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SLK_HUMAN_18_320

STE20-like serine/threonine-protein kinase [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (SLK_HUMAN):D: Protein kinase (40, 41, 45, 48, 61, 63, 79, 83, 92, 106, 108:112, 114, 115, 159, 160, 162, 172:176)40, 41, 45, 48, 61, 63, 79, 83, 92, 106, 108:112, 114, 115, 159, 160, 162, 172:176

Full PDB list

2j51, 2jfl, 2jfm, 2uv2, 4usf (redundant Pocketome entry)

Pocket contact map

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PDB.ch
   
ligand
A1
L
4
0
F
4
5
V
4
8
A
6
1
K
6
3
L
8
3
I
1
0
6
I
1
0
8
E
1
0
9
F
1
1
0
C
1
1
1
A
1
1
2
G
1
1
4
A
1
1
5
N
1
6
0
L
1
6
2
A
1
7
2
D
1
7
3
F
1
7
4
[1]2j51.a dki28 . . . . . . . . . . . . . . . . . . .
[1]2jfm.a none . . . . . . . . . . . . . . . . . . .
[1]2uv2.a gvd29 . . . . . . . . . . . . . . . . . . .
[1]4usf.a 6ui23 . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
L
4
0
G
4
1
F
4
5
V
4
8
A
6
1
K
6
3
E
7
9
L
8
3
V
9
2
I
1
0
6
I
1
0
8
E
1
0
9
F
1
1
0
C
1
1
1
A
1
1
2
G
1
1
4
A
1
1
5
G
1
5
9
N
1
6
0
L
1
6
2
A
1
7
2
D
1
7
3
F
1
7
4
G
1
7
5
V
1
7
6
[1]2j51.a . . . . . . . . . . * . . . . . . . . . . . . . .
[1]2jfm.a . . . . . . . . . . * . . . . . . . . . . * . . .
[1]2uv2.a . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4usf.a . . . . . * . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2j51.a:dki
2jfm.a is apo
2uv2.a:gvd
4usf.a:6ui
[1] 2j51.a
0
- 0 0.8
[1] 2jfm.a 1.2
-
0.5 0.8
[1] 2uv2.a 0.1 -
0
0.6
[1] 4usf.a 1.6 - 1.8
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2j51.a
2jfm.a
2uv2.a
4usf.a
[1] 2j51.a
0
.06 .01 .08
[1] 2jfm.a .06
0
.06 .13
[1] 2uv2.a .01 .06
0
.08
[1] 4usf.a .08 .13 .08
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2j51.a
2jfm.a
2uv2.a
4usf.a
[1] 2j51.a
0
0.5 0.4 3.9
[1] 2jfm.a 0.5
0
0.6 3.8
[1] 2uv2.a 0.4 0.6
0
4.0
[1] 4usf.a 3.9 3.8 4.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2j51.a
2jfm.a
2uv2.a
4usf.a
[1] 2j51.a
0
0.6 0.5 4.0
[1] 2jfm.a 0.6
0
0.8 4.1
[1] 2uv2.a 0.5 0.8
0
4.2
[1] 4usf.a 4.0 4.1 4.2
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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