WNK1_HUMAN_199_482

Serine/threonine-protein kinase WNK1 [Protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (WNK1_HUMAN):D: Protein kinase (227:231,233,235,248,250,252,265,268,269,271,272,275,281,283,299,301:304,308,345,351,354,356,367:370,372,374)227:231,233,235,248,250,252,265,268,269,271,272,275,281,283,299,301:304,308,345,351,354,356,367:370,372,374

Full PDB list

3fpq,4pwn,4q2a,5drb,5tf9 (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
I
2
2
7
G
2
2
8
R
2
2
9
G
2
3
0
S
2
3
1
K
2
3
3
V
2
3
5
A
2
4
8
C
2
5
0
L
2
5
2
F
2
6
5
E
2
6
8
A
2
6
9
M
2
7
1
L
2
7
2
L
2
7
5
V
2
8
1
F
2
8
3
L
2
9
9
T
3
0
1
E
3
0
2
L
3
0
3
M
3
0
4
T
3
0
8
I
3
4
5
K
3
5
1
N
3
5
4
F
3
5
6
G
3
6
7
D
3
6
8
L
3
6
9
G
3
7
0
A
3
7
2
L
3
7
4
[3]5drb.a 5fj 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]5tf9.a 7av,anp,mn 65 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]5tf9.b 7av,anp 64 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3fpq.b none . . . . . . . . . . . . . * . . . . . . . . * . . . . . . . . . . .
[1]4q2a.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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