NR1H2_HUMAN_213_460

Oxysterols receptor LXR-beta [Nuclear hormone receptor family. NR1 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (NR1H2_HUMAN):R: Transactivation AF-2
required for ligand-dependent transactivation function
mediates interaction with CCAR2 (238,241,242,267,270,271,273,274,276,277,280,308,311,312,314,315,318,326,328,329,334,339,342:344,348,349,352,353,434,437,438,441,448,452,456)
R: Ligand-binding (238,241,242,267,270,271,273,274,276,277,280,308,311,312,314,315,318,326,328,329,334,339,342:344,348,349,352,353,434,437,438,441,448,452,456)
238,241,242,267,270,271,273,274,276,277,280,308,311,312,314,315,318,326,328,329,334,339,342:344,348,349,352,353,434,437,438,441,448,452,456

Full PDB list

1p8d,1pq6,1pq9,1pqc,1upv,1upw,3kfc,3l0e,4dk7,4dk8,4nqa,4rak,5hjp,5i4v,5jy3,5kya,5kyj (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
N
2
3
8
S
2
4
1
F
2
4
2
F
2
6
7
F
2
7
0
T
2
7
1
L
2
7
3
A
2
7
4
I
2
7
6
S
2
7
7
E
2
8
0
I
3
0
8
M
3
1
1
L
3
1
2
E
3
1
4
T
3
1
5
R
3
1
8
I
3
2
6
F
3
2
8
L
3
2
9
Y
3
3
4
F
3
3
9
A
3
4
2
G
3
4
3
L
3
4
4
F
3
4
8
I
3
4
9
I
3
5
2
F
3
5
3
H
4
3
4
Q
4
3
7
V
4
3
8
L
4
4
1
L
4
4
8
L
4
5
2
W
4
5
6
[1]4dk7.a 0ks 27 . . . . . . . . . . . . * . . . . . . . . . . . . . . . . . . . . . . .
[1]4dk8.a 0kt 32 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3kfc.d 61x 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5i4v.e 67s 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5kya.e 6y4 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5kyj.e 6y8 30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1p8d.a co1 29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4rak.b 652 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3l0e.a g58 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5hjp.b 668 35 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1pq9.b 44b,bns 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5jy3.b 6ox 40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1pqc.b 444 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1pq6.b 965 41 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]1pq6.c none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - - - - -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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