MK11_HUMAN_2_361

Mitogen-activated protein kinase 11 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MK11_HUMAN):D: Protein kinase (30,34,35,38,51:53,67,71,74,75,83,84,104,106:111,148,154,155,157,167:169)
R: Inhibitor-binding (106:110)
R: Inhibitor-binding (168,169)
30,34,35,38,51:53,67,71,74,75,83,84,104,106:111,148,154,155,157,167:169
Metals (Me):Na

Full PDB list

3gc8,3gc9,3gp0 (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1 Me
V
3
0
A
3
4
Y
3
5
V
3
8
A
5
1
V
5
2
K
5
3
R
6
7
E
7
1
L
7
4
L
7
5
V
8
3
I
8
4
L
1
0
4
T
1
0
6
T
1
0
7
L
1
0
8
M
1
0
9
G
1
1
0
A
1
1
1
H
1
4
8
S
1
5
4
N
1
5
5
A
1
5
7
L
1
6
7
D
1
6
8
F
1
6
9
[1]3gp0.a nil 39 . - - . . . . . . . . . . . . . . . . . . . . . . . .
[1]3gc9.a b45 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . Na

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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