[POCKETOME]
 

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36 entries [expand]
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5HT1B_HUMAN_31_390 [text] 5-hydroxytryptamine receptor 1B [G-protein coupled receptor 1 family]

volume: 376. Å3; shape: 0.55; buriedness: 0.89

negative: 0.1; positive: 0.; polar: 0.12; backbone: 0.27; hydrophobic: 0.51

Domains/regions: [R] Agonist binding

PDB: 4iaq, 4iar

HET: 2gm, erm

5HT2B_HUMAN_33_405 [text] 5-hydroxytryptamine receptor 2B [G-protein coupled receptor 1 family]

volume: 418. Å3; shape: 0.65; buriedness: 0.93

negative: 0.04; positive: 0.02; polar: 0.17; backbone: 0.28; hydrophobic: 0.49

Domains/regions: [R] Agonist binding

PDB: 4ib4, 4nc3

HET: erm

AA2AR_HUMAN_1_315 [text] Adenosine receptor A2a [G-protein coupled receptor 1 family]

volume: 734. Å3; shape: 0.82; buriedness: 0.78

negative: 0.05; positive: 0.15; polar: 0.22; backbone: 0.11; hydrophobic: 0.48

Domains/regions: [R] Agonist binding

PDB: 2ydo, 2ydv, 3eml, 3pwh, 3qak, 3rey, 3uza, 3uzc, 3vg9, 3vga, 4eiy, 4ug2, 4uhr, 5g53, 5iu4, 5iu7, 5iu8, 5iua, 5iub, 5k2a, 5k2b, 5k2c, 5k2d

HET: 6dv, 6dx, 6dy, 6dz, adn, nec, ngi, ola, olc, t4e, t4g, uka, xac, zma

ACM1_HUMAN_1_460 [text] Muscarinic acetylcholine receptor M1 [G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily]

volume: 217. Å3; shape: 0.7; buriedness: 0.99

negative: 0.07; positive: 0.; polar: 0.53; backbone: 0.13; hydrophobic: 0.27

PDB: 5cxv

HET: 0hk

ACM2_HUMAN_1_466_TM [text] Muscarinic acetylcholine receptor M2 [G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily]

volume: 220. Å3; shape: 0.77; buriedness: 0.99

negative: 0.06; positive: 0.; polar: 0.36; backbone: 0.18; hydrophobic: 0.39

Domains/regions: [R] Agonist binding

PDB: 3uon, 4mqs

HET: ixo, qnb

ACM3_HUMAN_57_580 [text] Muscarinic acetylcholine receptor M3 [G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily]

volume: 238. Å3; shape: 0.75; buriedness: 0.99

negative: 0.07; positive: 0.; polar: 0.47; backbone: 0.1; hydrophobic: 0.36

Domains/regions: [R] Agonist binding

PDB: 4daj, 4u15

HET: 0hk

ACM4_HUMAN_20_479 [text] Muscarinic acetylcholine receptor M4 [G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily]

volume: 216. Å3; shape: 0.7; buriedness: 0.99

negative: 0.; positive: 0.; polar: 0.48; backbone: 0.16; hydrophobic: 0.35

PDB: 5dsg

HET: 0hk

ADRB1_MELGA_31_367_TM [text] Beta-1 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily]

volume: 298. Å3; shape: 0.54; buriedness: 0.92

negative: 0.07; positive: 0.; polar: 0.37; backbone: 0.12; hydrophobic: 0.45

Domains/regions: [R] Agonist and antagonist binding

PDB: 2vt4, 2y00, 2y01, 2y02, 2y03, 2y04, 2ycw, 2ycx, 2ycy, 3zpq, 3zpr, 4ami, 4amj, 4bvn, 4gpo, 5a8e, 5f8u

HET: 3wc, 5fw, 68h, cau, cvd, g90, p32, whj, xf5, xtk, y00

ADRB2_HUMAN_26_357_cholesterol [text] Beta-2 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily]

volume: 532. Å3; shape: 0.58; buriedness: 0.54

negative: 0.; positive: 0.09; polar: 0.21; backbone: 0.; hydrophobic: 0.7

PDB: 2r4r, 2r4s, 2rh1, 3d4s, 3kj6, 3ny8, 3ny9, 3nya, 3p0g, 3pds, 3sn6, 4lde, 4ldl, 4ldo, 4qkx, 5d5a, 5d6l, 5jqh

HET: clr

ADRB2_HUMAN_26_357_Galpha [text] Beta-2 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily]

volume: 527. Å3; shape: 0.78; buriedness: 0.56

negative: 0.04; positive: 0.19; polar: 0.15; backbone: 0.45; hydrophobic: 0.17

PDB: 2r4r, 2r4s, 2rh1, 3d4s, 3kj6, 3ny8, 3ny9, 3nya, 3p0g, 3pds, 3sn6, 4lde, 4ldl, 4ldo, 4qkx, 5d5a, 5d6l, 5jqh

ADRB2_HUMAN_26_357_TM [text] Beta-2 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily]

volume: 306. Å3; shape: 0.53; buriedness: 0.94

negative: 0.07; positive: 0.04; polar: 0.38; backbone: 0.1; hydrophobic: 0.42

Domains/regions: [R] Agonist and antagonist binding

PDB: 2r4r, 2r4s, 2rh1, 3d4s, 3kj6, 3ny8, 3ny9, 3nya, 3p0g, 3pds, 3sn6, 4lde, 4ldl, 4ldo, 4qkx, 5d5a, 5d6l, 5jqh

HET: 35v, ale, cau, erc, jrz, jsz, jtz, p0g, tim, xqc

AGTR1_HUMAN_14_317 [text] Type-1 angiotensin II receptor [G-protein coupled receptor 1 family]

volume: 338. Å3; shape: 0.55; buriedness: 0.81

negative: 0.; positive: 0.08; polar: 0.31; backbone: 0.15; hydrophobic: 0.46

PDB: 4yay, 4zud

HET: olm, zd7

CCR5_HUMAN_1_352 [text] C-C chemokine receptor type 5 [G-protein coupled receptor 1 family]

volume: 400. Å3; shape: 0.57; buriedness: 0.82

negative: 0.06; positive: 0.; polar: 0.38; backbone: 0.09; hydrophobic: 0.47

PDB: 4mbs

HET: mrv

CXCR4_HUMAN_1_319_TM [text] C-X-C chemokine receptor type 4 [G-protein coupled receptor 1 family]

volume: 2417. Å3; shape: 0.82; buriedness: 0.71

negative: 0.13; positive: 0.08; polar: 0.13; backbone: 0.35; hydrophobic: 0.31

Domains/regions: [R] Chemokine binding, [R] Chemokine binding, important for signaling and HIV-1 coreceptor activity, [R] Involved in dimerization

PDB: 3odu, 3oe0, 3oe6, 3oe8, 3oe9, 4rws

HET: aln, cir, dpr, itd, ola, olc

DRD3_HUMAN_1_400 [text] D(3) dopamine receptor [G-protein coupled receptor 1 family]

volume: 211. Å3; shape: 0.55; buriedness: 0.96

negative: 0.08; positive: 0.08; polar: 0.25; backbone: 0.17; hydrophobic: 0.42

Domains/regions: [R] Agonist binding

PDB: 3pbl

HET: etq

EDNRB_HUMAN_64_407_TM [text] Endothelin B receptor [G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily]

volume: 1857. Å3; shape: 0.66; buriedness: 0.72

negative: 0.06; positive: 0.13; polar: 0.13; backbone: 0.24; hydrophobic: 0.44

PDB: 5glh, 5gli

FFAR1_HUMAN_1_300 [text] Free fatty acid receptor 1 [G-protein coupled receptor 1 family]

volume: 422. Å3; shape: 0.37; buriedness: 0.64

negative: 0.; positive: 0.11; polar: 0.11; backbone: 0.32; hydrophobic: 0.47

Domains/regions: [R] Agonist binding

PDB: 4phu

HET: 2yb

HRH1_HUMAN_20_487 [text] Histamine H1 receptor [G-protein coupled receptor 1 family]

volume: 200. Å3; shape: 0.79; buriedness: 0.98

negative: 0.07; positive: 0.; polar: 0.4; backbone: 0.2; hydrophobic: 0.33

Domains/regions: [R] Important for agonist binding

PDB: 3rze

HET: 5eh, d7v

LPAR1_HUMAN_1_326 [text] Lysophosphatidic acid receptor 1 [G-protein coupled receptor 1 family]

volume: 433. Å3; shape: 0.57; buriedness: 0.96

negative: 0.09; positive: 0.12; polar: 0.09; backbone: 0.25; hydrophobic: 0.45

Domains/regions: [R] Lysophosphatidic acid binding

PDB: 4z34, 4z35, 4z36

HET: on3, on7, on9

NTR1_RAT_41_396_TM [text] Neurotensin receptor type 1 [G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily]

volume: 759. Å3; shape: 0.69; buriedness: 0.79

negative: 0.03; positive: 0.15; polar: 0.15; backbone: 0.37; hydrophobic: 0.3

Domains/regions: [R] Neurotensin binding

PDB: 3zev, 4buo, 4bv0, 4grv, 4xee, 4xes

OPRD_HUMAN_36_339 [text] Delta-type opioid receptor [G-protein coupled receptor 1 family]

volume: 431. Å3; shape: 0.59; buriedness: 0.69

negative: 0.09; positive: 0.1; polar: 0.16; backbone: 0.; hydrophobic: 0.64

PDB: 4ej4, 4n6h, 4rwa, 4rwd

HET: di7, di8, ej4, nh2

OPRK_HUMAN_55_347_TM [text] Kappa-type opioid receptor [G-protein coupled receptor 1 family]

volume: 369. Å3; shape: 0.69; buriedness: 0.9

negative: 0.05; positive: 0.05; polar: 0.21; backbone: 0.19; hydrophobic: 0.5

PDB: 4djh

HET: jdc

OPRM_MOUSE_52_354 [text] Mu-type opioid receptor [G-protein coupled receptor 1 family]

volume: 354. Å3; shape: 0.87; buriedness: 0.85

negative: 0.11; positive: 0.19; polar: 0.19; backbone: 0.11; hydrophobic: 0.41

PDB: 4dkl, 5c1m

HET: 4vo, bf0

OPRX_HUMAN_40_339 [text] Nociceptin receptor [G-protein coupled receptor 1 family]

volume: 309. Å3; shape: 0.42; buriedness: 0.86

negative: 0.15; positive: 0.; polar: 0.46; backbone: 0.05; hydrophobic: 0.34

PDB: 4ea3, 5dhg, 5dhh

HET: 0nn, dgv, dgw

OPSD_HUMAN_1_348_allosteric [text] Rhodopsin [G-protein coupled receptor 1 family. Opsin subfamily]

volume: 819. Å3; shape: 0.38; buriedness: 0.42

negative: 0.; positive: 0.; polar: 0.05; backbone: 0.57; hydrophobic: 0.38

Domains/regions: [R] Retinal chromophore binding

PDB: 1f88, 1gzm, 1hzx, 1l9h, 1u19, 2g87, 2hpy, 2j4y, 2ped, 2x72, 3c9l, 3c9m, 3cap, 3dqb, 3oax, 3pqr, 3pxo, 4a4m, 4bey, 4bez, 4j4q, 4pxf, 4x1h, 4zwj, 5dys, 5en0

HET: bng, htg, id3, lda

OPSD_HUMAN_1_348_Galpha [text] Rhodopsin [G-protein coupled receptor 1 family. Opsin subfamily]

volume: 1548. Å3; shape: 0.75; buriedness: 0.55

negative: 0.09; positive: 0.11; polar: 0.22; backbone: 0.42; hydrophobic: 0.17

PDB: 1f88, 1gzm, 1hzx, 1l9h, 1u19, 2g87, 2hpy, 2j4y, 2ped, 2x72, 3c9l, 3c9m, 3cap, 3dqb, 3oax, 3pqr, 3pxo, 4a4m, 4bey, 4bez, 4j4q, 4pxf, 4x1h, 4zwj, 5dys, 5en0

HET: bng

OPSD_HUMAN_1_348_TM [text] Rhodopsin [G-protein coupled receptor 1 family. Opsin subfamily]

volume: 351. Å3; shape: 0.51; buriedness: 0.99

negative: 0.05; positive: 0.05; polar: 0.16; backbone: 0.35; hydrophobic: 0.39

Domains/regions: [R] Retinal chromophore binding

PDB: 1f88, 1gzm, 1hzx, 1l9h, 1u19, 2g87, 2hpy, 2j4y, 2ped, 2x72, 3c9l, 3c9m, 3cap, 3dqb, 3oax, 3pqr, 3pxo, 4a4m, 4bey, 4bez, 4j4q, 4pxf, 4x1h, 4zwj, 5dys, 5en0

HET: bng, bog, ret

OPSD_TODPA_3_363 [text] Rhodopsin [G-protein coupled receptor 1 family. Opsin subfamily]

volume: 248. Å3; shape: 0.49; buriedness: 1.

negative: 0.; positive: 0.06; polar: 0.24; backbone: 0.28; hydrophobic: 0.42

PDB: 2z73, 3aym, 3ayn, 4ww3

HET: ret

OX1R_HUMAN_1_380 [text] Orexin receptor type 1 [G-protein coupled receptor 1 family]

volume: 285. Å3; shape: 0.63; buriedness: 0.89

negative: 0.03; positive: 0.07; polar: 0.3; backbone: 0.13; hydrophobic: 0.47

PDB: 4zj8, 4zjc

HET: 4ot, suv

OX2R_HUMAN_2_386 [text] Orexin receptor type 2 [G-protein coupled receptor 1 family]

volume: 266. Å3; shape: 0.69; buriedness: 0.9

negative: 0.08; positive: 0.08; polar: 0.46; backbone: 0.08; hydrophobic: 0.31

PDB: 4s0v

HET: suv

P2RY1_HUMAN_2_373_allosteric [text] P2Y purinoceptor 1 [G-protein coupled receptor 1 family]

volume: 299. Å3; shape: 0.47; buriedness: 0.59

negative: 0.; positive: 0.; polar: 0.16; backbone: 0.38; hydrophobic: 0.46

PDB: 4xnv, 4xnw

HET: bur

P2RY1_HUMAN_2_373_TM [text] P2Y purinoceptor 1 [G-protein coupled receptor 1 family]

volume: 269. Å3; shape: 0.65; buriedness: 0.87

negative: 0.06; positive: 0.18; polar: 0.37; backbone: 0.29; hydrophobic: 0.1

PDB: 4xnv, 4xnw

HET: 2id

P2Y12_HUMAN_1_342 [text] P2Y purinoceptor 12 [G-protein coupled receptor 1 family]

volume: 510. Å3; shape: 0.69; buriedness: 0.97

negative: 0.; positive: 0.13; polar: 0.27; backbone: 0.4; hydrophobic: 0.19

PDB: 4ntj, 4pxz, 4py0

HET: 6ad, 6at, azj

PAR1_HUMAN_84_397 [text] Proteinase-activated receptor 1 [G-protein coupled receptor 1 family]

volume: 406. Å3; shape: 0.51; buriedness: 0.91

negative: 0.; positive: 0.08; polar: 0.24; backbone: 0.28; hydrophobic: 0.4

PDB: 3vw7

HET: vpx

S1PR1_HUMAN_1_327_TM [text] Sphingosine 1-phosphate receptor 1 [G-protein coupled receptor 1 family]

volume: 289. Å3; shape: 0.46; buriedness: 0.96

negative: 0.11; positive: 0.11; polar: 0.19; backbone: 0.11; hydrophobic: 0.47

Domains/regions: [R] Sphingosine 1-phosphate binding

PDB: 3v2w, 3v2y

HET: ml5

US28_HCMVA_1_354_TM [text] G-protein coupled receptor homolog US28 [G-protein coupled receptor 1 family]

volume: 1019. Å3; shape: 0.54; buriedness: 0.57

negative: 0.07; positive: 0.; polar: 0.25; backbone: 0.29; hydrophobic: 0.39

PDB: 4xt1

HET: pca