MP2K2_HUMAN_55_400

Dual specificity mitogen-activated protein kinase kinase 2 [Protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MP2K2_HUMAN):D: Protein kinase (82,101,119,122,131,132,145,147,194,211:216,219,220,223)82,101,119,122,131,132,145,147,194,211:216,219,220,223
Cofactors (cF):atp
Metals (Me):Mg

Full PDB list

1s9i

Contact map

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ligand
A1 cF Me
N
8
2
K
1
0
1
L
1
1
9
L
1
2
2
V
1
3
1
G
1
3
2
I
1
4
5
M
1
4
7
D
1
9
4
C
2
1
1
D
2
1
2
F
2
1
3
G
2
1
4
V
2
1
5
S
2
1
6
L
2
1
9
I
2
2
0
M
2
2
3
[1]1s9i.a 5ea 31 . . . . . . . . . . . . . . . . . . atp Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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