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TYRO3_HUMAN_494_810

Tyrosine-protein kinase receptor TYRO3 [Protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (TYRO3_HUMAN):D: Protein kinase (524, 525, 529, 532, 548, 550, 581, 603:610, 659, 660, 662, 672, 673)524, 525, 529, 532, 548, 550, 581, 603:610, 659, 660, 662, 672, 673

Full PDB list

3qup, 4feq, 4ff8

Pocket contact map

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PDB.ch
   
ligand
A1
L
5
2
4
G
5
2
5
F
5
2
9
V
5
3
2
A
5
4
8
K
5
5
0
A
5
8
1
L
6
0
3
P
6
0
4
F
6
0
5
M
6
0
6
K
6
0
7
H
6
0
8
G
6
0
9
D
6
1
0
R
6
5
9
M
6
6
2
A
6
7
2
D
6
7
3
[1]3qup.a lun31 . . . . . . . . . . . . . . . . . . .
[1]4feq.a 0t833 . . - . . . . . . . . . . . . . . . .
[1]4ff8.a 14s34 - - - - - - . . . . . . . . . . . . -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
L
5
2
4
G
5
2
5
F
5
2
9
V
5
3
2
A
5
4
8
K
5
5
0
A
5
8
1
L
6
0
3
P
6
0
4
F
6
0
5
M
6
0
6
K
6
0
7
H
6
0
8
G
6
0
9
D
6
1
0
R
6
5
9
N
6
6
0
M
6
6
2
A
6
7
2
D
6
7
3
[1]3qup.a . . . . . . . . . . . . . . . . . . . *
[1]4feq.a . . - . . . . . . . . . . . . . . . . .
[1]4ff8.a - - - - - - . . . . . . . . . . . . . -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3qup.a:lun
4feq.a:0t8
4ff8.a:14s
[1] 3qup.a
0
1.6 1.1
[1] 4feq.a 0.7
0
0.7
[1] 4ff8.a 0.1 0.4
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3qup.a
4feq.a
4ff8.a
[1] 3qup.a
0
.15 .16
[1] 4feq.a .15
0
.05
[1] 4ff8.a .16 .05
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3qup.a
4feq.a
4ff8.a
[1] 3qup.a
0
0.8 0.9
[1] 4feq.a 0.8
0
0.8
[1] 4ff8.a 0.9 0.8
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3qup.a
4feq.a
4ff8.a
[1] 3qup.a
0
1.1 1.2
[1] 4feq.a 1.1
0
1.1
[1] 4ff8.a 1.2 1.1
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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