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ST14_HUMAN_614_855

Suppressor of tumorigenicity 14 protein [Peptidase S1 family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (ST14_HUMAN):D: Peptidase S1 (637, 639:641, 656, 657, 659:661, 666, 705:708, 752, 755, 756, 783, 799:805, 824:830, 837)637, 639:641, 656, 657, 659:661, 666, 705:708, 752, 755, 756, 783, 799:805, 824:830, 837

Full PDB list

1eaw, 1eax, 2gv6, 2gv7, 3bn9, 3ncl, 3nps, 3p8f, 3p8g, 3so3, 4is5, 4isl, 4isn, 4iso, 4jyt, 4jz1, 4jzi, 4o97, 4o9v, 4r0i, 5lyo (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
Q
6
3
7
H
6
3
9
I
6
4
0
C
6
4
1
H
6
5
6
C
6
5
7
I
6
5
9
D
6
6
1
Y
6
6
6
D
7
0
5
F
7
0
6
T
7
0
7
F
7
0
8
Y
7
5
5
G
7
5
6
Q
7
8
3
D
7
9
9
S
8
0
0
C
8
0
1
Q
8
0
2
G
8
0
3
D
8
0
4
S
8
0
5
V
8
2
4
S
8
2
5
W
8
2
6
G
8
2
7
D
8
2
8
G
8
2
9
C
8
3
0
G
8
3
7
[1]1eaw.a TGPCKAR-YGGC75 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2gv6.a 73039 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2gv7.a 67249 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3bn9.a RRGP33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3bn9.b PQRRGP49 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ncl.a ccz20 . . . . . . . . . . . . . . . . . . . . . . * . . . . . . . .
[1]3nps.a HIRRYRS69 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3p8f.a RCTKSIPPIC75 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3p8g.a ben9 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3so3.a IAARRFV58 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4is5.a none . . . . . . . . . . . . . . . . . . . . . . A . . . . . . . .
[1]4isl.a VGRCRGSF-GGC74 . . . . . . . . . . . . . . . . . . . . . . A . . . . . . . .
[1]4isn.a VGRCRGSF-GGC74 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4jyt.a n4a40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4jz1.a f4d37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4jzi.a n4c36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4o97.a ntx38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4o9v.a nt436 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4r0i.a 3km37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
Q
6
3
7
H
6
3
9
I
6
4
0
C
6
4
1
H
6
5
6
C
6
5
7
I
6
5
9
D
6
6
0
D
6
6
1
Y
6
6
6
D
7
0
5
F
7
0
6
T
7
0
7
F
7
0
8
H
7
5
2
Y
7
5
5
G
7
5
6
Q
7
8
3
D
7
9
9
S
8
0
0
C
8
0
1
Q
8
0
2
G
8
0
3
D
8
0
4
S
8
0
5
V
8
2
4
S
8
2
5
W
8
2
6
G
8
2
7
D
8
2
8
G
8
2
9
C
8
3
0
G
8
3
7
[1]1eaw.a . . . . . . . . . . . . . * . * . . . . . * . . * . . . . . . . .
[1]2gv6.a . . . . . . . . . . . . . * . . . * . . . . . . * . . . . . . . .
[1]2gv7.a . . . . . . . . . . . . . * . . . * . . . * . . * . . . . . . . .
[1]3bn9.a . . . . . . . . . . . . . * . . . * . . . * . . * . . . . . . . .
[1]3bn9.b . . . . . . . . . . . . . * . . . * . . . * . . * . . . . . . . .
[1]3ncl.a . . . . . . . . . . . . . * . * . . . . . . . . * . . . . . . . .
[1]3nps.a . . . . . . . . . . . . . * . . . * . . . * . . * . . . . . . . .
[1]3p8f.a . . . . . . . . . . . . . * . * . . . . . * . . * . . . . . . . .
[1]3p8g.a . . . . . . . . . . . . . * . * . . . . . . . . * . . . . . . . .
[1]3so3.a . . . . . . . . . . . . . * . * . . . . . . . . * . . . . . . . .
[1]4is5.a . . . . . . . . . . . . . * . * . . . . . . . . A . . . . . . . .
[1]4isl.a . . . . . . . . . . . . . * . * . . . . . * . . A . . . . . . . .
[1]4isn.a . . . . . . . . . . . . . * . * . . . . . * . . * . . . . . . . .
[1]4jyt.a . . . . . . . . . . . . . * . * . . . . . . . . * . . . . . . . .
[1]4jz1.a . . . . . . . . . . . . . * . * . . . . . . . . * . . . . . . . .
[1]4jzi.a . . . . . . . . . . . . . * . * . . . . . . . . * . . . . . . . .
[1]4o97.a . . . . . . . . . . . . . * . . . . . . . . . . * . . . . . . . .
[1]4o9v.a . . . . . . . . . . . . . * . * . * . . . . . . * . . . . . . . .
[1]4r0i.a . . . . . . . . . . . . . * . * . . . . . . . . * . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1eaw.a:TGPCKAR-YGGC
2gv6.a:730
2gv7.a:672
3bn9.a:RRGP
3bn9.b:PQRRGP
3ncl.a:ccz
3nps.a:HIRRYRS
3p8f.a:RCTKSIPPIC
3p8g.a:ben
3so3.a:IAARRFV
4is5.a is apo
4isl.a:VGRCRGSF-GGC
4isn.a:VGRCRGSF-GGC
4jyt.a:n4a
4jz1.a:f4d
4jzi.a:n4c
4o97.a:ntx
4o9v.a:nt4
4r0i.a:3km
[1] 1eaw.a
0.2
1.5 1.3 3.4 4.0 1.6 5.5 1.3 0.3 0.8 - 0.8 0.5 0.5 2.4 0.5 4.7 2.7 2.0
[1] 2gv6.a 2.3
0
0.1 0 0.2 1.7 0.4 2.6 0.1 0 - 2.7 2.6 0.2 0.2 0 0.6 0 0
[1] 2gv7.a 2.3 0.3
0
0 0.2 1.4 0.9 2.2 0.1 0.2 - 2.8 2.7 0.5 0.5 0 0.6 0.2 0.2
[1] 3bn9.a 2.9 0.5 0.6
0
0 2.0 1.3 3.2 0.4 0.2 - 3.7 3.8 1.2 1.0 0.3 1.7 0.5 0.7
[1] 3bn9.b 3.4 0.6 0.7 0
0
2.4 1.2 4.0 0.4 0.2 - 4.5 4.7 1.4 1.4 0.3 2.6 0.5 0.7
[1] 3ncl.a 2.0 0.1 0.4 0 0.3
0.5
1.3 1.9 0.2 0 - 2.6 2.7 0.2 0.2 0.1 0.5 0 0.1
[1] 3nps.a 2.6 0.4 0.6 0.2 0.2 1.5
0
2.5 0.3 0 - 4.0 4.0 0.9 0.8 0.1 0.9 0.2 0.3
[1] 3p8f.a 0.4 1.5 1.1 2.1 2.4 1.4 5.0
0.1
0.3 1.3 - 0.8 0.8 0.3 1.3 0.4 2.6 1.7 1.6
[1] 3p8g.a 1.7 0.3 0.5 0 0.2 1.5 1.5 2.1
0.3
0 - 2.6 2.5 0.4 0.2 0.2 0.6 0.1 0.1
[1] 3so3.a 2.2 0.3 0.6 0 0.1 1.7 1.6 2.3 0.4
0
- 3.1 2.9 0.5 0.4 0.1 1.2 0.3 0.3
[1] 4is5.a 1.7 0.3 0.5 0 0.4 0.6 1.5 2.1 0.2 0
-
2.4 2.2 0.4 0.2 0.1 0.5 0.1 0.1
[1] 4isl.a 0 1.6 1.0 3.3 3.6 0.5 6.1 0.3 0.1 1.5 -
0
0.2 0.3 1.8 0.4 3.4 2.0 2.0
[1] 4isn.a 0.1 1.1 0.8 2.9 3.2 1.1 5.3 0.3 0.1 1.0 - 0.4
0.1
0.2 1.3 0.3 3.7 1.7 2.0
[1] 4jyt.a 2.0 0.1 0.4 0.1 0.2 1.4 1.3 2.0 0.2 0 - 2.6 2.3
0.2
0.1 0.1 0.4 0.1 0.1
[1] 4jz1.a 2.1 0.2 0.2 0.1 0.2 1.4 1.3 2.3 0.1 0 - 2.6 2.6 0.2
0.1
0 0.4 0 0
[1] 4jzi.a 2.0 0.1 0.3 0.1 0.2 1.4 1.2 1.7 0.2 0 - 2.6 2.2 0.1 0.1
0.1
0.4 0 0.1
[1] 4o97.a 2.3 0 0.3 0.1 0.4 1.1 0.5 1.6 0.3 0 - 2.6 2.8 0.2 0.1 0.1
0.1
0.1 0.1
[1] 4o9v.a 2.3 0.2 0.2 0.1 0.3 1.2 1.5 2.3 0.2 0.1 - 2.7 2.5 0.1 0.1 0 0.6
0
0
[1] 4r0i.a 2.3 0.3 0.2 0 0.4 1.2 1.3 2.0 0.1 0.1 - 2.6 2.7 0.3 0.1 0 0.5 0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1eaw.a
2gv6.a
2gv7.a
3bn9.a
3bn9.b
3ncl.a
3nps.a
3p8f.a
3p8g.a
3so3.a
4is5.a
4isl.a
4isn.a
4jyt.a
4jz1.a
4jzi.a
4o97.a
4o9v.a
4r0i.a
[1] 1eaw.a
0
.16 .15 .12 .14 .16 .15 .07 .12 .10 .14 .09 .04 .14 .14 .13 .13 .13 .12
[1] 2gv6.a .16
0
.05 .10 .12 .09 .06 .12 .07 .09 .08 .17 .15 .05 .05 .04 .06 .06 .05
[1] 2gv7.a .15 .05
0
.09 .11 .09 .08 .11 .08 .12 .09 .18 .15 .08 .06 .07 .08 .07 .06
[1] 3bn9.a .12 .10 .09
0
.05 .11 .08 .09 .08 .09 .10 .16 .11 .09 .09 .09 .12 .10 .09
[1] 3bn9.b .14 .12 .11 .05
0
.12 .11 .12 .12 .10 .14 .19 .13 .12 .13 .12 .15 .13 .12
[1] 3ncl.a .16 .09 .09 .11 .12
0
.11 .12 .07 .12 .03 .14 .15 .05 .05 .05 .09 .07 .06
[1] 3nps.a .15 .06 .08 .08 .11 .11
0
.10 .09 .13 .10 .18 .15 .10 .10 .09 .08 .10 .09
[1] 3p8f.a .07 .12 .11 .09 .12 .12 .10
0
.08 .09 .09 .09 .07 .10 .10 .09 .09 .09 .09
[1] 3p8g.a .12 .07 .08 .08 .12 .07 .09 .08
0
.06 .04 .16 .13 .04 .04 .03 .08 .05 .04
[1] 3so3.a .10 .09 .12 .09 .10 .12 .13 .09 .06
0
.09 .15 .09 .08 .08 .08 .11 .08 .08
[1] 4is5.a .14 .08 .09 .10 .14 .03 .10 .09 .04 .09
0
.13 .14 .04 .05 .04 .08 .04 .05
[1] 4isl.a .09 .17 .18 .16 .19 .14 .18 .09 .16 .15 .13
0
.08 .16 .16 .15 .15 .14 .14
[1] 4isn.a .04 .15 .15 .11 .13 .15 .15 .07 .13 .09 .14 .08
0
.14 .13 .13 .12 .12 .12
[1] 4jyt.a .14 .05 .08 .09 .12 .05 .10 .10 .04 .08 .04 .16 .14
0
.02 .01 .06 .05 .03
[1] 4jz1.a .14 .05 .06 .09 .13 .05 .10 .10 .04 .08 .05 .16 .13 .02
0
.01 .07 .04 .02
[1] 4jzi.a .13 .04 .07 .09 .12 .05 .09 .09 .03 .08 .04 .15 .13 .01 .01
0
.06 .04 .02
[1] 4o97.a .13 .06 .08 .12 .15 .09 .08 .09 .08 .11 .08 .15 .12 .06 .07 .06
0
.07 .07
[1] 4o9v.a .13 .06 .07 .10 .13 .07 .10 .09 .05 .08 .04 .14 .12 .05 .04 .04 .07
0
.03
[1] 4r0i.a .12 .05 .06 .09 .12 .06 .09 .09 .04 .08 .05 .14 .12 .03 .02 .02 .07 .03
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.9 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1eaw.a
2gv6.a
2gv7.a
3bn9.a
3bn9.b
3ncl.a
3nps.a
3p8f.a
3p8g.a
3so3.a
4is5.a
4isl.a
4isn.a
4jyt.a
4jz1.a
4jzi.a
4o97.a
4o9v.a
4r0i.a
[1] 1eaw.a
0
0.5 0.5 0.7 0.7 0.5 0.7 0.5 0.5 0.6 0.5 0.5 0.5 0.6 0.5 0.5 0.6 0.5 0.5
[1] 2gv6.a 0.5
0
0.3 0.6 0.6 0.3 0.6 0.4 0.3 0.5 0.3 0.5 0.5 0.3 0.2 0.2 0.2 0.3 0.2
[1] 2gv7.a 0.5 0.3
0
0.7 0.7 0.4 0.5 0.4 0.4 0.6 0.4 0.5 0.5 0.4 0.4 0.3 0.4 0.4 0.3
[1] 3bn9.a 0.7 0.6 0.7
0
0.2 0.5 0.8 0.6 0.6 0.3 0.6 0.7 0.6 0.5 0.6 0.5 0.6 0.6 0.7
[1] 3bn9.b 0.7 0.6 0.7 0.2
0
0.5 0.8 0.5 0.6 0.3 0.6 0.7 0.6 0.5 0.6 0.5 0.6 0.6 0.6
[1] 3ncl.a 0.5 0.3 0.4 0.5 0.5
0
0.6 0.3 0.3 0.5 0.2 0.5 0.5 0.3 0.3 0.3 0.4 0.4 0.4
[1] 3nps.a 0.7 0.6 0.5 0.8 0.8 0.6
0
0.6 0.7 0.8 0.7 0.9 0.8 0.7 0.7 0.6 0.6 0.7 0.6
[1] 3p8f.a 0.5 0.4 0.4 0.6 0.5 0.3 0.6
0
0.3 0.5 0.4 0.5 0.5 0.3 0.4 0.3 0.4 0.4 0.4
[1] 3p8g.a 0.5 0.3 0.4 0.6 0.6 0.3 0.7 0.3
0
0.5 0.2 0.4 0.5 0.2 0.2 0.2 0.3 0.2 0.3
[1] 3so3.a 0.6 0.5 0.6 0.3 0.3 0.5 0.8 0.5 0.5
0
0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5
[1] 4is5.a 0.5 0.3 0.4 0.6 0.6 0.2 0.7 0.4 0.2 0.5
0
0.5 0.5 0.2 0.3 0.2 0.3 0.3 0.4
[1] 4isl.a 0.5 0.5 0.5 0.7 0.7 0.5 0.9 0.5 0.4 0.5 0.5
0
0.2 0.5 0.5 0.5 0.5 0.5 0.5
[1] 4isn.a 0.5 0.5 0.5 0.6 0.6 0.5 0.8 0.5 0.5 0.5 0.5 0.2
0
0.5 0.5 0.5 0.5 0.5 0.5
[1] 4jyt.a 0.6 0.3 0.4 0.5 0.5 0.3 0.7 0.3 0.2 0.5 0.2 0.5 0.5
0
0.2 0.1 0.3 0.2 0.3
[1] 4jz1.a 0.5 0.2 0.4 0.6 0.6 0.3 0.7 0.4 0.2 0.5 0.3 0.5 0.5 0.2
0
0.2 0.2 0.2 0.3
[1] 4jzi.a 0.5 0.2 0.3 0.5 0.5 0.3 0.6 0.3 0.2 0.5 0.2 0.5 0.5 0.1 0.2
0
0.3 0.2 0.3
[1] 4o97.a 0.6 0.2 0.4 0.6 0.6 0.4 0.6 0.4 0.3 0.5 0.3 0.5 0.5 0.3 0.2 0.3
0
0.3 0.2
[1] 4o9v.a 0.5 0.3 0.4 0.6 0.6 0.4 0.7 0.4 0.2 0.5 0.3 0.5 0.5 0.2 0.2 0.2 0.3
0
0.3
[1] 4r0i.a 0.5 0.2 0.3 0.7 0.6 0.4 0.6 0.4 0.3 0.5 0.4 0.5 0.5 0.3 0.3 0.3 0.2 0.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1eaw.a
2gv6.a
2gv7.a
3bn9.a
3bn9.b
3ncl.a
3nps.a
3p8f.a
3p8g.a
3so3.a
4is5.a
4isl.a
4isn.a
4jyt.a
4jz1.a
4jzi.a
4o97.a
4o9v.a
4r0i.a
[1] 1eaw.a
0
1.0 1.0 1.1 1.2 1.2 1.3 0.8 1.0 1.2 1.2 0.7 0.7 1.2 1.1 1.1 1.1 1.1 1.1
[1] 2gv6.a 1.0
0
0.3 0.9 0.9 0.8 1.0 1.0 0.5 0.9 0.7 1.0 1.0 0.6 0.6 0.6 0.5 0.5 0.5
[1] 2gv7.a 1.0 0.3
0
0.9 0.9 0.8 0.9 1.0 0.6 0.9 0.8 1.1 1.0 0.7 0.6 0.6 0.6 0.6 0.6
[1] 3bn9.a 1.1 0.9 0.9
0
0.4 1.0 1.2 0.9 0.9 0.9 1.0 1.1 1.1 0.9 0.9 0.9 1.0 1.0 1.0
[1] 3bn9.b 1.2 0.9 0.9 0.4
0
0.9 1.2 0.9 0.9 0.9 1.0 1.1 1.1 0.9 0.9 0.9 1.0 0.9 1.0
[1] 3ncl.a 1.2 0.8 0.8 1.0 0.9
0
0.9 1.0 0.7 0.9 0.6 1.2 1.2 0.7 0.7 0.7 0.8 0.8 0.9
[1] 3nps.a 1.3 1.0 0.9 1.2 1.2 0.9
0
1.2 1.0 1.1 1.0 1.4 1.4 1.1 1.0 1.0 1.0 1.1 1.0
[1] 3p8f.a 0.8 1.0 1.0 0.9 0.9 1.0 1.2
0
1.0 1.0 1.1 0.9 0.9 1.0 1.1 1.0 1.0 1.1 1.1
[1] 3p8g.a 1.0 0.5 0.6 0.9 0.9 0.7 1.0 1.0
0
0.8 0.6 1.0 1.0 0.5 0.5 0.5 0.5 0.5 0.5
[1] 3so3.a 1.2 0.9 0.9 0.9 0.9 0.9 1.1 1.0 0.8
0
0.9 1.1 1.0 0.9 0.9 0.9 0.9 0.9 0.9
[1] 4is5.a 1.2 0.7 0.8 1.0 1.0 0.6 1.0 1.1 0.6 0.9
0
1.1 1.1 0.6 0.6 0.6 0.7 0.7 0.8
[1] 4isl.a 0.7 1.0 1.1 1.1 1.1 1.2 1.4 0.9 1.0 1.1 1.1
0
0.4 1.1 1.1 1.1 1.1 1.1 1.1
[1] 4isn.a 0.7 1.0 1.0 1.1 1.1 1.2 1.4 0.9 1.0 1.0 1.1 0.4
0
1.1 1.1 1.1 1.1 1.1 1.1
[1] 4jyt.a 1.2 0.6 0.7 0.9 0.9 0.7 1.1 1.0 0.5 0.9 0.6 1.1 1.1
0
0.4 0.1 0.6 0.5 0.7
[1] 4jz1.a 1.1 0.6 0.6 0.9 0.9 0.7 1.0 1.1 0.5 0.9 0.6 1.1 1.1 0.4
0
0.4 0.4 0.4 0.6
[1] 4jzi.a 1.1 0.6 0.6 0.9 0.9 0.7 1.0 1.0 0.5 0.9 0.6 1.1 1.1 0.1 0.4
0
0.5 0.5 0.6
[1] 4o97.a 1.1 0.5 0.6 1.0 1.0 0.8 1.0 1.0 0.5 0.9 0.7 1.1 1.1 0.6 0.4 0.5
0
0.4 0.5
[1] 4o9v.a 1.1 0.5 0.6 1.0 0.9 0.8 1.1 1.1 0.5 0.9 0.7 1.1 1.1 0.5 0.4 0.5 0.4
0
0.5
[1] 4r0i.a 1.1 0.5 0.6 1.0 1.0 0.9 1.0 1.1 0.5 0.9 0.8 1.1 1.1 0.7 0.6 0.6 0.5 0.5
0
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