PDPK1_HUMAN_53_359_PIFsite

3-phosphoinositide-dependent protein kinase 1 [Protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (PDPK1_HUMAN):D: Protein kinase (111,115,118,119,124,127,128,130,131,135,144:150,155:157)
R: PIF-pocket (115,118,119,124,127,128,130,131,135,144:150,155:157)
75:77
75:77,111,115,118,119,124,127,128,130,131,135,144:150,155:157
Cofactors (cF):atp

Full PDB list

1h1w,1oky,1okz,1uu3,1uu7,1uu8,1uu9,1uvr,1z5m,2biy,2pe0,2pe1,2pe2,2r7b,2xch,2xck,3h9o,3hrc,3hrf,3ion,3iop,3nax,3nay,3nun,3nus,3nuu,3nuy,3orx,3orz,3otu,3pwy,3qc4,3qcq,3qcs,3qcx,3qcy,3qd0,3qd3,3qd4,3rcj,3rwp,3rwq,3sc1,4a06,4a07,4aw0,4aw1,4ct1,4ct2,4rqk,4rqv,4rrv,4xx9,5ack,5hkm,5hng,5ho7,5ho8,5lvl,5lvm,5lvn,5lvo,5lvp (redundant pocketome entry)

Contact map

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ligand
A1 cF
R
7
5
K
7
6
K
7
7
K
1
1
1
K
1
1
5
I
1
1
8
I
1
1
9
V
1
2
4
V
1
2
7
T
1
2
8
E
1
3
0
R
1
3
1
S
1
3
5
K
1
4
4
L
1
4
5
Y
1
4
6
F
1
4
7
T
1
4
8
F
1
4
9
Q
1
5
0
L
1
5
5
Y
1
5
6
F
1
5
7
[1]3hrf.a p47 20 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]4aw1.a 21o 27 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]4ct1.a 31s 26 - . . . . V H I . Q . K . . . . . C . . . . L atp
[1]5ack.a svq 26 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]5lvo.a 78w 22 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]4xx9.a rf4 25 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]4a07.a az7 24 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]4aw0.a mjf 24 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]1uu3.a none . . . . . . . . . . . . . . . . . . . . . . .
[1]4a06.a a06 19 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]3otu.a j30 23 - - . . . . . . . . . . . . . . . C . . . . .
[1]4rqk.a r1s 23 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]4rqv.a r2s 23 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]3orz.b 2a2 19 . . . . . . . . . . . . . . . . . C . . . . .
[1]3orx.a 1f8 16 . . . . . . . . . . . . . . . . . C . . . . .
[1]4ct2.a none . . . . . V . - . Q . K . . . . . C . . . . L atp
[1]4rrv.a MFRDFDYIA 73 - . . . . . . . . . . . . . . . . . . . . . . atp
[1]5lvp.b FPQFsepYSA 64 . . . . . . . . . . . . . . . . . . . . . . . atp
[1]5lvp.d FPQFsepYS 62 . . . . . . . . . . . . . . . . . . . . . . . atp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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