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7OMT8_MEDSA_1_352 Isoflavone-7-O-methyltransferase 8 [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 196. Å3; shape: 0.42; buriedness: 0.9

negative: 0.; positive: 0.07; polar: 0.27; backbone: 0.27; hydrophobic: 0.4

Domains/regions: [R] Substrate binding

PDB: 1fp2, 1fpx

HET: hmo

ANM3_HUMAN_209_531 Protein arginine N-methyltransferase 3 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family]

volume: 237. Å3; shape: 0.38; buriedness: 0.67

negative: 0.13; positive: 0.19; polar: 0.07; backbone: 0.26; hydrophobic: 0.35

Domains/regions: [D] SAM-dependent MTase PRMT-type

PDB: 1f3l, 2fyt, 3smq, 4hsg, 4qqn, 4ryl

HET: 3bq, 3zg, ktd, tdu

ANM5_HUMAN_2_637 Protein arginine N-methyltransferase 5 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family]

volume: 516. Å3; shape: 0.72; buriedness: 0.88

negative: 0.08; positive: 0.04; polar: 0.24; backbone: 0.32; hydrophobic: 0.32

Domains/regions: [D] SAM-dependent MTase PRMT-type, [R] Beta barrel, [R] S-adenosyl-L-methionine binding

PDB: 4gqb, 4x60, 4x61, 4x63, 5c9z, 5emj, 5emk, 5eml, 5emm, 5fa5

HET: 3xv, 4z2, 5qh, 5qj, 5qk, 5ql, ace

ANM6_HUMAN_5_375 Protein arginine N-methyltransferase 6 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family. PRMT6 subfamily]

volume: 322. Å3; shape: 0.5; buriedness: 0.66

negative: 0.; positive: 0.; polar: 0.11; backbone: 0.55; hydrophobic: 0.34

Domains/regions: [D] SAM-dependent MTase PRMT-type

PDB: 4hc4, 4qpp, 4qqk, 4y2h, 4y30, 5e8r, 5egs, 5hzm, 5wcf

HET: 36s, 5nr

ASMT_HUMAN_1_345 Acetylserotonin O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family]

volume: 144. Å3; shape: 0.59; buriedness: 0.94

negative: 0.08; positive: 0.17; polar: 0.46; backbone: 0.; hydrophobic: 0.29

PDB: 4a6d, 4a6e

HET: ase

CARM1_HUMAN_130_485 Histone-arginine methyltransferase CARM1 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family]

volume: 1674. Å3; shape: 0.73; buriedness: 0.94

negative: 0.08; positive: 0.08; polar: 0.22; backbone: 0.37; hydrophobic: 0.25

Domains/regions: [D] SAM-dependent MTase PRMT-type

PDB: 2v74, 2v7e, 2y1w, 2y1x, 3b3f, 3b3g, 3b3j, 4ikp, 5dwq, 5dx0, 5dx1, 5dx8, 5dxa, 5dxj, 5ih3, 5is6, 5is7, 5is8, 5is9, 5isa, 5isb, 5isc, 5isd, 5ise, 5isf, 5isg, 5ish, 5isi, 5k8v, 5k8w, 5k8x, 5lgp, 5lgq, 5lgr, 5lgs, 5lkj, 5lv2, 5lv3, 5tbh, 5tbi, 5tbj, 5u4x

HET: 4ik, 5n5, 6cx, 6cz, 6d0, 6d1, 6d2, 6d3, 6d4, 6d5, 6d6, 6re, 6yb, 6zh, 765, 78k, 78v, 7vm, 845, 849, ace, dsh, dxe, gjv, lhb, lhd, lhf, lpd, m2m, nmm, pg4, pge, qvr, sah, sao, sfg

CHOMT_MEDSA_1_372 Isoliquiritigenin 2'-O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 194. Å3; shape: 0.44; buriedness: 0.8

negative: 0.; positive: 0.07; polar: 0.13; backbone: 0.; hydrophobic: 0.8

PDB: 1fp1, 1fpq

HET: hcc

COMT1_MEDSA_1_365 Caffeic acid 3-O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 173. Å3; shape: 0.6; buriedness: 0.88

negative: 0.06; positive: 0.11; polar: 0.11; backbone: 0.; hydrophobic: 0.72

Domains/regions: [R] Substrate binding

PDB: 1kyw, 1kyz

HET: fer, hfl

COMT_HUMAN_51_267 Catechol O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family]

volume: 274. Å3; shape: 0.63; buriedness: 0.76

negative: 0.21; positive: 0.09; polar: 0.09; backbone: 0.2; hydrophobic: 0.41

PDB: 3a7e, 3bwm, 3bwy, 4pyi, 4pyj, 4pyk, 4xuc, 4xud, 4xue, 5lsa

HET: 43g, 43h, 43j, dnc

COMT_MOUSE_44_264 Catechol O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family]

volume: 674. Å3; shape: 0.36; buriedness: 0.8

negative: 0.12; positive: 0.09; polar: 0.12; backbone: 0.41; hydrophobic: 0.27

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 1h1d, 1jr4, 1vid, 2cl5, 2zlb, 2zth, 2zvj, 3a7d, 3hvh, 3hvi, 3hvj, 3hvk, 3nw9, 3nwb, 3nwe, 3oe4, 3oe5, 3ozr, 3ozs, 3ozt, 3r6t, 3s68, 3u81, 4p58, 4p7f, 4p7g, 4p7j, 4p7k, 4pyl, 4pym, 4pyn, 4pyo, 4pyq, 5fhq, 5fhr, 5k01, 5k03, 5k05, 5k0b, 5k0c, 5k0e, 5k0f, 5k0g, 5k0j, 5k0l, 5k0n, 5lqa, 5lqc, 5lqj, 5lqk, 5lqn, 5lqr, 5lqu, 5lr6, 5p8w, 5p8x, 5p8y, 5p8z, 5p90, 5p91, 5p92, 5p93, 5p94, 5p95, 5p96, 5p97, 5p98, 5p99, 5p9a, 5p9b, 5p9c, 5p9d, 5p9e, 5p9n, 5p9o, 5p9p, 5p9q, 5p9r, 5p9s, 5p9t, 5p9u, 5p9v, 5p9w, 5p9x, 5p9y, 5p9z, 5pa0, 5pa1, 5pa2, 5pa3, 5pa4, 5pa5, 5pa6, 5pa7

HET: 2f6, 2x1, 542, 610, 611, 619, 637, 659, 662, 6ow, 6oz, 6p0, 6p1, 6p2, 6p4, 6p5, 6pm, 6ps, 705, 719, 72m, 72o, 72w, 731, 75z, 763, 766, 769, 76b, 76g, 76s, 76t, 77g, 77h, 77k, 77l, 77m, 77n, 77p, 77q, 77r, 77s, 7jd, 7je, 7jf, 7jg, 7jh, 7jj, 7jk, 7jl, 7jm, 7jn, 7jo, 7jp, 7jq, 7jr, 7js, 7ju, 7jv, 7jw, 7jx, 8je, bia, bie, cl4, d1d, dnc, dtd, fbn, k, kom, lu1, mg, nhe, o01, ozr, ozs, ozz, sah, sam, sfg, tcw

DNMT1_HUMAN_1129_1600_catalytic DNA (cytosine-5)-methyltransferase 1 [Class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family]

volume: 283. Å3; shape: 0.42; buriedness: 0.88

negative: 0.07; positive: 0.; polar: 0.04; backbone: 0.53; hydrophobic: 0.36

Domains/regions: [D] SAM-dependent MTase C5-type, [R] Catalytic, [R] S-adenosyl-L-methionine binding

PDB: 3swr, 4wxx, 4yoc

HET: sah, sfg

DNMT1_MOUSE_730_1609 DNA (cytosine-5)-methyltransferase 1 [Class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family]

volume: 569. Å3; shape: 0.54; buriedness: 0.89

negative: 0.09; positive: 0.06; polar: 0.06; backbone: 0.49; hydrophobic: 0.29

Domains/regions: [D] SAM-dependent MTase C5-type, [R] Catalytic, [R] S-adenosyl-L-methionine binding

PDB: 3av4, 3av5, 3av6, 3pt6, 3pt9, 4da4, 5gut, 5guv, 5wy1

HET: c49, sah, sam

DNRK_STRPE_3_355 Carminomycin 4-O-methyltransferase DnrK [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family]

volume: 763. Å3; shape: 0.5; buriedness: 0.92

negative: 0.08; positive: 0.07; polar: 0.12; backbone: 0.3; hydrophobic: 0.44

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 1tw2, 1tw3, 4wxh, 5eeg, 5eeh, 5jr3

HET: 3vl, 4mu, ert, p9p, s8m, sah

DOT1L_HUMAN_1_334 Histone-lysine N-methyltransferase, H3 lysine-79 specific [Class I-like SAM-binding methyltransferase superfamily. DOT1 family]

volume: 743. Å3; shape: 0.45; buriedness: 0.89

negative: 0.09; positive: 0.03; polar: 0.14; backbone: 0.49; hydrophobic: 0.26

Domains/regions: [D] DOT1, [R] S-adenosyl-L-methionine binding

PDB: 1nw3, 3qow, 3qox, 3sr4, 3sx0, 3uwp, 4ek9, 4ekg, 4eki, 4eqz, 4er0, 4er3, 4er5, 4er6, 4er7, 4hra, 4wvl, 5drt, 5dry, 5dsx, 5dt2, 5dtm, 5dtq, 5dtr, 5juw, 5mvs, 5mw3, 5mw4

HET: 0qj, 0qk, 3us, 5eg, 5ek, 5ev, 5ew, 5f4, 5f6, 5f7, 5id, 5jj, 5jt, 5ju, 6nr, adn, aw0, aw1, aw2, aw3, ep4, ep6, sah, sam, sx0, tt8

GNMT_HUMAN_2_295 Glycine N-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family]

volume: 508. Å3; shape: 0.38; buriedness: 0.48

negative: 0.; positive: 0.37; polar: 0.18; backbone: 0.; hydrophobic: 0.44

PDB: 1bhj, 1d2c, 1d2g, 1d2h, 1kia, 1nbh, 1nbi, 1r74, 1xva, 2azt, 2idj, 2idk, 3thr, 3ths

HET: 03o, c2f, ggl

HNMT_HUMAN_1_292 Histamine N-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. HNMT family]

volume: 672. Å3; shape: 0.72; buriedness: 0.88

negative: 0.13; positive: 0.; polar: 0.27; backbone: 0.24; hydrophobic: 0.37

PDB: 1jqd, 1jqe, 2aot, 2aou, 2aov, 2aow, 2aox

HET: 2pm, 4di, c2m, cqa, hsm, qun, sah, tha

I4OMT_MEDTR_8_364 Isoflavone 4'-O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 205. Å3; shape: 0.56; buriedness: 0.86

negative: 0.; positive: 0.; polar: 0.16; backbone: 0.16; hydrophobic: 0.67

PDB: 1zg3, 1zga, 1zgj, 1zhf

HET: 2hi, hmk, p1s

IEMT_CLABR_1_368 (Iso)eugenol O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 187. Å3; shape: 0.76; buriedness: 0.98

negative: 0.06; positive: 0.06; polar: 0.12; backbone: 0.12; hydrophobic: 0.64

PDB: 3reo, 3tky, 5cvj, 5cvu, 5cvv

HET: 55b, eug, n7i

MCE_VACCW_1_302 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family]

volume: 259. Å3; shape: 0.67; buriedness: 0.65

negative: 0.34; positive: 0.; polar: 0.19; backbone: 0.18; hydrophobic: 0.3

Domains/regions: [R] Binding to NPH-I, [R] Binding to Rap94, [R] mRNA cap binding

PDB: 1av6, 1b42, 1bky, 1eam, 1eqa, 1jsz, 1jte, 1jtf, 1p39, 1v39, 1vp3, 1vp9, 1vpt, 2ga9, 2gaf, 2vp3, 3er8, 3er9, 3erc, 3mag, 3mct, 4dcg

HET: 1mc, 3ma, 3mc, m1a, m7g, mg7, mgt, ndm

MMCR_STRLA_2_349 Mitomycin biosynthesis 6-O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family. COMT subfamily]

volume: 209. Å3; shape: 0.79; buriedness: 0.89

negative: 0.17; positive: 0.16; polar: 0.09; backbone: 0.18; hydrophobic: 0.4

PDB: 3gwz, 3gxo

HET: mqa

MTH1_HAEPH_1_327 Modification methylase HhaI [Class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family]

volume: 706. Å3; shape: 0.59; buriedness: 0.9

negative: 0.07; positive: 0.04; polar: 0.16; backbone: 0.51; hydrophobic: 0.21

Domains/regions: [D] SAM-dependent MTase C5-type

PDB: 10mh, 1fjx, 1hmy, 1m0e, 1mht, 1skm, 1svu, 2c7o, 2c7p, 2c7q, 2c7r, 2hmy, 2hr1, 2i9k, 2uyc, 2uyh, 2uz4, 2z6a, 2z6q, 2z6u, 2zcj, 3eeo, 3mht, 4mht, 5ciy, 5lod, 5mht, 6mht, 7mht, 8mht, 9mht

HET: 4sc, 5cm, sah, sam

NCSB1_STRCZ_1_332 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family]

volume: 141. Å3; shape: 0.86; buriedness: 0.88

negative: 0.; positive: 0.21; polar: 0.09; backbone: 0.; hydrophobic: 0.7

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 3i53, 3i58, 3i5u, 3i64

HET: 5na, 7na, dna

PNMT_HUMAN_1_282 Phenylethanolamine N-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family]

volume: 283. Å3; shape: 0.46; buriedness: 0.99

negative: 0.13; positive: 0.12; polar: 0.26; backbone: 0.12; hydrophobic: 0.38

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 1hnn, 1n7i, 1n7j, 1yz3, 2an3, 2an4, 2an5, 2g70, 2g71, 2g72, 2g8n, 2obf, 2ony, 2onz, 2opb, 3hca, 3hcb, 3hcc, 3hcd, 3hce, 3hcf, 3kpj, 3kpu, 3kpv, 3kpw, 3kpy, 3kqm, 3kqo, 3kqp, 3kqq, 3kqs, 3kqt, 3kqv, 3kqw, 3kqy, 3kr0, 3kr1, 3kr2, 4dm3, 4mik, 4mq4

HET: 172, 1sq, 2d5, ade, ax7, ctl, es0, es1, es2, es3, es4, es5, es6, es7, es9, et2, f21, f83, fan, fts, hnt, idi, jil, lnr, lt2, lt3, lt5, ly1, otr, rco, sah, sam, ska, skf, tmj, ttl, vgd

RDMB_STREF_6_374 Aclacinomycin 10-hydroxylase RdmB [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family]

volume: 297. Å3; shape: 0.44; buriedness: 0.88

negative: 0.1; positive: 0.; polar: 0.13; backbone: 0.46; hydrophobic: 0.32

Domains/regions: [R] S-adenosyl-L-methionine binding

PDB: 1qzz, 1r00, 1xds, 1xdu

HET: act, sah, sam, sfg

TCMN_STRGA_2_166 Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN [Class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family]

volume: 221. Å3; shape: 0.53; buriedness: 0.83

negative: 0.11; positive: 0.21; polar: 0.; backbone: 0.21; hydrophobic: 0.47

PDB: 2rer, 2res, 2rez, 3tvq

HET: dqh

TPMT_MOUSE_2_240 Thiopurine S-methyltransferase [Class I-like SAM-binding methyltransferase superfamily. TPMT family]

volume: 87. Å3; shape: 0.91; buriedness: 0.89

negative: 0.; positive: 0.12; polar: 0.; backbone: 0.48; hydrophobic: 0.39

PDB: 2gb4, 3bgd, 3bgi

HET: pm6