MP2K4_HUMAN_79_399_ATPsite

Dual specificity mitogen-activated protein kinase kinase 4 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MP2K4_HUMAN):D: Protein kinase (108:111,116,129,131,148,178:181,184,187,229,231,233,234,236,247)108:111,116,129,131,148,178:181,184,187,229,231,233,234,236,247
Metals (Me):Mg

Full PDB list

3aln,3alo,3vut (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1 Me
I
1
0
8
G
1
0
9
R
1
1
0
G
1
1
1
V
1
1
6
A
1
2
9
K
1
3
1
D
1
4
8
M
1
7
8
E
1
7
9
L
1
8
0
M
1
8
1
S
1
8
4
K
1
8
7
D
2
2
9
K
2
3
1
S
2
3
3
N
2
3
4
L
2
3
6
D
2
4
7
[1]3aln.b anp 31 . . . . . . . . . . . . . . . . . . . . Mg
[1]3aln.c anp 31 - - - - - - - A . . . . . . - . . . . .
[1]3vut.a none - - - - - - - . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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