MTH1_HAEPH_1_327

Modification methylase HhaI [Class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MTH1_HAEPH):D: SAM-dependent MTase C5-type (78:81,85:87,119:121,162:165,250:253,303,304)78:81,85:87,119:121,162:165,250:253,303,304
Cofactors (cF):sah

Full PDB list

10mh,1fjx,1hmy,1m0e,1mht,1skm,1svu,2c7o,2c7p,2c7q,2c7r,2hmy,2hr1,2i9k,2uyc,2uyh,2uz4,2z6a,2z6q,2z6u,2zcj,3eeo,3mht,4mht,5ciy,5mht,6mht,7mht,8mht,9mht (redundant pocketome entry)

Contact map

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ligand
A1 cF
G
7
8
F
7
9
P
8
0
C
8
1
S
8
5
I
8
6
S
8
7
E
1
1
9
N
1
2
0
V
1
2
1
K
1
6
2
R
1
6
3
E
1
6
4
R
1
6
5
T
2
5
0
L
2
5
1
S
2
5
2
A
2
5
3
G
3
0
3
N
3
0
4
[1]1mht.a c36 21 . . . * . . . . . . . . . . . . . . . . sah
[1]6mht.a 4sc 20 . . . . . . . . . . . . . . . . . . . .
[1]10mh.a 5nc 19 . . . . . . . . . . . . . . . . . . . . sah
[1]1m0e.a z 18 . . . * . . . . . . . . . . . . . . . . sah
[1]1skm.a hcx 12 . . . . . . . . . . . . . . . . . . . . sah
[1]2uyc.a C 19 . . . . . . . . . . . N . . . . . . . .
[1]2z6q.a dcz 16 . . . . . . . . . . . . . A . . . . . . sah
[1]1fjx.a C 19 . . . . . . . . . . . . . . G . . . . . sah
[1]2uyh.a C 19 . . . . . . Q . . . . . . . . . . . . .
[1]1svu.a none . . - - - - - . . . . . . . . . . . . .
[1]2c7q.a C 19 . . . . . . . . . . . . . . . . . . . .
[1]2uz4.a C 19 . . . . . . . . . . . . . N . . . . . .
[1]3eeo.a pdi 8 . . . . . . . . . . . . . . . . . . . .
[1]2c7r.a 2pr 21 . . . . . . . . . . . . . . G . . . . .
[1]4mht.a 5cm 20 . . . . . . . . . . . . . . . . . . . . sah
[1]2z6a.a C 19 . . . A . . . . . . . . . . . . . . . . sah
[1]2z6u.a C 19 . . . . . . . A . . . . . . . . . . . . sah
[1]2zcj.a C 19 . . . . . . . Q . . . . . . . . . . . . sah
[1]5ciy.a 3dr 11 . . . . . . . . . . . . . . . . . . . .
[1]7mht.a A 21 . . . . . . . . . . . . . . . . . . . . sah
[1]8mht.a du 19 . . . . . . . . . . . . . . . . . . . . sah

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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