If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

MK11_HUMAN_2_361

Mitogen-activated protein kinase 11 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (MK11_HUMAN):D: Protein kinase (30, 34, 35, 38, 51:53, 67, 71, 74, 75, 83, 84, 104, 106:112, 148, 154, 155, 157, 167:169, 171)
R: Inhibitor-binding (106:110)
R: Inhibitor-binding (168, 169)
30, 34, 35, 38, 51:53, 67, 71, 74, 75, 83, 84, 104, 106:112, 148, 154, 155, 157, 167:169, 171
Metals (Me):Na

Full PDB list

3gc8, 3gc9, 3gp0 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 Me
V
3
0
A
3
4
Y
3
5
V
3
8
A
5
1
V
5
2
K
5
3
R
6
7
E
7
1
L
7
4
L
7
5
V
8
3
I
8
4
L
1
0
4
T
1
0
6
T
1
0
7
L
1
0
8
M
1
0
9
G
1
1
0
A
1
1
1
H
1
4
8
S
1
5
4
N
1
5
5
A
1
5
7
L
1
6
7
D
1
6
8
F
1
6
9
[1]3gc9.a b4536 . . . . . . . . . . . . . . . . . . . . . . . . . . . Na
[1]3gp0.a nil39 . - - . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 Me
V
3
0
A
3
4
Y
3
5
V
3
8
A
5
1
V
5
2
K
5
3
R
6
7
E
7
1
L
7
4
L
7
5
V
8
3
I
8
4
L
1
0
4
T
1
0
6
T
1
0
7
L
1
0
8
M
1
0
9
G
1
1
0
A
1
1
1
D
1
1
2
H
1
4
8
S
1
5
4
N
1
5
5
A
1
5
7
L
1
6
7
D
1
6
8
F
1
6
9
L
1
7
1
[1]3gc9.a . . . . . . . . . . . . . . . . . . . . . . . . . . . * * Na
[1]3gp0.a . - - . . . . . . . . . . . . . . . . . . . . . . . . * -

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3gc9.a:b45
3gp0.a:nil
[1] 3gc9.a
0
7.1
[1] 3gp0.a 4.9
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3gc9.a
3gp0.a
[1] 3gc9.a
0
.18
[1] 3gp0.a .18
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3gc9.a
3gp0.a
[1] 3gc9.a
0
2.3
[1] 3gp0.a 2.3
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3gc9.a
3gp0.a
[1] 3gc9.a
0
3.1
[1] 3gp0.a 3.1
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...