If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

PAK6_HUMAN_383_676

Serine/threonine-protein kinase PAK 6 [Protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (PAK6_HUMAN):D: Protein kinase (413:416, 418:421, 434, 436, 465, 481:487, 530, 533, 543, 544)413:416, 418:421, 434, 436, 465, 481:487, 530, 533, 543, 544

Full PDB list

2c30, 4ks7, 4ks8

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
4
1
3
G
4
1
6
T
4
1
8
I
4
2
0
V
4
2
1
A
4
3
4
K
4
3
6
V
4
6
5
M
4
8
1
E
4
8
2
F
4
8
3
L
4
8
4
Q
4
8
5
G
4
8
7
D
5
3
0
L
5
3
3
S
5
4
3
D
5
4
4
[1]2c30.a none . . . . . . . . . . . . . . . . . .
[1]4ks7.a x4z35 . . . . . . . . . . . . . . . . . .
[1]4ks8.a b4929 . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
4
1
3
G
4
1
4
E
4
1
5
G
4
1
6
T
4
1
8
G
4
1
9
I
4
2
0
V
4
2
1
A
4
3
4
K
4
3
6
V
4
6
5
M
4
8
1
E
4
8
2
F
4
8
3
L
4
8
4
Q
4
8
5
G
4
8
6
G
4
8
7
D
5
3
0
L
5
3
3
S
5
4
3
D
5
4
4
[1]2c30.a . . . . . . . . . . . . . . . . . . . . . .
[1]4ks7.a . . . . . . . . . . . . . . . . . . . . . .
[1]4ks8.a . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2c30.a is apo
4ks7.a:x4z
4ks8.a:b49
[1] 2c30.a
-
0.1 0.4
[1] 4ks7.a -
0.1
0.4
[1] 4ks8.a - 1.9
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2c30.a
4ks7.a
4ks8.a
[1] 2c30.a
0
.02 .10
[1] 4ks7.a .02
0
.10
[1] 4ks8.a .10 .10
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2c30.a
4ks7.a
4ks8.a
[1] 2c30.a
0
2.9 3.7
[1] 4ks7.a 2.9
0
1.0
[1] 4ks8.a 3.7 1.0
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2c30.a
4ks7.a
4ks8.a
[1] 2c30.a
0
2.8 3.8
[1] 4ks7.a 2.8
0
1.4
[1] 4ks8.a 3.8 1.4
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...