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TIE2_HUMAN_806_1124

Angiopoietin-1 receptor [Protein kinase superfamily. Tyr protein kinase family. Tie subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (TIE2_HUMAN):D: Protein kinase (830:838, 853:855, 857, 871:873, 875:877, 879, 885, 886, 888, 900, 902:906, 908, 909, 955, 960, 962, 963, 968:971, 980:987)830:838, 853:855, 857, 871:873, 875:877, 879, 885, 886, 888, 900, 902:906, 908, 909, 955, 960, 962, 963, 968:971, 980:987

Full PDB list

1fvr, 2oo8, 2osc, 2p4i, 2wqb, 3l8p, 4x3j

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
8
3
0
G
8
3
1
E
8
3
2
G
8
3
3
V
8
3
8
A
8
5
3
I
8
5
4
K
8
5
5
E
8
7
2
V
8
7
5
L
8
7
6
L
8
7
9
I
8
8
6
L
9
0
0
I
9
0
2
E
9
0
3
Y
9
0
4
A
9
0
5
G
9
0
8
L
9
5
5
F
9
6
0
H
9
6
2
R
9
6
8
N
9
6
9
L
9
7
1
I
9
8
0
A
9
8
1
D
9
8
2
F
9
8
3
R
9
8
7
[1]2oo8.x raj39 - - - - . . . . . . . . . . . . . . . . . . . . . . . . . -
[1]2osc.a muh33 - - - - . . . . . . . . . . . . . . . . . . . . . . . . . -
[1]2p4i.a mr941 - - - - . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2wqb.a qq128 . . . . . . . . - . . . . . . . . . . . . . . . . . . . . .
[1]3l8p.a 0ce34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4x3j.a 3wr33 - - - - . . . . . . . . . . . . . . . . . . . . . . . . . -
[2]1fvr.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
8
3
0
G
8
3
1
E
8
3
2
G
8
3
3
N
8
3
4
F
8
3
5
G
8
3
6
Q
8
3
7
V
8
3
8
A
8
5
3
I
8
5
4
K
8
5
5
M
8
5
7
G
8
7
1
E
8
7
2
L
8
7
3
V
8
7
5
L
8
7
6
C
8
7
7
L
8
7
9
I
8
8
5
I
8
8
6
L
8
8
8
L
9
0
0
I
9
0
2
E
9
0
3
Y
9
0
4
A
9
0
5
P
9
0
6
G
9
0
8
N
9
0
9
L
9
5
5
F
9
6
0
H
9
6
2
R
9
6
3
R
9
6
8
N
9
6
9
I
9
7
0
L
9
7
1
I
9
8
0
A
9
8
1
D
9
8
2
F
9
8
3
G
9
8
4
L
9
8
5
S
9
8
6
R
9
8
7
[1]2oo8.x - - - - - - . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . . . * . . - -
[1]2osc.a - - - - - - - . . . . . . . * . . * . . . . . . . . . . . . . . . . . . . . . . . . * . . - -
[1]2p4i.a - - - - - - - - . . . . - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . . . .
[1]2wqb.a . . . . - - . . . . . . . - - . . . . . . . . . . . . . . . . . . . . . . . . . * * * * . . .
[1]3l8p.a . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . . . .
[1]4x3j.a - - - - - - - - . . . . - - * . . * . . . . . . * . . . . . . . . . . . . . . . . . * . - - -
[2]1fvr.a . * * * . * * . * . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * * * . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2oo8.x:raj
2osc.a:muh
2p4i.a:mr9
2wqb.a:qq1
3l8p.a:0ce
4x3j.a:3wr
1fvr.a is apo
[1] 2oo8.x
0
0 2.2 4.3 6.0 0.6 -
[1] 2osc.a 0
0
1.9 4.8 5.6 0.3 -
[1] 2p4i.a 1.7 0
0
3.6 4.5 0.3 -
[1] 2wqb.a 12 10 9.6
0
3.4 11 -
[1] 3l8p.a 6.1 5.8 5.4 2.2
0
4.8 -
[1] 4x3j.a 0.7 0.7 2.9 5.8 5.7
0
-
[2] 1fvr.a 16 15 17 12 16 15
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2oo8.x
2osc.a
2p4i.a
2wqb.a
3l8p.a
4x3j.a
1fvr.a
[1] 2oo8.x
0
.02 .11 .26 .16 .05 .56
[1] 2osc.a .02
0
.10 .24 .14 .05 .55
[1] 2p4i.a .11 .10
0
.20 .13 .14 .50
[1] 2wqb.a .26 .24 .20
0
.23 .27 .47
[1] 3l8p.a .16 .14 .13 .23
0
.15 .55
[1] 4x3j.a .05 .05 .14 .27 .15
0
.58
[2] 1fvr.a .56 .55 .50 .47 .55 .58
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 3.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2oo8.x
2osc.a
2p4i.a
2wqb.a
3l8p.a
4x3j.a
1fvr.a
[1] 2oo8.x
0
0.4 1.9 3.8 4.1 1.2 3.4
[1] 2osc.a 0.4
0
1.8 3.8 4.0 1.2 3.2
[1] 2p4i.a 1.9 1.8
0
4.0 3.8 1.6 3.3
[1] 2wqb.a 3.8 3.8 4.0
0
2.4 3.3 3.0
[1] 3l8p.a 4.1 4.0 3.8 2.4
0
3.4 2.5
[1] 4x3j.a 1.2 1.2 1.6 3.3 3.4
0
3.0
[2] 1fvr.a 3.4 3.2 3.3 3.0 2.5 3.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 3.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2oo8.x
2osc.a
2p4i.a
2wqb.a
3l8p.a
4x3j.a
1fvr.a
[1] 2oo8.x
0
0.6 1.7 3.8 4.1 1.5 3.5
[1] 2osc.a 0.6
0
1.6 3.8 4.1 1.5 3.5
[1] 2p4i.a 1.7 1.6
0
4.2 4.1 1.8 3.7
[1] 2wqb.a 3.8 3.8 4.2
0
2.9 3.4 3.4
[1] 3l8p.a 4.1 4.1 4.1 2.9
0
3.5 3.5
[1] 4x3j.a 1.5 1.5 1.8 3.4 3.5
0
3.3
[2] 1fvr.a 3.5 3.5 3.7 3.4 3.5 3.3
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

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