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STK10_HUMAN_18_316

Serine/threonine-protein kinase 10 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (STK10_HUMAN):D: Protein kinase (42:45, 47, 50, 63:65, 67, 78, 81, 84, 85, 93, 94, 108, 110:117, 119, 120, 124, 155, 161, 162, 164, 173:183)
R: Activation segment (175:183)
310, 311, 314
42:45, 47, 50, 63:65, 67, 78, 81, 84, 85, 93, 94, 108, 110:117, 119, 120, 124, 155, 161, 162, 164, 173:183, 310, 311, 314

Full PDB list

2j7t, 4aot, 4bc6, 4equ, 4usd, 4use, 5ajq, 5owq, 5owr (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
4
2
G
4
3
F
4
7
V
5
0
A
6
3
A
6
4
K
6
5
Y
7
8
E
8
1
I
8
4
L
8
5
I
9
3
V
9
4
I
1
0
8
I
1
1
0
E
1
1
1
F
1
1
2
C
1
1
3
P
1
1
4
G
1
1
6
A
1
1
7
A
1
2
0
E
1
2
4
H
1
5
5
G
1
6
1
N
1
6
2
L
1
6
4
A
1
7
4
D
1
7
5
F
1
7
6
V
1
7
8
K
1
8
1
A
3
1
0
V
3
1
4
[1]2j7t.a 274,ca40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4bc6.a xzn36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4equ.a g6i42 . - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4use.b r0935 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5owr.a 1n133 . . - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]4aot.a gw845 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - . .
[2]5owq.a 38o29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - - . .
[3]5ajq.a db836 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
4
2
G
4
3
D
4
4
G
4
5
F
4
7
V
5
0
A
6
3
A
6
4
K
6
5
I
6
7
Y
7
8
E
8
1
I
8
4
L
8
5
I
9
3
V
9
4
I
1
0
8
I
1
1
0
E
1
1
1
F
1
1
2
C
1
1
3
P
1
1
4
G
1
1
5
G
1
1
6
A
1
1
7
D
1
1
9
A
1
2
0
E
1
2
4
H
1
5
5
G
1
6
1
N
1
6
2
L
1
6
4
L
1
7
3
A
1
7
4
D
1
7
5
F
1
7
6
G
1
7
7
V
1
7
8
S
1
7
9
A
1
8
0
K
1
8
1
N
1
8
2
L
1
8
3
A
3
1
0
K
3
1
1
V
3
1
4
[1]2j7t.a . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . *
[1]4bc6.a . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . . * * . . . . * . . . . .
[1]4equ.a . - - - - . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . * . * * . . . . . . *
[1]4use.b . . . . . . . . * . . * . . . . . . . . . . . . . . . . . . . . . * . * * . . . . . . . . *
[1]5owr.a . . - - - . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . . . .
[2]4aot.a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . * . . . . . - - - . . *
[2]5owq.a . . . . . . . . . . . * . . . . . * . . . . . . . . . . . . . . . . * - - - - - - - - . . *
[3]5ajq.a . . . . . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . * . * . . * . . . . -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2j7t.a:274,ca
4bc6.a:xzn
4equ.a:g6i
4use.b:r09
5owr.a:1n1
4aot.a:gw8
5owq.a:38o
5ajq.a:db8
[1] 2j7t.a
0
0.2 6.3 0.1 0.1 4.4 0.1 1.2
[1] 4bc6.a 0.6
0
6.1 0.5 0.9 4.8 0.1 0.9
[1] 4equ.a 2.3 1.0
0
1.2 3.4 7.6 0.6 4.5
[1] 4use.b 0.4 1.1 7.1
0
1.2 3.5 0.1 1.3
[1] 5owr.a 1.4 0.5 5.5 0.9
0
3.1 0.4 0.9
[2] 4aot.a 2.0 1.1 4.1 1.3 1.0
0
0.1 0.9
[2] 5owq.a 1.2 1.9 5.0 0.9 1.7 2.5
0
2.4
[3] 5ajq.a 1.8 0.2 6.6 1.0 0.1 5.4 0.1
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (3 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2j7t.a
4bc6.a
4equ.a
4use.b
5owr.a
4aot.a
5owq.a
5ajq.a
[1] 2j7t.a
0
.11 .18 .09 .12 .32 .28 .29
[1] 4bc6.a .11
0
.25 .12 .12 .31 .28 .21
[1] 4equ.a .18 .25
0
.22 .20 .34 .31 .28
[1] 4use.b .09 .12 .22
0
.13 .33 .28 .31
[1] 5owr.a .12 .12 .20 .13
0
.29 .26 .25
[2] 4aot.a .32 .31 .34 .33 .29
0
.13 .28
[2] 5owq.a .28 .28 .31 .28 .26 .13
0
.35
[3] 5ajq.a .29 .21 .28 .31 .25 .28 .35
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2j7t.a
4bc6.a
4equ.a
4use.b
5owr.a
4aot.a
5owq.a
5ajq.a
[1] 2j7t.a
0
0.9 2.5 1.0 1.2 4.9 1.2 4.5
[1] 4bc6.a 0.9
0
2.5 0.8 0.8 5.0 1.1 4.5
[1] 4equ.a 2.5 2.5
0
2.6 2.6 4.2 1.0 5.0
[1] 4use.b 1.0 0.8 2.6
0
1.2 5.1 0.9 4.7
[1] 5owr.a 1.2 0.8 2.6 1.2
0
5.1 1.3 4.7
[2] 4aot.a 4.9 5.0 4.2 5.1 5.1
0
1.1 3.6
[2] 5owq.a 1.2 1.1 1.0 0.9 1.3 1.1
0
1.4
[3] 5ajq.a 4.5 4.5 5.0 4.7 4.7 3.6 1.4
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2j7t.a
4bc6.a
4equ.a
4use.b
5owr.a
4aot.a
5owq.a
5ajq.a
[1] 2j7t.a
0
1.1 2.7 1.1 1.3 4.7 1.4 5.0
[1] 4bc6.a 1.1
0
2.8 1.0 1.1 4.8 1.4 4.4
[1] 4equ.a 2.7 2.8
0
2.8 2.9 4.0 1.5 4.7
[1] 4use.b 1.1 1.0 2.8
0
1.3 4.8 1.1 5.0
[1] 5owr.a 1.3 1.1 2.9 1.3
0
4.9 1.4 5.0
[2] 4aot.a 4.7 4.8 4.0 4.8 4.9
0
1.5 3.9
[2] 5owq.a 1.4 1.4 1.5 1.1 1.4 1.5
0
1.9
[3] 5ajq.a 5.0 4.4 4.7 5.0 5.0 3.9 1.9
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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