If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

MLKL_HUMAN_185_471

Mixed lineage kinase domain-like protein [Protein kinase superfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (MLKL_HUMAN):D: Protein kinase (209:212, 215:217, 228, 230, 250, 253, 254, 263, 283:286, 289, 290, 293, 320, 329, 335, 336, 338, 347:350)209:212, 215:217, 228, 230, 250, 253, 254, 263, 283:286, 289, 290, 293, 320, 329, 335, 336, 338, 347:350

Full PDB list

4m67, 4mwi, 5knj, 5ko1 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
2
0
9
R
2
1
0
E
2
1
1
N
2
1
2
S
2
1
5
L
2
1
7
A
2
2
8
K
2
3
0
E
2
5
0
M
2
5
4
L
2
6
3
M
2
8
3
E
2
8
4
Y
2
8
5
C
2
8
6
G
2
8
9
E
2
9
3
L
3
2
0
S
3
3
5
N
3
3
6
L
3
3
8
A
3
4
8
G
3
4
9
[1]5ko1.a 6uy27 . . . . . . . . . . . . . . . . . . . . . . .
[2]4mwi.a none . . . . . . . . . . . . . . . . . . . . . . .
[3]5knj.b 6ux40 . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
2
0
9
R
2
1
0
E
2
1
1
N
2
1
2
S
2
1
5
T
2
1
6
L
2
1
7
A
2
2
8
K
2
3
0
E
2
5
0
T
2
5
3
M
2
5
4
L
2
6
3
M
2
8
3
E
2
8
4
Y
2
8
5
C
2
8
6
G
2
8
9
T
2
9
0
E
2
9
3
L
3
2
0
H
3
2
9
S
3
3
5
N
3
3
6
L
3
3
8
L
3
4
7
A
3
4
8
G
3
4
9
F
3
5
0
[1]5ko1.a . . . . . . . . . * . . . . . . . . . * . . . . . . . . *
[2]4mwi.a . * * * . . * . . * . . . . . . . . . * . . . . . . . . *
[3]5knj.b . * . . . . * . . . . . . . . . . . . . . . . . . . . . -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
5ko1.a:6uy
4mwi.a is apo
5knj.b:6ux
[1] 5ko1.a
0
- 6.9
[2] 4mwi.a 4.7
-
11
[3] 5knj.b 2.8 -
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (3 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
5ko1.a
4mwi.a
5knj.b
[1] 5ko1.a
0
.27 .29
[2] 4mwi.a .27
0
.40
[3] 5knj.b .29 .40
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5ko1.a
4mwi.a
5knj.b
[1] 5ko1.a
0
1.0 1.1
[2] 4mwi.a 1.0
0
1.4
[3] 5knj.b 1.1 1.4
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.0 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5ko1.a
4mwi.a
5knj.b
[1] 5ko1.a
0
1.3 1.4
[2] 4mwi.a 1.3
0
1.5
[3] 5knj.b 1.4 1.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...