THB_HUMAN_205_461_allosteric

Thyroid hormone receptor beta [Nuclear hormone receptor family. NR1 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (THB_HUMAN):R: Interaction with NR2F6 (281,284,288,301,302,306,453,454,457,458)
R: Ligand-binding (281,284,288,301,302,306,453,454,457,458)
281,284,288,301,302,306,453,454,457,458

Full PDB list

1n46,1nax,1nq0,1nq1,1nq2,1nuo,1q4x,1r6g,1xzx,1y0x,2j4a,2pin,3d57,3gws,3imy,3jzc,4zo1 (redundant pocketome entry)

Contact map

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ligand
A1
T
2
8
1
V
2
8
4
K
2
8
8
Q
3
0
1
I
3
0
2
K
3
0
6
P
4
5
3
L
4
5
4
E
4
5
7
V
4
5
8
[1]2pin.a leg 16 . . . . . . . . . .
[1]1n46.a none . . . . . . . . . .
[1]4zo1.x HKILHRLL 60 . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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