If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

STRAA_HUMAN_59_431_ATPsite

STE20-related kinase adapter protein alpha [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (STRAA_HUMAN):D: Protein kinase (75:79, 83, 85, 98, 100, 147:150, 153, 154, 157, 197, 199, 200, 202, 215, 239)
415
75:79, 83, 85, 98, 100, 147:150, 153, 154, 157, 197, 199, 200, 202, 215, 239, 415

Full PDB list

2wtk, 3gni

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
7
5
G
7
6
K
7
7
G
7
8
F
7
9
M
8
3
V
8
5
T
9
8
R
1
0
0
T
1
4
7
S
1
4
8
F
1
4
9
M
1
5
0
S
1
5
4
D
1
5
7
K
1
9
7
S
1
9
9
H
2
0
0
L
2
0
2
R
2
1
5
K
2
3
9
F
4
1
5
[1]2wtk.b anp31 . . . . . . . . . . . . . . . . . . . . . .
[1]3gni.b atp31 . . . . . . . . . . . . . . . . . . . . . -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
7
5
G
7
6
K
7
7
G
7
8
F
7
9
M
8
3
V
8
5
T
9
8
R
1
0
0
T
1
4
7
S
1
4
8
F
1
4
9
M
1
5
0
G
1
5
3
S
1
5
4
D
1
5
7
K
1
9
7
S
1
9
9
H
2
0
0
L
2
0
2
R
2
1
5
K
2
3
9
F
4
1
5
[1]2wtk.b . . . . . . . . . . . . . . . . . . . . . . .
[1]3gni.b . . . . . . . . . . . . . . . . . . . . . . -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2wtk.b:anp
3gni.b:atp
[1] 2wtk.b
0.3
0.1
[1] 3gni.b 0.2
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2wtk.b
3gni.b
[1] 2wtk.b
0
0
[1] 3gni.b 0
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2wtk.b
3gni.b
[1] 2wtk.b
0
0.4
[1] 3gni.b 0.4
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2wtk.b
3gni.b
[1] 2wtk.b
0
0.9
[1] 3gni.b 0.9
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...