THA_HUMAN_148_375

Thyroid hormone receptor alpha [Nuclear hormone receptor family. NR1 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (THA_HUMAN):R: Ligand-binding (215,218,219,221,222,225,228,256,259,260,262,263,266,276:278,287,290:292,299)
381,388,401
215,218,219,221,222,225,228,256,259,260,262,263,266,276:278,287,290:292,299,381,388,401

Full PDB list

1nav,2h77,2h79,3hzf,3ilz,3jzb,4lnw,4lnx (redundant pocketome entry)

Contact map

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ligand
A1
F
2
1
5
F
2
1
8
T
2
1
9
I
2
2
1
I
2
2
2
A
2
2
5
R
2
2
8
M
2
5
6
M
2
5
9
S
2
6
0
R
2
6
2
A
2
6
3
R
2
6
6
L
2
7
6
S
2
7
7
G
2
7
8
L
2
8
7
G
2
9
0
G
2
9
1
L
2
9
2
I
2
9
9
H
3
8
1
M
3
8
8
F
4
0
1
[1]1nav.a ih5 23 . . . . . . . . . . . . . . . . . . . . . . . .
[1]3jzb.a 4hy 21 . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ilz.a b72 24 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2h79.a t3 23 . . . . . . . . . . . . . . . . . . . . . . * .
[1]4lnw.a t3 23 . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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