THB_HUMAN_205_461_ligBind

Thyroid hormone receptor beta [Nuclear hormone receptor family. NR1 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (THB_HUMAN):R: Interaction with NR2F6 (269,272,273,275,276,279,282,310,313,314,316,317,320,330,331,341,344:346,353,435,438,439,442,451,455,459)
R: Ligand-binding (269,272,273,275,276,279,282,310,313,314,316,317,320,330,331,341,344:346,353,435,438,439,442,451,455,459)
269,272,273,275,276,279,282,310,313,314,316,317,320,330,331,341,344:346,353,435,438,439,442,451,455,459

Full PDB list

1n46,1nax,1nq0,1nq1,1nq2,1nuo,1q4x,1r6g,1xzx,1y0x,2j4a,2pin,3d57,3gws,3imy,3jzc,4zo1 (redundant pocketome entry)

Contact map

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ligand
A1
F
2
6
9
F
2
7
2
T
2
7
3
I
2
7
5
I
2
7
6
A
2
7
9
R
2
8
2
M
3
1
0
M
3
1
3
S
3
1
4
R
3
1
6
A
3
1
7
R
3
2
0
L
3
3
0
N
3
3
1
L
3
4
1
G
3
4
4
G
3
4
5
L
3
4
6
I
3
5
3
H
4
3
5
R
4
3
8
F
4
3
9
M
4
4
2
F
4
5
1
F
4
5
5
F
4
5
9
[1]1r6g.a 442 31 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1n46.a pfa 27 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2j4a.a oef 24 . . . . . . . . . . . . . . S . . . . . . . . . . . .
[1]1q4x.a g24 28 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1nax.a ih5 23 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3imy.a b72 24 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1y0x.x t44 24 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4zo1.x t3 23 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1nq2.a 4hy 21 . . . . . . . . . . . T . . . . . . . . . . . . . . .
[1]1nuo.a 4hy 21 . . . . . . . . . . H . . . . . . . . . . . . . . . .
[1]3d57.a 4hy 21 . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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