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ZAP70_HUMAN_2_258

Tyrosine-protein kinase ZAP-70 [Protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily]

Composition of the binding site

Protein chains monomer
A1 (ZAP70_HUMAN):117, 118, 121, 122, 160, 161

Full PDB list

2oq1, 4xz0, 4xz1 (Pocketome entry); 1m61, 2ozo, 4k2r (unprocessed)

Pocket contact map

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PDB.ch
   
ligand
A1
C
1
1
7
A
1
2
1
M
1
2
2
M
1
6
1
[1]4xz0.a 4n514 * . . .
[1]4xz1.a none S . . .
[2]2oq1.a none . . * *

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
C
1
1
7
L
1
1
8
A
1
2
1
M
1
2
2
R
1
6
0
M
1
6
1
[1]4xz0.a * . . . . .
[1]4xz1.a S . . . . .
[2]2oq1.a . . . * * *

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4xz0.a:4n5
4xz1.a is apo
2oq1.a is apo
[1] 4xz0.a
0.4
- -
[1] 4xz1.a 0.4
-
-
[2] 2oq1.a 2.0 -
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4xz0.a
4xz1.a
2oq1.a
[1] 4xz0.a
0
.13 .40
[1] 4xz1.a .13
0
.30
[2] 2oq1.a .40 .30
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4xz0.a
4xz1.a
2oq1.a
[1] 4xz0.a
0
1.5 1.8
[1] 4xz1.a 1.5
0
1.0
[2] 2oq1.a 1.8 1.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4xz0.a
4xz1.a
2oq1.a
[1] 4xz0.a
0
2.6 3.6
[1] 4xz1.a 2.6
0
1.7
[2] 2oq1.a 3.6 1.7
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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