[POCKETOME]
 

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ANDR_HUMAN_666_919_allosteric [text] Androgen receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 382. Å3; shape: 0.59; buriedness: 0.82

negative: 0.16; positive: 0.06; polar: 0.16; backbone: 0.36; hydrophobic: 0.25

Domains/regions: [R] Interaction with KAT7, [R] Interaction with LPXN, [R] Ligand-binding

PDB: 1e3g, 1gs4, 1i37, 1i38, 1t5z, 1t63, 1t65, 1t73, 1t74, 1t76, 1t79, 1t7f, 1t7m, 1t7r, 1t7t, 1xj7, 1xnn, 1xow, 1xq3, 1z95, 2am9, 2ama, 2amb, 2ao6, 2ax6, 2ax7, 2ax8, 2ax9, 2axa, 2hvc, 2ihq, 2nw4, 2oz7, 2pio, 2pip, 2piq, 2pir, 2pit, 2piu, 2piv, 2piw, 2pix, 2pkl, 2pnu, 2q7i, 2q7j, 2q7k, 2q7l, 2qpy, 2yhd, 2ylo, 2ylp, 2ylq, 2z4j, 3b5r, 3b65, 3b66, 3b67, 3b68, 3g0w, 3l3x, 3l3z, 3rlj, 3rll, 3v49, 3v4a, 3zqt, 4hlw, 4k7a, 4oea, 4oed, 4oey, 4oez, 4ofr, 4ofu, 4ogh, 4oh5, 4oha, 4oil, 4oiu, 4oj9, 4ojb, 4ok1, 4okb, 4okt, 4okw, 4okx, 4olm, 4ql8, 5cj6

HET: 056, 17w, 2mi, 30z, 4hy, flf, ico, t3, ylo, ylq

ANDR_HUMAN_666_919_ligBind [text] Androgen receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 336. Å3; shape: 0.68; buriedness: 1.

negative: 0.; positive: 0.04; polar: 0.11; backbone: 0.26; hydrophobic: 0.59

Domains/regions: [R] Interaction with LPXN, [R] Ligand-binding

PDB: 1e3g, 1gs4, 1i37, 1i38, 1t5z, 1t63, 1t65, 1t73, 1t74, 1t76, 1t79, 1t7f, 1t7m, 1t7r, 1t7t, 1xj7, 1xnn, 1xow, 1xq3, 1z95, 2am9, 2ama, 2amb, 2ao6, 2ax6, 2ax7, 2ax8, 2ax9, 2axa, 2hvc, 2ihq, 2nw4, 2oz7, 2pio, 2pip, 2piq, 2pir, 2pit, 2piu, 2piv, 2piw, 2pix, 2pkl, 2pnu, 2q7i, 2q7j, 2q7k, 2q7l, 2qpy, 2yhd, 2ylo, 2ylp, 2ylq, 2z4j, 3b5r, 3b65, 3b66, 3b67, 3b68, 3g0w, 3l3x, 3l3z, 3rlj, 3rll, 3v49, 3v4a, 3zqt, 4hlw, 4k7a, 4oea, 4oed, 4oey, 4oez, 4ofr, 4ofu, 4ogh, 4oh5, 4oha, 4oil, 4oiu, 4oj9, 4ojb, 4ok1, 4okb, 4okt, 4okw, 4okx, 4olm, 4ql8, 5cj6

HET: 17h, 198, 3b6, 51y, 8nh, b5r, b66, b67, b68, bhm, ca4, dht, enm, fhm, hft, hyq, jad, lg7, lgb, lgd, pk0, pk1, r18, rlj, rll, tes, zk5

ECR_HELVI_304_550 [text] Ecdysone receptor [Nuclear hormone receptor family. NR1 subfamily]

volume: 512. Å3; shape: 0.57; buriedness: 0.99

negative: 0.03; positive: 0.03; polar: 0.23; backbone: 0.26; hydrophobic: 0.45

Domains/regions: [R] Hormone-binding

PDB: 1r1k, 1r20, 2r40, 3ixp

HET: 20e, 834, hwg, p1a

ERR1_HUMAN_192_423 [text] Steroid hormone receptor ERR1 [Nuclear hormone receptor family. NR3 subfamily]

volume: 351. Å3; shape: 0.53; buriedness: 0.95

negative: 0.05; positive: 0.; polar: 0.; backbone: 0.33; hydrophobic: 0.61

Domains/regions: [R] Ligand binding domain

PDB: 1xb7, 2pjl, 3d24, 3k6p

HET: 047, 5fb

ERR3_HUMAN_228_458 [text] Estrogen-related receptor gamma [Nuclear hormone receptor family. NR3 subfamily]

volume: 358. Å3; shape: 0.56; buriedness: 0.96

negative: 0.04; positive: 0.07; polar: 0.08; backbone: 0.33; hydrophobic: 0.48

PDB: 1kv6, 1s9p, 1s9q, 1tfc, 1vjb, 2e2r, 2ewp, 2gp7, 2gpo, 2gpp, 2gpu, 2gpv, 2p7a, 2p7g, 2p7z, 2zas, 2zbs, 2zkc

HET: 1ba, 1oh, 2oh, 43m, bpz, des, oht, txf

ESR1_HUMAN_300_553 [text] Estrogen receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 463. Å3; shape: 0.91; buriedness: 0.99

negative: 0.04; positive: 0.08; polar: 0.04; backbone: 0.26; hydrophobic: 0.59

Domains/regions: [R] Interaction with AKAP13, [R] Transactivation AF-2

PDB: 1a52, 1ere, 1err, 1g50, 1gwq, 1gwr, 1l2i, 1pcg, 1qkt, 1qku, 1r5k, 1sj0, 1uom, 1x7e, 1x7r, 1xp1, 1xp6, 1xp9, 1xpc, 1xqc, 1yim, 1yin, 1zky, 2ayr, 2b1v, 2b1z, 2b23, 2bj4, 2fai, 2g44, 2g5o, 2i0j, 2iog, 2iok, 2jf9, 2jfa, 2ocf, 2ouz, 2p15, 2pog, 2q6j, 2q70, 2qa6, 2qa8, 2qab, 2qe4, 2qgt, 2qgw, 2qh6, 2qr9, 2qse, 2qxm, 2qxs, 2qzo, 2r6w, 2r6y, 2yat, 2yja, 3dt3, 3erd, 3ert, 3hlv, 3hm1, 3l03, 3os8, 3os9, 3osa, 3q95, 3q97, 3uu7, 3uua, 3uuc, 3uud, 4dma, 4iu7, 4iui, 4iv2, 4iv4, 4ivw, 4ivy, 4iw6, 4iw8, 4iwc, 4iwf, 4mg5, 4mg6, 4mg7, 4mg8, 4mg9, 4mga, 4mgb, 4mgc, 4mgd, 4pp6, 4ppp, 4pps, 4pxm, 4q13, 4q50, 4tuz, 4tv1, 4xi3, 4zn7, 4zn9, 4znh, 4zns, 4znt, 4znu, 4znv, 4znw, 5aau, 5aav, 5acc, 5ak2, 5di7, 5did, 5die, 5dig, 5dk9, 5dkb, 5dke, 5dkg, 5dks, 5dl4, 5dlr, 5dmc, 5dmf, 5dp0, 5drj, 5drm, 5dtv, 5du5, 5due, 5dug, 5duh, 5dvs, 5dvv, 5dwe, 5dwg, 5dwi, 5dwj, 5dx3, 5dxb, 5dxe, 5dxg, 5dxk, 5dxm, 5dxp, 5dxq, 5dxr, 5dy8, 5dyb, 5dyd, 5dz0, 5dz1, 5dz3, 5dzh, 5dzi, 5e0w, 5e0x, 5e14, 5e15, 5e19, 5e1c, 5egv, 5ehj, 5ei1, 5eit, 5fqp, 5fqr, 5fqs, 5fqt, 5fqv, 5hyr, 5kcc, 5kcd, 5kce, 5kcf, 5kct, 5kcu, 5kcw, 5kd9

HET: 0cz, 1gj, 1gm, 1gq, 1gr, 1gs, 1gt, 1gu, 27g, 27h, 29s, 369, 4q7, 4q9, 5c4, 5c6, 5c7, 5c8, 5c9, 5cc, 5dg, 5dh, 5es, 5ft, 5fv, 5fy, 5g3, 5g4, 5hz, 5j0, 5j1, 5j2, 5k2, 5k5, 5k7, 5k8, 5ka, 5kb, 5kd, 5ke, 5kf, 5kg, 7qn, 85z, aej, aih, aij, c3d, cm3, cm4, drq, e4d, ezt, gqd, gw5, hz3, iok, j0w, ke9, kn0, kn3, llb, llc, ob1, ob2, ob3, ob5, ob7, ob9, obb, obc, obh, obm, ode, ofb, pti, q97, qhg, srr, vqi, xbr

ESR2_HUMAN_260_502 [text] Estrogen receptor beta [Nuclear hormone receptor family. NR3 subfamily]

volume: 1500. Å3; shape: 0.44; buriedness: 0.58

negative: 0.07; positive: 0.08; polar: 0.05; backbone: 0.27; hydrophobic: 0.53

Domains/regions: [R] Steroid-binding

PDB: 1hj1, 1l2j, 1nde, 1qkm, 1qkn, 1u3q, 1u3r, 1u3s, 1u9e, 1x76, 1x78, 1x7b, 1x7j, 1yy4, 1yye, 1zaf, 2fsz, 2giu, 2i0g, 2j7x, 2j7y, 2jj3, 2nv7, 2qtu, 2yjd, 2yly, 2z4b, 3oll, 3ols, 3omo, 3omp, 3omq, 4j24, 4j26, 4zi1

HET: 041, 196, 244, 272, 338, 397, 3as, 4na, 555, 697, 789, 797, ace, aoe, dc8, e3o, est, etc, fbr, gen, i0g, jj3, kb0, mk8, mon, oht, ral, su4, w14, w23, wv7, yjd

GCR_HUMAN_509_777 [text] Glucocorticoid receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 504. Å3; shape: 0.51; buriedness: 0.99

negative: 0.; positive: 0.04; polar: 0.16; backbone: 0.32; hydrophobic: 0.49

Domains/regions: [R] Interaction with CLOCK, [R] Interaction with CRY1, [R] Steroid-binding

PDB: 1m2z, 1nhz, 1p93, 3bqd, 3cld, 3e7c, 3h52, 3k22, 3k23, 3mne, 3mno, 3mnp, 4csj, 4lsj, 4mdd, 4p6w, 4p6x, 4udc, 4udd

HET: 29m, 486, 866, cv7, day, dex, gw6, hcy, jzn, jzs, lsj, mof, nn7

HNF4G_HUMAN_92_328_ligBind [text] Hepatocyte nuclear factor 4-gamma [Nuclear hormone receptor family. NR2 subfamily]

volume: 256. Å3; shape: 0.47; buriedness: 0.99

negative: 0.04; positive: 0.04; polar: 0.13; backbone: 0.22; hydrophobic: 0.57

PDB: 1lv2

HET: plm

MCR_HUMAN_723_984 [text] Mineralocorticoid receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 309. Å3; shape: 0.65; buriedness: 1.

negative: 0.; positive: 0.05; polar: 0.16; backbone: 0.19; hydrophobic: 0.6

Domains/regions: [R] Steroid-binding

PDB: 1y9r, 1ya3, 2a3i, 2aa2, 2aa5, 2aa6, 2aa7, 2aax, 2ab2, 2abi, 2oax, 3vhu, 3vhv, 3wff, 3wfg, 4pf3, 4uda, 4udb, 5hcv

HET: 1ca, 60r, as4, c0r, cv7, dex, hfn, ld1, pdn, snl, str, wff, wfg

NR1D2_HUMAN_385_579_ligBind [text] Nuclear receptor subfamily 1 group D member 2 [Nuclear hormone receptor family. NR1 subfamily]

volume: 462. Å3; shape: 0.8; buriedness: 0.92

negative: 0.03; positive: 0.03; polar: 0.; backbone: 0.48; hydrophobic: 0.47

Domains/regions: [R] Interaction with ZNHIT1, [R] Ligand-binding

PDB: 2v0v, 2v7c, 3cqv, 4n73

HET: co, coh, fe, hem

NR1H2_HUMAN_213_460 [text] Oxysterols receptor LXR-beta [Nuclear hormone receptor family. NR1 subfamily]

volume: 471. Å3; shape: 0.52; buriedness: 0.99

negative: 0.05; positive: 0.07; polar: 0.13; backbone: 0.23; hydrophobic: 0.52

Domains/regions: [R] Ligand-binding, [R] Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2

PDB: 1p8d, 1pq6, 1pq9, 1pqc, 1upv, 1upw, 3kfc, 3l0e, 4dk7, 4dk8, 4nqa, 4rak, 5hjp, 5i4v, 5jy3, 5kya, 5kyj

HET: 0ks, 0kt, 444, 44b, 61x, 652, 668, 67s, 6ox, 6y4, 6y8, 965, bns, co1, g58

NR1H3_HUMAN_189_447 [text] Oxysterols receptor LXR-alpha [Nuclear hormone receptor family. NR1 subfamily]

volume: 473. Å3; shape: 0.5; buriedness: 0.97

negative: 0.05; positive: 0.08; polar: 0.14; backbone: 0.21; hydrophobic: 0.53

Domains/regions: [R] Ligand-binding, [R] Transactivation AF-2; required for ligand-dependent transactivation function; mediates interaction with CCAR2

PDB: 1uhl, 2acl, 3fal, 3fc6, 3ipq, 3ips, 3ipu, 5avi, 5avl, 5hjs

HET: 444, 4km, 4kq, 668, 965, l05, lo2, lx2, o40, o90

NR1H4_HUMAN_257_485 [text] Bile acid receptor [Nuclear hormone receptor family. NR1 subfamily]

volume: 785. Å3; shape: 0.63; buriedness: 0.97

negative: 0.; positive: 0.11; polar: 0.1; backbone: 0.31; hydrophobic: 0.48

Domains/regions: [R] Agonist binding, [R] Ligand-binding

PDB: 1osh, 1osv, 1ot7, 3bej, 3dct, 3dcu, 3fli, 3fxv, 3gd2, 3hc5, 3hc6, 3l1b, 3okh, 3oki, 3olf, 3omk, 3omm, 3oof, 3ook, 3p88, 3p89, 3rut, 3ruu, 3rvf, 4oiv, 4qe6, 4qe8, 4wvd

HET: 034, 064, 088, 31d, 33y, 37g, 59g, 635, 643, 708, 82x, 89p, chc, fex, iu5, ivm, jn3, muf, o62, okh, oki, olf, omk, omm, oof, ook, p88, xx9

NR1I2_HUMAN_130_434 [text] Nuclear receptor subfamily 1 group I member 2 [Nuclear hormone receptor family. NR1 subfamily]

volume: 578. Å3; shape: 0.78; buriedness: 0.94

negative: 0.; positive: 0.12; polar: 0.18; backbone: 0.05; hydrophobic: 0.65

Domains/regions: [R] Ligand-binding

PDB: 1ilg, 1ilh, 1m13, 1nrl, 1skx, 2o9i, 2qnv, 3ctb, 3hvl, 3r8d, 4j5w, 4j5x, 4ny9, 4s0s, 4s0t, 4x1f, 4x1g, 4xao, 4xhd, 5a86

HET: 2q4, 3wf, 3wg, 40u, 444, cdz, d7e, hyf, rfp, srl

NR1I3_HUMAN_103_352 [text] Nuclear receptor subfamily 1 group I member 3 [Nuclear hormone receptor family. NR1 subfamily]

volume: 277. Å3; shape: 0.69; buriedness: 0.97

negative: 0.; positive: 0.09; polar: 0.26; backbone: 0.13; hydrophobic: 0.53

PDB: 1xv9, 1xvp

HET: ci2, cid

NR1I3_MOUSE_114_358 [text] Nuclear receptor subfamily 1 group I member 3 [Nuclear hormone receptor family. NR1 subfamily]

volume: 318. Å3; shape: 0.56; buriedness: 0.98

negative: 0.06; positive: 0.; polar: 0.21; backbone: 0.08; hydrophobic: 0.65

PDB: 1xls, 1xnx

HET: ate, tcd

NR4A1_HUMAN_350_598 [text] Nuclear receptor subfamily 4 group A member 1 [Nuclear hormone receptor family. NR4 subfamily]

volume: 507. Å3; shape: 0.81; buriedness: 0.72

negative: 0.1; positive: 0.07; polar: 0.1; backbone: 0.48; hydrophobic: 0.25

Domains/regions: [R] Ligand-binding

PDB: 1yje, 2qw4, 3v3e, 3v3q, 4jgv, 4kzi, 4kzj, 4kzm, 4re8, 4ree, 4ref, 4rze, 4rzf, 4rzg, 4whf, 4whg

HET: tmy, zhn, zj0

NR5A2_HUMAN_295_540 [text] Nuclear receptor subfamily 5 group A member 2 [Nuclear hormone receptor family. NR5 subfamily]

volume: 827. Å3; shape: 0.62; buriedness: 0.89

negative: 0.; positive: 0.07; polar: 0.14; backbone: 0.29; hydrophobic: 0.5

Domains/regions: [R] Ligand-binding, [R] Lipid binding

PDB: 1yok, 1yuc, 1zdu, 3plz, 3tx7, 4dor, 4dos, 4is8, 4oni, 4pld, 4ple, 4rwv, 5l11, 5syz

HET: 470, 71w, eph, p3a, p6l, piz, plc, rjw

PPARA_HUMAN_197_468 [text] Peroxisome proliferator-activated receptor alpha [Nuclear hormone receptor family. NR1 subfamily]

volume: 602. Å3; shape: 0.57; buriedness: 0.96

negative: 0.03; positive: 0.04; polar: 0.18; backbone: 0.15; hydrophobic: 0.6

Domains/regions: [R] Ligand-binding, [R] Required for heterodimerization with RXRA

PDB: 1i7g, 1k7l, 1kkq, 2npa, 2p54, 2rew, 2znn, 3et1, 3fei, 3g8i, 3kdt, 3kdu, 3sp6, 3vi8, 4bcr, 4ci4, 5azt, 5hyk

HET: 13m, 471, 4m5, 544, 65w, 735, 7ha, az2, ctm, et1, il2, mmb, nks, rew, ro7, s44, wy1, y1n

PPARD_HUMAN_169_441 [text] Peroxisome proliferator-activated receptor delta [Nuclear hormone receptor family. NR1 subfamily]

volume: 535. Å3; shape: 0.73; buriedness: 0.96

negative: 0.; positive: 0.16; polar: 0.14; backbone: 0.14; hydrophobic: 0.56

Domains/regions: [R] Ligand-binding

PDB: 1gwx, 1y0s, 2awh, 2b50, 2baw, 2gwx, 2j14, 2q5g, 2xyj, 2xyw, 2xyx, 2znp, 2znq, 3d5f, 3dy6, 3et2, 3gwx, 3gz9, 3oz0, 3peq, 3sp9, 3tkm

HET: 08s, 1fa, 331, 3eq, 3oz, 401, 433, d32, dy6, epa, et1, gni, gw0, il2, k55, l41, vca, wlm, z00

PPARG_HUMAN_229_505 [text] Peroxisome proliferator-activated receptor gamma [Nuclear hormone receptor family. NR1 subfamily]

volume: 756. Å3; shape: 0.83; buriedness: 0.92

negative: 0.; positive: 0.13; polar: 0.13; backbone: 0.31; hydrophobic: 0.43

Domains/regions: [R] Interaction with FAM120B, [R] Ligand-binding

PDB: 1fm6, 1fm9, 1i7i, 1k74, 1knu, 1nyx, 1prg, 1rdt, 1wm0, 1zeo, 1zgy, 2ath, 2f4b, 2fvj, 2g0g, 2g0h, 2gtk, 2hfp, 2hwq, 2hwr, 2i4j, 2i4p, 2i4z, 2om9, 2p4y, 2pob, 2prg, 2q59, 2q5p, 2q5s, 2q61, 2q6r, 2q6s, 2q8s, 2vsr, 2vst, 2vv0, 2vv1, 2vv2, 2vv3, 2vv4, 2xkw, 2yfe, 2zk0, 2zk1, 2zk2, 2zk3, 2zk4, 2zk5, 2zk6, 2zno, 2zvt, 3ads, 3adt, 3adu, 3adv, 3adw, 3adx, 3an3, 3an4, 3b0q, 3b0r, 3b1m, 3b3k, 3bc5, 3cdp, 3cds, 3cs8, 3cwd, 3d6d, 3dzu, 3dzy, 3e00, 3et0, 3et3, 3fej, 3fur, 3g9e, 3gbk, 3h0a, 3ho0, 3hod, 3ia6, 3k8s, 3kmg, 3lmp, 3noa, 3osi, 3osw, 3pba, 3po9, 3prg, 3qt0, 3r5n, 3r8a, 3r8i, 3s9s, 3sz1, 3t03, 3ty0, 3u9q, 3v9t, 3v9v, 3v9y, 3vjh, 3vji, 3vn2, 3vso, 3vsp, 3wj4, 3wj5, 3wmh, 3x1h, 3x1i, 4a4v, 4a4w, 4ci5, 4e4k, 4e4q, 4em9, 4ema, 4f9m, 4fgy, 4hee, 4jaz, 4jl4, 4l96, 4l98, 4o8f, 4oj4, 4prg, 4pvu, 4pwl, 4r06, 4r2u, 4r6s, 4xld, 4xta, 4xuh, 4xum, 4y29, 4yt1, 5azv, 5dsh, 5dv3, 5dv6, 5dv8, 5dvc, 5dwl, 5f9b, 5hzc

HET: 082, 14r, 17l, 208, 240, 241, 3e7, 3ea, 3t0, 486, 538, 544, 570, 5ox, 65w, 66b, 6bh, aja, axy, az2, b05, c01, c03, cek, cti, ctm, d30, dkd, drf, drj, dry, eha, ek1, ek8, et1, fcm, grr, hig, imn, j35, j53, jja, krc, l92, lna, lnb, m0t, mc5, nro, nsi, nza, ocx, p1b, plb, ptg, ro0, ro7, rrg, s44, sf1, sf2, sfi, sp0, sp3, tls, unt, xcx, y1n, yfb, yfd, yfe, ypa, z12, z27, zaa, zxg, zzh

PRGR_HUMAN_677_933 [text] Progesterone receptor [Nuclear hormone receptor family. NR3 subfamily]

volume: 348. Å3; shape: 0.67; buriedness: 1.

negative: 0.; positive: 0.05; polar: 0.16; backbone: 0.27; hydrophobic: 0.53

Domains/regions: [R] Steroid-binding

PDB: 1a28, 1e3k, 1sqn, 1sr7, 1zuc, 2ovh, 2ovm, 2w8y, 3d90, 3g8o, 3hq5, 3kba, 3zr7, 3zra, 3zrb, 4a2j, 4apu, 4oar

HET: 2s0, 30x, 486, a2k, as0, gkk, mof, ndr, nog, or8, orb, orc, r18, str, t98, wow

RARA_HUMAN_173_420 [text] Retinoic acid receptor alpha [Nuclear hormone receptor family. NR1 subfamily]

volume: 422. Å3; shape: 0.54; buriedness: 0.96

negative: 0.; positive: 0.06; polar: 0.09; backbone: 0.35; hydrophobic: 0.51

Domains/regions: [R] Ligand-binding

PDB: 1dkf, 3a9e, 3kmr, 3kmz, 4dqm, 5k13

HET: 6q7, bms, eqn, eqo, luf, rea

RARB_HUMAN_171_421 [text] Retinoic acid receptor beta [Nuclear hormone receptor family. NR1 subfamily]

volume: 314. Å3; shape: 0.52; buriedness: 0.99

negative: 0.; positive: 0.05; polar: 0.05; backbone: 0.32; hydrophobic: 0.59

Domains/regions: [R] Hinge, [R] Ligand-binding

PDB: 1xap, 1xdk, 4dm6, 4dm8, 4jyg, 4jyh, 4jyi

HET: 1ny, jyh, jyi, rea, ttb

RARG_HUMAN_177_420 [text] Retinoic acid receptor gamma [Nuclear hormone receptor family. NR1 subfamily]

volume: 314. Å3; shape: 0.42; buriedness: 0.99

negative: 0.; positive: 0.07; polar: 0.04; backbone: 0.34; hydrophobic: 0.55

Domains/regions: [R] Hinge, [R] Ligand-binding

PDB: 1exa, 1exx, 1fcx, 1fcy, 1fcz, 1fd0, 2lbd, 3lbd, 4lbd

HET: 156, 184, 254, 394, 564, 961, rea

RORA_HUMAN_270_523 [text] Nuclear receptor ROR-alpha [Nuclear hormone receptor family. NR1 subfamily]

volume: 380. Å3; shape: 0.38; buriedness: 0.95

negative: 0.; positive: 0.12; polar: 0.06; backbone: 0.3; hydrophobic: 0.52

Domains/regions: [R] Ligand-binding

PDB: 1n83, 1s0x, 4s15

HET: 4d8, c3s, clr

RORB_RAT_214_465 [text] Nuclear receptor ROR-beta [Nuclear hormone receptor family. NR1 subfamily]

volume: 347. Å3; shape: 0.49; buriedness: 0.95

negative: 0.; positive: 0.06; polar: 0.08; backbone: 0.25; hydrophobic: 0.62

Domains/regions: [R] Ligand-binding

PDB: 1k4w, 1n4h, 1nq7

HET: arl, rea, ste

RORG_HUMAN_262_504 [text] Nuclear receptor ROR-gamma [Nuclear hormone receptor family. NR1 subfamily]

volume: 697. Å3; shape: 0.53; buriedness: 0.93

negative: 0.; positive: 0.14; polar: 0.03; backbone: 0.22; hydrophobic: 0.61

Domains/regions: [R] Ligand-binding

PDB: 3b0w, 3kyt, 3l0j, 3l0l, 4nb6, 4nie, 4qm0, 4wlb, 4wpf, 4wqp, 4xt9, 4ymq, 4ypq, 4zjr, 4zjw, 4zom, 5aph, 5apj, 5apk, 5ayg, 5c4o, 5c4s, 5c4t, 5c4u, 5ejv, 5eth, 5g42, 5g43, 5g44, 5g45, 5g46, 5ixk, 5iz0, 5lwp

HET: 39k, 3qq, 3sn, 3sx, 43v, 444, 4lq, 4p1, 4p3, 4q3, 4tu, 5im, 5rt, 6ew, 6f1, 76e, a7w, dgx, hc2, hc3, hc9, i6g, nbh, swx, vyi, ytz, zbd

RXRA_HUMAN_222_461 [text] Retinoic acid receptor RXR-alpha [Nuclear hormone receptor family. NR2 subfamily]

volume: 428. Å3; shape: 0.63; buriedness: 0.99

negative: 0.; positive: 0.07; polar: 0.07; backbone: 0.24; hydrophobic: 0.62

Domains/regions: [R] Ligand-binding

PDB: 1dkf, 1fby, 1fm6, 1fm9, 1g1u, 1g5y, 1k74, 1lbd, 1mv9, 1mvc, 1mzn, 1rdt, 1xdk, 1xls, 1xv9, 1xvp, 2acl, 2p1t, 2p1u, 2p1v, 2zxz, 2zy0, 3a9e, 3dzu, 3dzy, 3e00, 3e94, 3fal, 3fc6, 3fug, 3h0a, 3kwy, 3nsp, 3nsq, 3oap, 3ozj, 3pcu, 3r29, 3r2a, 3r5m, 3uvv, 4j5w, 4j5x, 4k4j, 4k6i, 4m8e, 4m8h, 4n5g, 4n8r, 4nqa, 4oc7, 4poh, 4poj, 4pp3, 4pp5, 4rfw, 4rmc, 4rmd, 4rme, 4zo1, 4zsh, 5ec9

HET: 1o8, 21p, 29v, 2e3, 2qo, 2vp, 2vr, 2vz, 2w0, 3rb, 3sv, 3sw, 3t2, 3tn, 4tn, 4xw, 5lo, 5tn, 754, 9cr, 9ra, bgv, bm6, chz, f15, hxa, k08, k09, l79, lx8, mlo, ola, p26, r4m, rea, rhn, t9t, tby

RXRB_HUMAN_289_527 [text] Retinoic acid receptor RXR-beta [Nuclear hormone receptor family. NR2 subfamily]

volume: 258. Å3; shape: 0.54; buriedness: 0.98

negative: 0.; positive: 0.09; polar: 0.08; backbone: 0.25; hydrophobic: 0.57

Domains/regions: [R] Ligand-binding

PDB: 1h9u, 1uhl, 5hjp, 5i4v, 5kya, 5kyj

HET: lg2, mei

RXR_BIOGL_195_436 [text] Retinoic acid receptor RXR [Nuclear hormone receptor family. NR2 subfamily]

volume: 241. Å3; shape: 0.48; buriedness: 0.98

negative: 0.; positive: 0.11; polar: 0.06; backbone: 0.28; hydrophobic: 0.56

Domains/regions: [R] 9-cis-retinoic acid-binding, [R] Ligand-binding

PDB: 1xiu

HET: rea

STF1_HUMAN_220_461_ligBind [text] Steroidogenic factor 1 [Nuclear hormone receptor family. NR5 subfamily]

volume: 788. Å3; shape: 0.54; buriedness: 0.83

negative: 0.; positive: 0.06; polar: 0.1; backbone: 0.3; hydrophobic: 0.54

Domains/regions: [R] Important for dimerization, [R] Ligand-binding

PDB: 1ymt, 1yow, 1yp0, 1zdt, 3f7d, 4qjr, 4qk4

HET: dr9, p0e, p42, pef, pik, piz

THA_CHICK_146_408 [text] Thyroid hormone receptor alpha [Nuclear hormone receptor family. NR1 subfamily]

volume: 250. Å3; shape: 0.43; buriedness: 0.98

negative: 0.; positive: 0.16; polar: 0.; backbone: 0.26; hydrophobic: 0.58

Domains/regions: [R] Ligand-binding

PDB: 3uvv

HET: t3

THA_HUMAN_148_375 [text] Thyroid hormone receptor alpha [Nuclear hormone receptor family. NR1 subfamily]

volume: 270. Å3; shape: 0.45; buriedness: 1.

negative: 0.; positive: 0.15; polar: 0.07; backbone: 0.24; hydrophobic: 0.54

Domains/regions: [R] Ligand-binding

PDB: 1nav, 2h77, 2h79, 3hzf, 3ilz, 3jzb, 4lnw, 4lnx

HET: 4hy, b72, ih5, t3

THB_HUMAN_205_461_allosteric [text] Thyroid hormone receptor beta [Nuclear hormone receptor family. NR1 subfamily]

volume: 716. Å3; shape: 0.82; buriedness: 0.52

negative: 0.12; positive: 0.23; polar: 0.07; backbone: 0.09; hydrophobic: 0.49

Domains/regions: [R] Interaction with NR2F6, [R] Ligand-binding

PDB: 1n46, 1nax, 1nq0, 1nq1, 1nq2, 1nuo, 1q4x, 1r6g, 1xzx, 1y0x, 2j4a, 2pin, 3d57, 3gws, 3imy, 3jzc, 4zo1

HET: leg

THB_HUMAN_205_461_ligBind [text] Thyroid hormone receptor beta [Nuclear hormone receptor family. NR1 subfamily]

volume: 312. Å3; shape: 0.44; buriedness: 0.99

negative: 0.; positive: 0.15; polar: 0.06; backbone: 0.21; hydrophobic: 0.57

Domains/regions: [R] Interaction with NR2F6, [R] Ligand-binding

PDB: 1n46, 1nax, 1nq0, 1nq1, 1nq2, 1nuo, 1q4x, 1r6g, 1xzx, 1y0x, 2j4a, 2pin, 3d57, 3gws, 3imy, 3jzc, 4zo1

HET: 442, 4hy, b72, g24, ih5, oef, pfa, t3, t44

USP_DROME_230_508_ligBind [text] Protein ultraspiracle [Nuclear hormone receptor family. NR2 subfamily]

volume: 673. Å3; shape: 0.43; buriedness: 0.87

negative: 0.; positive: 0.05; polar: 0.1; backbone: 0.23; hydrophobic: 0.61

Domains/regions: [R] Ligand-binding

PDB: 1hg4

HET: lpp

VDRA_DANRE_155_453 [text] Vitamin D3 receptor A [Nuclear hormone receptor family. NR1 subfamily]

volume: 442. Å3; shape: 0.52; buriedness: 0.99

negative: 0.; positive: 0.13; polar: 0.26; backbone: 0.07; hydrophobic: 0.54

Domains/regions: [R] Hinge, [R] Ligand-binding, [R] Vitamin D3 binding

PDB: 2hbh, 2hc4, 2hcd, 3dr1, 3o1d, 3o1e, 4fhh, 4fhi, 4g1d, 4g1y, 4g1z, 4g20, 4g21, 4g2h, 4ia1, 4ia2, 4ia3, 4ia7, 4q0a, 4ruj, 4ruo, 4rup, 5e7v, 5lga

HET: 0s4, 0u3, 0vk, 0vo, 0vp, 0vq, 484, 4oa, 6vh, biv, c5d, g72, h97, m7e, vdx, xe4

VDR_HUMAN_119_426 [text] Vitamin D3 receptor [Nuclear hormone receptor family. NR1 subfamily]

volume: 418. Å3; shape: 0.51; buriedness: 0.99

negative: 0.; positive: 0.15; polar: 0.3; backbone: 0.05; hydrophobic: 0.5

Domains/regions: [R] Hinge, [R] Ligand-binding, [R] Vitamin D3 binding

PDB: 1db1, 1ie8, 1ie9, 1rjk, 1rk3, 1rkg, 1rkh, 1s0z, 1s19, 1txi, 2ham, 2har, 2has, 2hb7, 2hb8, 2o4j, 2o4r, 2zfx, 3a2h, 3a2i, 3a2j, 3a3z, 3a40, 3a78, 3aun, 3auq, 3aur, 3ax8, 3az1, 3az2, 3az3, 3b0t, 3cs4, 3cs6, 3kpz, 3m7r, 3ogt, 3p8x, 3tkc, 3vhw, 3w0a, 3w0c, 3w0g, 3w0i, 3w0j, 3w0y, 3wgp, 3wwr, 3x31, 3x36, 4g2i, 4ite, 4itf, 5gt4

HET: 0co, 0vq, 23r, 2kb, 2mv, 3aj, 3ev, 41v, 41w, 6ds, c33, c3o, ca9, cov, ds2, ds3, ds4, ds5, ds6, eb1, ed9, eim, fmv, kh1, mc9, mcz, mvd, o11, o1c, occ, t08, tej, tey, tfy, tx5, vd1, vd2, vd4, vd5, vdx, vdz, vhw, w07, yr3, yr4, zne, zyd

VDR_RAT_116_422 [text] Vitamin D3 receptor [Nuclear hormone receptor family. NR1 subfamily]

volume: 497. Å3; shape: 0.5; buriedness: 0.99

negative: 0.; positive: 0.12; polar: 0.23; backbone: 0.07; hydrophobic: 0.58

Domains/regions: [R] Hinge, [R] Ligand-binding, [R] Vitamin D3 binding

PDB: 2zl9, 2zla, 2zlc, 2zmh, 2zmi, 2zmj, 2zxm, 2zxn, 3afr, 3vjs, 3vjt, 3vrt, 3vru, 3vrv, 3vrw, 3vt3, 3vt4, 3vt5, 3vt6, 3vt7, 3vt8, 3vt9, 3vtb, 3vtc, 3vtd, 3w0h, 3w5p, 3w5q, 3w5r, 3w5t, 3wt5, 3wt6, 3wt7, 3wtq, 4ynk, 5awj, 5awk, 5b5b

HET: 10r, 10s, 3kl, 4oa, 5yi, akx, icj, jb1, jc1, lhp, loa, mi4, nya, tk3, tka, tkd, tt2, vda, vdb, vdx, w12, ya1, ya2, yi2, yi3, yi4, ys2, ys3, ys5, ys9, ysd, yse, ysl, yw2