NTRK1_HUMAN_491_793

High affinity nerve growth factor receptor [Protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (NTRK1_HUMAN):D: Protein kinase (516,517,521,524,542,544,560,563,564,567,572,573,589:593,595,596,599,641,646,648,654,655,657,666:671,673)516,517,521,524,542,544,560,563,564,567,572,573,589:593,595,596,599,641,646,648,654,655,657,666:671,673

Full PDB list

4aoj,4f0i,4gt5,4pmm,4pmp,4pms,4pmt,4yne,4yps (redundant pocketome entry)

Contact map

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ligand
A1
L
5
1
6
G
5
1
7
F
5
2
1
V
5
2
4
A
5
4
2
K
5
4
4
E
5
6
0
L
5
6
3
L
5
6
4
L
5
6
7
I
5
7
2
V
5
7
3
F
5
8
9
E
5
9
0
Y
5
9
1
M
5
9
2
R
5
9
3
G
5
9
5
D
5
9
6
R
5
9
9
L
6
4
1
F
6
4
6
H
6
4
8
R
6
5
4
N
6
5
5
L
6
5
7
I
6
6
6
G
6
6
7
D
6
6
8
F
6
6
9
G
6
7
0
M
6
7
1
R
6
7
3
[1]4pmp.a 31w 30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4pms.a 31x 34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4pmt.a 31y 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - .
[1]4yne.a 4ek 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -
[1]4yps.a 4f6 30 . . - . . . . . . . . . . . . . . . . . . . . . . . . . . - - . .
[1]4aoj.a v4z 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - -
[1]4pmm.a 31v 37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4f0i.b none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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