MK08_HUMAN_2_364_JIP

Mitogen-activated protein kinase 8 [Protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (MK08_HUMAN):D: Protein kinase (83,112,113,117,118,121,123,126,127,130,133,159:163,286,289)
323,324,326,327,329
83,112,113,117,118,121,123,126,127,130,133,159:163,286,289,323,324,326,327,329

Full PDB list

1ukh,1uki,2g01,2gmx,2h96,2no3,2xrw,2xs0,3elj,3o17,3o2m,3pze,3v3v,3vud,3vug,3vuh,3vui,3vuk,3vul,3vum,4awi,4e73,4g1w,4hys,4hyu,4izy,4l7f,4qtd,4ux9,4yr8 (redundant pocketome entry)

Contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
K
8
3
D
1
1
2
A
1
1
3
Q
1
1
7
V
1
1
8
M
1
2
1
L
1
2
3
E
1
2
6
R
1
2
7
Y
1
3
0
Y
1
3
3
V
1
5
9
K
1
6
0
S
1
6
1
D
1
6
2
C
1
6
3
H
2
8
6
L
2
8
9
V
3
2
3
W
3
2
4
D
3
2
6
P
3
2
7
E
3
2
9
[1]2gmx.a PKRPTTLNLF 84 . . . . . . . . . . . . . . . . . . . . . . .
[1]4hys.a PKRPTTLNL 72 . . . . . . . . . . . . . . . . - - . . . . .
[1]2xs0.a RPSRDHLYLPLE 106 . . . . . . . . . . . . . . . . . . . . . . .
[1]3vui.a PKRPTTLNLF 84 . . . . . . . . . . . . . . . A . . . . . . .
[1]3vum.a RPKRPTTLNLF 95 . . . . . . . . . . . . . . . A . . . . . . .
[1]4ux9.a PRPTLQLPLA 77 . . . . . . . . . . . . . . . . . . . . . . .
[1]4ux9.b PTLQLPLA 59 . . . . . . . . . . . . . . . . - . . . . . .
[1]4ux9.c QRPRPTLQLPLA 97 . . . . . . . . . . . . . . . . - . . . . . .
[1]4ux9.d QRPRP-QLPL 77 . . . . . . . . . . . . . . . . - . . . . . .
[1]4yr8.a none . . . . . . . . . . . . . . . . . . . . . . .
[1]4yr8.c K 9 . . . . . . . . . . . . . . . . . . . . . . .
[1]4yr8.f KKIKN 43 . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
Similar entries
Feedback