If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

NEK7_HUMAN_1_302

Serine/threonine-protein kinase Nek7 [Protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (NEK7_HUMAN):D: Protein kinase (40:46, 48, 61, 63, 112:114, 179:181)40:46, 48, 61, 63, 112:114, 179:181

Full PDB list

2wqm, 2wqn, 5de2 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
4
0
G
4
1
G
4
3
Q
4
4
F
4
5
S
4
6
V
4
8
A
6
1
K
6
3
E
1
1
2
L
1
1
3
A
1
1
4
D
1
7
9
[1]2wqn.a adp27 . . . . . . . . . . . . .
[2]5de2.a none . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
4
0
G
4
1
R
4
2
G
4
3
Q
4
4
F
4
5
S
4
6
V
4
8
A
6
1
K
6
3
E
1
1
2
L
1
1
3
A
1
1
4
D
1
7
9
L
1
8
0
G
1
8
1
[1]2wqn.a . . . . . . . . . . . . . . . -
[2]5de2.a . . . . . . . . . . . . . . * .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2wqn.a:adp
5de2.a is apo
[1] 2wqn.a
0
-
[2] 5de2.a 5.3
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2wqn.a
5de2.a
[1] 2wqn.a
0
.31
[2] 5de2.a .31
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2wqn.a
5de2.a
[1] 2wqn.a
0
2.8
[2] 5de2.a 2.8
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2wqn.a
5de2.a
[1] 2wqn.a
0
3.6
[2] 5de2.a 3.6
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...