TYK2_HUMAN_880_1178

Non-receptor tyrosine-protein kinase TYK2 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (TYK2_HUMAN):D: Protein kinase 2 (901,903:906,908:911,928,930,960,962,976,978:985,1027,1028,1030,1040:1043)901,903:906,908:911,928,930,960,962,976,978:985,1027,1028,1030,1040:1043

Full PDB list

3lxn,3lxp,3nyx,3nz0,4gfo,4gih,4gii,4gj2,4gj3,4gvj,4oli,4py1,5f1z,5f20

Contact map

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ligand
A1
R
9
0
1
L
9
0
3
G
9
0
4
E
9
0
5
G
9
0
6
F
9
0
8
G
9
0
9
K
9
1
0
V
9
1
1
A
9
2
8
K
9
3
0
I
9
6
0
Y
9
6
2
L
9
7
6
M
9
7
8
E
9
7
9
Y
9
8
0
V
9
8
1
P
9
8
2
L
9
8
3
G
9
8
4
S
9
8
5
R
1
0
2
7
N
1
0
2
8
L
1
0
3
0
G
1
0
4
0
D
1
0
4
1
F
1
0
4
2
G
1
0
4
3
[1]4gj3.a 0xp 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4py1.a 2yk 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5f1z.a 5u3 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4gii.a 0x6 25 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]3nyx.a tz1 25 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4gj2.a 0xh 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5f20.a 5u4 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4oli.a 2tt 22 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4gih.a 0x5 23 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4gfo.a 0x2 18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3lxp.a iza 23 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3lxn.a mi1 23 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4gvj.a adp,mg,mg 29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3nz0.a iza 23 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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