ROCK1_HUMAN_5_414

Rho-associated protein kinase 1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (ROCK1_HUMAN):D: Protein kinase (82:90,92,103,105,107,120,128,137,153:156,160,202,203,205,215,216)
D: AGC-kinase C-terminal (368)
R: Interaction with FHOD1 (368)
82:90,92,103,105,107,120,128,137,153:156,160,202,203,205,215,216,368

Full PDB list

2esm,2etk,2etr,3d9v,3ncz,3ndm,3tv7,3twj,3v8s,4w7p,4yvc,4yve,5bml

Contact map

[download in TSV format]
   
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ligand
A1
I
8
2
G
8
3
R
8
4
G
8
5
A
8
6
F
8
7
G
8
8
E
8
9
V
9
0
L
9
2
A
1
0
3
K
1
0
5
L
1
0
7
F
1
2
0
M
1
2
8
V
1
3
7
M
1
5
3
E
1
5
4
Y
1
5
5
M
1
5
6
D
1
6
0
D
2
0
2
N
2
0
3
L
2
0
5
A
2
1
5
D
2
1
6
F
3
6
8
[1]3ndm.b 3nd 27 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5bml.a 4tw 27 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3tv7.a 07q 25 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4w7p.a 3j7 25 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3twj.a 07r 23 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[2]3twj.b none . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4yve.a 4kk 23 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ncz.c 3nc 22 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3v8s.a 0hd 21 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4yvc.a 4kh 21 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2etk.b hfs 21 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3d9v.a h52 22 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2esm.a m77 20 . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2etr.a y27 18 . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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