TYK2_HUMAN_562_880

Non-receptor tyrosine-protein kinase TYK2 [Protein kinase superfamily. Tyr protein kinase family. JAK subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (TYK2_HUMAN):D: Protein kinase 1 (595:599,601,603,640,642,687:694,697,734,738,739,741,758,760,761)595:599,601,603,640,642,687:694,697,734,738,739,741,758,760,761

Full PDB list

3zon,4oli,4wov,5c01,5c03

Contact map

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ligand
A1
L
5
9
5
G
5
9
6
Q
5
9
7
G
5
9
8
T
5
9
9
T
6
0
1
V
6
0
3
V
6
4
0
K
6
4
2
T
6
8
7
E
6
8
8
Y
6
8
9
V
6
9
0
E
6
9
1
H
6
9
2
G
6
9
3
P
6
9
4
V
6
9
7
N
7
3
4
R
7
3
8
N
7
3
9
L
7
4
1
S
7
5
8
P
7
6
0
G
7
6
1
[1]4wov.a 3sm 28 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4oli.a 2tt 22 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3zon.a ik1 18 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5c01.b unl 30 . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5c03.a ags,mg 32 . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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