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STK10_HUMAN_18_316

Serine/threonine-protein kinase 10 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (STK10_HUMAN):D: Protein kinase (42:45, 47, 50, 63:65, 67, 78, 81, 84, 85, 88, 93, 94, 108, 110:117, 119, 120, 124, 148, 155, 161, 162, 164, 173:183, 186)
R: Activation segment (175:183, 186)
310, 311, 314, 317
42:45, 47, 50, 63:65, 67, 78, 81, 84, 85, 88, 93, 94, 108, 110:117, 119, 120, 124, 148, 155, 161, 162, 164, 173:183, 186, 310, 311, 314, 317

Full PDB list

2j7t, 4aot, 4bc6, 4equ, 4usd, 4use, 5ajq, 5owq, 5owr, 6eim (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
4
2
G
4
3
F
4
7
V
5
0
A
6
3
A
6
4
K
6
5
Y
7
8
E
8
1
I
8
4
L
8
5
I
9
3
V
9
4
I
1
0
8
I
1
1
0
E
1
1
1
F
1
1
2
C
1
1
3
P
1
1
4
G
1
1
6
A
1
1
7
A
1
2
0
E
1
2
4
L
1
4
8
H
1
5
5
G
1
6
1
N
1
6
2
L
1
6
4
A
1
7
4
D
1
7
5
F
1
7
6
V
1
7
8
K
1
8
1
L
1
8
3
L
1
8
6
A
3
1
0
V
3
1
4
[1]2j7t.a 274,ca40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4bc6.a xzn36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4equ.a g6i42 . - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - . .
[1]4use.b r0935 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ajq.a db836 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - . -
[1]5owr.a 1n133 . . - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]6eim.b b6e39 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]4aot.a gw845 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - - . .
[2]5owq.a 38o29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - - - - . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
4
2
G
4
3
D
4
4
G
4
5
F
4
7
V
5
0
A
6
3
A
6
4
K
6
5
I
6
7
Y
7
8
E
8
1
I
8
4
L
8
5
C
8
8
I
9
3
V
9
4
I
1
0
8
I
1
1
0
E
1
1
1
F
1
1
2
C
1
1
3
P
1
1
4
G
1
1
5
G
1
1
6
A
1
1
7
D
1
1
9
A
1
2
0
E
1
2
4
L
1
4
8
H
1
5
5
G
1
6
1
N
1
6
2
L
1
6
4
L
1
7
3
A
1
7
4
D
1
7
5
F
1
7
6
G
1
7
7
V
1
7
8
S
1
7
9
A
1
8
0
K
1
8
1
N
1
8
2
L
1
8
3
L
1
8
6
A
3
1
0
K
3
1
1
V
3
1
4
E
3
1
7
[1]2j7t.a . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . * .
[1]4bc6.a . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . * * . . . . * . . . . . . -
[1]4equ.a . - - - - . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . * . * * . . . . - . . * .
[1]4use.b . . . . . . . . * . . * . . . . . . . . . . . . . . . . . . . . . . . * . * * . . . . . . . . . * -
[1]5ajq.a . . . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . * . * . . * . . - . . - -
[1]5owr.a . . - - - . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . . . .
[1]6eim.b . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . * . * * . . . . . . . * .
[2]4aot.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . . . . . - - - - . . * -
[2]5owq.a . . . . . . . . . . . * . . . . . . * . . . . . . . . . . . . . . . . . * - - - - - - - - - . . * .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2j7t.a:274,ca
4bc6.a:xzn
4equ.a:g6i
4use.b:r09
5ajq.a:db8
5owr.a:1n1
6eim.b:b6e
4aot.a:gw8
5owq.a:38o
[1] 2j7t.a
0
0.2 6.3 0.1 1.2 0.1 5.8 4.4 0.1
[1] 4bc6.a 0.6
0
6.1 0.5 0.9 0.9 6.4 4.8 0.1
[1] 4equ.a 2.3 1.0
0
1.2 4.5 3.4 0.8 7.6 0.6
[1] 4use.b 0.4 1.1 7.1
0
1.3 1.2 7.2 3.5 0.1
[1] 5ajq.a 1.8 0.2 6.6 1.0
0
0.1 5.1 5.4 0.1
[1] 5owr.a 1.4 0.5 5.5 0.9 0.9
0
5.8 3.1 0.4
[1] 6eim.b 2.9 1.7 0.9 3.2 5.1 3.8
0
6.6 1.2
[2] 4aot.a 2.0 1.1 4.1 1.3 0.9 1.0 3.3
0
0.1
[2] 5owq.a 1.2 1.9 5.0 0.9 2.4 1.7 3.5 2.5
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2j7t.a
4bc6.a
4equ.a
4use.b
5ajq.a
5owr.a
6eim.b
4aot.a
5owq.a
[1] 2j7t.a
0
.11 .17 .08 .26 .11 .18 .30 .26
[1] 4bc6.a .11
0
.23 .13 .20 .12 .24 .29 .27
[1] 4equ.a .17 .23
0
.21 .26 .19 .10 .32 .29
[1] 4use.b .08 .13 .21
0
.30 .13 .18 .31 .27
[1] 5ajq.a .26 .20 .26 .30
0
.22 .21 .27 .32
[1] 5owr.a .11 .12 .19 .13 .22
0
.19 .26 .24
[1] 6eim.b .18 .24 .10 .18 .21 .19
0
.32 .28
[2] 4aot.a .30 .29 .32 .31 .27 .26 .32
0
.13
[2] 5owq.a .26 .27 .29 .27 .32 .24 .28 .13
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 2.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2j7t.a
4bc6.a
4equ.a
4use.b
5ajq.a
5owr.a
6eim.b
4aot.a
5owq.a
[1] 2j7t.a
0
0.9 2.4 1.0 4.5 1.2 2.5 4.8 1.2
[1] 4bc6.a 0.9
0
2.5 0.9 4.4 0.8 2.7 4.9 1.1
[1] 4equ.a 2.4 2.5
0
2.5 4.9 2.5 2.8 4.1 1.0
[1] 4use.b 1.0 0.9 2.5
0
4.6 1.1 2.7 5.0 0.9
[1] 5ajq.a 4.5 4.4 4.9 4.6
0
4.6 3.9 3.5 1.4
[1] 5owr.a 1.2 0.8 2.5 1.1 4.6
0
3.1 5.0 1.3
[1] 6eim.b 2.5 2.7 2.8 2.7 3.9 3.1
0
4.6 1.6
[2] 4aot.a 4.8 4.9 4.1 5.0 3.5 5.0 4.6
0
1.1
[2] 5owq.a 1.2 1.1 1.0 0.9 1.4 1.3 1.6 1.1
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 2.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2j7t.a
4bc6.a
4equ.a
4use.b
5ajq.a
5owr.a
6eim.b
4aot.a
5owq.a
[1] 2j7t.a
0
1.1 2.6 1.1 4.9 1.3 3.2 4.6 1.4
[1] 4bc6.a 1.1
0
2.7 1.0 4.3 1.1 3.1 4.7 1.3
[1] 4equ.a 2.6 2.7
0
2.8 4.6 2.8 2.8 3.9 1.4
[1] 4use.b 1.1 1.0 2.8
0
4.9 1.3 3.1 4.7 1.1
[1] 5ajq.a 4.9 4.3 4.6 4.9
0
4.9 4.3 3.9 1.9
[1] 5owr.a 1.3 1.1 2.8 1.3 4.9
0
3.6 4.8 1.4
[1] 6eim.b 3.2 3.1 2.8 3.1 4.3 3.6
0
4.5 2.1
[2] 4aot.a 4.6 4.7 3.9 4.7 3.9 4.8 4.5
0
1.5
[2] 5owq.a 1.4 1.3 1.4 1.1 1.9 1.4 2.1 1.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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