MP2K4_HUMAN_79_399_allosteric

Dual specificity mitogen-activated protein kinase kinase 4 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MP2K4_HUMAN):D: Protein kinase (121,128,165,167:169,177)
95:98
95:98,121,128,165,167:169,177
Metals (Me):Mg

Full PDB list

3aln,3alo,3vut

Contact map

[download in TSV format]
   
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ligand
A1 Me
W
9
5
D
9
6
F
9
7
T
9
8
H
1
2
1
M
1
2
8
Y
1
6
5
A
1
6
7
L
1
6
8
F
1
6
9
C
1
7
7
[1]3alo.a DDEMtpoGYA 65 . . . . . . . . . . . Mg
[1]3aln.a none . . . . . . . . . . . Mg
[2]3vut.b none . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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