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OPRM_MOUSE_52_354

Mu-type opioid receptor [G-protein coupled receptor 1 family]

Composition of the binding site

Protein chains monomer
A1 (OPRM_MOUSE):53:55, 57, 124, 143, 144, 147, 148, 151, 229, 233, 236, 293, 296, 297, 300, 303, 318, 322, 325, 32653:55, 57, 124, 143, 144, 147, 148, 151, 229, 233, 236, 293, 296, 297, 300, 303, 318, 322, 325, 326

Full PDB list

4dkl, 5c1m

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
H
5
4
S
5
5
Q
1
2
4
V
1
4
3
D
1
4
7
Y
1
4
8
M
1
5
1
E
2
2
9
K
2
3
3
V
2
3
6
W
2
9
3
I
2
9
6
H
2
9
7
V
3
0
0
W
3
1
8
I
3
2
2
Y
3
2
6
[1]4dkl.a bf033 - - . . . . . . * . . . . . . . .
[1]5c1m.a 4vo32 . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
S
5
3
H
5
4
S
5
5
C
5
7
Q
1
2
4
V
1
4
3
I
1
4
4
D
1
4
7
Y
1
4
8
M
1
5
1
E
2
2
9
K
2
3
3
V
2
3
6
W
2
9
3
I
2
9
6
H
2
9
7
V
3
0
0
K
3
0
3
W
3
1
8
I
3
2
2
G
3
2
5
Y
3
2
6
[1]4dkl.a - - - - . . . . . . . * . . . . . . . . . .
[1]5c1m.a . . . * . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4dkl.a:bf0
5c1m.a:4vo
[1] 4dkl.a
0.6
0.5
[1] 5c1m.a 1.4
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4dkl.a
5c1m.a
[1] 4dkl.a
0
.10
[1] 5c1m.a .10
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4dkl.a
5c1m.a
[1] 4dkl.a
0
1.3
[1] 5c1m.a 1.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4dkl.a
5c1m.a
[1] 4dkl.a
0
1.5
[1] 5c1m.a 1.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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