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PTPRZ_HUMAN_1697_2000

Receptor-type tyrosine-protein phosphatase zeta [Protein-tyrosine phosphatase family. Receptor class 5 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (PTPRZ_HUMAN):D: Tyrosine-protein phosphatase 1 (1826, 1896, 1898:1900, 1902:1905, 1911, 1915, 1938, 1939, 1943, 1946, 1977, 1978, 1980, 1981, 1984)
R: Substrate binding (1938, 1939)
1826, 1896, 1898:1900, 1902:1905, 1911, 1915, 1938, 1939, 1943, 1946, 1977, 1978, 1980, 1981, 1984

Full PDB list

5awx, 5h08

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
1
8
2
6
Y
1
8
9
6
Q
1
8
9
8
W
1
8
9
9
P
1
9
0
5
V
1
9
1
1
V
1
9
1
5
G
1
9
3
8
R
1
9
3
9
Y
1
9
4
3
L
1
9
4
6
Q
1
9
7
7
T
1
9
7
8
E
1
9
8
0
Q
1
9
8
1
F
1
9
8
4
[1]5h08.a 7wl32 . . . . . . . . . . . . . . . .
[2]5awx.a none . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
I
1
8
2
6
Y
1
8
9
6
Q
1
8
9
8
W
1
8
9
9
P
1
9
0
0
M
1
9
0
2
G
1
9
0
3
V
1
9
0
4
P
1
9
0
5
V
1
9
1
1
V
1
9
1
5
G
1
9
3
8
R
1
9
3
9
Y
1
9
4
3
L
1
9
4
6
Q
1
9
7
7
T
1
9
7
8
E
1
9
8
0
Q
1
9
8
1
F
1
9
8
4
[1]5h08.a . . . . . . . . . . . . . . . . . . . .
[2]5awx.a . . . * . . . * . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
5h08.a:7wl
5awx.a is apo
[1] 5h08.a
0
-
[2] 5awx.a 6.5
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
5h08.a
5awx.a
[1] 5h08.a
0
.32
[2] 5awx.a .32
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5h08.a
5awx.a
[1] 5h08.a
0
2.5
[2] 5awx.a 2.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5h08.a
5awx.a
[1] 5h08.a
0
2.8
[2] 5awx.a 2.8
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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