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ZAP70_HUMAN_327_607

Tyrosine-protein kinase ZAP-70 [Protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (ZAP70_HUMAN):D: Protein kinase (344:349, 352, 367, 369, 399, 414:418, 420, 421, 461, 465, 466, 468, 478, 479, 482)344:349, 352, 367, 369, 399, 414:418, 420, 421, 461, 465, 466, 468, 478, 479, 482
Metals (Me):Mg

Full PDB list

1u59, 2ozo, 4k2r (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 Me
L
3
4
4
G
3
4
5
C
3
4
6
G
3
4
7
N
3
4
8
F
3
4
9
V
3
5
2
A
3
6
7
K
3
6
9
V
3
9
9
M
4
1
4
E
4
1
5
M
4
1
6
A
4
1
7
G
4
2
0
P
4
2
1
R
4
6
5
N
4
6
6
L
4
6
8
S
4
7
8
D
4
7
9
[1]1u59.a stu35 . . . . . . . . . . . . . . . . . . . . .
[1]2ozo.a anp31 . . . . . . . . . . . . . . . . . . . . . Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 Me
L
3
4
4
G
3
4
5
C
3
4
6
G
3
4
7
N
3
4
8
F
3
4
9
V
3
5
2
A
3
6
7
K
3
6
9
V
3
9
9
M
4
1
4
E
4
1
5
M
4
1
6
A
4
1
7
G
4
1
8
G
4
2
0
P
4
2
1
D
4
6
1
R
4
6
5
N
4
6
6
L
4
6
8
S
4
7
8
D
4
7
9
L
4
8
2
[1]1u59.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]2ozo.a . . . . . . . . * . . . . . . . . N . . . . . . Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1u59.a:stu
2ozo.a:anp
[1] 1u59.a
0
0.5
[1] 2ozo.a 2.4
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1u59.a
2ozo.a
[1] 1u59.a
0
.11
[1] 2ozo.a .11
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1u59.a
2ozo.a
[1] 1u59.a
0
2.0
[1] 2ozo.a 2.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1u59.a
2ozo.a
[1] 1u59.a
0
2.4
[1] 2ozo.a 2.4
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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