RET_HUMAN_702_1013

Proto-oncogene tyrosine-protein kinase receptor Ret [Protein kinase superfamily. Tyr protein kinase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (RET_HUMAN):D: Protein kinase (730:733,738,756,758,775,779,788,802,804:811,878,879,881,891,892)
R: Inhibitors binding (805:807)
730:733,738,756,758,775,779,788,802,804:811,878,879,881,891,892

Full PDB list

2ivs,2ivt,2ivu,2ivv,2x2k,2x2l,2x2m,4cki,4ckj,5amn (redundant pocketome entry)

Contact map

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ligand
A1
L
7
3
0
G
7
3
1
E
7
3
2
G
7
3
3
V
7
3
8
A
7
5
6
K
7
5
8
E
7
7
5
L
7
7
9
I
7
8
8
L
8
0
2
V
8
0
4
E
8
0
5
Y
8
0
6
A
8
0
7
K
8
0
8
Y
8
0
9
G
8
1
0
S
8
1
1
R
8
7
8
N
8
7
9
L
8
8
1
S
8
9
1
D
8
9
2
[1]2ivu.a zd6 30 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2x2l.a x2l 20 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2ivv.a pp1 21 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2x2k.a x2k 19 . . . . . . . . . . . . . . . . . . . . . . . .
[1]5amn.a dtq 22 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2x2m.a x2m 18 . . . - . . . . . . . . . . . . . . . . . . . .
[1]2ivs.a ack 22 . . . . . . . . . . . . . . . . . . . . . . . .
[1]2ivt.a amp 23 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4cki.a adn 19 . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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