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MKNK2_HUMAN_70_385

MAP kinase-interacting serine/threonine-protein kinase 2 [Protein kinase superfamily. CAMK Ser/Thr protein kinase family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (MKNK2_HUMAN):D: Protein kinase (90:92, 98, 111, 113, 143, 159:162, 165, 166, 209, 210, 212, 225)
R: Staurosporine binding (160:162)
90:92, 98, 111, 113, 143, 159:162, 165, 166, 209, 210, 212, 225

Full PDB list

2ac3, 2ac5, 2hw7 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
9
0
G
9
1
E
9
2
V
9
8
A
1
1
1
K
1
1
3
L
1
4
3
F
1
5
9
E
1
6
0
K
1
6
1
M
1
6
2
G
1
6
5
E
2
0
9
L
2
1
2
C
2
2
5
[1]2ac3.a none . . . . . . . . . . . . . . .
[1]2hw7.a stu35 . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
9
0
G
9
1
E
9
2
V
9
8
A
1
1
1
K
1
1
3
L
1
4
3
F
1
5
9
E
1
6
0
K
1
6
1
M
1
6
2
G
1
6
5
S
1
6
6
E
2
0
9
N
2
1
0
L
2
1
2
C
2
2
5
[1]2ac3.a . . . . . . . . . . . . . . . . .
[1]2hw7.a . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2ac3.a is apo
2hw7.a:stu
[1] 2ac3.a
-
1.1
[1] 2hw7.a -
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2ac3.a
2hw7.a
[1] 2ac3.a
0
.06
[1] 2hw7.a .06
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2ac3.a
2hw7.a
[1] 2ac3.a
0
0.8
[1] 2hw7.a 0.8
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2ac3.a
2hw7.a
[1] 2ac3.a
0
1.3
[1] 2hw7.a 1.3
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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