NR1H3_HUMAN_189_447

Oxysterols receptor LXR-alpha [Nuclear hormone receptor family. NR1 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (NR1H3_HUMAN):R: Transactivation AF-2
required for ligand-dependent transactivation function
mediates interaction with CCAR2 (225,232,254,257,258,260,261,263,264,267,295,298,299,301,302,305,313,315,316,326,329:331,335,336,339,340,421,424,428,435,439,443)
R: Ligand-binding (225,232,254,257,258,260,261,263,264,267,295,298,299,301,302,305,313,315,316,326,329:331,335,336,339,340,421,424,428)
225,232,254,257,258,260,261,263,264,267,295,298,299,301,302,305,313,315,316,326,329:331,335,336,339,340,421,424,428,435,439,443

Full PDB list

1uhl,2acl,3fal,3fc6,3ipq,3ips,3ipu,5avi,5avl,5hjs

Contact map

[download in TSV format]
   
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ligand
A1
N
2
2
5
R
2
3
2
F
2
5
4
F
2
5
7
T
2
5
8
L
2
6
0
A
2
6
1
V
2
6
3
S
2
6
4
E
2
6
7
I
2
9
5
M
2
9
8
L
2
9
9
E
3
0
1
T
3
0
2
R
3
0
5
I
3
1
3
F
3
1
5
L
3
1
6
F
3
2
6
A
3
2
9
G
3
3
0
L
3
3
1
F
3
3
5
I
3
3
6
I
3
3
9
F
3
4
0
H
4
2
1
Q
4
2
4
L
4
2
8
L
4
3
5
L
4
3
9
W
4
4
3
[1]5avi.a 4km 30 - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2acl.f l05 29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3fal.b lo2 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ipu.a o40 34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ips.a o90 32 - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5avl.a 4kq 36 - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5hjs.a 668 35 - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1uhl.b 444 31 . - . . . . . . . . . . . . . . . - - . . . . . . . . . . . . . .
[1]3fc6.b lx2 44 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ipq.a 965 41 - - . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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