If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

OPRK_HUMAN_55_347_TM

Kappa-type opioid receptor [G-protein coupled receptor 1 family]

Composition of the binding site

Protein chains monomer
A1 (OPRK_HUMAN):108, 111, 114, 115, 118, 124, 134, 135, 138, 139, 141, 142, 210, 227, 230, 287, 290, 291, 294, 312, 316, 319, 320108, 111, 114, 115, 118, 124, 134, 135, 138, 139, 141, 142, 210, 227, 230, 287, 290, 291, 294, 312, 316, 319, 320

Full PDB list

4djh, 6b73

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
V
1
0
8
T
1
1
1
F
1
1
4
Q
1
1
5
W
1
2
4
V
1
3
4
I
1
3
5
D
1
3
8
Y
1
3
9
M
1
4
2
C
2
1
0
K
2
2
7
V
2
3
0
W
2
8
7
I
2
9
0
I
2
9
4
Y
3
1
2
I
3
1
6
G
3
1
9
Y
3
2
0
[1]4djh.a jdc34 . . . . . . L . . . . . . . . . . . . .
[1]6b73.b cvv33 . . . . . . L . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
V
1
0
8
T
1
1
1
F
1
1
4
Q
1
1
5
V
1
1
8
W
1
2
4
V
1
3
4
I
1
3
5
D
1
3
8
Y
1
3
9
N
1
4
1
M
1
4
2
C
2
1
0
K
2
2
7
V
2
3
0
W
2
8
7
I
2
9
0
H
2
9
1
I
2
9
4
Y
3
1
2
I
3
1
6
G
3
1
9
Y
3
2
0
[1]4djh.a . . . . . . . L . . . . . . . . . . . . . . .
[1]6b73.b . . . * . . . L . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4djh.a:jdc
6b73.b:cvv
[1] 4djh.a
0
1.4
[1] 6b73.b 3.8
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4djh.a
6b73.b
[1] 4djh.a
0
.20
[1] 6b73.b .20
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.9 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4djh.a
6b73.b
[1] 4djh.a
0
1.4
[1] 6b73.b 1.4
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4djh.a
6b73.b
[1] 4djh.a
0
1.8
[1] 6b73.b 1.8
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...