1h1w, 1oky, 1okz, 1uu3, 1uu7, 1uu8, 1uu9, 1uvr, 1z5m, 2biy, 2pe0, 2pe1, 2pe2, 2r7b, 2xch, 2xck, 3h9o, 3hrc, 3hrf, 3ion, 3iop, 3nax, 3nay, 3nun, 3nus, 3nuu, 3nuy, 3orx, 3orz, 3otu, 3pwy, 3qc4, 3qcq, 3qcs, 3qcx, 3qcy, 3qd0, 3qd3, 3qd4, 3rcj, 3rwp, 3rwq, 3sc1, 4a06, 4a07, 4aw0, 4aw1, 4ct1, 4ct2, 4rqk, 4rqv, 4rrv, 4xx9, 5ack, 5hkm, 5hng, 5ho7, 5ho8, 5lvl, 5lvm, 5lvn, 5lvo, 5lvp

HET: 1f8, 21o, 2a2, 31s, 78w, a06, az7, j30, mjf, p47, r1s, r2s, rf4, sep, svq

PHKG1_RABIT_6_296_ATPsite [text] Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [Protein kinase superfamily. CAMK Ser/Thr protein kinase family]

volume: 311. Å3; shape: 0.47; buriedness: 0.84

negative: 0.11; positive: 0.09; polar: 0.11; backbone: 0.38; hydrophobic: 0.3

Domains/regions: [D] Protein kinase

PDB: 1phk, 1ql6, 2phk

HET: atp

PHKG2_HUMAN_3_293 [text] Phosphorylase b kinase gamma catalytic chain, liver/testis isoform [Protein kinase superfamily. CAMK Ser/Thr protein kinase family]

volume: 339. Å3; shape: 0.44; buriedness: 0.66

negative: 0.07; positive: 0.; polar: 0.; backbone: 0.41; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 2y7j

HET: b49

PHO85_YEAST_6_305_ATPsite [text] Cyclin-dependent protein kinase PHO85 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily]

volume: 369. Å3; shape: 0.5; buriedness: 0.72

negative: 0.11; positive: 0.08; polar: 0.1; backbone: 0.33; hydrophobic: 0.38

Domains/regions: [D] Protein kinase

PDB: 2pk9, 2pmi, 4krc, 4krd

HET: ags, mg

PIM1_HUMAN_120_403 [text] Serine/threonine-protein kinase pim-1 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily]

volume: 646. Å3; shape: 0.92; buriedness: 0.85

negative: 0.13; positive: 0.09; polar: 0.04; backbone: 0.32; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 1xqz, 1xr1, 1xws, 1yhs, 1yi3, 1yi4, 1ywv, 1yxs, 1yxt, 1yxu, 1yxv, 1yxx, 2bik, 2bil, 2bzh, 2bzi, 2bzj, 2bzk, 2c3i, 2j2i, 2o3p, 2o63, 2o64, 2o65, 2obj, 2oi4, 2xix, 2xiy, 2xiz, 2xj0, 2xj1, 2xj2, 3a99, 3bgp, 3bgq, 3bgz, 3bwf, 3c4e, 3cxw, 3cy2, 3cy3, 3dcv, 3f2a, 3jpv, 3jxw, 3jy0, 3jya, 3ma3, 3qf9, 3r00, 3r01, 3r02, 3r04, 3t9i, 3uix, 3umw, 3umx, 3vbq, 3vbt, 3vbv, 3vbw, 3vbx, 3vby, 3vc4, 3we8, 4a7c, 4alu, 4alv, 4alw, 4as0, 4bzn, 4bzo, 4dtk, 4enx, 4eny, 4gw8, 4i41, 4iaa, 4jx3, 4jx7, 4k0y, 4k18, 4k1b, 4ll5, 4lm5, 4lmu, 4mbi, 4mbl, 4med, 4mta, 4n6y, 4n6z, 4n70, 4rbl, 4rc2, 4rc3, 4rc4, 4rpv, 4ty1, 4wrs, 4wsy, 4wt6, 4xh6, 4xhk, 5c1q, 5dgz, 5dhj, 5dia, 5dwr, 5eol, 5iis, 5ipj, 5kzi

HET: 01i, 0f5, 0fr, 0fs, 1dr, 1n6, 1oa, 1ob, 1oc, 26k, 26l, 2d2, 2hv, 2hw, 2hx, 38w, 3o7, 3o8, 3oa, 3ok, 3ra, 3t9, 3u1, 3u5, 3u6, 3ur, 3yr, 4yk, 55e, 596, 5e5, 5e6, 5h7, 5qo, 676, 6cb, 6cd, 6yn, 79o, 7cp, 7li, 985, bi1, c4e, ca, e46, hul, hy7, iyz, j19, jn5, l20, li7, lwg, lxg, ly2, ly4, lyg, mb9, mix, myc, myf, myu, nm8, q17, q18, que, r9p, rtx, rtz, sk8, ugx, une, unm, unq, vrv, vx1, vx2, vx3, xj1, z20

PIM2_HUMAN_1_311_ATPsite [text] Serine/threonine-protein kinase pim-2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily]

volume: 283. Å3; shape: 0.87; buriedness: 0.9

negative: 0.12; positive: 0.07; polar: 0.; backbone: 0.24; hydrophobic: 0.57

Domains/regions: [D] Protein kinase

PDB: 2iwi, 4x7q

HET: 3yr, hb1

PKN1_HUMAN_604_942 [text] Serine/threonine-protein kinase N1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily]

volume: 303. Å3; shape: 0.91; buriedness: 0.88

negative: 0.07; positive: 0.; polar: 0.06; backbone: 0.4; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 4otd, 4otg, 4oth, 4oti

HET: 2v9, drn, mi1

PKNB_MYCTU_2_279 [text] Serine/threonine-protein kinase PknB [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 440. Å3; shape: 0.66; buriedness: 0.86

negative: 0.04; positive: 0.07; polar: 0.14; backbone: 0.4; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 1mru, 1o6y, 2fum, 3f61, 3f69, 3ori, 3ork, 3orl, 3orm, 3oro, 3orp, 3ort

HET: acp, adp, ags, mg, mix, mn, xdr

PKNG_MYCTU_74_405 [text] Serine/threonine-protein kinase PknG [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 282. Å3; shape: 0.6; buriedness: 0.85

negative: 0.09; positive: 0.06; polar: 0.08; backbone: 0.33; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 2pzi, 4y0x, 4y12

HET: adp, ags, axx

PLK1_HUMAN_28_342 [text] Serine/threonine-protein kinase PLK1 [Protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily]

volume: 686. Å3; shape: 0.68; buriedness: 0.77

negative: 0.1; positive: 0.12; polar: 0.04; backbone: 0.41; hydrophobic: 0.33

Domains/regions: [D] Protein kinase, [R] Activation loop

PDB: 2ou7, 2owb, 2rku, 2v5q, 2yac, 3fc2, 3kb7, 3thb, 4a4l, 4a4o, 4j52, 4j53

HET: 071, 1j3, 1j4, 3ta, 626, 664, 937, 939, anp, ibi, r78

PLK1_HUMAN_368_599 [text] Serine/threonine-protein kinase PLK1 [Protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily]

volume: 1200. Å3; shape: 0.77; buriedness: 0.54

negative: 0.04; positive: 0.16; polar: 0.15; backbone: 0.39; hydrophobic: 0.27

Domains/regions: [D] POLO box 1, [D] POLO box 2, [R] Important for interaction with phosphorylated proteins, [R] Linker

PDB: 1q4k, 1q4o, 1umw, 2ogq, 2ojx, 3bzi, 3c5l, 3fvh, 3hih, 3hik, 3p2w, 3p2z, 3p34, 3p35, 3p36, 3p37, 3q1i, 3rq7, 4dfw, 4e67, 4e9c, 4e9d, 4h5x, 4h71, 4hab, 4hco, 4hy2, 4lkl, 4lkm, 4o56, 4o6w, 4o9w, 4rcp, 4whh, 4whk, 4whl, 4x9r, 4x9v, 4x9w, 5dms, 5dmv, 5dnj, 5j19

HET: 0lf, 0ob, 11q, 1c3, 2so, 3zh, 4ky, 4l0, 56a, 707, ace, hci, imw, kac, nh2, pxe, qac, sep, tpo, yac, yth

PLK2_HUMAN_63_360 [text] Serine/threonine-protein kinase PLK2 [Protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily]

volume: 317. Å3; shape: 0.83; buriedness: 0.83

negative: 0.; positive: 0.11; polar: 0.06; backbone: 0.42; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 4i5m, 4i5p, 4i6b, 4i6f, 4i6h

HET: 11g, 1c7, 1c8, 1d1, r78

PLK3_HUMAN_52_332 [text] Serine/threonine-protein kinase PLK3 [Protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily]

volume: 339. Å3; shape: 0.61; buriedness: 0.84

negative: 0.; positive: 0.2; polar: 0.; backbone: 0.4; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 4b6l

HET: 9zp

PLK4_HUMAN_1_277_ATPsite [text] Serine/threonine-protein kinase PLK4 [Protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily]

volume: 611. Å3; shape: 0.55; buriedness: 0.72

negative: 0.04; positive: 0.11; polar: 0.; backbone: 0.43; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 3cok, 4jxf, 4yur

HET: 4j7, 631, anp

PRP4B_HUMAN_656_1007 [text] Serine/threonine-protein kinase PRP4 homolog [Protein kinase superfamily. CMGC Ser/Thr protein kinase family]

volume: 426. Å3; shape: 0.59; buriedness: 0.79

negative: 0.09; positive: 0.08; polar: 0.13; backbone: 0.34; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4ian, 4ifc, 4iir, 4ijp

HET: 1eh, adp, anp, mg

PTK6_HUMAN_182_446 [text] Protein-tyrosine kinase 6 [Protein kinase superfamily. Tyr protein kinase family. BRK/PTK6/SIK subfamily]

volume: 310. Å3; shape: 0.44; buriedness: 0.71

negative: 0.14; positive: 0.13; polar: 0.07; backbone: 0.24; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 5d7v, 5da3

HET: 58v

RET_HUMAN_702_1013 [text] Proto-oncogene tyrosine-protein kinase receptor Ret [Protein kinase superfamily. Tyr protein kinase family]

volume: 296. Å3; shape: 0.7; buriedness: 0.82

negative: 0.04; positive: 0.06; polar: 0.1; backbone: 0.4; hydrophobic: 0.39

Domains/regions: [D] Protein kinase, [R] Inhibitors binding

PDB: 2ivs, 2ivt, 2ivu, 2ivv, 2x2k, 2x2l, 2x2m, 4cki, 4ckj, 5amn

HET: ack, adn, amp, dtq, pp1, x2k, x2l, x2m, zd6

RIO1_ARCFU_1_258 [text] RIO-type serine/threonine-protein kinase Rio1 [Protein kinase superfamily. RIO-type Ser/Thr kinase family]

volume: 263. Å3; shape: 0.67; buriedness: 0.85

negative: 0.06; positive: 0.06; polar: 0.07; backbone: 0.21; hydrophobic: 0.6

Domains/regions: [D] Protein kinase

PDB: 1zp9, 1ztf, 1zth, 3re4, 4jin

HET: 1l7, adp, atp, to1, xya

RIO2_ARCFU_1_282 [text] RIO-type serine/threonine-protein kinase Rio2 [Protein kinase superfamily. RIO-type Ser/Thr kinase family]

volume: 311. Å3; shape: 0.54; buriedness: 0.83

negative: 0.16; positive: 0.05; polar: 0.08; backbone: 0.27; hydrophobic: 0.43

Domains/regions: [D] Protein kinase

PDB: 1tqi, 1tqm, 1tqp, 1zao, 1zar

HET: adp, anp, atp, mn

RIOK1_HUMAN_143_494 [text] Serine/threonine-protein kinase RIO1 [Protein kinase superfamily. RIO-type Ser/Thr kinase family]

volume: 242. Å3; shape: 0.5; buriedness: 0.89

negative: 0.; positive: 0.07; polar: 0.13; backbone: 0.2; hydrophobic: 0.6

Domains/regions: [D] Protein kinase

PDB: 4otp

HET: adp

RIPK1_HUMAN_1_294 [text] Receptor-interacting serine/threonine-protein kinase 1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family]

volume: 410. Å3; shape: 0.57; buriedness: 0.98

negative: 0.04; positive: 0.07; polar: 0.03; backbone: 0.34; hydrophobic: 0.52

Domains/regions: [D] Protein kinase

PDB: 4ith, 4iti, 4itj, 4neu, 5hx6

HET: 1hw, 1hx, 65u, q1a, rcm

RIPK2_HUMAN_2_311 [text] Receptor-interacting serine/threonine-protein kinase 2 [Protein kinase superfamily. TKL Ser/Thr protein kinase family]

volume: 621. Å3; shape: 0.51; buriedness: 0.86

negative: 0.09; positive: 0.05; polar: 0.1; backbone: 0.41; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 4c8b, 5ar2, 5ar3, 5ar4, 5ar5, 5ar7, 5ar8, 5j79, 5j7b

HET: 0li, 6gd, 6ge, acp, iq7, mg, sb2, sr8, xyw

RK_BOVIN_30_535 [text] Rhodopsin kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily]

volume: 444. Å3; shape: 0.78; buriedness: 0.78

negative: 0.1; positive: 0.03; polar: 0.05; backbone: 0.44; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 3c4w, 3c4x, 3c4z, 3c50, 3qc9, 3t8o, 4l9i, 4pni, 4wbo

HET: 8pr, adp, anw, atp, kqq, mg

RN5A_HUMAN_337_719 [text] 2-5A-dependent ribonuclease [Protein kinase superfamily]

volume: 295. Å3; shape: 0.47; buriedness: 0.8

negative: 0.1; positive: 0.08; polar: 0.19; backbone: 0.25; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 4oau, 4oav

HET: acp, adp

ROCK1_HUMAN_5_414 [text] Rho-associated protein kinase 1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family]

volume: 310. Å3; shape: 0.46; buriedness: 0.86

negative: 0.05; positive: 0.06; polar: 0.06; backbone: 0.32; hydrophobic: 0.52

Domains/regions: [D] AGC-kinase C-terminal, [D] Protein kinase, [R] Interaction with FHOD1

PDB: 2esm, 2etk, 2etr, 3d9v, 3ncz, 3ndm, 3tv7, 3twj, 3v8s, 4w7p, 4yvc, 4yve, 5bml

HET: 07q, 07r, 0hd, 3j7, 3nc, 3nd, 4kh, 4kk, 4tw, h52, hfs, m77, y27

ROCK2_HUMAN_19_417 [text] Rho-associated protein kinase 2 [Protein kinase superfamily. AGC Ser/Thr protein kinase family]

volume: 358. Å3; shape: 0.38; buriedness: 0.86

negative: 0.06; positive: 0.05; polar: 0.11; backbone: 0.29; hydrophobic: 0.48

Domains/regions: [D] AGC-kinase C-terminal, [D] Protein kinase, [R] Interaction with NPM1

PDB: 2f2u, 2h9v, 4l6q, 4wot

HET: 1wu, 3sg, m77, y27

ROCO4_DICDI_1009_1292 [text] Probable serine/threonine-protein kinase roco4 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily]

volume: 525. Å3; shape: 0.84; buriedness: 0.68

negative: 0.05; positive: 0.07; polar: 0.; backbone: 0.49; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 4f0f, 4f0g, 4f1m, 4f1o, 4f1t, 4yzm, 4yzn

HET: 4k4, 4k5, acp, h52

RON_HUMAN_1060_1357_ATPsite [text] Macrophage-stimulating protein receptor [Protein kinase superfamily. Tyr protein kinase family]

volume: 283. Å3; shape: 0.51; buriedness: 0.79

negative: 0.12; positive: 0.12; polar: 0.12; backbone: 0.35; hydrophobic: 0.29

Domains/regions: [D] Protein kinase

PDB: 3pls

HET: anp

ROS1_HUMAN_1932_2232 [text] Proto-oncogene tyrosine-protein kinase ROS [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

volume: 295. Å3; shape: 0.74; buriedness: 0.77

negative: 0.04; positive: 0.; polar: 0.; backbone: 0.52; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 3zbf, 4uxl

HET: 5p8, vgh

SGK1_HUMAN_59_431 [text] Serine/threonine-protein kinase Sgk1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family]

volume: 370. Å3; shape: 0.53; buriedness: 0.79

negative: 0.08; positive: 0.06; polar: 0.14; backbone: 0.38; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 2r5t, 3hdm, 3hdn

HET: anp, gmg, mg, mmg

SKY1_YEAST_138_742 [text] Serine/threonine-protein kinase SKY1 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 227. Å3; shape: 0.57; buriedness: 0.75

negative: 0.08; positive: 0.; polar: 0.; backbone: 0.36; hydrophobic: 0.55

Domains/regions: [D] Protein kinase

PDB: 1how, 1q8y, 1q8z, 1q97, 1q99, 2jd5

HET: ade, adn, adp, anp, atp, mg

SLK_HUMAN_18_320 [text] STE20-like serine/threonine-protein kinase [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 344. Å3; shape: 0.6; buriedness: 0.74

negative: 0.; positive: 0.07; polar: 0.04; backbone: 0.38; hydrophobic: 0.51

Domains/regions: [D] Protein kinase

PDB: 2j51, 2jfl, 2jfm, 2uv2, 4usf

HET: 6ui, dki, gvd

SRC_HUMAN_145_253 [text] Proto-oncogene tyrosine-protein kinase Src [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

volume: 813. Å3; shape: 0.48; buriedness: 0.56

negative: 0.04; positive: 0.22; polar: 0.21; backbone: 0.4; hydrophobic: 0.13

Domains/regions: [D] SH2

PDB: 1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e, 1bkl, 1bkm, 1f1w, 1f2f, 1fmk, 1is0, 1kc2, 1ksw, 1nzl, 1nzv, 1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4c, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4i, 1o4j, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r, 1p13, 1sha, 1shb, 1shd, 1skj, 1spr, 1sps, 1y57, 2h8h, 2ptk, 2src, 4f59, 4f5a, 4f5b, 4k11

HET: 197, 1c5, 219, 256, 262, 299, 300, 493, 687, 772, 787, 790, 791, 821, 822, 843, 852, 853, 876, 903, ace, ay0, dip, dix, diy, fty, hps, i59, is2, mla, oxd, psn, pth, ptr, ur2

SRC_HUMAN_253_536 [text] Proto-oncogene tyrosine-protein kinase Src [Protein kinase superfamily. Tyr protein kinase family. SRC subfamily]

volume: 827. Å3; shape: 0.53; buriedness: 0.79

negative: 0.07; positive: 0.05; polar: 0.07; backbone: 0.49; hydrophobic: 0.32

Domains/regions: [D] Protein kinase

PDB: 1fmk, 1ksw, 1y57, 1yi6, 1yoj, 1yol, 1yom, 2bdf, 2bdj, 2h8h, 2hwo, 2hwp, 2oiq, 2ptk, 2qi8, 2qlq, 2qq7, 2src, 3d7t, 3dqw, 3dqx, 3el7, 3el8, 3en4, 3en5, 3en6, 3en7, 3f3t, 3f3u, 3f3v, 3f3w, 3f6x, 3g5d, 3g6g, 3g6h, 3geq, 3lok, 3oez, 3of0, 3qlf, 3qlg, 3svv, 3tz7, 3tz8, 3tz9, 3u4w, 3u51, 3uqf, 3uqg, 4agw, 4dgg, 4fic, 4k11, 4lgg, 4lgh, 4mcv, 4mxo, 4mxx, 4mxy, 4mxz, 4o2p, 4u5j, 4ybj, 4ybk, 5bmm, 5d10, 5d11, 5d12, 5j5s

HET: 08l, 08x, 0j9, 0jn, 0ul, 11v, 1au, 1aw, 1bu, 1n1, 24a, 29k, 4a9, 4b7, 563, 56g, 6g3, abj, ags, alc, amp, anp, aqb, aqm, aqu, b5a, bk5, db8, djk, fum, g6g, g6h, g97, h8h, het, i76, ihh, ks1, ks4, ks5, mg, mpz, nbs, ng7, orn, p01, pd3, pd5, pff, pp2, ppn, rbs, rxt, s03, sr2, sti, stu, vgg, vsp

SRPK1_HUMAN_46_655 [text] SRSF protein kinase 1 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family]

volume: 387. Å3; shape: 0.6; buriedness: 0.63

negative: 0.; positive: 0.05; polar: 0.11; backbone: 0.37; hydrophobic: 0.47

Domains/regions: [D] Protein kinase

PDB: 1wak, 1wbp, 3beg, 4wua

HET: 3ul, adp, anp

SRPK2_HUMAN_49_688 [text] SRSF protein kinase 2 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family]

volume: 297. Å3; shape: 0.69; buriedness: 0.76

negative: 0.; positive: 0.11; polar: 0.06; backbone: 0.44; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 2x7g

HET: pvb

ST17B_HUMAN_24_329 [text] Serine/threonine-protein kinase 17B [Protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily]

volume: 294. Å3; shape: 0.6; buriedness: 0.89

negative: 0.14; positive: 0.06; polar: 0.03; backbone: 0.39; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 3lm0, 3lm5

HET: ebd, que

ST32A_HUMAN_8_390 [text] Serine/threonine-protein kinase 32A [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 294. Å3; shape: 0.93; buriedness: 0.88

negative: 0.11; positive: 0.06; polar: 0.06; backbone: 0.37; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 4fr4

HET: stu

STK10_HUMAN_18_316 [text] Serine/threonine-protein kinase 10 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 752. Å3; shape: 0.47; buriedness: 0.75

negative: 0.05; positive: 0.07; polar: 0.02; backbone: 0.47; hydrophobic: 0.39

Domains/regions: [D] Protein kinase, [R] Activation segment

PDB: 2j7t, 4aot, 4bc6, 4equ, 4usd, 4use, 5ajq

HET: 274, ca, db8, g6i, gw8, r09, xzn

STK16_HUMAN_12_305 [text] Serine/threonine-protein kinase 16 [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 302. Å3; shape: 0.92; buriedness: 0.71

negative: 0.; positive: 0.05; polar: 0.; backbone: 0.41; hydrophobic: 0.55

Domains/regions: [D] Protein kinase

PDB: 2buj

HET: stu

STK24_HUMAN_14_314 [text] Serine/threonine-protein kinase 24 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 539. Å3; shape: 0.55; buriedness: 0.79

negative: 0.13; positive: 0.05; polar: 0.08; backbone: 0.41; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 3a7f, 3a7g, 3a7h, 3a7i, 3a7j, 3ckw, 3ckx, 3zhp, 4o27, 4qml, 4qmm, 4qmn, 4qmo, 4qmp, 4qmq, 4qms, 4qmt, 4qmu, 4qmv, 4qmw, 4qmx, 4qmy, 4qmz, 4qna, 4qo9, 4u8z, 4w8d, 4w8e

HET: 1n1, 34l, 34u, 34w, 35r, 3fe, 3ja, 3jb, 627, ade, adp, anp, atp, b49, db8, dki, h1n, h8h, ks1, mg, mn, ske, stu, x11

STK25_HUMAN_1_293 [text] Serine/threonine-protein kinase 25 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 264. Å3; shape: 0.49; buriedness: 0.76

negative: 0.08; positive: 0.; polar: 0.15; backbone: 0.31; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 2xik

HET: j60

STK26_HUMAN_9_298 [text] Serine/threonine-protein kinase 26 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 295. Å3; shape: 0.65; buriedness: 0.81

negative: 0.07; positive: 0.; polar: 0.14; backbone: 0.43; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 3ggf, 4fza, 4fzd

HET: gvd

STK3_HUMAN_11_312 [text] Serine/threonine-protein kinase 3 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 462. Å3; shape: 0.65; buriedness: 0.8

negative: 0.12; positive: 0.05; polar: 0.05; backbone: 0.5; hydrophobic: 0.29

Domains/regions: [D] Protein kinase

PDB: 4lg4, 4lgd, 5dh3

HET: 5bs, anp, mg

STRAA_HUMAN_59_431_ATPsite [text] STE20-related kinase adapter protein alpha [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 322. Å3; shape: 0.47; buriedness: 0.89

negative: 0.04; positive: 0.18; polar: 0.15; backbone: 0.35; hydrophobic: 0.28

Domains/regions: [D] Protein kinase

PDB: 2wtk, 3gni

HET: anp, atp

TAOK2_RAT_5_320 [text] Serine/threonine-protein kinase TAO2 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 320. Å3; shape: 0.66; buriedness: 0.84

negative: 0.05; positive: 0.04; polar: 0.; backbone: 0.52; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 1u5q, 1u5r, 2gcd

HET: atp, mg, stu

TBK1_HUMAN_1_303 [text] Serine/threonine-protein kinase TBK1 [Protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily]

volume: 452. Å3; shape: 0.55; buriedness: 0.75

negative: 0.04; positive: 0.04; polar: 0.08; backbone: 0.48; hydrophobic: 0.36

Domains/regions: [D] Protein kinase

PDB: 4eut, 4euu, 4im0, 4im2, 4im3, 4iwo, 4iwp, 4iwq, 4jl9, 4jlc

HET: 1fv, 1h4, bx7, su6

TGFR1_HUMAN_199_503 [text] TGF-beta receptor type-1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 397. Å3; shape: 0.72; buriedness: 0.88

negative: 0.1; positive: 0.08; polar: 0.13; backbone: 0.43; hydrophobic: 0.26

Domains/regions: [D] Protein kinase

PDB: 1b6c, 1ias, 1py5, 1rw8, 1vjy, 2wot, 2wou, 3faa, 3gxl, 3hmm, 3kcf, 3tzm, 4x0m, 4x2f, 4x2g, 4x2j, 4x2k, 4x2n, 5e8s, 5e8t, 5e8u, 5e8w, 5e8x, 5e8z, 5e90, 5fri

HET: 085, 3wa, 3wj, 3wk, 3wn, 3wo, 460, 55f, 580, 5l4, 855, jzo, py1, qig, stu, zuq, zzf, zzg

TGFR2_HUMAN_236_549 [text] TGF-beta receptor type-2 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 356. Å3; shape: 0.66; buriedness: 0.84

negative: 0.05; positive: 0.05; polar: 0.13; backbone: 0.43; hydrophobic: 0.34

Domains/regions: [D] Protein kinase

PDB: 5e8v, 5e8y, 5e91, 5e92

HET: 5l4, anp, mg, stu

TGFR2_HUMAN_42_156 [text] TGF-beta receptor type-2 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

volume: 144. Å3; shape: 0.59; buriedness: 0.63

negative: 0.; positive: 0.; polar: 0.12; backbone: 0.38; hydrophobic: 0.5

PDB: 1ktz, 1m9z, 2pjy, 3kfd, 4p7u, 4xjj

HET: 1ps, 41d

TIE2_HUMAN_806_1124 [text] Angiopoietin-1 receptor [Protein kinase superfamily. Tyr protein kinase family. Tie subfamily]

volume: 536. Å3; shape: 0.51; buriedness: 0.86

negative: 0.04; positive: 0.06; polar: 0.06; backbone: 0.4; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 1fvr, 2oo8, 2osc, 2p4i, 2wqb, 3l8p, 4x3j

HET: 0ce, 3wr, mr9, muh, qq1, raj

TNI3K_HUMAN_410_730 [text] Serine/threonine-protein kinase TNNI3K [Protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily]

volume: 251. Å3; shape: 0.79; buriedness: 0.88

negative: 0.07; positive: 0.05; polar: 0.15; backbone: 0.44; hydrophobic: 0.3

Domains/regions: [D] Protein kinase

PDB: 4yff, 4yfi

HET: 4cv, 4cw

TNIK_HUMAN_3_325 [text] TRAF2 and NCK-interacting protein kinase [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

volume: 345. Å3; shape: 0.62; buriedness: 0.87

negative: 0.1; positive: 0.05; polar: 0.; backbone: 0.36; hydrophobic: 0.49

Domains/regions: [D] Protein kinase

PDB: 2x7f, 5ax9, 5cwz, 5d7a

HET: 4kt, 58c, 824

TOPK_HUMAN_20_320 [text] Lymphokine-activated killer T-cell-originated protein kinase [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

volume: 135. Å3; shape: 0.54; buriedness: 0.87

negative: 0.; positive: 0.24; polar: 0.29; backbone: 0.24; hydrophobic: 0.24

Domains/regions: [D] Protein kinase

PDB: 5j0a

HET: hc4

TTBK1_HUMAN_6_314 [text] Tau-tubulin kinase 1 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family]

volume: 335. Å3; shape: 0.92; buriedness: 0.84

negative: 0.1; positive: 0.05; polar: 0.13; backbone: 0.36; hydrophobic: 0.37

Domains/regions: [D] Protein kinase

PDB: 4btj, 4btk, 4btm, 4nfm, 4nfn

HET: 2kc, adp, atp, dtq, f8e

TTK_HUMAN_516_808 [text] Dual specificity protein kinase TTK [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 545. Å3; shape: 0.56; buriedness: 0.82

negative: 0.05; positive: 0.05; polar: 0.12; backbone: 0.38; hydrophobic: 0.41

Domains/regions: [D] Protein kinase

PDB: 2x9e, 2zmc, 2zmd, 3cek, 3dbq, 3gfw, 3h9f, 3hmn, 3hmo, 3hmp, 3vqu, 3w1f, 3wyx, 3wyy, 3wzj, 3wzk, 4bhz, 4bi0, 4bi1, 4bi2, 4c4e, 4c4f, 4c4g, 4c4h, 4c4i, 4c4j, 4cv8, 4cv9, 4cva, 4d2s, 4js8, 4jt3, 4o6l, 4zeg, 5ap0, 5ap1, 5ap2, 5ap3, 5ap4, 5ap5, 5ap6, 5ap7, 5eh0, 5ehl, 5eho, 5ehy, 5ei2, 5ei6, 5ei8, 5ljj

HET: 052, 0sq, 1ka, 1o5, 1pe, 1pf, 1ph, 2qk, 3d7, 4t9, 537, 5nw, 5o1, 5o4, 5o7, 5oe, 5oq, 7ce, 7pe, 7ro, 92m, ad5, atp, au5, cx4, dyk, mg, o17, o22, o23, o38, o43, p4c, pwu, s22, stu, sve, w2k, wbi, x20, x21, z0b, z0w, zo6, zo8

TYK2_HUMAN_562_880 [text] Non-receptor tyrosine-protein kinase TYK2 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

volume: 354. Å3; shape: 0.9; buriedness: 0.84

negative: 0.; positive: 0.07; polar: 0.12; backbone: 0.46; hydrophobic: 0.35

Domains/regions: [D] Protein kinase 1

PDB: 3zon, 4oli, 4wov, 5c01, 5c03

HET: 2tt, 3sm, ags, ik1, mg, unl

TYK2_HUMAN_880_1178 [text] Non-receptor tyrosine-protein kinase TYK2 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

volume: 370. Å3; shape: 0.69; buriedness: 0.87

negative: 0.05; positive: 0.03; polar: 0.09; backbone: 0.5; hydrophobic: 0.32

Domains/regions: [D] Protein kinase 2

PDB: 3lxn, 3lxp, 3nyx, 3nz0, 4gfo, 4gih, 4gii, 4gj2, 4gj3, 4gvj, 4oli, 4py1, 5f1z, 5f20

HET: 0x2, 0x5, 0x6, 0xh, 0xp, 2tt, 2yk, 5u3, 5u4, adp, iza, mg, mi1, tz1

TYK2_MOUSE_877_1170 [text] Non-receptor tyrosine-protein kinase TYK2 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

volume: 280. Å3; shape: 0.5; buriedness: 0.89

negative: 0.04; positive: 0.13; polar: 0.09; backbone: 0.52; hydrophobic: 0.22

Domains/regions: [D] Protein kinase 2

PDB: 4e1z, 4e20

HET: 0mx, 0my

TYRO3_HUMAN_494_810 [text] Tyrosine-protein kinase receptor TYRO3 [Protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily]

volume: 459. Å3; shape: 0.57; buriedness: 0.68

negative: 0.08; positive: 0.02; polar: 0.02; backbone: 0.44; hydrophobic: 0.44

Domains/regions: [D] Protein kinase

PDB: 3qup, 4feq, 4ff8

HET: 0t8, 14s, lun

ULK1_HUMAN_1_283 [text] Serine/threonine-protein kinase ULK1 [Protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily]

volume: 320. Å3; shape: 0.74; buriedness: 0.79

negative: 0.03; positive: 0.; polar: 0.11; backbone: 0.44; hydrophobic: 0.42

Domains/regions: [D] Protein kinase

PDB: 4wno, 4wnp, 5ci7

HET: 3rf, 3rj, 51w

VGFR1_HUMAN_800_1158 [text] Vascular endothelial growth factor receptor 1 [Protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily]

volume: 265. Å3; shape: 0.53; buriedness: 0.96

negative: 0.08; positive: 0.04; polar: 0.04; backbone: 0.38; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 3hng

HET: 8st

VGFR2_HUMAN_808_1171 [text] Vascular endothelial growth factor receptor 2 [Protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily]

volume: 639. Å3; shape: 0.4; buriedness: 0.89

negative: 0.06; positive: 0.05; polar: 0.01; backbone: 0.41; hydrophobic: 0.46

Domains/regions: [D] Protein kinase

PDB: 1vr2, 1y6a, 1y6b, 1ywn, 2oh4, 2p2h, 2p2i, 2qu5, 2qu6, 2rl5, 2xir, 3b8q, 3b8r, 3be2, 3c7q, 3cjf, 3cjg, 3cp9, 3cpb, 3cpc, 3dtw, 3efl, 3ewh, 3u6j, 3vhe, 3vhk, 3vid, 3vnt, 3vo3, 3wzd, 3wze, 4ag8, 4agc, 4agd, 4asd, 4ase, 5ew3

HET: 00j, 03x, 0ja, 0kf, 276, 2rl, 42q, 4tt, 5t2, 608, 706, 857, 887, 900, 994, a96, aax, aaz, av9, axi, b49, bax, bpk, c19, c52, c92, gig, k11, kim, lev, lif, raj, sav, xin

VRK1_HUMAN_2_362 [text] Serine/threonine-protein kinase VRK1 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily]

volume: 248. Å3; shape: 0.79; buriedness: 0.8

negative: 0.; positive: 0.; polar: 0.07; backbone: 0.28; hydrophobic: 0.65

Domains/regions: [D] Protein kinase

PDB: 3op5

HET: reb

VRK2_HUMAN_12_335 [text] Serine/threonine-protein kinase VRK2 [Protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily]

volume: 240. Å3; shape: 0.71; buriedness: 0.87

negative: 0.05; positive: 0.08; polar: 0.05; backbone: 0.31; hydrophobic: 0.51

Domains/regions: [D] Protein kinase

PDB: 2v62, 5tkx

HET: 7dz

WEE1_HUMAN_289_575 [text] Wee1-like protein kinase [Protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily]

volume: 315. Å3; shape: 0.58; buriedness: 0.85

negative: 0.12; positive: 0.06; polar: 0.12; backbone: 0.35; hydrophobic: 0.35

Domains/regions: [D] Protein kinase

PDB: 1x8b, 2in6, 2io6, 2z2w, 3bi6, 3biz, 3cqe, 3cr0

HET: 330, 396, 61e, 770, 809, 824, 839, p91

WNK1_HUMAN_199_482 [text] Serine/threonine-protein kinase WNK1 [Protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily]

volume: 766. Å3; shape: 0.55; buriedness: 0.81

negative: 0.08; positive: 0.07; polar: 0.06; backbone: 0.41; hydrophobic: 0.39

Domains/regions: [D] Protein kinase

PDB: 3fpq, 4pwn, 4q2a, 5drb, 5tf9

HET: 5fj, 7av, anp, mn

YPKA_YERPS_90_433 [text] Protein kinase YpkA [Protein kinase superfamily. Ser/Thr protein kinase family]

volume: 256. Å3; shape: 0.54; buriedness: 0.82

negative: 0.07; positive: 0.18; polar: 0.11; backbone: 0.31; hydrophobic: 0.33

Domains/regions: [D] Protein kinase

PDB: 4ci6, 5ce3

HET: adp

ZAP70_HUMAN_2_258 [text] Tyrosine-protein kinase ZAP-70 [Protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily]

volume: 129. Å3; shape: 0.58; buriedness: 0.48

negative: 0.; positive: 0.08; polar: 0.; backbone: 0.31; hydrophobic: 0.62

PDB: 1m61, 2oq1, 2ozo, 4k2r, 4xz0, 4xz1

HET: 4n5

ZAP70_HUMAN_327_607 [text] Tyrosine-protein kinase ZAP-70 [Protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily]

volume: 336. Å3; shape: 0.72; buriedness: 0.89

negative: 0.06; positive: 0.08; polar: 0.04; backbone: 0.42; hydrophobic: 0.4

Domains/regions: [D] Protein kinase

PDB: 1u59, 2ozo, 4k2r

HET: anp, stu