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STK26_HUMAN_9_298

Serine/threonine-protein kinase 26 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (STK26_HUMAN):D: Protein kinase (30, 38, 51, 53, 99:103, 105, 106, 109, 148, 149, 151, 161, 163)30, 38, 51, 53, 99:103, 105, 106, 109, 148, 149, 151, 161, 163
Metals (Me):Cd

Full PDB list

3ggf, 4fza, 4fzd (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 Me
I
3
0
V
3
8
A
5
1
K
5
3
M
9
9
E
1
0
0
Y
1
0
1
L
1
0
2
G
1
0
5
D
1
0
9
A
1
4
8
N
1
4
9
L
1
5
1
A
1
6
1
[1]3ggf.a gvd29 . . . . . . . . . . . . . . Cd
[1]4fza.b none . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1 Me
I
3
0
V
3
8
A
5
1
K
5
3
M
9
9
E
1
0
0
Y
1
0
1
L
1
0
2
G
1
0
3
G
1
0
5
S
1
0
6
D
1
0
9
A
1
4
8
N
1
4
9
L
1
5
1
A
1
6
1
F
1
6
3
[1]3ggf.a . . . . . . . . . . . . . . . . . Cd
[1]4fza.b . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3ggf.a:gvd
4fza.b is apo
[1] 3ggf.a
0
-
[1] 4fza.b 0.3
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3ggf.a
4fza.b
[1] 3ggf.a
0
.02
[1] 4fza.b .02
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3ggf.a
4fza.b
[1] 3ggf.a
0
1.6
[1] 4fza.b 1.6
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3ggf.a
4fza.b
[1] 3ggf.a
0
3.4
[1] 4fza.b 3.4
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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