STK10_HUMAN_18_316

Serine/threonine-protein kinase 10 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (STK10_HUMAN):D: Protein kinase (42,43,50,63:65,67,78,81,84,85,93,94,108,110:114,116,117,120,124,161,162,164,174:176,178,181)
R: Activation segment (175,176,178,181)
310,314
42,43,50,63:65,67,78,81,84,85,93,94,108,110:114,116,117,120,124,161,162,164,174:176,178,181,310,314

Full PDB list

2j7t,4aot,4bc6,4equ,4usd,4use,5ajq (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
L
4
2
G
4
3
V
5
0
A
6
3
A
6
4
K
6
5
I
6
7
Y
7
8
E
8
1
I
8
4
L
8
5
I
9
3
V
9
4
I
1
0
8
I
1
1
0
E
1
1
1
F
1
1
2
C
1
1
3
P
1
1
4
G
1
1
6
A
1
1
7
A
1
2
0
E
1
2
4
G
1
6
1
N
1
6
2
L
1
6
4
A
1
7
4
D
1
7
5
F
1
7
6
V
1
7
8
K
1
8
1
A
3
1
0
V
3
1
4
[1]4bc6.a xzn 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2j7t.a 274,ca 40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4equ.b g6i 42 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[3]5ajq.a db8 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -
[2]4aot.b gw8 45 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4use.a r09 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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