MK12_HUMAN_1_367_ATPsite

Mitogen-activated protein kinase 12 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MK12_HUMAN):D: Protein kinase (41,54,56,87,109:112,115,155,157,158,170,171)41,54,56,87,109:112,115,155,157,158,170,171
Metals (Me):Mg

Full PDB list

1cm8

Contact map

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ligand
A1 Me
V
4
1
A
5
4
K
5
6
I
8
7
M
1
0
9
P
1
1
0
F
1
1
1
M
1
1
2
D
1
1
5
K
1
5
5
G
1
5
7
N
1
5
8
L
1
7
0
D
1
7
1
[1]1cm8.a anp 31 . . . . . . . . . . . . . . Mg

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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