ROCK2_HUMAN_19_417

Rho-associated protein kinase 2 [Protein kinase superfamily. AGC Ser/Thr protein kinase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (ROCK2_HUMAN):D: Protein kinase (98,99,101,103:106,119,121,123,136,153,169:172,176,214,216,218,219,221,231,232,235)
D: AGC-kinase C-terminal (384)
R: Interaction with NPM1 (384)
98,99,101,103:106,119,121,123,136,153,169:172,176,214,216,218,219,221,231,232,235,384

Full PDB list

2f2u,2h9v,4l6q,4wot

Contact map

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ligand
A1
I
9
8
G
9
9
G
1
0
1
F
1
0
3
G
1
0
4
E
1
0
5
V
1
0
6
A
1
1
9
K
1
2
1
L
1
2
3
F
1
3
6
V
1
5
3
M
1
6
9
E
1
7
0
Y
1
7
1
M
1
7
2
D
1
7
6
D
2
1
4
K
2
1
6
D
2
1
8
N
2
1
9
L
2
2
1
A
2
3
1
D
2
3
2
T
2
3
5
F
3
8
4
[1]4wot.b 3sg 37 . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]2f2u.b m77 20 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2h9v.a y27 18 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4l6q.a 1wu 20 . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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