MK08_HUMAN_2_364_allosteric

Mitogen-activated protein kinase 8 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MK08_HUMAN):D: Protein kinase (180,184,197:199,230,231,234,253,255,256,259,260)180,184,197:199,230,231,234,253,255,256,259,260

Full PDB list

1ukh,1uki,2g01,2gmx,2h96,2no3,2xrw,2xs0,3elj,3o17,3o2m,3pze,3v3v,3vud,3vug,3vuh,3vui,3vuk,3vul,3vum,4awi,4e73,4g1w,4hys,4hyu,4izy,4l7f,4qtd,4ux9,4yr8 (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
F
1
8
0
P
1
8
4
I
1
9
7
L
1
9
8
G
1
9
9
Y
2
3
0
I
2
3
1
W
2
3
4
Q
2
5
3
T
2
5
5
V
2
5
6
Y
2
5
9
V
2
6
0
[1]3o2m.a 46a 31 . . . . . . . . . . . . .
[2]2gmx.a none . . . . . . . . . . . . .
[1]3v3v.a none - . . . . H . . . . . . .
[1]3vui.a none - . . . . H . . . . . . .
[2]4ux9.d none . . . . . . . . . . . . .
[1]4yr8.e F-PNF 37 - - . . . H . . . . . . .
[1]4yr8.c F-NF 30 - - . . . H . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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