If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

MUP11_MOUSE_16_181

Major urinary protein 11 [Calycin superfamily. Lipocalin family]

Composition of the binding site

Protein chains monomer
A1 (MUP11_MOUSE):43, 57, 59, 61, 64, 73, 75, 88, 101, 103, 107, 109, 111, 120, 122, 124, 135:137, 13943, 57, 59, 61, 64, 73, 75, 88, 101, 103, 107, 109, 111, 120, 122, 124, 135:137, 139
Metals (Me):Cd/Na

Full PDB list

1jv4, 1mup, 1qy0, 1qy1, 1qy2, 1yp6, 1yp7, 1znd, 1zne, 1zng, 1znh, 1znk, 1znl, 2dm5, 2nnd, 2nne, 2ozq (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 Me
L
4
3
F
5
7
L
5
9
L
6
1
I
6
4
L
7
3
F
7
5
M
8
8
V
1
0
1
Y
1
0
3
N
1
0
7
F
1
0
9
I
1
1
1
L
1
2
0
A
1
2
2
L
1
2
4
L
1
3
5
M
1
3
6
G
1
3
7
Y
1
3
9
[1]1jv4.a tzl9 . . . . . . . . . . . . . . . . . . . .
[1]1qy2.a ipz11 . . . . . . . . . . . . . . . . . . . . Cd,Na
[1]1yp6.a prz12 . . . . . . . . . . . . . . . . . . . F Cd
[1]1yp7.a none . . . . . . . . . . . . . . . . . . . F
[1]1znd.a pe9,pe912 . . . . . . . . . . . . . . . . . . . . Cd
[1]1zne.a he27 . . . . . . . . . . . . . . . . . . . . Cd
[1]1zng.a he48 . . . . . . . . . . . . . . . . . . . . Cd
[1]1znh.a oc99 . . . . . . . . . . . . . . . . . . . . Cd
[1]1znk.a f0910 . . . . . . . . . . . . . . . . . . . . Cd
[1]1znl.a de111 . . . . . . . . . . . . . . . . . . . . Cd
[1]2dm5.a odi10 . . . . . . . . . . . . . . . . . . . . Cd
[1]2nnd.a prz12 . . . . . . . . . . . . . . . . . . . . Cd
[1]2nne.a none . . . . . . . . . . . . . . . . . . . . Cd

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 Me
L
4
3
F
5
7
L
5
9
L
6
1
I
6
4
L
7
3
F
7
5
M
8
8
V
1
0
1
Y
1
0
3
N
1
0
7
F
1
0
9
I
1
1
1
L
1
2
0
A
1
2
2
L
1
2
4
L
1
3
5
M
1
3
6
G
1
3
7
Y
1
3
9
[1]1jv4.a . . . . . . . . . . . . . . . . . . . .
[1]1qy2.a . . . . . . . . . . . . . . . . . . . . Cd,Na
[1]1yp6.a . . . . . . . . . . . . . . . . . . . F Cd
[1]1yp7.a . . * . . . . . . . . . . . . . . . . F
[1]1znd.a . . . . . . . . . . . . . . . . . . . . Cd
[1]1zne.a . . . . . . . . . . . . . . . . . . . . Cd
[1]1zng.a . . . . . . . . . . . . . . . . . . . . Cd
[1]1znh.a . . . . . . . . . . . . . . . . . . . . Cd
[1]1znk.a . . . . . . . . . . . . . . . . . . . . Cd
[1]1znl.a . . . . . . . . . . . . . . . . . . . . Cd
[1]2dm5.a . . . . . . . . . . . . . . . . . . . . Cd
[1]2nnd.a . . . . . . . . . . . . . . . . . . . . Cd
[1]2nne.a . . . . . . . . . . . . . . . . . . . . Cd

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1jv4.a:tzl
1qy2.a:ipz
1yp6.a:prz
1yp7.a is apo
1znd.a:pe9
1zne.a:he2
1zng.a:he4
1znh.a:oc9
1znk.a:f09
1znl.a:de1
2dm5.a:odi
2nnd.a:prz
2nne.a is apo
[1] 1jv4.a
0
0.1 0.1 - 0 0 0.1 0 0 0 0.1 0.1 -
[1] 1qy2.a 0
0
0.1 - 0.1 0 0.2 0 0 0 0 0 -
[1] 1yp6.a 0 0.3
0
- 0.4 0.2 0 0.4 0.4 0.4 0.5 0.5 -
[1] 1yp7.a 0.1 0.5 0
-
0.6 0.5 0 0.5 0.4 0.4 0.8 0.6 -
[1] 1znd.a 0 0.1 0.1 -
0
0 0.1 0 0 0 0 0.1 -
[1] 1zne.a 0 0.1 0.1 - 0
0
0.1 0 0 0 0 0.1 -
[1] 1zng.a 0 0.1 0 - 0.1 0
0
0 0.1 0 0 0.1 -
[1] 1znh.a 0 0.1 0.1 - 0 0 0.1
0
0 0 0 0.1 -
[1] 1znk.a 0 0.1 0.1 - 0 0 0.1 0
0
0 0 0.1 -
[1] 1znl.a 0 0.1 0.1 - 0 0 0.1 0 0
0
0 0.1 -
[1] 2dm5.a 0 0.1 0.1 - 0 0 0.2 0 0 0
0
0.2 -
[1] 2nnd.a 0 0 0 - 0.2 0 0.2 0 0.1 0 0.1
0.1
-
[1] 2nne.a 0 0.1 0.1 - 0 0 0.1 0 0 0 0 0.1
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1jv4.a
1qy2.a
1yp6.a
1yp7.a
1znd.a
1zne.a
1zng.a
1znh.a
1znk.a
1znl.a
2dm5.a
2nnd.a
2nne.a
[1] 1jv4.a
0
.01 .03 .04 .01 .01 .01 .01 .01 .01 0 .01 .01
[1] 1qy2.a .01
0
.03 .05 0 0 0 0 0 0 .01 .01 0
[1] 1yp6.a .03 .03
0
.02 .03 .03 .03 .03 .03 .03 .03 .04 .03
[1] 1yp7.a .04 .05 .02
0
.05 .05 .05 .05 .05 .05 .04 .05 .05
[1] 1znd.a .01 0 .03 .05
0
0 0 0 0 0 .01 .01 0
[1] 1zne.a .01 0 .03 .05 0
0
0 0 0 0 .01 .01 0
[1] 1zng.a .01 0 .03 .05 0 0
0
0 0 0 .01 .01 0
[1] 1znh.a .01 0 .03 .05 0 0 0
0
0 0 .01 .01 0
[1] 1znk.a .01 0 .03 .05 0 0 0 0
0
0 .01 .01 0
[1] 1znl.a .01 0 .03 .05 0 0 0 0 0
0
.01 .01 0
[1] 2dm5.a 0 .01 .03 .04 .01 .01 .01 .01 .01 .01
0
.01 .01
[1] 2nnd.a .01 .01 .04 .05 .01 .01 .01 .01 .01 .01 .01
0
.01
[1] 2nne.a .01 0 .03 .05 0 0 0 0 0 0 .01 .01
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1jv4.a
1qy2.a
1yp6.a
1yp7.a
1znd.a
1zne.a
1zng.a
1znh.a
1znk.a
1znl.a
2dm5.a
2nnd.a
2nne.a
[1] 1jv4.a
0
0.2 0.2 0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2
[1] 1qy2.a 0.2
0
0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2
[1] 1yp6.a 0.2 0.1
0
0.2 0.1 0.2 0.2 0.2 0.1 0.1 0.1 0.2 0.2
[1] 1yp7.a 0.3 0.3 0.2
0
0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.4
[1] 1znd.a 0.2 0.1 0.1 0.3
0
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
[1] 1zne.a 0.2 0.1 0.2 0.3 0.1
0
0.1 0.1 0.1 0.1 0.1 0.2 0.2
[1] 1zng.a 0.2 0.1 0.2 0.3 0.1 0.1
0
0.1 0.1 0.1 0.1 0.2 0.1
[1] 1znh.a 0.2 0.1 0.2 0.3 0.1 0.1 0.1
0
0.1 0.1 0.1 0.2 0.2
[1] 1znk.a 0.2 0.1 0.1 0.3 0.1 0.1 0.1 0.1
0
0.1 0.1 0.2 0.2
[1] 1znl.a 0.2 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.1
0
0.1 0.2 0.1
[1] 2dm5.a 0.2 0.1 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.1
0
0.2 0.1
[1] 2nnd.a 0.2 0.1 0.2 0.3 0.1 0.2 0.2 0.2 0.2 0.2 0.2
0
0.1
[1] 2nne.a 0.2 0.2 0.2 0.4 0.1 0.2 0.1 0.2 0.2 0.1 0.1 0.1
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1jv4.a
1qy2.a
1yp6.a
1yp7.a
1znd.a
1zne.a
1zng.a
1znh.a
1znk.a
1znl.a
2dm5.a
2nnd.a
2nne.a
[1] 1jv4.a
0
0.3 0.5 0.6 0.3 0.4 0.3 0.4 0.2 0.4 0.2 0.3 0.4
[1] 1qy2.a 0.3
0
0.5 0.6 0.2 0.3 0.3 0.3 0.2 0.3 0.2 0.3 0.4
[1] 1yp6.a 0.5 0.5
0
0.3 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.6
[1] 1yp7.a 0.6 0.6 0.3
0
0.6 0.6 0.5 0.6 0.5 0.6 0.5 0.6 0.7
[1] 1znd.a 0.3 0.2 0.5 0.6
0
0.3 0.1 0.3 0.1 0.3 0.1 0.2 0.3
[1] 1zne.a 0.4 0.3 0.5 0.6 0.3
0
0.3 0.1 0.3 0.1 0.3 0.3 0.2
[1] 1zng.a 0.3 0.3 0.5 0.5 0.1 0.3
0
0.3 0.2 0.3 0.2 0.2 0.3
[1] 1znh.a 0.4 0.3 0.5 0.6 0.3 0.1 0.3
0
0.3 0.1 0.3 0.3 0.2
[1] 1znk.a 0.2 0.2 0.5 0.5 0.1 0.3 0.2 0.3
0
0.3 0.1 0.3 0.3
[1] 1znl.a 0.4 0.3 0.5 0.6 0.3 0.1 0.3 0.1 0.3
0
0.3 0.3 0.2
[1] 2dm5.a 0.2 0.2 0.5 0.5 0.1 0.3 0.2 0.3 0.1 0.3
0
0.3 0.3
[1] 2nnd.a 0.3 0.3 0.5 0.6 0.2 0.3 0.2 0.3 0.3 0.3 0.3
0
0.3
[1] 2nne.a 0.4 0.4 0.6 0.7 0.3 0.2 0.3 0.2 0.3 0.2 0.3 0.3
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...