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STK24_HUMAN_14_314

Serine/threonine-protein kinase 24 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (STK24_HUMAN):D: Protein kinase (40:50, 63:65, 82, 86, 95, 109, 111:118, 121, 160, 161, 163, 173:176)
300, 303, 304, 307
40:50, 63:65, 82, 86, 95, 109, 111:118, 121, 160, 161, 163, 173:176, 300, 303, 304, 307

Full PDB list

3a7f, 3a7g, 3a7h, 3a7i, 3a7j, 3ckw, 3ckx, 3zhp, 4o27, 4qml, 4qmm, 4qmn, 4qmo, 4qmp, 4qmq, 4qms, 4qmt, 4qmu, 4qmv, 4qmw, 4qmx, 4qmy, 4qmz, 4qna, 4qo9, 4u8z, 4w8d, 4w8e (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
E
4
0
I
4
2
G
4
3
K
4
4
G
4
5
S
4
6
F
4
7
V
5
0
A
6
3
I
6
4
K
6
5
E
8
2
L
8
6
T
9
5
I
1
0
9
M
1
1
1
E
1
1
2
Y
1
1
3
L
1
1
4
G
1
1
5
G
1
1
6
G
1
1
7
S
1
1
8
D
1
2
1
A
1
6
0
N
1
6
1
L
1
6
3
A
1
7
3
D
1
7
4
F
1
7
5
I
3
0
0
Y
3
0
3
K
3
0
4
K
3
0
7
[1]3a7f.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3a7h.a atp27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3a7i.a ade10 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3a7j.a adp,mn,mn29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ckx.a stu35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4o27.b adp,mn28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qml.a anp,mg32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmm.a 35r28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmn.a db836 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmo.a 34l19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmp.a dki28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmq.a 34u31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qms.a 1n133 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmt.a h1n37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmu.a mg,ske28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmv.a 34w34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmw.a ks124 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmx.a h8h38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmz.a b4929 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qna.a x1115 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qo9.b 62735 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4u8z.a 3fe,mn24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4w8d.a 3ja21 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4w8e.a 3jb29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
E
4
0
K
4
1
I
4
2
G
4
3
K
4
4
G
4
5
S
4
6
F
4
7
G
4
8
E
4
9
V
5
0
A
6
3
I
6
4
K
6
5
E
8
2
L
8
6
T
9
5
I
1
0
9
M
1
1
1
E
1
1
2
Y
1
1
3
L
1
1
4
G
1
1
5
G
1
1
6
G
1
1
7
S
1
1
8
D
1
2
1
A
1
6
0
N
1
6
1
L
1
6
3
A
1
7
3
D
1
7
4
F
1
7
5
G
1
7
6
I
3
0
0
Y
3
0
3
K
3
0
4
K
3
0
7
[1]3a7f.a . . * * * * . . . . . . . . . . . . . . . . . . . . . . . . . * . . . . . .
[1]3a7h.a . . . . . . . . . . . . . . * . . . * . . . . . . . . . . . . . . . . . . *
[1]3a7i.a . . . . . * * . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . *
[1]3a7j.a . . . . . . * . . . . . . * . . . . * . . . . . . . . . . . . . . . . . . *
[1]3ckx.a . . * . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . .
[1]4o27.b . . * . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qml.a . . . . . . . . . . . . . * . . . . * . . . . . . . . . . . . . . . . . . *
[1]4qmm.a . . . . * * * . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmn.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . *
[1]4qmo.a . . * * * * . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . .
[1]4qmp.a . . * . . * * . . . . . . . . . . . * . . . . . . . . . . . . . . . . * . .
[1]4qmq.a . . * * * * * . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . .
[1]4qms.a . . . . * . . * . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmt.a . . . . . * * . . . . . . * . . . . * . . . . . . . . . . . . . . . . . . .
[1]4qmu.a . . . . . * * . . . . . . * . . . . * . . . . . . . . . . . . * . . . . . .
[1]4qmv.a . . * . . * * . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . *
[1]4qmw.a . . . . . * * . . . . . . * . . . . * . . . . . . . . . . . . . . . . . . .
[1]4qmx.a . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qmz.a . . . . * * * . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . .
[1]4qna.a . . . . . . . * . . . . . . . . . . * . . . . . . . . . . . . . . . . . . .
[1]4qo9.b . . . . . . . * . . . . . * . . . . * . . . . . . . . . . . . . . . . . . .
[1]4u8z.a . . . . * * . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . .
[1]4w8d.a . . . . * * * . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . .
[1]4w8e.a . . . . * * * . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3a7f.a is apo
3a7h.a:atp
3a7i.a:ade
3a7j.a:adp,mn
3ckx.a:stu
4o27.b:adp,mn
4qml.a:anp,mg
4qmm.a:35r
4qmn.a:db8
4qmo.a:34l
4qmp.a:dki
4qmq.a:34u
4qms.a:1n1
4qmt.a:h1n
4qmu.a:mg,ske
4qmv.a:34w
4qmw.a:ks1
4qmx.a:h8h
4qmz.a:b49
4qna.a:x11
4qo9.b:627
4u8z.a:3fe,mn
4w8d.a:3ja
4w8e.a:3jb
[1] 3a7f.a
-
3.8 0.1 5.0 2.4 4.0 4.2 0.4 2.9 0.5 1.1 1.2 2.8 2.2 0.8 0.1 1.8 1.2 1.1 0.1 2.2 1.4 1.1 1.6
[1] 3a7h.a -
0
0 0.3 0 0.3 0.3 1.0 1.4 0.1 0.3 0.6 1.8 0.4 0.5 0.8 0.6 1.3 2.0 0.1 0.4 0.2 0.1 0.2
[1] 3a7i.a - 1.6
0.1
2.5 0.4 2.9 1.4 0.3 1.1 0.1 0.3 0.9 1.4 0.2 0.3 0.1 0.2 0.6 1.3 0 0.5 1.4 0.1 0.5
[1] 3a7j.a - 0.9 0.2
0.4
0.8 0.7 2.1 0.3 2.1 0.7 0.1 1.5 2.6 0.5 0.3 0.7 0.6 0.9 1.9 0.5 0.3 1.8 0.4 0.9
[1] 3ckx.a - 0.3 0.2 0.7
0
0.4 1.0 0.1 2.0 0.1 0.2 0.4 1.9 0.2 0.3 0.2 1.0 1.3 0.8 0.1 0.6 0.2 0 0.2
[1] 4o27.b - 0 0.1 0.2 0.4
0.2
0.9 0.2 2.1 0.2 0.3 0.8 2.5 0.3 0.4 0.7 0.8 0.8 1.0 0.2 0 0.8 0.1 0.5
[1] 4qml.a - 0.3 0.4 0.4 0.6 0.4
0.1
0.3 1.9 0.5 0.6 1.1 4.0 1.6 0.3 0.5 0.6 2.1 1.0 0.6 1.0 1.1 0.4 1.0
[1] 4qmm.a - 2.7 0 3.6 0.5 3.6 3.3
0
1.8 0 0.2 0.2 2.2 0.7 0.1 0 0.8 0.5 1.1 0.2 1.0 0.8 0 0.4
[1] 4qmn.a - 0 0 1.0 0 0.9 0.2 0.1
0
0.1 0.1 0.1 0.2 0.4 0.4 0.1 0 0.4 1.1 0.1 0.4 0.2 0 0.1
[1] 4qmo.a - 4.1 0.2 3.5 1.5 2.8 4.7 0.5 3.4
0
0.6 0.2 3.1 1.7 0.7 0.2 2.3 2.7 1.9 0.5 1.6 0.7 0.3 0.7
[1] 4qmp.a - 2.7 0.2 3.9 0.5 2.9 3.0 0.1 3.4 0
0
0.6 3.5 1.7 0.5 0.2 1.6 2.0 1.5 0.5 0.9 0.6 0.1 0.7
[1] 4qmq.a - 4.6 0.3 3.5 1.0 3.7 5.1 0.2 4.0 0 0.2
0
2.7 2.1 0.6 0.6 2.9 2.8 2.0 0.8 0.8 0.6 0.4 1.0
[1] 4qms.a - 3.1 0 2.0 1.2 2.0 2.7 0.5 0.2 0.4 1.2 0.4
0
0.9 0.5 0.4 0 0.6 0.2 0.1 1.5 0.1 0.1 0.2
[1] 4qmt.a - 3.0 0.1 3.8 1.0 3.4 2.2 0.6 1.3 0.1 0.3 0.7 1.8
0
0.1 0 0.3 1.1 0 0.1 0.6 1.1 0 0.5
[1] 4qmu.a - 3.0 0.1 5.2 1.0 4.9 1.8 0.2 1.6 0.7 0.5 1.9 2.0 1.5
0.2
0.3 0.2 0.6 0.6 0.4 1.6 1.9 1.0 0.9
[1] 4qmv.a - 2.4 0.2 3.8 0.5 2.6 2.0 0.5 1.8 0 0.1 0.2 2.4 1.1 0.3
0
0.7 1.2 1.8 0.4 1.1 0.4 0 0.3
[1] 4qmw.a - 3.0 0.1 3.8 0.5 3.5 2.0 0.4 1.5 0.4 0.7 0.9 1.9 0.1 0.5 0.4
0
1.0 0.3 0.3 0.8 1.1 0.3 0.7
[1] 4qmx.a - 1.1 0 2.1 0.1 1.7 1.3 0.1 0.3 0.2 0.2 0.1 0.3 0.1 0.3 0.1 0
0
0.3 0 0.4 0.3 0 0.1
[1] 4qmz.a - 2.8 0.1 3.9 1.1 2.8 2.6 0.7 1.3 0.1 0.4 0.5 1.1 0.1 0.3 0.1 0.2 1.0
0
0 0.4 0.8 0.2 0.2
[1] 4qna.a - 1.0 0.1 2.6 0.2 2.1 0.8 0.2 1.1 0.1 0.1 0.3 1.3 0.4 0.5 0.1 0.5 0.6 0.5
0
0.3 0.4 0.1 0.2
[1] 4qo9.b - 1.0 0 0.5 0.1 0.3 0.9 0.2 1.8 0 0.1 0.5 2.5 0 0.1 0.5 0.5 1.9 0.6 0.1
0.1
1.0 0.2 0.4
[1] 4u8z.a - 2.6 0.2 3.6 0.9 2.7 2.9 0.1 2.4 0 0.5 0.3 1.7 0.4 0.6 0 0.9 1.5 0.4 0.2 1.6
0.1
0.1 0.2
[1] 4w8d.a - 2.9 0.2 4.7 1.3 2.9 3.2 0.2 1.8 0 0.5 0.5 1.9 0.7 0.4 0 0.9 1.5 0.8 0.1 1.8 0.2
0
0.1
[1] 4w8e.a - 3.0 0.1 4.5 1.5 3.2 3.1 0.5 1.8 0.2 0.8 0.6 1.4 0.3 0.4 0.2 0.3 1.0 0.3 0.1 1.4 0.1 0.1
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3a7f.a
3a7h.a
3a7i.a
3a7j.a
3ckx.a
4o27.b
4qml.a
4qmm.a
4qmn.a
4qmo.a
4qmp.a
4qmq.a
4qms.a
4qmt.a
4qmu.a
4qmv.a
4qmw.a
4qmx.a
4qmz.a
4qna.a
4qo9.b
4u8z.a
4w8d.a
4w8e.a
[1] 3a7f.a
0
.34 .30 .32 .24 .26 .33 .16 .29 .14 .17 .18 .23 .28 .26 .22 .28 .21 .26 .29 .36 .13 .17 .21
[1] 3a7h.a .34
0
.18 .12 .14 .16 .08 .28 .10 .30 .29 .32 .22 .23 .25 .27 .24 .16 .24 .17 .12 .25 .27 .26
[1] 3a7i.a .30 .18
0
.08 .18 .16 .13 .18 .15 .30 .25 .32 .23 .10 .14 .13 .11 .13 .10 .19 .16 .23 .19 .15
[1] 3a7j.a .32 .12 .08
0
.15 .13 .09 .20 .15 .30 .25 .31 .26 .12 .17 .17 .15 .16 .15 .18 .14 .22 .19 .18
[1] 3ckx.a .24 .14 .18 .15
0
.08 .13 .18 .14 .18 .17 .23 .19 .18 .23 .21 .18 .13 .19 .13 .15 .13 .16 .19
[1] 4o27.b .26 .16 .16 .13 .08
0
.13 .18 .16 .23 .19 .24 .21 .15 .22 .19 .17 .16 .17 .15 .13 .16 .19 .18
[1] 4qml.a .33 .08 .13 .09 .13 .13
0
.24 .11 .28 .28 .32 .22 .18 .23 .22 .18 .16 .21 .15 .10 .24 .25 .23
[1] 4qmm.a .16 .28 .18 .20 .18 .18 .24
0
.24 .19 .13 .19 .24 .17 .22 .09 .19 .17 .16 .24 .27 .09 .07 .12
[1] 4qmn.a .29 .10 .15 .15 .14 .16 .11 .24
0
.30 .30 .33 .12 .24 .23 .22 .22 .10 .22 .12 .11 .24 .27 .25
[1] 4qmo.a .14 .30 .30 .30 .18 .23 .28 .19 .30
0
.14 .09 .23 .25 .31 .25 .26 .23 .24 .28 .31 .13 .18 .19
[1] 4qmp.a .17 .29 .25 .25 .17 .19 .28 .13 .30 .14
0
.16 .31 .21 .26 .15 .22 .22 .21 .27 .31 .11 .12 .17
[1] 4qmq.a .18 .32 .32 .31 .23 .24 .32 .19 .33 .09 .16
0
.29 .27 .33 .26 .28 .25 .26 .32 .34 .14 .19 .17
[1] 4qms.a .23 .22 .23 .26 .19 .21 .22 .24 .12 .23 .31 .29
0
.26 .27 .29 .25 .16 .21 .16 .17 .21 .26 .22
[1] 4qmt.a .28 .23 .10 .12 .18 .15 .18 .17 .24 .25 .21 .27 .26
0
.09 .16 .06 .15 .06 .21 .19 .18 .15 .11
[1] 4qmu.a .26 .25 .14 .17 .23 .22 .23 .22 .23 .31 .26 .33 .27 .09
0
.21 .11 .17 .10 .22 .22 .24 .20 .18
[1] 4qmv.a .22 .27 .13 .17 .21 .19 .22 .09 .22 .25 .15 .26 .29 .16 .21
0
.17 .18 .17 .26 .27 .17 .12 .15
[1] 4qmw.a .28 .24 .11 .15 .18 .17 .18 .19 .22 .26 .22 .28 .25 .06 .11 .17
0
.13 .07 .21 .20 .19 .16 .11
[1] 4qmx.a .21 .16 .13 .16 .13 .16 .16 .17 .10 .23 .22 .25 .16 .15 .17 .18 .13
0
.15 .15 .16 .17 .19 .16
[1] 4qmz.a .26 .24 .10 .15 .19 .17 .21 .16 .22 .24 .21 .26 .21 .06 .10 .17 .07 .15
0
.22 .21 .17 .14 .10
[1] 4qna.a .29 .17 .19 .18 .13 .15 .15 .24 .12 .28 .27 .32 .16 .21 .22 .26 .21 .15 .22
0
.12 .22 .24 .23
[1] 4qo9.b .36 .12 .16 .14 .15 .13 .10 .27 .11 .31 .31 .34 .17 .19 .22 .27 .20 .16 .21 .12
0
.27 .29 .24
[1] 4u8z.a .13 .25 .23 .22 .13 .16 .24 .09 .24 .13 .11 .14 .21 .18 .24 .17 .19 .17 .17 .22 .27
0
.07 .11
[1] 4w8d.a .17 .27 .19 .19 .16 .19 .25 .07 .27 .18 .12 .19 .26 .15 .20 .12 .16 .19 .14 .24 .29 .07
0
.08
[1] 4w8e.a .21 .26 .15 .18 .19 .18 .23 .12 .25 .19 .17 .17 .22 .11 .18 .15 .11 .16 .10 .23 .24 .11 .08
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3a7f.a
3a7h.a
3a7i.a
3a7j.a
3ckx.a
4o27.b
4qml.a
4qmm.a
4qmn.a
4qmo.a
4qmp.a
4qmq.a
4qms.a
4qmt.a
4qmu.a
4qmv.a
4qmw.a
4qmx.a
4qmz.a
4qna.a
4qo9.b
4u8z.a
4w8d.a
4w8e.a
[1] 3a7f.a
0
2.3 1.2 1.7 1.3 1.5 1.9 0.7 2.1 0.4 0.6 0.8 2.1 1.2 1.4 0.7 1.2 1.4 1.2 1.4 2.3 0.5 0.6 0.8
[1] 3a7h.a 2.3
0
1.5 1.1 1.6 1.4 0.8 2.2 1.4 2.4 2.4 2.6 1.4 1.6 1.5 2.1 1.6 1.5 1.7 1.4 0.9 2.3 2.2 2.2
[1] 3a7i.a 1.2 1.5
0
0.9 0.9 1.1 1.2 1.1 1.4 1.3 1.3 1.5 1.3 0.7 0.5 1.1 0.4 0.5 0.6 0.8 1.5 1.1 1.1 0.8
[1] 3a7j.a 1.7 1.1 0.9
0
1.0 0.9 0.8 1.6 1.5 1.7 1.7 1.9 1.3 1.1 1.0 1.6 1.1 1.0 1.2 1.0 1.3 1.7 1.6 1.5
[1] 3ckx.a 1.3 1.6 0.9 1.0
0
0.7 1.1 1.2 1.3 1.3 1.3 1.4 1.2 1.1 1.2 1.3 1.1 1.0 1.1 0.8 1.4 1.3 1.3 1.3
[1] 4o27.b 1.5 1.4 1.1 0.9 0.7
0
1.0 1.4 1.4 1.5 1.5 1.6 1.3 1.2 1.2 1.4 1.2 1.2 1.3 1.0 1.4 1.5 1.5 1.5
[1] 4qml.a 1.9 0.8 1.2 0.8 1.1 1.0
0
1.8 1.1 2.0 1.9 2.1 1.1 1.4 1.2 1.7 1.3 1.1 1.4 1.0 0.8 1.9 1.9 1.9
[1] 4qmm.a 0.7 2.2 1.1 1.6 1.2 1.4 1.8
0
2.2 0.8 0.5 0.8 2.0 1.1 1.1 0.5 1.1 1.4 1.1 1.4 2.2 0.8 0.7 0.9
[1] 4qmn.a 2.1 1.4 1.4 1.5 1.3 1.4 1.1 2.2
0
2.2 2.2 2.5 0.7 1.8 1.6 2.1 1.6 1.2 1.6 1.0 0.9 2.0 2.1 2.0
[1] 4qmo.a 0.4 2.4 1.3 1.7 1.3 1.5 2.0 0.8 2.2
0
0.7 0.8 2.1 1.3 1.5 0.9 1.4 1.5 1.4 1.5 2.4 0.7 0.8 1.0
[1] 4qmp.a 0.6 2.4 1.3 1.7 1.3 1.5 1.9 0.5 2.2 0.7
0
0.6 2.1 1.3 1.4 0.7 1.4 1.6 1.3 1.5 2.4 0.8 0.8 1.1
[1] 4qmq.a 0.8 2.6 1.5 1.9 1.4 1.6 2.1 0.8 2.5 0.8 0.6
0
2.3 1.5 1.6 1.1 1.6 1.8 1.6 1.7 2.6 1.1 1.1 1.3
[1] 4qms.a 2.1 1.4 1.3 1.3 1.2 1.3 1.1 2.0 0.7 2.1 2.1 2.3
0
1.6 1.4 1.9 1.4 1.1 1.5 0.9 1.0 1.9 2.0 1.9
[1] 4qmt.a 1.2 1.6 0.7 1.1 1.1 1.2 1.4 1.1 1.8 1.3 1.3 1.5 1.6
0
0.7 1.0 0.7 1.0 0.4 1.1 1.7 1.1 0.9 0.8
[1] 4qmu.a 1.4 1.5 0.5 1.0 1.2 1.2 1.2 1.1 1.6 1.5 1.4 1.6 1.4 0.7
0
1.0 0.6 0.7 0.6 1.0 1.6 1.2 1.2 1.0
[1] 4qmv.a 0.7 2.1 1.1 1.6 1.3 1.4 1.7 0.5 2.1 0.9 0.7 1.1 1.9 1.0 1.0
0
1.1 1.3 1.0 1.4 2.1 0.8 0.5 1.0
[1] 4qmw.a 1.2 1.6 0.4 1.1 1.1 1.2 1.3 1.1 1.6 1.4 1.4 1.6 1.4 0.7 0.6 1.1
0
0.7 0.6 1.0 1.6 1.1 1.1 0.9
[1] 4qmx.a 1.4 1.5 0.5 1.0 1.0 1.2 1.1 1.4 1.2 1.5 1.6 1.8 1.1 1.0 0.7 1.3 0.7
0
0.8 0.8 1.4 1.3 1.3 1.1
[1] 4qmz.a 1.2 1.7 0.6 1.2 1.1 1.3 1.4 1.1 1.6 1.4 1.3 1.6 1.5 0.4 0.6 1.0 0.6 0.8
0
1.0 1.7 1.0 0.9 0.8
[1] 4qna.a 1.4 1.4 0.8 1.0 0.8 1.0 1.0 1.4 1.0 1.5 1.5 1.7 0.9 1.1 1.0 1.4 1.0 0.8 1.0
0
1.2 1.4 1.4 1.3
[1] 4qo9.b 2.3 0.9 1.5 1.3 1.4 1.4 0.8 2.2 0.9 2.4 2.4 2.6 1.0 1.7 1.6 2.1 1.6 1.4 1.7 1.2
0
2.2 2.2 2.2
[1] 4u8z.a 0.5 2.3 1.1 1.7 1.3 1.5 1.9 0.8 2.0 0.7 0.8 1.1 1.9 1.1 1.2 0.8 1.1 1.3 1.0 1.4 2.2
0
0.5 0.6
[1] 4w8d.a 0.6 2.2 1.1 1.6 1.3 1.5 1.9 0.7 2.1 0.8 0.8 1.1 2.0 0.9 1.2 0.5 1.1 1.3 0.9 1.4 2.2 0.5
0
0.7
[1] 4w8e.a 0.8 2.2 0.8 1.5 1.3 1.5 1.9 0.9 2.0 1.0 1.1 1.3 1.9 0.8 1.0 1.0 0.9 1.1 0.8 1.3 2.2 0.6 0.7
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3a7f.a
3a7h.a
3a7i.a
3a7j.a
3ckx.a
4o27.b
4qml.a
4qmm.a
4qmn.a
4qmo.a
4qmp.a
4qmq.a
4qms.a
4qmt.a
4qmu.a
4qmv.a
4qmw.a
4qmx.a
4qmz.a
4qna.a
4qo9.b
4u8z.a
4w8d.a
4w8e.a
[1] 3a7f.a
0
2.5 1.4 1.9 1.4 1.5 2.2 1.1 2.4 1.0 1.1 1.3 2.2 1.4 1.5 1.1 1.6 1.7 1.5 2.0 2.9 0.9 0.9 1.2
[1] 3a7h.a 2.5
0
1.7 1.4 1.7 1.5 1.2 2.4 1.8 2.6 2.7 2.9 2.1 2.0 2.0 2.4 2.1 1.8 2.0 1.8 1.4 2.6 2.5 2.5
[1] 3a7i.a 1.4 1.7
0
1.1 1.1 1.2 1.4 1.3 1.7 1.6 1.6 1.9 1.7 1.0 0.9 1.3 1.1 0.9 0.9 1.4 2.0 1.4 1.4 1.2
[1] 3a7j.a 1.9 1.4 1.1
0
1.1 1.1 1.2 1.8 1.8 1.9 1.9 2.1 1.7 1.4 1.4 1.8 1.6 1.3 1.5 1.5 1.9 1.9 1.8 1.8
[1] 3ckx.a 1.4 1.7 1.1 1.1
0
1.0 1.3 1.3 1.5 1.3 1.5 1.6 1.6 1.3 1.4 1.4 1.3 1.2 1.2 1.1 1.6 1.4 1.4 1.5
[1] 4o27.b 1.5 1.5 1.2 1.1 1.0
0
1.3 1.4 1.6 1.5 1.4 1.6 1.4 1.2 1.3 1.5 1.4 1.3 1.3 1.2 1.5 1.4 1.5 1.5
[1] 4qml.a 2.2 1.2 1.4 1.2 1.3 1.3
0
2.0 1.3 2.2 2.2 2.4 1.8 1.8 1.5 1.9 1.7 1.4 1.7 1.6 1.4 2.2 2.2 2.1
[1] 4qmm.a 1.1 2.4 1.3 1.8 1.3 1.4 2.0
0
2.3 1.0 0.8 1.0 2.1 1.2 1.3 0.8 1.4 1.4 1.2 1.8 2.7 1.1 1.1 1.2
[1] 4qmn.a 2.4 1.8 1.7 1.8 1.5 1.6 1.3 2.3
0
2.5 2.5 2.7 1.5 2.0 1.8 2.2 1.9 1.3 1.9 1.5 1.4 2.4 2.4 2.3
[1] 4qmo.a 1.0 2.6 1.6 1.9 1.3 1.5 2.2 1.0 2.5
0
1.0 1.1 2.2 1.5 1.6 1.1 1.7 1.8 1.5 1.9 2.9 0.9 1.0 1.4
[1] 4qmp.a 1.1 2.7 1.6 1.9 1.5 1.4 2.2 0.8 2.5 1.0
0
0.8 2.2 1.4 1.5 1.0 1.6 1.7 1.5 2.0 2.9 1.0 1.0 1.3
[1] 4qmq.a 1.3 2.9 1.9 2.1 1.6 1.6 2.4 1.0 2.7 1.1 0.8
0
2.4 1.6 1.7 1.4 1.8 2.0 1.7 2.2 3.1 1.2 1.4 1.4
[1] 4qms.a 2.2 2.1 1.7 1.7 1.6 1.4 1.8 2.1 1.5 2.2 2.2 2.4
0
1.8 1.6 2.1 1.8 1.4 1.7 1.3 2.0 2.1 2.1 2.0
[1] 4qmt.a 1.4 2.0 1.0 1.4 1.3 1.2 1.8 1.2 2.0 1.5 1.4 1.6 1.8
0
0.9 1.3 1.1 1.2 0.8 1.6 2.3 1.3 1.2 1.1
[1] 4qmu.a 1.5 2.0 0.9 1.4 1.4 1.3 1.5 1.3 1.8 1.6 1.5 1.7 1.6 0.9
0
1.2 1.0 1.0 0.9 1.5 2.2 1.4 1.4 1.2
[1] 4qmv.a 1.1 2.4 1.3 1.8 1.4 1.5 1.9 0.8 2.2 1.1 1.0 1.4 2.1 1.3 1.2
0
1.4 1.5 1.3 1.9 2.6 1.0 0.9 1.3
[1] 4qmw.a 1.6 2.1 1.1 1.6 1.3 1.4 1.7 1.4 1.9 1.7 1.6 1.8 1.8 1.1 1.0 1.4
0
1.1 0.9 1.6 2.2 1.4 1.4 1.2
[1] 4qmx.a 1.7 1.8 0.9 1.3 1.2 1.3 1.4 1.4 1.3 1.8 1.7 2.0 1.4 1.2 1.0 1.5 1.1
0
0.9 1.3 1.9 1.6 1.6 1.4
[1] 4qmz.a 1.5 2.0 0.9 1.5 1.2 1.3 1.7 1.2 1.9 1.5 1.5 1.7 1.7 0.8 0.9 1.3 0.9 0.9
0
1.4 2.2 1.3 1.3 1.1
[1] 4qna.a 2.0 1.8 1.4 1.5 1.1 1.2 1.6 1.8 1.5 1.9 2.0 2.2 1.3 1.6 1.5 1.9 1.6 1.3 1.4
0
1.8 1.9 1.9 1.9
[1] 4qo9.b 2.9 1.4 2.0 1.9 1.6 1.5 1.4 2.7 1.4 2.9 2.9 3.1 2.0 2.3 2.2 2.6 2.2 1.9 2.2 1.8
0
2.8 2.8 2.7
[1] 4u8z.a 0.9 2.6 1.4 1.9 1.4 1.4 2.2 1.1 2.4 0.9 1.0 1.2 2.1 1.3 1.4 1.0 1.4 1.6 1.3 1.9 2.8
0
0.6 1.1
[1] 4w8d.a 0.9 2.5 1.4 1.8 1.4 1.5 2.2 1.1 2.4 1.0 1.0 1.4 2.1 1.2 1.4 0.9 1.4 1.6 1.3 1.9 2.8 0.6
0
1.1
[1] 4w8e.a 1.2 2.5 1.2 1.8 1.5 1.5 2.1 1.2 2.3 1.4 1.3 1.4 2.0 1.1 1.2 1.3 1.2 1.4 1.1 1.9 2.7 1.1 1.1
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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