If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

MRCKB_HUMAN_2_416

Serine/threonine-protein kinase MRCK beta [Protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (MRCKB_HUMAN):D: Protein kinase (82:87, 90, 103, 105, 124, 137, 153:156, 160, 204, 205, 207, 217, 218)
D: AGC-kinase C-terminal (370)
82:87, 90, 103, 105, 124, 137, 153:156, 160, 204, 205, 207, 217, 218, 370

Full PDB list

3qfv, 3tku, 4uak, 4ual

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
8
2
G
8
3
R
8
4
V
9
0
A
1
0
3
K
1
0
5
T
1
3
7
M
1
5
3
D
1
5
4
Y
1
5
5
Y
1
5
6
D
2
0
4
N
2
0
5
L
2
0
7
D
2
1
8
F
3
7
0
[1]3qfv.a nm719 . . . . . . . . . . . . . . . .
[1]3tku.b m7720 . . . . . . . . . . . . . . . .
[1]4uak.a adp,mg,mg29 . . . . . . . . . . . . . . . .
[1]4ual.a 3fv26 . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
8
2
G
8
3
R
8
4
G
8
5
A
8
6
F
8
7
V
9
0
A
1
0
3
K
1
0
5
E
1
2
4
T
1
3
7
M
1
5
3
D
1
5
4
Y
1
5
5
Y
1
5
6
D
1
6
0
D
2
0
4
N
2
0
5
L
2
0
7
A
2
1
7
D
2
1
8
F
3
7
0
[1]3qfv.a . . . . . . . . . . . . . . . . . . . . . *
[1]3tku.b . . . * . . . . . . . . . . . . . . . . . *
[1]4uak.a . . . . . . . . . . . . . . . . . . . . . *
[1]4ual.a . . . * . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3qfv.a:nm7
3tku.b:m77
4uak.a:adp,mg
4ual.a:3fv
[1] 3qfv.a
0.1
0 1.0 1.7
[1] 3tku.b 0.6
0
2.2 1.7
[1] 4uak.a 0.6 0.1
0.4
2.1
[1] 4ual.a 0.2 0.1 1.9
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3qfv.a
3tku.b
4uak.a
4ual.a
[1] 3qfv.a
0
.07 .05 .14
[1] 3tku.b .07
0
.12 .13
[1] 4uak.a .05 .12
0
.16
[1] 4ual.a .14 .13 .16
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3qfv.a
3tku.b
4uak.a
4ual.a
[1] 3qfv.a
0
0.7 1.3 0.7
[1] 3tku.b 0.7
0
1.8 0.6
[1] 4uak.a 1.3 1.8
0
1.6
[1] 4ual.a 0.7 0.6 1.6
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3qfv.a
3tku.b
4uak.a
4ual.a
[1] 3qfv.a
0
0.8 1.2 1.1
[1] 3tku.b 0.8
0
1.5 1.0
[1] 4uak.a 1.2 1.5
0
1.6
[1] 4ual.a 1.1 1.0 1.6
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...