PLK1_HUMAN_28_342

Serine/threonine-protein kinase PLK1 [Protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (PLK1_HUMAN):D: Protein kinase (57:62,65:67,69,80:82,114,130:134,136,137,139,140,180,183,193,194,196,197)
R: Activation loop (194,196,197)
57:62,65:67,69,80:82,114,130:134,136,137,139,140,180,183,193,194,196,197
Metals (Me):Zn

Full PDB list

2ou7,2owb,2rku,2v5q,2yac,3fc2,3kb7,3thb,4a4l,4a4o,4j52,4j53

Contact map

[download in TSV format]
   
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ligand
A1 Me
R
5
7
F
5
8
L
5
9
G
6
0
K
6
1
G
6
2
A
6
5
K
6
6
C
6
7
E
6
9
A
8
0
G
8
1
K
8
2
V
1
1
4
L
1
3
0
E
1
3
1
L
1
3
2
C
1
3
3
R
1
3
4
R
1
3
6
S
1
3
7
L
1
3
9
E
1
4
0
G
1
8
0
F
1
8
3
G
1
9
3
D
1
9
4
G
1
9
6
L
1
9
7
[1]3kb7.a 071 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3thb.a 3ta 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4a4l.a 939 34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]2owb.a 626 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4a4o.a 664 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]2yac.a 937 38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4j52.a 1j3 40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4j53.a 1j4 40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]2rku.a r78 38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]3fc2.a ibi 41 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]2ou7.a anp 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]2v5q.a M 8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2v5q.b none . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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