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TGFR1_HUMAN_199_503

TGF-beta receptor type-1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (TGFR1_HUMAN):D: Protein kinase (211:216, 219, 230:232, 245, 249, 260, 262, 278:287, 290, 335, 337, 338, 340, 350, 351)211:216, 219, 230:232, 245, 249, 260, 262, 278:287, 290, 335, 337, 338, 340, 350, 351

Full PDB list

1b6c, 1ias, 1py5, 1rw8, 1vjy, 2wot, 2wou, 3faa, 3gxl, 3hmm, 3kcf, 3tzm, 4x0m, 4x2f, 4x2g, 4x2j, 4x2k, 4x2n, 5e8s, 5e8t, 5e8u, 5e8w, 5e8x, 5e8z, 5e90, 5fri, 5usq, 6b8y (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
2
1
1
G
2
1
2
K
2
1
3
G
2
1
4
R
2
1
5
F
2
1
6
V
2
1
9
A
2
3
0
V
2
3
1
K
2
3
2
E
2
4
5
Y
2
4
9
L
2
6
0
F
2
6
2
L
2
7
8
V
2
7
9
S
2
8
0
D
2
8
1
Y
2
8
2
H
2
8
3
E
2
8
4
G
2
8
6
S
2
8
7
D
2
9
0
K
3
3
5
K
3
3
7
N
3
3
8
L
3
4
0
A
3
5
0
D
3
5
1
[1]1py5.a py121 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1rw8.a 58022 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1vjy.a 46022 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2wot.a zzg34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2wou.a zzf26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3faa.c 55f27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3gxl.a qig27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3hmm.a 85524 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3kcf.c jzo27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3tzm.a 08529 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4x0m.a 3wa12 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4x2f.a 3wj19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4x2g.a 3wk19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4x2j.a 3wn19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4x2k.a 3wo19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5e8t.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5e8u.a none V . . . . . . . . . . F . . . . T . F . . . N . . . . . C .
[1]5e8w.a stu35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5e8x.a stu35 V . . . . . . . . . . F . . . . T . F . . . N . . . . . C .
[1]5e8z.a 5l431 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5e90.a 5l431 V . . . . . . . . . . F . . . . T . F . . . N . . . . . C .
[1]5fri.a zuq23 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5usq.a 8ly31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]6b8y.a d0a27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
2
1
1
G
2
1
2
K
2
1
3
G
2
1
4
R
2
1
5
F
2
1
6
V
2
1
9
A
2
3
0
V
2
3
1
K
2
3
2
E
2
4
5
Y
2
4
9
L
2
6
0
F
2
6
2
L
2
7
8
V
2
7
9
S
2
8
0
D
2
8
1
Y
2
8
2
H
2
8
3
E
2
8
4
H
2
8
5
G
2
8
6
S
2
8
7
D
2
9
0
K
3
3
5
K
3
3
7
N
3
3
8
L
3
4
0
A
3
5
0
D
3
5
1
[1]1py5.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]1rw8.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1vjy.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]2wot.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2wou.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]3faa.c . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3gxl.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3hmm.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3kcf.c . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3tzm.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4x0m.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]4x2f.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]4x2g.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]4x2j.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]4x2k.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]5e8t.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]5e8u.a V . . . . . . . . . . F . . . . T . F . . . . N . . . . . C .
[1]5e8w.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5e8x.a V . . . . . . . . . . F . . * . T . F . . . . N . . . . . C .
[1]5e8z.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5e90.a V . . . . . . . . . . F . . . . T . F . . . . N . . . . . C .
[1]5fri.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]5usq.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]6b8y.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1py5.a:py1
1rw8.a:580
1vjy.a:460
2wot.a:zzg
2wou.a:zzf
3faa.c:55f
3gxl.a:qig
3hmm.a:855
3kcf.c:jzo
3tzm.a:085
4x0m.a:3wa
4x2f.a:3wj
4x2g.a:3wk
4x2j.a:3wn
4x2k.a:3wo
5e8t.a is apo
5e8u.a is apo
5e8w.a:stu
5e8x.a:stu
5e8z.a:5l4
5e90.a:5l4
5fri.a:zuq
5usq.a:8ly
6b8y.a:d0a
[1] 1py5.a
0
1.0 0.6 1.9 1.1 0.7 1.4 1.3 1.6 1.0 0 0.6 0.4 0 0 - - 0.8 1.0 0.7 0.7 0.5 1.2 1.8
[1] 1rw8.a 0.1
0
0.2 0.1 0.2 0.9 0.7 0.2 0.9 0.7 0 0.4 0.6 0.1 0.1 - - 0.7 0.7 0.2 0.4 0.2 0.6 0.3
[1] 1vjy.a 0.1 0.6
0
0.7 0.7 0.5 1.2 0.6 1.5 1.0 0 0.4 0.5 0.1 0.1 - - 0.5 0.6 0.4 0.6 0 0.5 0.5
[1] 2wot.a 0 0.1 0.2
0
0.1 0.3 0.7 0.1 1.4 0.3 0 0.3 0.3 0 0 - - 0.4 0.3 0.1 0.2 0.3 0.3 0.1
[1] 2wou.a 0.3 1.1 0.7 1.6
0.1
0.9 2.0 1.3 2.3 1.4 0 0.1 0.1 0 0 - - 1.5 1.2 1.1 1.2 0.4 1.0 1.3
[1] 3faa.c 0.1 0.1 0 0.2 0.1
0.1
0.6 0.2 0.6 0.4 0 0.1 0.3 0.2 0.2 - - 0.4 0.3 0.1 0.2 0.1 0.4 0
[1] 3gxl.a 0.1 0 0 0.1 0.2 0.1
0.1
0 0.9 0 0 0.3 0.5 0 0 - - 0.7 0.3 0 0.1 0.1 0.2 0
[1] 3hmm.a 0 0 0.1 0.1 0.2 0.2 0.2
0
0.8 0 0 0.4 0.5 0 0 - - 0.4 0.5 0.1 0.1 0 0.1 0
[1] 3kcf.c 0 0 0 0.1 0.2 0 0.2 0
0
1.2 0 0.3 0.2 0 0 - - 0.4 0.3 0.1 0.2 0 0.3 0
[1] 3tzm.a 0.1 0 0 0.1 0.2 0.1 0.2 0 0.9
0
0 0.1 0.2 0.1 0.1 - - 0.4 0.3 0 0.1 0 0.6 0.2
[1] 4x0m.a 0.2 1.2 0.7 1.8 0.4 0.9 1.6 1.4 2.5 1.3
0
0 0.1 0.1 0.1 - - 1.0 1.0 1.1 1.1 0.5 1.0 1.1
[1] 4x2f.a 0.2 1.0 0.6 1.5 0.1 1.6 2.1 1.8 2.6 1.2 0
0
0 0.1 0.1 - - 1.4 1.2 1.1 1.3 0.7 0.7 1.4
[1] 4x2g.a 0.3 1.1 0.3 1.5 0.2 0.9 1.3 1.1 2.3 0.8 0 0
0
0.1 0.1 - - 0.3 0.5 0.4 0.5 0.3 0.4 1.2
[1] 4x2j.a 0.2 1.0 0.5 1.5 0.1 1.0 1.5 1.6 2.0 1.0 0 0 0
0.1
0.1 - - 1.1 1.1 1.1 1.1 0.5 1.0 1.1
[1] 4x2k.a 0.2 1.0 0.5 1.5 0.1 1.0 1.5 1.6 2.0 1.0 0 0 0 0.1
0.1
- - 1.1 1.1 1.1 1.1 0.5 1.0 1.1
[1] 5e8t.a 0.2 1.1 0.2 1.9 0.4 0.5 1.0 1.3 1.6 0.9 0 0.3 0.4 0.1 0.1
-
- 1.0 0.9 0.6 0.7 0.2 0.6 1.2
[1] 5e8u.a 0.4 0.6 0.4 0.4 0.3 0.9 0.6 0.6 1.0 0.8 0 0.3 0.4 0.1 0.1 -
-
0.9 0.9 0.3 0.3 0.3 1.2 1.2
[1] 5e8w.a 0.1 0.1 0.1 0.2 0.5 0.3 0.2 0.2 0.5 0 0 0.4 0.4 0.1 0.1 - -
0
0.1 0.1 0.1 0.2 0.2 0.3
[1] 5e8x.a 0.3 0.4 0.7 0.7 0.5 0.6 0.8 1.0 1.3 0.6 0 0.1 0.2 0.1 0.1 - - 0.1
0
0.1 0.1 0.3 1.3 1.4
[1] 5e8z.a 0.1 0 0.1 0.2 0.6 0.3 0.5 0.1 1.0 0.3 0 0.2 0.2 0.1 0.1 - - 0.4 0.4
0
0 0.3 0.7 0.1
[1] 5e90.a 0.1 0.5 0.4 0.7 0.6 0.6 0.7 0.6 1.1 0.2 0 0.1 0.1 0 0 - - 0.5 0.4 0
0
0.4 1.0 0.9
[1] 5fri.a 0.1 0.2 0 0.5 0.2 0.3 0.7 0.5 0.8 0.6 0 0.3 0.5 0.1 0.1 - - 0.6 0.5 0.4 0.6
0
0.7 0.3
[1] 5usq.a 0.1 0.8 0.2 0.8 0.2 0.5 1.1 1.0 1.4 0.7 0 0.3 0.3 0.1 0.1 - - 0.2 0.4 0.4 0.5 0.1
0
0.8
[1] 6b8y.a 0.1 0.1 0.1 0.3 0.6 0.3 0.9 0.1 1.1 0.6 0 0.3 0.5 0.1 0.1 - - 0.9 0.6 0.4 0.5 0.2 0.5
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1py5.a
1rw8.a
1vjy.a
2wot.a
2wou.a
3faa.c
3gxl.a
3hmm.a
3kcf.c
3tzm.a
4x0m.a
4x2f.a
4x2g.a
4x2j.a
4x2k.a
5e8t.a
5e8u.a
5e8w.a
5e8x.a
5e8z.a
5e90.a
5fri.a
5usq.a
6b8y.a
[1] 1py5.a
0
.14 .09 .14 .11 .12 .14 .12 .15 .12 .09 .11 .09 .07 .07 .07 .13 .11 .14 .11 .14 .09 .09 .11
[1] 1rw8.a .14
0
.10 .08 .14 .10 .07 .06 .12 .06 .14 .13 .11 .11 .11 .10 .08 .07 .12 .05 .10 .06 .11 .08
[1] 1vjy.a .09 .10
0
.08 .10 .06 .09 .07 .12 .08 .07 .08 .07 .06 .06 .07 .12 .08 .13 .06 .13 .05 .05 .05
[1] 2wot.a .14 .08 .08
0
.07 .08 .06 .06 .11 .07 .10 .07 .08 .10 .10 .14 .13 .08 .12 .07 .09 .08 .08 .06
[1] 2wou.a .11 .14 .10 .07
0
.11 .13 .13 .17 .11 .04 .04 .06 .05 .05 .09 .16 .14 .15 .12 .15 .10 .10 .10
[1] 3faa.c .12 .10 .06 .08 .11
0
.06 .06 .09 .05 .10 .08 .07 .07 .07 .11 .12 .07 .11 .07 .13 .05 .07 .05
[1] 3gxl.a .14 .07 .09 .06 .13 .06
0
.03 .08 .05 .14 .13 .11 .11 .11 .12 .11 .07 .14 .07 .10 .06 .09 .06
[1] 3hmm.a .12 .06 .07 .06 .13 .06 .03
0
.09 .05 .13 .12 .10 .10 .10 .12 .11 .06 .14 .06 .09 .06 .07 .06
[1] 3kcf.c .15 .12 .12 .11 .17 .09 .08 .09
0
.09 .16 .15 .14 .14 .14 .14 .13 .09 .15 .11 .12 .09 .10 .10
[1] 3tzm.a .12 .06 .08 .07 .11 .05 .05 .05 .09
0
.10 .10 .07 .06 .06 .10 .09 .05 .09 .05 .09 .04 .09 .07
[1] 4x0m.a .09 .14 .07 .10 .04 .10 .14 .13 .16 .10
0
.04 .05 .03 .03 .07 .15 .11 .13 .11 .15 .08 .09 .09
[1] 4x2f.a .11 .13 .08 .07 .04 .08 .13 .12 .15 .10 .04
0
.04 .04 .04 .09 .15 .11 .13 .11 .14 .09 .08 .09
[1] 4x2g.a .09 .11 .07 .08 .06 .07 .11 .10 .14 .07 .05 .04
0
.03 .03 .08 .13 .08 .10 .10 .13 .06 .05 .09
[1] 4x2j.a .07 .11 .06 .10 .05 .07 .11 .10 .14 .06 .03 .04 .03
0
0 .06 .12 .08 .11 .09 .13 .06 .07 .08
[1] 4x2k.a .07 .11 .06 .10 .05 .07 .11 .10 .14 .06 .03 .04 .03 0
0
.06 .12 .08 .11 .09 .13 .06 .07 .08
[1] 5e8t.a .07 .10 .07 .14 .09 .11 .12 .12 .14 .10 .07 .09 .08 .06 .06
0
.09 .10 .14 .09 .13 .08 .09 .10
[1] 5e8u.a .13 .08 .12 .13 .16 .12 .11 .11 .13 .09 .15 .15 .13 .12 .12 .09
0
.10 .08 .10 .07 .08 .12 .11
[1] 5e8w.a .11 .07 .08 .08 .14 .07 .07 .06 .09 .05 .11 .11 .08 .08 .08 .10 .10
0
.08 .07 .08 .07 .06 .07
[1] 5e8x.a .14 .12 .13 .12 .15 .11 .14 .14 .15 .09 .13 .13 .10 .11 .11 .14 .08 .08
0
.11 .07 .10 .10 .12
[1] 5e8z.a .11 .05 .06 .07 .12 .07 .07 .06 .11 .05 .11 .11 .10 .09 .09 .09 .10 .07 .11
0
.08 .06 .10 .05
[1] 5e90.a .14 .10 .13 .09 .15 .13 .10 .09 .12 .09 .15 .14 .13 .13 .13 .13 .07 .08 .07 .08
0
.11 .12 .11
[1] 5fri.a .09 .06 .05 .08 .10 .05 .06 .06 .09 .04 .08 .09 .06 .06 .06 .08 .08 .07 .10 .06 .11
0
.06 .05
[1] 5usq.a .09 .11 .05 .08 .10 .07 .09 .07 .10 .09 .09 .08 .05 .07 .07 .09 .12 .06 .10 .10 .12 .06
0
.09
[1] 6b8y.a .11 .08 .05 .06 .10 .05 .06 .06 .10 .07 .09 .09 .09 .08 .08 .10 .11 .07 .12 .05 .11 .05 .09
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1py5.a
1rw8.a
1vjy.a
2wot.a
2wou.a
3faa.c
3gxl.a
3hmm.a
3kcf.c
3tzm.a
4x0m.a
4x2f.a
4x2g.a
4x2j.a
4x2k.a
5e8t.a
5e8u.a
5e8w.a
5e8x.a
5e8z.a
5e90.a
5fri.a
5usq.a
6b8y.a
[1] 1py5.a
0
0.8 0.9 1.0 1.0 0.9 1.0 0.9 0.8 0.9 1.0 1.0 1.0 0.9 0.9 0.9 1.0 0.9 1.0 0.8 0.8 0.9 1.2 0.8
[1] 1rw8.a 0.8
0
1.0 1.1 1.0 0.8 1.1 1.1 0.8 1.1 0.8 0.8 0.8 0.8 0.8 1.1 1.2 1.0 1.1 1.0 1.1 1.0 1.2 1.0
[1] 1vjy.a 0.9 1.0
0
0.5 0.8 1.1 0.4 0.4 0.6 0.4 0.8 0.8 0.9 0.7 0.7 0.4 0.5 0.4 0.5 0.3 0.4 0.4 0.8 0.3
[1] 2wot.a 1.0 1.1 0.5
0
0.4 1.1 0.6 0.6 0.7 0.5 0.6 0.6 0.7 0.6 0.6 0.6 0.7 0.5 0.5 0.5 0.6 0.4 0.6 0.5
[1] 2wou.a 1.0 1.0 0.8 0.4
0
1.0 0.8 0.8 0.8 0.7 0.5 0.5 0.5 0.5 0.5 0.8 0.9 0.8 0.8 0.7 0.8 0.5 0.7 0.7
[1] 3faa.c 0.9 0.8 1.1 1.1 1.0
0
1.2 1.1 0.8 1.1 0.8 0.8 0.8 0.8 0.8 1.1 1.3 1.1 1.2 1.1 1.1 1.1 1.0 1.1
[1] 3gxl.a 1.0 1.1 0.4 0.6 0.8 1.2
0
0.2 0.8 0.3 0.9 0.9 1.0 0.9 0.9 0.3 0.4 0.5 0.6 0.3 0.4 0.6 0.9 0.5
[1] 3hmm.a 0.9 1.1 0.4 0.6 0.8 1.1 0.2
0
0.7 0.2 0.9 0.9 1.0 0.9 0.9 0.3 0.4 0.4 0.5 0.3 0.4 0.6 0.8 0.5
[1] 3kcf.c 0.8 0.8 0.6 0.7 0.8 0.8 0.8 0.7
0
0.7 0.7 0.7 0.8 0.7 0.7 0.8 0.9 0.8 0.8 0.7 0.8 0.6 0.9 0.6
[1] 3tzm.a 0.9 1.1 0.4 0.5 0.7 1.1 0.3 0.2 0.7
0
0.9 0.8 0.9 0.8 0.8 0.3 0.4 0.4 0.5 0.3 0.4 0.5 0.7 0.5
[1] 4x0m.a 1.0 0.8 0.8 0.6 0.5 0.8 0.9 0.9 0.7 0.9
0
0.2 0.2 0.2 0.2 0.9 1.1 0.8 0.9 0.8 0.8 0.7 0.7 0.8
[1] 4x2f.a 1.0 0.8 0.8 0.6 0.5 0.8 0.9 0.9 0.7 0.8 0.2
0
0.2 0.2 0.2 0.9 1.1 0.8 0.9 0.8 0.8 0.7 0.7 0.8
[1] 4x2g.a 1.0 0.8 0.9 0.7 0.5 0.8 1.0 1.0 0.8 0.9 0.2 0.2
0
0.2 0.2 1.0 1.2 0.8 0.9 0.9 0.9 0.7 0.7 0.8
[1] 4x2j.a 0.9 0.8 0.7 0.6 0.5 0.8 0.9 0.9 0.7 0.8 0.2 0.2 0.2
0
0 0.9 1.0 0.7 0.8 0.8 0.8 0.6 0.7 0.7
[1] 4x2k.a 0.9 0.8 0.7 0.6 0.5 0.8 0.9 0.9 0.7 0.8 0.2 0.2 0.2 0
0
0.9 1.0 0.7 0.8 0.8 0.8 0.6 0.7 0.7
[1] 5e8t.a 0.9 1.1 0.4 0.6 0.8 1.1 0.3 0.3 0.8 0.3 0.9 0.9 1.0 0.9 0.9
0
0.3 0.4 0.5 0.3 0.3 0.6 0.8 0.4
[1] 5e8u.a 1.0 1.2 0.5 0.7 0.9 1.3 0.4 0.4 0.9 0.4 1.1 1.1 1.2 1.0 1.0 0.3
0
0.6 0.5 0.4 0.5 0.7 1.0 0.5
[1] 5e8w.a 0.9 1.0 0.4 0.5 0.8 1.1 0.5 0.4 0.8 0.4 0.8 0.8 0.8 0.7 0.7 0.4 0.6
0
0.5 0.4 0.4 0.6 0.7 0.5
[1] 5e8x.a 1.0 1.1 0.5 0.5 0.8 1.2 0.6 0.5 0.8 0.5 0.9 0.9 0.9 0.8 0.8 0.5 0.5 0.5
0
0.5 0.5 0.6 0.8 0.5
[1] 5e8z.a 0.8 1.0 0.3 0.5 0.7 1.1 0.3 0.3 0.7 0.3 0.8 0.8 0.9 0.8 0.8 0.3 0.4 0.4 0.5
0
0.2 0.5 0.9 0.3
[1] 5e90.a 0.8 1.1 0.4 0.6 0.8 1.1 0.4 0.4 0.8 0.4 0.8 0.8 0.9 0.8 0.8 0.3 0.5 0.4 0.5 0.2
0
0.6 0.8 0.5
[1] 5fri.a 0.9 1.0 0.4 0.4 0.5 1.1 0.6 0.6 0.6 0.5 0.7 0.7 0.7 0.6 0.6 0.6 0.7 0.6 0.6 0.5 0.6
0
0.7 0.4
[1] 5usq.a 1.2 1.2 0.8 0.6 0.7 1.0 0.9 0.8 0.9 0.7 0.7 0.7 0.7 0.7 0.7 0.8 1.0 0.7 0.8 0.9 0.8 0.7
0
0.9
[1] 6b8y.a 0.8 1.0 0.3 0.5 0.7 1.1 0.5 0.5 0.6 0.5 0.8 0.8 0.8 0.7 0.7 0.4 0.5 0.5 0.5 0.3 0.5 0.4 0.9
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1py5.a
1rw8.a
1vjy.a
2wot.a
2wou.a
3faa.c
3gxl.a
3hmm.a
3kcf.c
3tzm.a
4x0m.a
4x2f.a
4x2g.a
4x2j.a
4x2k.a
5e8t.a
5e8u.a
5e8w.a
5e8x.a
5e8z.a
5e90.a
5fri.a
5usq.a
6b8y.a
[1] 1py5.a
0
1.3 1.7 1.7 1.4 1.6 1.8 1.9 1.5 1.9 1.7 1.5 1.7 1.5 1.5 1.3 1.5 1.7 1.3 1.4 1.7 1.4 1.8 1.4
[1] 1rw8.a 1.3
0
1.7 1.8 1.6 1.9 1.9 1.9 1.8 2.0 2.0 1.9 2.0 1.9 1.9 1.4 1.5 1.7 1.4 1.6 1.7 1.6 2.0 1.5
[1] 1vjy.a 1.7 1.7
0
0.9 1.0 2.2 1.1 1.0 1.3 0.8 1.4 1.5 1.4 1.4 1.4 0.6 0.9 0.7 0.8 0.7 0.7 0.9 1.1 0.7
[1] 2wot.a 1.7 1.8 0.9
0
0.6 2.0 1.1 1.2 1.3 1.1 1.2 1.2 1.1 1.2 1.2 0.8 0.9 1.0 0.8 0.9 1.0 0.5 0.7 0.6
[1] 2wou.a 1.4 1.6 1.0 0.6
0
1.9 1.1 1.2 1.3 1.1 1.0 0.9 0.9 0.9 0.9 0.9 1.1 1.1 1.0 0.9 1.1 0.7 0.8 0.8
[1] 3faa.c 1.6 1.9 2.2 2.0 1.9
0
2.2 2.3 1.7 2.3 2.0 1.9 2.0 1.9 1.9 1.7 2.0 2.1 1.8 1.8 2.1 1.9 2.0 2.0
[1] 3gxl.a 1.8 1.9 1.1 1.1 1.1 2.2
0
1.0 1.5 0.8 1.4 1.4 1.4 1.3 1.3 0.6 1.1 0.9 1.0 0.6 0.9 1.0 1.3 0.9
[1] 3hmm.a 1.9 1.9 1.0 1.2 1.2 2.3 1.0
0
1.4 0.8 1.6 1.7 1.6 1.6 1.6 0.9 1.3 0.9 1.1 0.9 0.9 1.2 1.4 1.1
[1] 3kcf.c 1.5 1.8 1.3 1.3 1.3 1.7 1.5 1.4
0
1.5 1.6 1.6 1.6 1.5 1.5 1.2 1.2 1.3 1.1 1.3 1.3 1.2 1.5 1.2
[1] 3tzm.a 1.9 2.0 0.8 1.1 1.1 2.3 0.8 0.8 1.5
0
1.4 1.6 1.5 1.5 1.5 0.6 1.1 0.6 0.9 0.6 0.6 1.1 1.2 0.9
[1] 4x0m.a 1.7 2.0 1.4 1.2 1.0 2.0 1.4 1.6 1.6 1.4
0
0.6 0.6 0.6 0.6 0.9 1.4 1.3 1.1 1.1 1.3 1.1 1.2 1.1
[1] 4x2f.a 1.5 1.9 1.5 1.2 0.9 1.9 1.4 1.7 1.6 1.6 0.6
0
0.6 0.3 0.3 1.0 1.4 1.5 1.1 1.1 1.4 1.1 1.3 1.2
[1] 4x2g.a 1.7 2.0 1.4 1.1 0.9 2.0 1.4 1.6 1.6 1.5 0.6 0.6
0
0.6 0.6 0.9 1.4 1.4 1.1 1.1 1.4 1.0 1.1 1.1
[1] 4x2j.a 1.5 1.9 1.4 1.2 0.9 1.9 1.3 1.6 1.5 1.5 0.6 0.3 0.6
0
0 0.9 1.3 1.4 1.0 1.1 1.4 1.1 1.3 1.1
[1] 4x2k.a 1.5 1.9 1.4 1.2 0.9 1.9 1.3 1.6 1.5 1.5 0.6 0.3 0.6 0
0
0.9 1.3 1.4 1.0 1.1 1.4 1.1 1.3 1.1
[1] 5e8t.a 1.3 1.4 0.6 0.8 0.9 1.7 0.6 0.9 1.2 0.6 0.9 1.0 0.9 0.9 0.9
0
0.8 0.6 0.9 0.5 0.6 0.8 0.9 0.6
[1] 5e8u.a 1.5 1.5 0.9 0.9 1.1 2.0 1.1 1.3 1.2 1.1 1.4 1.4 1.4 1.3 1.3 0.8
0
1.1 0.6 0.8 1.0 0.8 1.1 0.8
[1] 5e8w.a 1.7 1.7 0.7 1.0 1.1 2.1 0.9 0.9 1.3 0.6 1.3 1.5 1.4 1.4 1.4 0.6 1.1
0
0.8 0.5 0.6 1.0 1.0 0.9
[1] 5e8x.a 1.3 1.4 0.8 0.8 1.0 1.8 1.0 1.1 1.1 0.9 1.1 1.1 1.1 1.0 1.0 0.9 0.6 0.8
0
0.8 0.8 0.8 0.9 0.7
[1] 5e8z.a 1.4 1.6 0.7 0.9 0.9 1.8 0.6 0.9 1.3 0.6 1.1 1.1 1.1 1.1 1.1 0.5 0.8 0.5 0.8
0
0.4 0.7 1.2 0.5
[1] 5e90.a 1.7 1.7 0.7 1.0 1.1 2.1 0.9 0.9 1.3 0.6 1.3 1.4 1.4 1.4 1.4 0.6 1.0 0.6 0.8 0.4
0
1.0 1.1 0.8
[1] 5fri.a 1.4 1.6 0.9 0.5 0.7 1.9 1.0 1.2 1.2 1.1 1.1 1.1 1.0 1.1 1.1 0.8 0.8 1.0 0.8 0.7 1.0
0
0.8 0.5
[1] 5usq.a 1.8 2.0 1.1 0.7 0.8 2.0 1.3 1.4 1.5 1.2 1.2 1.3 1.1 1.3 1.3 0.9 1.1 1.0 0.9 1.2 1.1 0.8
0
0.9
[1] 6b8y.a 1.4 1.5 0.7 0.6 0.8 2.0 0.9 1.1 1.2 0.9 1.1 1.2 1.1 1.1 1.1 0.6 0.8 0.9 0.7 0.5 0.8 0.5 0.9
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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